• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.21 no.2
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• pp.133-138
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• 2010

Background and Objectives : High-speed imaging can be useful in studies of linguistic and artistic singing styles, and laryngeal examination of patients with voice disorders, particularly in irregular vocal fold vibrations. In this study, we introduce new laryngeal imaging systems which are commercially available high speed cameras connected with a laryngoscope. Materials and Method : The laryngeal images were captured from three different types of cameras. First, the adapter was made to connect with laryngoscope and Casio EX-F1 to capture the images using $2{\times}150$ Watt Halogen light source (EndoSTROB) at speeds of 1,200 tps (frame per second)($336{\times}96$). Second, Phantom Miro ex4 was used to capture the digital laryngeal images using Xenon Nova light source 175 Watt (STORZ) at speeds of 1,920 fps ($512{\times}384$). Finally, laryngeal images were captured using MotionXtra N-4 with 250 Watt halogen lamp (Olympus CLH-250) light source at speeds of 2,000tps ($384{\times}400$) by connecting with laryngoscope. All images were transformed into the Kymograph using KIPS (Kay's image processing Software) of Kay Pentex Inc. Results: Casio EX-F1 was too small to adjust the focus and screen size was diminished once the images were captured despite of high resolution images. High quality of color images could be obtained with Phantom Miro ex4 whereas good black and white images from Motion Xtra N-4 Despite of some limitations of illumination problems, limited recording time capacity, and time consuming procedures in Phantom Miro ex4 and Motion Xtra N-4, those portable devices provided high resolution images. Conclusion : All those high speed cameras could capture the laryngeal images by connecting with laryngoscope. High resolution images were able to be captured at the fixed position under the good lightness. Accordingly, these techniques could be applicable to observe the vocal fold vibration properties in the clinical practice.

• Journal of Advanced Navigation Technology
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• v.17 no.5
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• pp.560-567
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• 2013

In this paper, it is proposed the fault detection method of the ASIC, without the Test Requirement Document(TRD), extracting internal logic circuit and analyzed the function of the ASIC using the multipurpose development program and simulation. If there don't have the TRD, it is impossible to analyze the operation of the circuit and find out the fault detection in any chip. Therefore, we make the TRD based on the analyzed logic data of the ASIC, and diagnose of the ASIC circuit at the gate level through the signal control of I/O pins using the Dynamic Pattern signal. According to the experimental results of the proposed method, we is confirmed the good performance of the fault detection capabilities which applied to the non-memory circuit.

• Journal of Korean Neurosurgical Society
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• v.60 no.4
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• pp.471-474
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• 2017

Objective : The thromboembolic events during neuroendovascular therapy (NET) are the major complications of concern that can be occasionally fatal. The thrombotic occlusion of the guide catheter for NET is thought to be the risk of the thromboembolic events. We have developed an idea for inventing the monitoring system of the continuous irrigation through the guide catheter. We herein present a unique invention of the guide catheter irrigation monitoring device. Methods : We have developed ideas for preventing the thrombotic occlusion of the guide catheter. In order to design a convenient device working in the practical use, we have consulted and shared the ideas with the electrical engineers about putting the invention. Results : The guide catheter irrigation monitoring device (GCIMD) consisted of three parts of optical sensor, main body and electric adapter. In brief, the basic principles of working of the GCIMD are as follows. The optical sensor is attached to the dripping chamber of the line to irrigation solution. The main body had the small light and speaker to make an alarm sounds. The sensor monitors the dripping of flush solution. If the dripping stops more than three seconds, a warning alarm has been activated. So, the operating physicians can concentrate and check the guide catheter irrigation. After the use of the GCIMD, there was no major thromboembolic complication in conjunction with the thrombotic occlusion of the guide catheter in our institute. Conclusion : We have developed a brilliant invention of the GCIMD for NET.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.3
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• pp.173-186
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• 2013

Web-based map services provide various geographic information that users want to get by continuous updating of data. Those map services provide different information for a geographic object respectively. It causes several problems, and most of all various information cannot be integrated and provided. To resolve the problem, this paper proposes a system which can integrate diverse geographic information and provide users rich geographic information. In this paper, a hybrid schema matching (HSM) algorithm is proposed and the algorithm is a mixture of the adapter-based semantic processing method, static semantic management-based approach, and dynamic semantic management-based approach. A comparative evaluation is described to show effectiveness of the proposed algorithm. The proposed algorithm in this paper improves the accuracy of schema matching because of registration and management of schemas of new semantic information. The proposal enables vocabulary-based schema matching using various schemas, and it thus also supports high usability. Finally, the proposed algorithm is cost-effective by providing the progressive extension of relationships between schema meanings.

