• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.

• Journal of Arbitration Studies
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• v.28 no.4
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• pp.61-88
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• 2018

Myanmar has witnessed rapid economic growth in the 21st century. The cultural heritage of Myanmar (Burma) inherited from ancestors is law literature such as Dhammathat and Rajathat. Burma is a unique country in Southeast Asia in a sense that it already had a modern law system. For example, there has been a legal profession even in 12th century AD. According to Rajathat, lawyers were required to wear a uniform in court. Furthermore, lawyers and Judges participated in legal proceedings from the 15th century. As to the role of Dhammathat, there are conflicting views in the academic community. According to Professor Andrew Huxley, the profound literatures of Dhammathat had played an important role as a source of law in Burmese court in ancient times. Dhammathats have flourished in the struggle among the King, lawyers, and monks in old Burmese society. This customary law combined with Rajathat provided a guidance of legal proceedings in Burmese court, as well as village settlement. This traditional dispute resolution system reaches modern times in the form of Buddhist family law in Myanmar. Nowadays, the law system of Myanmar looks like a legal pluralism since the customary laws of Burma, as well as Shan and Arakan, are effective and co-exist with common law adopted at the colonial period. In recent times, Myanmar has enacted new arbitration laws (2016) in order to attract foreign direct investment.

• The Korean Journal of Ceramics
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• v.6 no.3
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• pp.309-314
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• 2000

In the present study, preliminary experimental results of the change in the properties of perovskite-type oxides caused by the $^{18}O$- exchange have been reported. Two systems were selected for the exchange, (1) $ATiO_3$(A=Ca,Sr,Ba) and (2) manganese perovskite. The dielectric properties of isotope-exchanged $SrTi^{18}O_3$showed a drastic change from a quantum paraelectricity below 3K to ferroelectric-like behavior with a peak at 23K and an enhanced dielectric constant, 35000 at the peak. On the contrary, the $T_c$ for $BaTiO_3$was found to increase by 0.9K. The observed isotope shift of $T_c$ as well as $T_co$ for the manganese perovskites is correlated with the key parameters controlling the lattice such as $Mn^{3+}$ content, average ionic radius of the A-site cation <$r_A$> ad A-site ionic disorder $\sigma^2$.

• Journal of Korean Foot and Ankle Society
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• v.26 no.1
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• pp.48-53
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• 2022

The current SARS-CoV-2 coronavirus disease 2019 (COVID-19) pandemic has been a particular challenge for diabetes patients. Since these patients are at a higher risk of COVID-19, they have been prioritized for vaccination. In this report, we describe the case of a patient scheduled for diabetic foot amputation who received the first dose of ChAdOx1 nCov-19 vaccine and subsequently developed severe purpura in his genitalia and both of his hands and feet, accompanied by acute renal failure. The operation had to be postponed as severe limb purpura appeared just before the operation. With adequate management for acute renal failure and topical steroid application for the severe purpura lesions, a successful outcome could be obtained after the delayed first ray amputation. We recommend that COVID-19 vaccination should be carefully administered in patients with a diabetic foot requiring amputation.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.11
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• pp.1238-1243
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• 2005

The batch experiments of biosorption were carried out for the removal of lead ion from metal solution using Laminaria japonica and Kjellmaniella crassifolia, two species of marine algaes as biosorbent. We have investigated biosorption kinetics and equilibrium of lead by using marine algaes. We observed that biosorption of lead occurred very rapidly by marine algaes ; the biosorption reached equilibrium less than 2 hr. These experimental data could be accurately described by a pseudo-second-order rate equation, obtaining values between $0.883{\times}10^{-3}$ and $0.628{\times}10^{-3}\;g/mg/min$ for the biosorption rate constant $k_{2,ad}$. It could be described with Langmuir, Redlich-Peterson, and Koble-Corrigan(Langmuir-Freundlich) equation. The biosorption capacity by L. japonica and K. crassifolia were in the sequence of Pb>Cd>Cr>Cu and Pb>Cu>Cd>Cr, respectively. The biosorption capacity of L. japonica were increased with pH increasing.

