• Journal of Korean Neurosurgical Society
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• v.67 no.2
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• pp.249-256
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• 2024

The Leksell frame-based transcerebellar approach was proposed with the arc support frame attached upside down to the Z coordinate. This study presented practical tips and considerations for obtaining adequate tissue samples for deep-seated cerebellar lesions or lower brainstem lesions specifically those accessible via the cerebellar peduncle. For practical insights, the Leksell coordinate frame G was fixed to prevent the anterior screw implantation within the temporalis muscle, to avoid interference with the magnetic resonance (MR)-adapter, and taking into account the magnetic field of MR in close proximity to the tentorium. After mounting of indicator box, the MR imaging evaluation should cover both the indicator box and the infratentorial region that deviated from it. The coordinates [X, Y, Za, Arc⁰, Ringa⁰] obtained from Leksell SurgiPlan^® software (Elekta, Stockholm, Sweden) with arc 0⁰ located on the patient's right side were converted to [X, Y, Zb=360-Za, Arc⁰, Ringb⁰=Ringa⁰-180⁰]. The operation was performed in the prone position under general anesthesia in four patients with deep cerebellar (n=3) and brainstem (n=1) tumors. The biopsy results showed two cases of diffuse large B-cell lymphoma, one metastatic braintumor and one glioblastoma. One patient required frame repositioning as a complication. Drawing upon the methodology outlined in existing literature, we anticipate that imparting supplementary expertise could render the stereotactic biopsy of infratentorial tumors more consistent and manageable for the practitioner, thereby facilitating adequate tissue samples and minimizing patient complications.

• Journal of Veterinary Science
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• v.25 no.3
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• pp.35.1-35.13
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• 2024

Importance: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis characterized by inflammation within the central nervous system. However, inflammation in non-neuronal tissues, including the lungs, has not been fully evaluated. Objective: This study evaluated the inflammatory response in lungs of EAE mice by immunohistochemistry and histochemistry. Methods: Eight adult C57BL/6 mice were injected with myelin oligodendrocyte glycoprotein_35-55 to induce the EAE. Lungs and spinal cords were sampled from the experimental mice at the time of sacrifice and used for the western blotting, histochemistry, and immunohistochemistry. Results: Histopathological examination revealed inflammatory lesions in the lungs of EAE mice, characterized by infiltration of myeloperoxidase (MPO)- and galectin-3-positive cells, as determined by immunohistochemistry. Increased numbers of collagen fibers in the lungs of EAE mice were confirmed by histopathological analysis. Western blotting revealed significantly elevated level of osteopontin (OPN), cluster of differentiation 44 (CD44), MPO and galectin-3 in the lungs of EAE mice compared with normal controls (p < 0.05). Immunohistochemical analysis revealed both OPN and CD44 in ionized calcium-binding adapter molecule 1-positive macrophages within the lungs of EAE mice. Conclusions and Relevance: Taken together, these findings suggest that the increased OPN level in lungs of EAE mice led to inflammation; concurrent increases in proinflammatory factors (OPN and galectin-3) caused pulmonary impairment.

• International Journal of Internet, Broadcasting and Communication
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• v.16 no.1
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• pp.241-252
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• 2024

We analyze the types of Web3 business model innovation (BMI) of the six major Korean game companies by market size. As a result of the analysis, Nexon is watched as the adapter. It introduces blockchain (BC) layer 2, 'Polygon' to the extended ecosystem such as the creator's secondary creation, item utility, and compensation experience using the existing core intellectual property (IP). KakaoGames and Neowiz are watched as the adventurers. KakaoGames introduces BC layer 2, 'Polygon' and 'Near Protocol' to various experiments using tokenomics models in casual games and massively multiplayer online role-playing games (MMORPGs) using several existing popular IPs. Neowiz also introduces BC layer 2, 'Polygon' and 'Avalanche' to the IntellaX platform using existing game IPs. As the reinventor, Netmable positions as a game publisher that releases third-party games based on multi-chain infrastructure such as Klaytn, BNB Chain, Near Protocol, Aptos Foundation, and introduces BC to new core IPs. Finally, there are Wemade and Com2us as the mavericks. They aim to be the Web3 platform operators that create a BC layer 1 ecosystem and provide services that encompass BC games, GameFi, and non-fungible tokens (NFTs). Here are the implications of the four types of BMI. In terms of infrastructure, Nexon, KakaoGames, and Neowiz try to introduce a part of cross-chain, whereas Netmable tries to move toward a complete multi-chain strategy, and Wemade and Com2us also try to consider multi-chain, even if they have the full BC introduction. In terms of defending against market decline, Nexon and Netmable have a different position. Nexon which has a greater market dominance, only tries to continuously experiment, but Netmable is aggressively focusing on monetizing new products. Attacks on growth aspirations also show two different positions. KakaoGames and Neowiz only try to aggressively explore, while WeMade and Com2us try to set new standards for industrial innovation.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1707-1714
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• 2012

