• Journal of Communications and Networks
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• v.15 no.2
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• pp.153-163
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• 2013

In recent years, more and more researches have been focusing on trust management of vehicle ad-hoc networks (VANETs) for improving the safety of vehicles. However, in these researches, little attention has been paid to the location privacy due to the natural conflict between trust and anonymity, which is the basic protection of privacy. Although traffic safety remains the most crucial issue in VANETs, location privacy can be just as important for drivers, and neither can be ignored. In this paper, we propose a beacon-based trust management system, called BTM, that aims to thwart internal attackers from sending false messages in privacy-enhanced VANETs. To evaluate the reliability and performance of the proposed system, we conducted a set of simulations under alteration attacks, bogus message attacks, and message suppression attacks. The simulation results show that the proposed system is highly resilient to adversarial attacks, whether it is under a fixed silent period or random silent period location privacy-enhancement scheme.

• Animal cells and systems
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• v.5 no.2
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• pp.139-143
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• 2001

Alzheimer's disease is the most common form of dementia and no cure is known so far. Extensive genetic works and in vitro experiments combined with clinical observations link amyloid $\beta$--protein (A$\beta$-) to the pathogenesis of Alzheimer's disease (AD). It was hypothesized that $A\beta$- becomes toxic when it adopts a fibrillar conformation. Recently, non-fibrillar form of $A\beta$- was observed and the potential role in the pathogenesis of AD became an interesting subject. In this study, the cytotoxicity of non-fibrillar $A\beta$- and fibrillar $A\beta$- was compared on oxidative stress, membrane damage, or nucleosome break down. Non-fibrillar $A\beta$- was not toxic in peripheral nervous system-derived cells but significantly toxic in central nervous system-derived cells while fibrillar $A\beta$- was non-selectively toxic in both cell culture. The neurotoxicity of non-fibrillar $A\beta$- was reproduced in semi-in vivo culture of mouse brain slice. In conclusion, non-fibrillar $A\beta$- could be more relevant to the selective neurodegeneration in Alzheimer's brains than fibrillar $A\beta$- and further research needs to be done for identification of the cause of AD.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.827-837
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• 2019

The present study was conducted with the aim to investigate the ameliorative effects of a new soybean product (cheonggukjang) fermented with Bacillus amyloliquefaciens SCGB1 (SFBA) in atopic dermatitis (AD) mouse model. Visual evaluation of AD induction in the mice indicated the remarkable control of SFBA in reducing the pathological severity of AD-like skin lesions reported as the SCORAD score of AD clinical symptoms. The results revealed that SFBA reduced dorsal skin and epidermal thickness to a similar extent with prednisolone. Further analysis revealed the dominance of SFBA in restraining mast cell infiltration in the dermis; immunoglobulin-E expression in serum; and TH2 IL-4 cytokine and itch-related IL-31 cytokine in the mice skin and serum. SFBA also suppressed scratching behaviours in mice induced by compound 48/80. Further histological findings also revealed the alleviation of collagen fiber deposition in dermal skin of the AD mice model. These actions of SFBA were examined to be mediated by its suppression of the phosphorylation activation of key signalling molecules such as $NF-{\kappa}B$ and MAPK responsible for the induction of cytokine production. Thus, SFBA can be considered as a promising functional food for managing clinical, histological and immunological spectra associated with AD.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.7
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• pp.68-75
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• 2013

Recently, there has been introduced various types of pairing computations to implement ID based cryptosystem for mobile ad hoc network. According to spreading the applications of pairing computations, various fault attacks have been proposed. Among them, a counter fault attack has been considered the strongest threat. Thus this paper proposes a new countermeasure to prevent the counter fault attack on Miller's algorithm. The proposed method is able to reduce the possibility of fault propagation by a random index of intermediate values. Additionally, it is difficult to challenge fault attacks on the proposed method since a simple side channel leakage of 'if' branch is eliminated.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.04a
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• pp.838-841
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• 2009