• Journal of Broadcast Engineering
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• v.13 no.6
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• pp.951-961
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• 2008

Cooperative diversity is a cooperative technique which exploits user diversity by decoding the combined signal of the relayed signal and the direct signal in wireless multi-hop networks. Using the cooperation, the performance of the network system can be improved because cooperative diversity which is very strong against the fading channels can be achieved. In this paper, we propose the technique that provides the enhanced visual quality of the reconstructed video using the cooperative diversity with the FMO which is the error resilience tool of H.264/AVC standardization over wireless networks. The eye-tracker can detect the gaze point of user and transmit the gaze information to the nodes. After receiving the gaze information of user, each node performs ROI encoding according to the received gaze information. After encoding, video sources are divided into ROI and Non-ROI. Through the simulation results, the better visual quality of the reconstructed video is achieved when ROI and Non-ROI are transmitted through different channels.

• 제어로봇시스템학회:학술대회논문집
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• 1992.10b
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• pp.503-508
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• 1992

A new method for making automatic electroencephalogram(EEG) report based on the automatic quantitative interpretation of awake EEG was developed. We first analysed a. relationship between EEG reports and quantitative EEG interpretation done by a qualified electroencephalographer(EEGer) for 22 subjects. Based on the analysed relationship and usual process of report making by the EEGer, we defined all terminology necessary for EEG report and established rules for EEG report making. By the combined use of the proposed EEG report making and the method for automatic quantitative EEG interpretation presented at '90 KACC, we were able to make the automatic EEG reports which were equivalent to the EEG reports written by the EEGer. As all the procedures were programmed in a personal computer equipped with an AD (analogue-to-digital) converter, the automatic EEG reports were obtained in almost real time in usual actual EEG recording situation with only a few seconds time lag for the analysis in the computer. The proposed report making method and the quantitative EEG interpretation method will be effectively applicable to the clinical use as an assistant tool for physicians.

• Journal of the Korean Society for Heat Treatment
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• v.35 no.1
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• pp.27-32
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• 2022

Microbubble technology has been widely applied in various industrial fields. Recently, research on many types of microbubble application technology has been conducted experimentally, but there is a limit in deriving the optimal design and operating conditions. Therefore, if the computational fluid dynamics (CFD) analysis of multiphase flow is used to supplement these experimental studies, it is expected that the time and cost required for prototype production and evaluation tests will be minimized and optimal results will be derived. However, few studies have been conducted on multiphase flow CFD analysis to interpret fluid flow in microbubble generators using swirl flow. In this study, CFD simulation of multiphase flow was performed to analyze the air-water mixing process and fluid flow characteristics in a microbubble generator with a dual-chamber structure. Based on the simulation results, it was confirmed that a negative pressure was formed on the central axis of rotation due to the strong swirling flow. And it could be seen that the air inside the suction tube was introduced into the inner chamber of the microbubble generator. In addition, as the high-speed mixed fluid collided with external water sucked by the negative pressure near the outlet, a large amount of microbubbles was ejected due to the shear force between the two flows flowing in opposite directions.

• Herbal Formula Science
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• v.21 no.1
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• pp.80-90
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• 2013

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.3
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• pp.44-50
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• 2006

The mono steel forged piston was improved a mechanical strength of an aluminum piston and reduced the weight of a articulated piston. The mono steel forged piston was composed of forged crown part and forged skirt part and was completed by friction welding process of two forged parts. Forging process analysis and friction welding analysis was done by finite element simulation using numerical package DEFORM. The preform shape and the initial billet dimension were decided by maximum stress of the die, amount of the flash and filling of die. The upset length of friction welding variable was decided by the shape of the flash that was created by friction welding analysis. Through this research, we developed a forging process of the mono steel forged piston, and decided the design variables of friction welding.