• 한국항행학회논문지
• /
• 제13권6호
• /
• pp.854-860
• /
• 2009

유비쿼터스는 정보통신 기술과 IT 기술 등이 접목된 새로운 컴퓨팅 환경으로서, PDA를 비롯한 다양한 기기와 여러 분야의 응용기술이 적용되었다. 최근엔 통신 기능과 다양한 IT 기능이 접목되고 휴대성이 좋은 스마트 폰의 출현으로 사용자들의 기기 이용 환경이 변화하고 있다. 이러한 스마트 폰의 활용은 환경의 제약없이 사용자들에게 학습 기기로서의 역할까지로 확장되고 있다. 따라서 본 연구에서는 스마트 폰에서 U-러닝을 제공하기 위하여 SCORM 기반의 메타데이터를 설계하였다. 이를 위하여, 기존의 LMS와 연동된 SCORM을 U-러닝 서버와 스마트 폰 처리 서버를 두어 이를 핸들링 하도록 하였다. 각기 다른 특성을 가지는 스마트 폰의 적용을 위하여 메타데이터에서는 CPU, 화면크기, 메모리 등의 자원 정보를 가지도록 하였으며, 메타데이터 아답터가 이를 처리하도록 하였다.

• 대한기계학회논문집A
• /
• 제21권2호
• /
• pp.189-198
• /
• 1997

This paper presents development of a practical tool deflection compensation system in order to reduce the machining error from the tool deflection compensation system in order to reduce the machining error from the tool deflection in the end-milling process. The devised system is a tool adapter which includes 1-axes force sensor for detecting tool deflection and 2-axes tool tilting device for adjusting tool position through computer interface on line process. Experimental in investigations for typical shaped workpieces representing various end milling situations are performed to verify the ability of the system to suppress the surface errors due to tool deflections. With the system, it is possible to get precise machining surface without any excessive machining error due to increased cutting force in more productive machining conditions.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2016년도 추계학술발표대회
• /
• pp.845-848
• /
• 2016

본 연구는 고층으로 이루어진 카페 고객의 전기 남용 문제를 해결하는 것을 목적으로 한다. 현재 각 카페는 콘센트를 고객에게 제공함으로써 고객의 편의를 돕고 있다. 하지만 고객이 이를 악용하여 장시간 전기를 이용하여 카페 회전율을 낮추고, 이에 따른 전기요금 과다 현상이 나타나고 있다. 따라서 본 연구는 이러한 문제점을 해결하기 위해 카페의 각 콘센트에 멀티 랩을 고정하고 소켓을 PC 응용 프로그램을 통하여 제어하고자 한다. 본 연구를 수행함으로써 장시간 전기를 이용하는 고객과 무단으로 침입하여 전기를 사용하는 고객을 배제 할 수 있다. 또한 전기 사용 기본 제공시간을 정하여 직원의 번거로움을 줄일 수 있다.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2005년도 추계학술대회 논문집 Vol.18
• /
• pp.226-229
• /
• 2005

In this study, a step-down piezoelectric transformer was fabricated to utilize as an adapter for charging batteries of mobile electronic appliances. The ceramic part of the transformer is $Pb[(Mn_{1/3}Sb_{2/3})_{0.05}Zr_{0.475}Ti_{0.475}]O_3$ with mechanical quality factor of 1600, electromechanical coupling coefficient 59 %, and piezoelectric constant d33 1300, which can be utilized as a piezoelectric transformer. A simply fabricated disk-typed test pattern of diameter 28 mm and thickness 2 mm was used to characterize resonant frequency, Qm, kp according to the different input/output electrode area. efficiency and power as a function of load resistance was also investigated. The sample APT showed some spurious mode and BPT showed better frequency property. Taking all properties which are admittance, effective electromechanical coupling coefficient and mechanical quality factor most suitable for piezoelectric transformer is BPT which has 12 mm diameter electrode and the condition of 15 Vrms, 30 $\Omega$ made the maximum efficiency of 93.7 % and maximum power is 6W with 50 Vrms.

• Molecules and Cells
• /
• 제28권4호
• /
• pp.365-368
• /
• 2009

Toll-like receptors (TLRs) play an important role in host defense by sensing invading microbial pathogens and initiating innate immune responses. The stimulation of TLRs by microbial components triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-${\beta}$ (TRIF)-dependent downstream signaling pathways. Isoliquiritigenin (ILG), an active ingredient of Licorice, has been used for centuries to treat many chronic diseases. ILG inhibits the MyD88-dependent pathway by inhibiting the activity of inhibitor-${\kappa}B$ kinase. However, it is not known whether ILG inhibits the TRIF-dependent pathway. To evaluate the therapeutic potential of ILG, we examined its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by several agonists. ILG inhibited nuclear factor-${\kappa}B$ and interferon regulatory factor 3 activation induced by lipopolysaccharide or polyinosinic-polycytidylic acid. ILG inhibited the lipopolysaccharide-induced phosphorylation of interferon regulatory factor 3 as well as interferon-inducible genes such as interferon inducible protein-10, and regulated activation of normal T-cell expressed and secreted (RANTES). These results suggest that ILG can modulate TRIF-dependent signaling pathways of TLRs, leading to decreased inflammatory gene expression.