• Journal of the Korea Society of Computer and Information
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• v.26 no.1
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• pp.163-170
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• 2021

As a big data is being used in various industries, big data market is expanding from hardware to infrastructure software to service software. Especially it is expanding into a huge platform market that provides applications for holistic and intuitive visualizations such as big data meaning interpretation understandability, and analysis results. Demand for big data extraction and analysis using social media such as SNS is very active not only for companies but also for individuals. However despite such high demand for the collection and analysis of social media data for user trend analysis and marketing, there is a lack of research to address the difficulty of dynamic interlocking and the complexity of building and operating software platforms due to the heterogeneity of various social media service interfaces. In this paper, we propose a method for developing a framework to operate the process from collection to extraction and classification of social media data. The proposed framework solves the problem of heterogeneous social media data collection channels through adapter patterns, and improves the accuracy of social topic extraction and classification through semantic association-based extraction techniques and topic association-based classification techniques.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.483-491
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• 2021

Parkinson's disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the progressive pathology of various inflammatory disorders. In this study, we administered an MMP-8 inhibitor (MMP-8i) in Leucine-rich repeat kinase 2 (LRRK2) G2019S transgenic mice, to determine the effects of MMP-8i on PD pathology. We observed a significant increase of ionized calcium-binding adapter molecule 1 (Iba1)-positive activated microglia in the striatum of LRRK2 G2019S mice compared to normal control mice, indicating enhanced neuro-inflammatory responses. The increased number of Iba1-positive activated microglia in LRRK2 G2019S PD mice was down-regulated by systemic administration of MMP-8i. Interestingly, this LRRK2 G2019S PD mice showed significantly reduced size of cell body area of tyrosine hydroxylase (TH) positive neurons in SN region and MMP-8i significantly recovered cellular atrophy shown in PD model indicating distinct neuro-protective effects of MMP-8i. Furthermore, MMP-8i administration markedly improved behavioral abnormalities of motor balancing coordination in rota-rod test in LRRK2 G2019S mice. These data suggest that MMP-8i attenuates the pathological symptoms of PD through anti-inflammatory processes.

• Journal of Software Assessment and Valuation
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• v.16 no.2
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• pp.109-115
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• 2020

In this paper, the problem that occurs when negative voltage is generated using an inexpensive buck device in an IT device that is supplied with a single power by an adapter or battery is analyzed. For the cause analysis, the principle of operation of the buck device and the principle of the inverter circuit were examined, and the circuit characteristics of the inverter circuit were analyzed using the buck device. As a result of the analysis, it was confirmed that the inverter circuit using the buck device initially needs a large starting current, and in particular, in the case of a current capacity that is less than the starting current in the circuit that supplies power, it was confirmed that it could fall into a state similar to the latch-up phenomenon. In order to confirm the analysis result, an experimental circuit was constructed and the input current was checked. If the supply current is sufficient, it is confirmed that over-current flows and starts. If the supply current is insufficient, the circuit cannot start and a latch-up phenomenon occurs.

• Molecules and Cells
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• v.45 no.8
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• pp.588-602
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• 2022

