• Journal of Pharmaceutical Investigation
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• 제21권2호
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• pp.103-110
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• 1991

Two new prodrugs of lonazolac, lonazolac acetic acid ester and lonazolac argininate, were prepared and examined for physicochemical properties and biopharmaceutical characteristics. The prodrugs were stable in solid state and lonazolac argininate showed higher dissolution rate than lonazolacca in both artificial gastric and intestinal juices. These prodrugs have higher analgegic effect than that of lonazolac-Ca in mice, and increased anti-inflammatory activities in rats. In addition, ulcerogenic effects and acute toxicity of these prodrugs were lower than those of lonaaolac-Ca. Lonazolac acetic acid ester showed larger area under the plasma concentration-time curves (AUC) than that of lonazolac. Therefore, it was suggested that these prodrugs of lonazolac have advantages over lonzolac-Ca for not only enhanced bioavailability but also decreased ulcerogenic and toxic effects.

• Steel and Composite Structures
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• 제32권6호
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• pp.821-832
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• 2019

An analysis on thermal buckling and postbuckling of composite laminated plates reinforced with a low amount of graphene platelets is performed in the current investigation. It is assumed that graphaene platelets are randomly oriented and uniformly dispersed in each layer of the composite media. Elastic properties of the nanocomposite media are obtained by means of the modified Halpin-Tsai approach which takes into account the size effects of the graphene reinforcements. By means of the von $K{\acute{a}}rm{\acute{a}}n$ type of geometrical nonlinearity, third order shear deformation theory and nonuniform rational B-spline (NURBS) based isogeometric finite element method, the governing equations for the thermal postbuckling of nanocomposite plates in rectangular shape are established. These equations are solved by means of a direct displacement control strategy. Numerical examples are given to study the effects of boundary conditions, weight fraction of graphene platelets and distribution pattern of graphene platelets. It is shown that, with introduction of a small amount of graphene platelets into the matrix of the composite media, the critical buckling temperature of the plate may be enhanced and thermal postbuckling deflection may be alleviated.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권6호
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• pp.357-362
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• 2023

Trigeminal neuralgia (TN) is neuropathic pain that affects the trigeminal nerve branches. Facial pain experienced by patients with TN is typically intense and excruciating. The second and third branches (maxillary and mandibular) are commonly affected. This case report focuses on the potential treatment options for acute TN attacks involving these branches. The proposed approach involves extra-oral peripheral blocks using local anesthetics. Pain levels were measured using a visual numeric scale (VNS) with potential side effects and other relevant documented information. The patients showed responses from high pain levels to almost complete remission (from 8 to 2 and from 10 to 2 on the final VNS), with no significant side effects. This technique provides immediate pain relief and complements oral medications by offering comfort and confidence until the desired drug effect is achieved.

• Advances in aircraft and spacecraft science
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• 제5권4호
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• pp.411-430
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• 2018

This computational study examines the augmentation of classic 2-D Rayleigh-$B{\acute{e}}nard$ convection by the addition of periodically-spaced transverse fins. The fins are attached to the heated base of the cavity and serve to partition the cavity into 'units' with different aspect ratios. The respective impacts upon heat transfer of the fin configuration parameters - including spacing, height, thickness and thermal conductivity - are systematically examined through numerical simulations for a range of laminar Rayleigh numbers (0 < Ra < $2{\times}10^5$) and reported in terms of an average Nusselt number. The selection of the low Rayleigh number regime is linked to likely scenarios within aerospace applications (e.g. avionics cooling) where the cavity length scale and/or gravitational acceleration is small. The net heat transfer augmentation is found to result from a combination of competing fin effects, most of which are hydrodynamic in nature. Heat transfer enhancement of up to $1.2{\times}$ that for a Rayleigh-$B{\acute{e}}nard$ cavity without fins was found to occur under favorable fin configurations. Such configurations are generally characterized by short, thin fins with half-spacings somewhat less than the convection cell diameter from classic Rayleigh-$B{\acute{e}}nard$ theory. In contrast, for unfavorable configurations, it is found that the introduction of fins can result in a significant reduction in the heat transfer performance.

