• The Journal of the Korea Contents Association
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• v.14 no.12
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• pp.796-807
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• 2014

This study examined effects of gender role conflicts, academic stress coping ability, and social support on adaptations to college life among male nursing students. Data were collected through self reported structured questionnaire form 225 male nursing students using convenient sampling methods from April 1 to June 4, 2014. Stepwise regression showed that academic stress coping ability had the greatest effect on adaptations to college life(${\beta}=0.33$, p<.001), followed by major satisfaction, social support, gender role conflicts and club activity. These variables together explained 33% of the adaptations to college life in male nursing students(F=23.50, p<.001). Therefore, programs for resolving gender role conflicts and reinforcing academic stress coping ability should be developed. And social support network which consist of professors and the senior-junior nursing students will help to improve adaptability to college life in male nursing students.

• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.14-22
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• 2022

This study was conducted to promote male nursing students' adaptation to college life by identifying life stress, grit, and degree of adaptation to college life, and the effect of grit mediating effect on the relationship between life stress and college life adjustment. became The subjects of this study were 209 male nursing college students enrolled in nursing departments in 5 major cities. The collected data were analyzed with SPSS/WIN 25.0. Life stress showed a significant negative correlation with college life adaptation and grit, but grit showed a positive correlation with college life adaptation. As a result of mediating effect verification, the final model explained 43.5% of college life adaptation. Therefore, in order to improve male nursing students' adaptation to college life, it is required to develop a program that can lower life stress and increase grit and college life adaptation level.

• Journal of Korean Academy of Nursing
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• v.41 no.4
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• pp.558-567
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• 2011

Purpose: The purpose of this study was to monitor the use of health-related quality of life (HRQOL) instruments in Korean studies of patients with diabetes. Methods: Of 86 Korean studies initially identified, 17 studies met the inclusion criteria. For each study, a description of the instrument and its psychometric properties were monitored by the Instrument Review Criteria of the Scientific Advisory Committee. These criteria include conceptual definition, attributes, taxonomy, reliability, validity, responsiveness, administrative mode, and language adaptations. Results: Five generic and one diabetes specific type questionnaires were identified from the 17 studies. Of those studies, conceptual definitions with the attributes of multi-dimension and subjectiveness were provided for 11 studies (71%). In the analysis of conceptual taxonomy, only 6 studies were classified as HRQOL, while other studies were done as QOL or health status. In monitoring of psychometric properties, reliability, validity, and responsiveness were reported for 88.2%, 64.7%, and 29.4%, respectively. One generic instrument was developed with a Korean population, while the other instruments were developed for Western countries. However, language adaptations were performed for only a few of the instruments. Conclusion: The psychometric properties including responsiveness of most instruments warrants further research, and the development of diabetes-specific HRQOL measurements should be sought to facilitate intervention outcomes across Korean studies of patients with diabetes.

• Korean Journal of Family Social Work
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• no.56
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• pp.69-104
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• 2017

This research aims to understand in depth and contextually of the grandchildren 's growth with their grandparents. The data were collected through in-depth interviews with observation and documents and analyzed using life history approach. The life history method was based on Mandelbaum(1973)'s framework including 'life dimensions', 'turning points', and 'adaptations'. After the analysis, central themes in each domain emerge as follows; 'social prejudice', 'growing poverty', 'a painstaking smile', 'more polite and honest', and 'being alone' in life dimensions, 'parentless children', 'a painful memory, outcast', and 'going to college' in turning points, and 'a willing person, parents', 'a blessed person', 'self-reliance and scale of economic life', and 'diligence and inborn cheerfulness' in adaptations, respectively. Based on these results, several intervention strategies and implications for healthy growth of grandchildren.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.1
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• pp.127-134
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• 2015

Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in the liver following castration. To understand changes in lipid metabolism following castration, hepatic expression levels of lipid metabolism genes were compared between Korean bulls and steers. Steers had higher (p<0.001) hepatic lipids contents and higher (p<0.01) mRNA levels of lipogenic acetyl-CoA carboxylase. This differential gene expression may, in part, contribute to increased hepatic lipid content following the castration of bulls. However, we found no differences in the hepatic expression levels of genes related to triglyceride synthesis (mitochondrial glycerol-3-phosphate acyltransferase, diacylglycerol O-acyltransferase 1 and 2) and fatty acid (FA) oxidation (carnitine palmitoyltransferase 1A, C-4 to C-12 straight chain acyl-CoA dehydrogenase, very long chain acyl-CoA dehydrogenase) between bulls and steers. No differences in gene expression for very-low-density lipoprotein (VLDL) secretion, including apolipoprotein B mRNA and microsomal triglyceride transfer protein (MTTP) protein, were observed in the liver although MTTP mRNA levels were higher in steers compared to bulls. In conclusion, FA synthesis may contribute to increased hepatic lipid deposition in steers following castration. However, hepatic lipid metabolism, including triglyceride synthesis, FA oxidation, and VLDL secretion, was not significantly altered by castration. Our results suggest that hepatic lipid metabolism does not significantly contribute to increased body fat deposition in steers following castration.