본 논문에서는 DSDV 프로토콜을 사용하여 MN의 이동으로 포워딩이 실패하면 smooth handoff방식을 사용하지 않고 바로 애드 혹 라우팅 기법을 통해 이동 노드를 통해 데이터그램을 전달하도록 하는 실험을 수행하였는데, DSDV 라우팅 프로토콜을 사용한 방식의 경우 핸드오프가 발생하지 않은 경우와 거의 같은 성능을 나타냈으며, MN의 개수에 따라서는 전송지연시간이 증가하나 핸드오프 발생간격에는 거의 무관하며 기존의 방식들에 비해 전송지연시간이 작아짐을 확인할 수 있다. 중계 노드의 이동은 DSDV 라우팅 방식의 가장 큰 문제점이지만 중계 노드의 이동속도가 실제로는 5m/sec이내가 대부분이므로 크게 문제되지는 않는다. 이와 같은 연구 결과를 캠퍼스와 같이 제한된 지역에서 활용할 경우 smooth handoff의 속도 지연에 대한 문제를 줄일 수 있을 것으로 예상된다.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.11a
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• pp.501-502
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• 2009

본 연구는 mobile IP에서 smooth handoff의 지연 요소를 최대한 줄이기 위해 지역 관리 방식의 FA를 사용하여 성능을 향상시키는 방안에 대해 연구하였다. 본 연구에서는 전송지연, 처리율 등의 분석을 실시하였으며 모든 FA에 버퍼를 내장한 방식과 지역관리용 FA를 이용한 방식에 대하여도 각종 성능을 측정하여 기존의 방식에 비해 어느 정도 성능 향상이 있는지 확인하였다. 본 연구를 통해 지역관리 기능을 수행하는 GFA를 핸드오프 발생 간격이 25초 이상에서는 바인딩 시간 단축에 의한 효과가 있음을 확인할 수 있었다. 이와 같은 연구 결과를 실제 무선 인터넷망 구축에 활용한다면 무선 인터넷망 구축에 관한 관련 자료가 많지 않은 현 상황에서 FA와 MN의 용량과 성능을 결정하는데 보탬이 될 것으로 확신한다.

• Journal of Medicine and Life Science
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• v.19 no.2
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• pp.74-77
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• 2022

We present a fatal case of cerebral arterial thrombosis after corona virus disease 19 (COVID-19) vaccination with ChAdOx1 nCOV-19. The deceased was a 63-year-old woman with no relevant medical history. She presented symptoms of nausea, fatigue, and headache immediately after vaccination. Ten days after vaccination, she suddenly started vomiting and developed high blood pressure. The patient eventually died 23 days after vaccination. Autopsy findings showed that the cerebral arteries and internal carotid arteries were fully enlarged and were compacted with thrombi. The brain stem showed ischemic necrosis, and extravasation from this necrotic lesion led to focal subarachnoid hemorrhage around the brain stem where large blood clots still remained. No aneurysms or atherosclerotic changes were found in these arteries. We note the following three facts. Firstly, all symptoms occurred immediately after vaccination; secondly, the main cause of death was consistent with known side effects of the vaccine; and lastly, the mechanism of thrombus formation in this case goes beyond the general category of thrombogenesis known so far. While the authors know that this case does not fall into known categories of vaccine side effects, we presenting this case to demonstrate that a comprehensive review of various possibilities related to vaccine side effects is needed to establish a COVID-19 defense system.