• 대한수의학회지
• /
• 제53권3호
• /
• pp.159-162
• /
• 2013

Galectin-3 is a ${\beta}$-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler's murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.

• Journal of Biosystems Engineering
• /
• 제12권3호
• /
• pp.7-16
• /
• 1987

This study was carried out to develop a microcomputer-based data acquisition and control system which was able to collect the data of engine performance test automatically and control the speed and load of the engine. The results of the study are summarized as follows: 1. The signal processing devices, which were able to measure cylinder pressure, coolant temperature, compositions of exhaust gas, fuel consumption, engine rpm and torque etc., were developed. The results of calibration showed that all of devices had high accuracy ranging from 0.3% to 0.69% respectively. 2. The PIA (peripheral interface adapter) for interfacing digital signal and PTM (programmable timer module) for displaying real time every 0.0408 sec were designed and developed. 3. An engine-speed control system using a stepping motor and driver was developed. The control system had the stability, and faster settling time than the manual control system. 4. The automatic control system of electrical dynamometer, which was able to control the speed and load of dynamometer, was developed with a SSD (shackleton system driver) and D/A converter. 5. The computer programs, which were able to collect and process the data of engine tests, were developed using both the machine language and BASIC.

• 한국전기전자재료학회논문지
• /
• 제18권11호
• /
• pp.1007-1013
• /
• 2005

In this study, a step-down piezoelectric transformer was fabricated to utilize as an adapter for charging batteries of mobile electronic appliances. The ceramic part of the transformer is $Pb[(Mn_{1/3}Sb_{2/3})_{_0.05}Zr_{0.475}Ti_{0.475}]O_3$ with mechanical quality factor of 1600, electromechanical coupling coefficient $59\%$, and piezoelectric constant $d_{33}$ 1300, which can be utilized as a piezoelectric transformer. A simply fabricated disk-typed test pattern of diameter 28 mm and thickness 2 mm was used to characterize output voltage, step-down ratio as a function of electrode area with the input remained constant, and power, efficiency as a function of input voltage, and temperature-dependent electric characteristics were evaluated. The sample APT1 showed the best properties. The highest admittance, effective electromechanical coupling coefficient and an appropriate mechanical quality factor were obtained at the sample with the input/output area ratio of 1:1.5 at the common electrode, and the condition of 20 $V_{rms}$, $50\;\Omega$ made the maximum efficiency of $95\%$. The temperature was increased by 14.7'E as the input voltage was increased for $50\;V_{rms},\;50\;\Omega$.

• Journal of Plant Biology
• /
• 제37권3호
• /
• pp.349-355
• /
• 1994

Viral RNA was extracted from a purified orchid strain of tobacco mosaic virus (TMV-O) from Cymbidium "Grace Kelly". Polyadenylated viral RNAs were primed with Not I-oligo (dT) primer-adapter. First-strand cDNAs were reversely transcribed by Moloney murine leukaemia virus reverse transcriptase (RNAse H-), and then second-strand cDNAs were synthesized by RNase H and DNA polymerase I. The resulting double-stranded cDNAs were ligated into pSPORT1 vector and transformed into competent E. coli strain JM109 cells. The size of cDNAs within the recombinant plasmids was ranging from 0.9 to 3.9 kb. Among the selected clones, pTMO-0205 and -0210 covered the 3' half and the 5' half of the viral genomic RNA, respectively, which were covering more than 99% of the viral genemo size based on sequencing analysis. Two cDNA fragments which were 3.1 kb BamHI and NotI fragement released from pTMO-0.205 and 3.3 kb SalI and BamHI fragment released from pTMO-0210 were ligated with T4 DNA ligase. The clone was almost entire length, lacking only 31 nucleotides from the 5' terminus based on the sequencing result. This method was shown to be efficiently applicable to other plant viral gnomic RNA for the construction of cDNA.n of cDNA.

• Bulletin of the Korean Chemical Society
• /
• 제31권11호
• /
• pp.3241-3246
• /
• 2010

NHERF ($Na^+/H^+$ exchanger regulatory factor) and E3KARP (NHE3 kinase A regulatory protein) play important roles in membrane targeting, trafficking and sorting of ion channels, transmembrane receptors and signaling proteins in many tissues. Each of these proteins contains two PDZ (PSD-95/Dlg-1/ZO-1) domains, which mediate the assembly of transmembrane and cytosolic proteins into functional signal transduction complexes. The interaction between NHERF and E3KARP was investigated by surface plasmon resonance spectroscopy (BIAcore), fluorescence measurement, His-tagged pull-down experiment, and size-exclusion column (SEC) chromatography. BIAcore experiments revealed that NHERF bound to E3KARP with an apparent $K_D$ of 7 nM. Fluorescence emission spectra of the NHERF-E3KARP complex suggested that the tight interaction between these proteins was accompanied by significant conformational changes in one or both. The CD spectra of NHERF and E3KARP show that the conformational changes of these proteins were dependent on pH and temperature. These results implicate that the NHERF-E3KARP complex allows intracellular signaling complexes to form through PDZ-PDZ interactions.