Grb2 is an adapter protein involved in the signal transduction and cell communication. The Grb2 is responsible for initiation of kinase signaling by Ras activation which leads to the modification in transcription. Ligand based pharmacophore approach was applied to built the suitable pharmacophore model for Grb2. The best pharmacophore model was selected based on the statistical values and then validated by Fischer's randomization method and test set. Hypo1 was selected as a best pharmacophore model based on its statistical values like high cost difference (182.22), lowest RMSD (1.273), and total cost (80.68). It contains four chemical features, one hydrogen bond acceptor (HBA), two hydrophobic (HY), and one ring aromatic (RA). Fischer's randomization results also shows that Hypo1 have a 95% significant level. The correlation coefficient of test set was 0.97 which was close to the training set value (0.94). Thus Hypo1 was used for virtual screening to find the potent inhibitors from various chemical databases. The screened compounds were filtered by Lipinski's rule of five, ADMET and subjected to molecular docking studies. Totally, 11 compounds were selected as a best potent leads from docking studies based on the consensus scoring function and critical interactions with the amino acids in Grb2 active site.

• Journal of Dental Rehabilitation and Applied Science
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• v.27 no.1
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• pp.91-97
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• 2011

The purpose of this study was to evaluate RPM maintenance in X-Smart according to the power supplied by the AC adapter and rechargeable battery. Five new X-Smart were used in this study. A handpiece with rubber disk which has reflective tape was mounted on the vice. To measure the RPM, a non-contact type digital tachometer was used. RPM measurements were recorded every 5 minutes to 180 minutes and repeated 3 times per motor from each power source. To evaluate a difference of the RPM changes, two-way repeated measures were performed using $SPSS^{TM}$ 14.0. All tests were conducted at the 95 percent confidence level. There was no significant difference in the RPM change between the power sources. Continuous use of X-Smart with a rechargeable battery for up to 180 minutes could be safely used as an endodontic wireless motor with a reliable RPM maintenance.

• Journal of KIISE:Computer Systems and Theory
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• v.34 no.9
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• pp.459-466
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• 2007

TCP/IP processing imposes a heavy load on the host CPU when it is processed by the host CPU on a very high-speed network. Recently the TCP/IP Offload Engine (TOE), which processes TCP/IP on a network adapter instead of the host CPU, has become an attractive solution to reduce the load in the host CPU. There have been two approaches to implement TOE. One is the software TOE in which TCP/IP is processed by an embedded processor and the other is the hardware TOE in which TCP/IP is processed by a dedicated ASIC. The software TOE has poor performance and the hardware TOE is neither flexible nor expandable enough to add new features. In this paper we designed and implemented a hybrid TOE architecture, in which TCP/IP is processed by cooperation of hardware and software, based on an FPGA that has two embedded processor cores. The hybrid TOE can have high performance by processing time-critical operations such as making and processing data packets in hardware. The software based on the embedded Linux performs operations that are not time-critical such as connection establishment, flow control and congestions, thus the hybrid TOE can have enough flexibility and expandability. To improve the performance of the hybrid TOE, we developed a hardware-based transmission/reception accelerator that processes important operations such as creating data packets. In the experiments the hybrid TOE shows the minimum latency of about $19{\mu}s$. The CPU utilization of the hybrid TOE is below 6 % and the maximum bandwidth of the hybrid TOE is about 675 Mbps.