• The Journal of Internal Korean Medicine
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• v.42 no.4
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• pp.590-604
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• 2021

Objectives: The purpose of this study is to examine the safety of Korean medicine treatment in patients vaccinated with the AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19/AZD1222). Methods: We investigated patients at Kyung Hee University Korean Medicine Hospital who were vaccinated with the AstraZeneca COVID-19 vaccine between June 1, 2021 and June 30, 2021. The safety of Korean medicine treatment was evaluated by examining adverse events that occurred within seven days of vaccination, including liver function and kidney function testing, assessment of the severity of adverse events, and examination of causality to vaccines and Korean medicine treatment. Results: Eleven patients vaccinated with the first dose of the AstraZeneca COVID-19 vaccine were included. A total of 19 adverse events were reported: 15 systemic adverse events, three local adverse events, and one alanine aminotransferase increase. The most commonly reported systemic adverse events were fatigue (4 cases, 36.4%), headache (4 cases, 36.4%), and myalgia (4 cases, 36.4%). All adverse events were rated below moderate (grade 2) in severity. Systemic and local adverse events were evaluated as definitely related to vaccination and unlikely to be related to Korean medicine treatment, while alanine aminotransferase increase was evaluated as unlikely to be related to either the vaccine or Korean medicine treatment. Aspartate transaminase, Blood urea nitrogen, and creatinine were measured within the reference range after vaccination. Conclusion: Our results suggest that the severity and frequency of adverse events in patients vaccinated with the AstraZeneca COVID-19 vaccine did not increase after Korean medicine treatment.

• Korean Journal of Veterinary Pathology
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• v.1 no.2
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• pp.119-124
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• 1997

The objective of this study was to develop digoxigenin (DIG)-labeled in situ hybridization (ISH) test for diagnosis of Aujeszky's Disease(AD) in infected organs. Specific DNA with well conserved gene sequences encoding gp50 antigen in AD virus (ADV) was obtained by Polymerase Chain Reaction (PCR) method. A pair of oligonucleotide primers used in PCR allowed amplification of a 217 bp sequence from the gp50 ADV gene. The DNA was then labeled with DIG by primer labeling method for use as probe in ISH test to detect ADV nucleic acids in various tissue. Positive hybridization was demonstrated by dark pigmentation in nuclei and cytoplasm of ADV infected cells particularly in brain tonsillar crypt epithelium and pulmonary alveolar cells. This result suggests that ISH is a valuable sensitive and rapid diagnostic test for AD.

• Food Science and Preservation
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• v.8 no.3
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• pp.239-245
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• 2001

The CA(Controlled Atmosphere) storage of cherry tomatoes were carried out under seven gas compositions including air. The weight loss of cherry tomatoes progressively increased with storage time. In the case of cherry tomatoes stored under CA conditions, increment of weight loss was reduced. However, cherry tomatoes (in air) tut about 15% weight at the end of storage. In CA stored cherry tomatoes lost about 10% weight at the same time. General trend was a decrease in titratable acidity with storage time. In air md 6.4% O$_2$, 4.2% CO$_2$, titratable acidity was lower than that in other storage conditions. During storage of cherry tomatoes, soluble solids increased till 8 days of storage, and then decreased. Stored cherry tomatoes in air and 6.4% O$_2$+4.2% CO$_2$ have lower values. Lycopene contents of cherry tomatoes with 6% O$_2$ storage condition increased and cherry tomatoes with 1% O$_2$+6% CO$_2$ and 3% O$_2$+3.1% CO$_2$maintained s initial contents. In air, flesh firmness decrease till 8 days, and then increase. At 1% O$_2$+6% CO$_2$ ethanol contents were ten times to that of other experimental conditions. Air and 6% O$_2$+7.8% CO$_2$ condition had lowest value for the ethanol content. In changes of organic acid and citric acid decreased slowly during storage, malic acid in air and below 3% O$_2$was disappeared at 8 days. Above 4% O$_2$concentration malic acid contents were maintained till 16 days. In over all acceptability, air and 6.4% O$_2$+7.8% CO$_2$ condition took a good score from the panel. Quality of stored cherry tomatoes was not edible condition in 1% O$_2$+6% CO$_2$. CA storage cherry tomatoes took a good score in firmness and juiciness where as control received good score in color and sweetness. This result was explained that in air ad 6.4% O$_2$+7.8% CO$_2$stored cherry tomato was ripened and full color development, but in CA was break stage because of suppressed ripening.