• BMB Reports
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• v.57 no.6
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• pp.273-280
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• 2024

Cancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different morphological states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a theory derived from tissue biopsy, which explains the acquisition of EMT transcription factors (TFs) that convey mesenchymal features during cancer migration and invasion. On the other hand, adherent-to-suspension transition (AST) is an emerging theory derived from liquid biopsy, which describes the acquisition of hematopoietic features by AST-TFs that reprograms anchorage dependency during the dissemination of circulating tumor cells (CTCs). The induction and plasticity of EMT and AST dynamically reprogram cell-cell interaction and cell-matrix interaction during cancer dissemination and colonization. Here, we review the mechanisms governing cellular plasticity of AST and EMT during the metastatic cascade and discuss therapeutic challenges posed by these two morphological adaptations to provide insights for establishing new therapeutic interventions.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.633-642
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• 2013

This study has attempted to investigate correlations among variables against 366 college students from cosmetology-related departments in Busan and figure out the effects of the variables which have an effect on adaptation to college life. First, in terms of 'college life stress', a positive correlation was observed with 'depression' while a negative correlation was found with 'adaptation to college life'. As 'social support' increased, 'self-efficacy' and 'adaptation to college life' were high as well. However, 'depression' was low. On the contrary, 'self-efficacy' revealed a negative correlation with 'depression' but a positive correlation with 'adaptation to college life'. Second, as peer support and professor support increased, and academic performance and value-related problems and depression decreased, 'adaptation to college life' was satisfying. Third, in terms of the effect of 'adaptation to academic achievements', 'academic matters' was the highest. In terms of the effect of social adaptation, 'peer support' was the highest. In terms of the effect of emotional and physical adaptations, 'depression' was the highest. In terms of the effect of attachment to college, 'professor issues' were the highest.

• Journal of Oriental Neuropsychiatry
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• v.26 no.2
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• pp.171-180
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• 2015

Donguibogam's views on human life provide us with insight into suicide prevention by perceiving life as priceless. In addition to the approaches of modern medicine, we can employ 'mentally and physically integrative treatment' and 'prevention-based treatment' from Korean medicine as a therapeutic point of view. We can also employ 'I-Jeong-Byeon-Gi Therapy' and 'Oh-Ji-Sang-Seung Therapy' as therapeutic methods. In this paper, we consider these approaches and clinical adaptations for suicide prevention from the perspectives of Korean medicine.

• Journal of Animal Science and Technology
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• v.63 no.6
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• pp.1411-1422
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• 2021

Lactobacillus acidophilus is a gram-positive, microaerophilic, and acidophilic bacterial species. L. acidophilus strains in the gastrointestinal tracts of humans and other animals have been profiled, but strains found in the canine gut have not been studied yet. Our study helps in understanding the genetic features of the L. acidophilus C5 strain found in the canine gut, determining its adaptive features evolved to survive in the canine gut environment, and in elucidating its probiotic functions. To examine the canine L. acidophilus C5 genome, we isolated the C5 strain from a Korean dog and sequenced it using PacBio SMRT sequencing technology. A comparative genomic approach was used to assess genetic relationships between C5 and six other strains and study the distinguishing features related to different hosts. We found that most genes in the C5 strain were related to carbohydrate transport and metabolism. The pan-genome of seven L. acidophilus strains contained 2,254 gene families, and the core genome contained 1,726 gene families. The phylogenetic tree of the core genes in the canine L. acidophilus C5 strain was very close to that of two strains (DSM20079 and NCFM) from humans. We identified 30 evolutionarily accelerated genes in the L. acidophilus C5 strain in the ratio of non-synonymous to synonymous substitutions (dN/dS) analysis. Five of these thirty genes were associated with carbohydrate transport and metabolism. This study provides insights into genetic features and adaptations of the L. acidophilus C5 strain to survive the canine intestinal environment. It also suggests that the evolution of the L. acidophilus genome is closely related to the host's evolutionary adaptation process.

• Korean Journal of Environmental Agriculture
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• v.33 no.2
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• pp.129-133
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• 2014

BACKGROUND: This study was performed for selecting yeast mutants with a high tolerance for targeted metals, and determining whether yeasts strains tolerant to multiple heavy metals could be induced by sequential adaptations. METHODS AND RESULTS: A mutant yeast strain tolerant to the heavy metals cadmium (Cd), copper (Cu), nickel (Ni), and zinc (Zn) was selected by sequential elevated exposures to each metal with intermittent mutant isolation steps. A Cd-tolerant mutant was isolated by growing yeast cells in media containing $CdCl_2$ concentrations that were gradually increased to 1 mM. Then the Cd-tolerant mutant was gradually exposed to increasing levels of $CuCl_2$ in growth media until a concentration of 7 mM was reached, thus generating a strain tolerant to both Cd and Cu. In the subsequent steps, this mutant was exposed to $NiCl_2$ (up to 8 mM), and a resultant isolate was further exposed to $ZnCl_2$ (up to 60 mM), allowing the derivation of a yeast mutant that was simultaneously tolerant to Cd, Cu, Ni, and Zn. CONCLUSION: This method of inducing tolerance to multiple targeted heavy metals in yeast will be useful in the bioremediation of heavy metals.