• KIPS Transactions on Computer and Communication Systems
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• v.5 no.11
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• pp.403-410
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• 2016

IoT(Internet of Things) has purpose for providing new kind of service though interaction with everything. With development of IoT, computer model which is based on internet is changed to distributed connection model between heterogeneous things. There is a problem that it is impossible to connect between each other different protocols. To solve this problem, we should abstract each of things of data through using adaptor of middleware structure in order to make consistent data unit. In this paper, we propose BLE(Bluetooth Low Energy) adaptor, which is interaction with things, based on DDS(Data Distribution Service) that is real-time standard middleware. It is possible to data interaction between BLE Devices as well as two-way data interaction with different protocol devices. Also existing BLE Devices and study have a problem that Data exchange without using a standard data format of a profile defined by the Bluetooth SIG. Using the data formats defined independently by a problem that should not exchange data according to the type and manufacturer of the device BLE. The BLE adapter to solve this problem, the classification and analysis of the 12 stand profile was applied to create a profile based on the standard data format. It is possible to get wide interoperability of not affected on the BLE devices type and manufacturer of the device because it is applied a profile that standard data format.

• Journal of KIISE:Computer Systems and Theory
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• v.32 no.11_12
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• pp.557-565
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• 2005

This paper presents the development and implementation of a zero-copy file transfer mechanism that improves the efficiency of file transfers for PC cluster systems using hardware-based VIA(Virtual Interface Architecture) network adapters. VIA is one of the representative user-level communication interfaces, but because there is no library for file transfer, one copy occurs between kernel buffer and user boilers. Our mechanism presents a file transfer primitive that does not require the file system to be modified and allows the NIC to transfer data from the kernel buffer to the remote node directly without copying. To do this, we have developed a hardware-based VIA network adapter, which supports the PCI 64bit/66MHz bus and Gigabit Ethernet, as a NIC, and implemented a zero-copy file transfer mechanism. The experimental results show that the overhead of data coy and context switching in the sender is greatly reduced and the CPU utilization of the sender is reduced to $30\%\~40\%$ of the VIA send/receive mechanism. We demonstrate the performance of the zero-copy file transfer mechanism experimentally. and compare the results with those from existing file transfer mechanisms.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.7
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• pp.413-420
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• 2006

The speed of present-day network technology exceeds a gigabit and is developing rapidly. When using TCP/IP in these high-speed networks, a high load is incurred in processing TCP/IP protocol in a host CPU. To solve this problem, research has been carried out into TCP/IP Offload Engine (TOE). The TOE processes TCP/IP on a network adapter instead of using a host CPU; this reduces the processing burden on the host CPU. In this paper, we developed two software-based TOEs. One is the TOE implementation using an embedded Linux. The other is the TOE implementation using Lightweight TCP/IP (lwIP). The TOE using an embedded Linux did not have the bandwidth more than 62Mbps. To overcome the poor performance of the TOE using an embedded Linux, we ported the lwIP to the embedded system and enhanced the lwIP for the high performance. We eliminated the memory copy overhead of the lwIP. We added a delayed ACK and a TCP Segmentation Offload (TSO) features to the lwIP and modified the default parameters of the lwIP for large data transfer. With the aid of these modifications, the TOE using the modified lwIP shows a bandwidth of 194 Mbps.

• Journal of Life Science
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• v.18 no.12
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• pp.1637-1643
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• 2008

This study has investigated whether extracellular HSP90 predisposes vascular smooth muscle cells (VSMCs) to pro-inflammatory phenotype. Exposure of rat aortic smooth muscle cells to HSP90 not only enhanced IL-6 release but also profoundly induced IL-6 transcript via promoter activation. HSP90-induced IL-6 promoter activation was suppressed by dominant-negative forms of Toll-like receptor (TLR)-4 and myeloid differentiation factor 88 (MyD88), but not by dominant-negative-forms of TLR-3 and TIR-domain-containing adapter-inducing interferon-${\beta}$ (TRIF). Curcumin, which inhibits dimerization of TLR-4, also attenuated the IL-6 induction by HSP90. Mutation at the NF-${\kappa}B$- or C/EBP-binding site in the IL-6 promoter region suppressed the promoter activation in response to HSP90. The gene delivery of $I{\kappa}B$ using recombinant adenoviruses and treatment with resveratrol, which inhibit NF-${\kappa}B$ activity, attenuated the HSP90-induced IL-6 release from VSMCs. The present study proposes that extracellular HSP90 would contribute to inflammatory reaction in the stressed vasculature by inducing IL-6 in VSMCs, and that TLR-4 and NF-${\kappa}B$ would play active roles in the process.