• Bulletin of the Korean Chemical Society
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• v.19 no.9
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• pp.968-973
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• 1998

Solvolyses of para-substituted phenyl chloroformates in water, $D_2O,\;CH_3OD$, 50% $D_2O-CH_3OD$, and in aqueous binary mixtures of acetone, ethanol, methanol are investigated at 25.0 ℃. Product selectivities are reported for a wide range of ethanol-water and methanol-water solvent compositions. These data are interpreted using the Grunwald-Winstein relationship, Hammett equation, and quantum mechanical model. Grunwald-Winstein plots of the first-order rate constants for phenyl chloroformates with $Y_{Cl}$ (based on 1-adamantyl chloride) show marked dispersions into three separate curves for the three aqueous mixtures with a small m value and a rate maximum for aqueous alcohol solvents. To account for these results, third-order rate constants, $k_{ww},\;k_{aw},\;k_{wa}$, and $k_{aa}$ were calculated from the observed $k_{ww}\;and\;k_{aa}$ values together with $k_{aw}\;and\;k_{wa}$ calculated from the computer fit. The kinetic solvent isotope effects determined in water and methanol are consistent with the proposed mechanism of the general base catalyzed carbonyl addition-elimination for para-substituted phenyl chloroformates solvolyses based on mass law and stoichiometric salvation effect studies. This study has shown that the quantum mechanical model predicts transition state variation correctly for $S_N2\;like\;S_AN$ reaction mechanism of para-substituted phenyl chloroformates.

• Journal of the Korea Society for Simulation
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• v.10 no.3
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• pp.47-58
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• 2001

Evaluation of Freeway Congestion Management Using Mesoscopic Traffic Simulator A mesoscopic simulation study to measure the effects of trip generation caused by rampant expansion of residential area around the Kyungbu corridor has been conducted. Some alternatives, which seem to be judgememtally plausible and technically feasible to mitigate such congestion, have been carefully examined and evaluated by the simulation model called INTEGRATION. Alternatives are mostly network improvements. Banpo IC dedicated ramp construction (A1), Seocho IC TSM based weaving elimination (A2), dedicated local and express separation over Seocho-Yangjae segment (A3), Heonleung IC (A4) and Daewang If installations (A5), Pangyo IC improvement (A6), Baikhyun IC (A7) and Dongbaek IC installations (A8) along with Shingal-Pangyo segment capacity addition (A9). The most capital intensive ones are A9, A5, and A4 in that order. A1, A6, A7, and A8 are short in distance but they are also capital intensive and need some construction periods. The least capital driven alternatives are h2 and A3, the h2 is easier to do, but A3 needs traffic diversion scheme during construction. The A1, A7, and A8 have been identified cost effective in terms of speed increase and travel time saving. Along with these results, some limitations and future research agenda regarding simulation have also been presented.

• Convergence Security Journal
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• v.21 no.1
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• pp.107-113
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• 2021

Recently, large-scale research and efforts aimed at the smart world such as smart city, smart home, smart transportation, and smart care are continuing. As these smart worlds become more common, the expansion of connectivity with the Internet and the threat of cyber terrorism will be inevitable. Increasing the threat of cyber terrorism is increasing the likelihood of a massive disaster and safety accident. Therefore, in this paper, we examine smart worlds that are expanded in various forms and derive the security threat factors that smart worlds have. In addition, it is proposed to block the threat of terrorism from abroad if access from abroad is not required when constructing a smart world. Through this, we intend to present a method to eliminate cyber terror threats for the establishment and operation of a safe smart world.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.68 no.1
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• pp.102-107
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• 2019

This paper proposes a method to improve the mass spectral detection performance of the residual gas analyzer. By improving the mode estimation method for setting the threshold value and improving the additive noise elimination method, it is possible to detect mass spectrums having low peak values of the threshold level difficult to distinguish from noise. Ion signal blocks for each mass index with noise removed by the improved method are effective for eliminating invalid ion signals based on the linear and quadratic fittings. The mass spectrum can be obtained from the quadratic fitted curves for the reconstructed ion signal block using only the valid ion signals. In addition, the resolution of the mass spectrum can be improved by correcting the error caused by the shift of the spectral peak position. To verify the performance of the proposed method, computer simulations were performed using real ion signals obtained from the residual gas analysis system under development. The simulation results show that the proposed method is valid.

• Structural Engineering and Mechanics
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• v.68 no.5
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• pp.621-632
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• 2018

Soft-story buildings have bottom stories much less rigid than the top stories and are susceptible to earthquake damage. Therefore, the seismic design specifications need strict design considerations in such cases. In this paper, a four-story building was investigated as a case study and the effects of X-braces elimination in its lower stories studied. In addition, the possibility of replacement of the X-braces in soft-stories with equivalent moment resisting frame inspected in two different phases. In first phase, the stiffness of X-braces and equivalent moment-resisting frames evaluated using classic equations. In final phase, diagonals removed from the lowest story to develop a soft-story and replaced with moment resisting frames. Then, the seismic stiffness variation of moment-resisting frame evaluated using nonlinear static and dynamic analyses. The results show that substitution of braced frames with an equivalent moment-resisting frame of the same stiffness increases story drift and reduces energy absorption capacity. However, it is enough to consider the needs of building codes, even using equivalent moment resisting frame instead of X-Braces, to avoid soft-story stiffness irregularity in seismic design of buildings. Besides, soft-story development in the second story may be more critical under strong ground excitations, because of interaction of adjacent stories.