Various RNA-binding proteins (RBPs) are key components in RNA metabolism and contribute to several neurodevelopmental disorders. To date, only a few of such RBPs have been characterized for their roles in neocortex development. Here, we show that the RBP, Rbms1, is required for radial migration, polarization and differentiation of neuronal progenitors to neurons in the neocortex development. Rbms1 expression is highest in the early development in the developing cortex, with its expression gradually diminishing from embryonic day 13.5 (E13.5) to postnatal day 0 (P0). From in utero electroporation (IUE) experiments when Rbms1 levels are knocked down in neuronal progenitors, their transition from multipolar to bipolar state is delayed and this is accompanied by a delay in radial migration of these cells. Reduced Rbms1 levels in vivo also reduces differentiation as evidenced by a decrease in levels of several differentiation markers, meanwhile having no significant effects on proliferation and cell cycle rates of these cells. As an RNA binding protein, we profiled the RNA binders of Rbms1 by a cross-linked-RIP sequencing assay, followed by quantitative real-time polymerase chain reaction verification and showed that Rbms1 binds and stabilizes the mRNA for Efr3a, a signaling adapter protein. We also demonstrate that ectopic Efr3a can recover the cells from the migration defects due to loss of Rbms1, both in vivo and in vitro migration assays with cultured cells. These imply that one of the functions of Rbms1 involves the stabilization of Efr3a RNA message, required for migration and maturation of neuronal progenitors in radial migration in the developing neocortex.

• Animal Bioscience
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• v.36 no.7
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• pp.1120-1129
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• 2023

Objective: This study aimed to determine the protective efficacy of Buddha's Temple (BT) extract against tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in Gallus gallus chicken embryo fibroblast cell line (DF-1) and its effects on the cell lipid metabolism. Methods: In this experimental study, Gallus gallus DF-1 fibroblast cells were pretreated with BT 10^-7 for 24 hours, followed by their six-hour exposure to t-BHP (100 μM). Water-soluble tetrazolium salt-8 (WST-8) assays were performed, and the growth curve was computed. The intracellular gene expression changes caused by BT extract were confirmed through quantitative polymerase chain reaction (qPCR). Flow cytometry, oil red O staining experiment, and thin-layer chromatography were performed for the detection of intracellular metabolic mechanism changes. Results: The WST-8 assay results showed that the BT pretreatment of Gallus gallus DF-1 fibroblast cell increased their cell survival rate by 1.08%±0.04%, decreased the reactive oxygen species (ROS) level by 0.93%±0.12% even after exposure to oxidants, and stabilized mitochondrial activity by 1.37%±0.36%. In addition, qPCR results confirmed that the gene expression levels of tumor necrosis factor α (TNFα), TIR domain-containing adapter inducing IFN-beta (TICAM1), and glucose-regulated protein 78 (GRP78) were regulated, which contributed to cell stabilization. Thin-layer chromatography and oil red O analyses showed a clear decrease in the contents of lipid metabolites such as triacylglycerol and free fatty acids. Conclusion: In this study, we confirmed that the examined BT extract exerted selective protective effects on Gallus gallus DF-1 fibroblast cells against cell damage caused by t-BHP, which is a strong oxidative inducer. Furthermore, we established that this extract significantly reduced the intracellular ROS accumulation due to oxidative stress, which contributes to an increase in poultry production and higher incomes.

• Journal of Information Science Theory and Practice
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• v.10 no.spc
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• pp.56-65
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• 2022

Korea Institute of Science and Technology Information (KISTI) is a Worldwide LHC Computing Grid (WLCG) Tier-1 center mandated to preserve raw data produced from A Large Ion Collider Experiment (ALICE) experiment using the world's largest particle accelerator, the Large Hadron Collider (LHC) at European Organization for Nuclear Research (CERN). Physical medium used widely for long-term data preservation is tape, thanks to its reliability and least price per capacity compared to other media such as optical disk, hard disk, and solid-state disk. However, decreasing numbers of manufacturers for both tape drives and cartridges, and patent disputes among them escalated risk of market. As alternative to tape-based data preservation strategy, we proposed disk-only erasure-coded archival storage system, Custodial Disk Storage (CDS), powered by Exascale Open Storage (EOS), an open-source storage management software developed by CERN. CDS system consists of 18 high density Just-Bunch-Of-Disks (JBOD) enclosures attached to 9 servers through 12 Gbps Serial Attached SCSI (SAS) Host Bus Adapter (HBA) interfaces via multiple paths for redundancy and multiplexing. For data protection, we introduced Reed-Solomon (RS) (16, 4) Erasure Coding (EC) layout, where the number of data and parity blocks are 12 and 4 respectively, which gives the annual data loss probability equivalent to 5×10^-14. In this paper, we discuss CDS system design based on JBOD products, performance limitations, and data protection strategy accommodating EOS EC implementation. We present CDS operations for ALICE experiment and long-term power consumption measurement.