• Journal of Ocean Engineering and Technology
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• v.33 no.2
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• pp.196-202
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• 2019

In this study, the excessive noise and vibration phenomena of a high-speed Ro/Ro passenger ship were analyzed, and a countermeasure was taken based on them. This ship was granted a comfort class notation by the classification society, which was COMFORT-VIBRATION-II and COMFORT-NOISE-CREW-II. However, unfortunately, excessive noise and vibration in the aft part of the ship were delivered from the twin shaft propellers, and therefore the Class Requirement was not satisfied before delivery. In order to obtain the class notation, all of the concerned parties came to an agreement to reduce the noise and vibration level during operation after delivery because a seasonal ferry service was already scheduled and the cabin was fully booked. The root cause of the massive amount of noise and vibration was mainly the propeller-induced excitation pulse and beating that occurred from the mismatch of the rotating speeds of the two shaft lines. A 1st order vibrating force and beating phenomena existed in the propeller. Thus, a reduction of the excitation force, elimination of the beating phenomena, and decrease of the noise level at the aft area cabins and public spaces were required. In addition, structural reinforcements were conducted using pillars and additional girders at the aft part of the decks.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.4
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• pp.1568-1589
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• 2021

Deployment of access point (AP) is a problem that must be considered in network planning. However, this problem is usually a NP-hard problem which is difficult to directly reach optimal solution. Thus, improved AP deployment optimization scheme based on swarm intelligence algorithm is proposed to research on this problem. First, the scheme estimates the number of APs. Second, the multi-objective particle swarm optimization (MOPSO) algorithm is used to optimize the location and transmit power of APs. Finally, the greedy algorithm is used to remove the redundant APs. Comparing with multi-objective whale swarm optimization algorithm (MOWOA), particle swarm optimization (PSO) and grey wolf optimization (GWO), the proposed deployment scheme can reduce AP's transmit power and improves energy efficiency under different numbers of users. From the experimental results, the proposed deployment scheme can reduce transmit power about 2%-7% and increase energy efficiency about 2%-25%, comparing with MOWOA. In addition, the proposed deployment scheme can reduce transmit power at most 50% and increase energy efficiency at most 200%, comparing with PSO and GWO.

• BMB Reports
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• v.55 no.1
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• pp.30-38
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• 2022

Cardiovascular disease, especially ischemic heart disease, is a major cause of mortality worldwide. Cardiac repair is one of the most promising strategies to address advanced cardiovascular diseases. Despite moderate improvement in heart function via stem cell therapy, there is no evidence of significant improvement in mortality and morbidity beyond standard therapy. The most salutary effect of stem cell therapy are attributed to the paracrine effects and the stem cell-derived exosomes are known as a major contributor. Hence, exosomes are emerging as a promising therapeutic agent and potent biomarkers of cardiovascular disease. Furthermore, they play a role as cellular cargo and facilitate intercellular communication. However, the clinical use of exosomes is hindered by the absence of a standard operating procedures for exosome isolation and characterization, problems related to yield, and heterogeneity. In addition, the successful clinical application of exosomes requires strategies to optimize cargo, improve targeted delivery, and reduce the elimination of exosomes. In this review, we discuss the basic concept of exosomes and stem cell-derived exosomes in cardiovascular disease, and introduce current efforts to overcome the limitations and maximize the benefit of exosomes including engineered biomimetic exosomes.

• The Journal of Korean Medical History
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• v.35 no.1
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• pp.69-86
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• 2022

This study examined guange (關格) in Yixuerumen (醫學入門) from a new perspective and evaluated its value in terms of emergency medicine. We compared and analyzed the definition, symptoms, and treatment methods of guange in Yixuerumen with related clinical presentations in modern medicine. Guange includes nausea and vomiting, dysphagia, dysuria, and constipation without diarrhea. A representative disease related to dysuria is uremia, while one related to constipation, nausea, and vomiting is enterocleisis, and and a third related to dysphagia is chronic esophagitis and esophagus cancer. Li Chan, the author of Yixuerumen, recognized guange as an emergency of serious eating and elimination disorder as various symptoms of diseases (病症) gradually get worse from the perspective of external diseases (外感病) and miscellaneous diseases (雜病) and handled it in various ways including yin-tonifying medicinals (補陰藥), qi-tonifying medicinals (補氣藥), qi-regulating formulas (理氣劑), phlegm-dispelling formulas (去痰劑), and "water rising, fire falling" formulas (水升火降) in addition to emetic formulas (催吐劑), diuretic formulas (滲利劑), and interior-attacking formula (攻裏劑). Concepts like guange in Yixuerumen were somewhat useful when handling the applicable emergencies at the level of then medical treatment.

• IMMUNE NETWORK
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• v.23 no.4
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• pp.30.1-30.18
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• 2023

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.