• 대한한방내과학회지
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• 제23권2호
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• pp.228-237
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• 2002

Acute hepatitis is caused by virus, alcohol. toxins and drugs. Clinical symptoms of acute hepatitis are severe fatigue, jaundice, nausea, hepatomely, lymphadenopathy. We encountered two cases of acute hepatitis, one C type viral hepatitis and the other hepatitis by overuse of medicine. The symptoms of the latter are severe fatigue, petechia and heartburning. The symptoms of the latter are severe fatigue, nausea, dyspepsia, yellow urine and skin. We recognized that total bilirubin. direct bilirubin, serum transaminase, alkaline phosphatase and gamma glutamyl transferase were elevated. We treated both patients with herb medicine(Gagamsaenggan-tang). Gagamsaenggan-tang has been used to hepatic diseases and have been known to have beneficial effects. The patients' symptoms began to improve after about two weeks of treatment. After 3 weeks on medication, the clinical symptoms and liver function of two patients were improved.

• Journal of Trauma and Injury
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• 제32권4호
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• pp.238-242
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• 2019

Extreme acidosis is a life-threatening physiological state that causes disturbances in the cardiovascular, pulmonary, immune, and hematological systems. Trauma patients commonly present to the operating room (OR) in hypovolemic shock, leading to tissue hypoperfusion and the development of acute metabolic acidosis with or without a respiratory component. It is often believed that trauma patients presenting to the OR in severe metabolic acidosis (pH <7.0) will have a nearly universal mortality rate despite aggressive resuscitation and damage control. The current literature does not include reports of successful resuscitations from a lower pH, which may lead providers to assume that a good outcome is not possible. However, here we describe a case of successful resuscitation from an initial pH of 6.5 with survival to discharge home 95 days after admission with almost full recovery. We describe the effects of acute acidosis on the respiratory and cardiovascular systems and hemostasis. Finally, we discuss the pillars of management in patients with extreme acute acidosis due to hemorrhage: transfusion, treatment of hyperkalemia, and consideration of buffering acidosis with bicarbonate and hyperventilation.

• 대한한의학회지
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• 제36권4호
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• pp.114-121
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• 2015

More and more patients suffering from hepatitis A, the number of patients representing symptoms that are uncharacteristic to hepatitis A is also increasing. There are occasions of serious complications among adult hepatitis A patients that can cause fulminant hepatitis or cirrhosis which can be fatal. A 43-year-old male was diagnosed as acute hepatitis A and was treated at a Western hospital over the course of three months, which included two months of hospitalization. However, his symptoms did not improve, so he was admitted to Oriental hospital. We prescribed Chunggan extract (CGX) four times a day. Acupuncture was performed twice a day. From the twenty-fourth day of admission, the total bilirubin fell under 10 mg/dL for the first time and next day he was discharged. Following his discharge, he consistently took CGX three times a day. 21 days after discharge all of his symptoms disappeared. This study demonstrated that traditional Korean medicine (TKM) for acute viral hepatitis with cholestatic hepatitis might be effective and safe with no adverse effects.

• Environmental Analysis Health and Toxicology
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• 제16권4호
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• pp.211-221
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• 2001

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of 1-hexene on Sprague-Dawley (SD) rats which were treated by inhalation. The results were as follows; 1. The median lethal concentration(LC$_{50}$) was estimated 52,694 ppm (confidence limit 95％; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the 1-Hexene were not observed with the acute inhalation dose. Cross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene. II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed 1-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

• 대한정형도수물리치료학회지
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• 제20권2호
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• pp.35-42
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• 2014

Background: The purpose of this study was to effect of the manual therapy and pelvic floor muscle exercise interventions in patient with acute lumbar sprain. Based on this, proceed to present an effective physical treatments. Methods: Subject was 55 year old female patient with acute lumbar sprain. Subject was damaged, wash in the morning. Subject was hoping to return to work and Activity daily living (ADL) without pain. I proceed in order screening, evaluation, diagnosis, prognosis, treatment planning and intervention, re-screening. To solving problem, was conducted in parallel to a manual therapy and therapeutic exercise. Results: To investigate changes in body functions and activities was measured, Visual analog scale (VAS) and Oswestry disability index (ODI), changes in posture, maintain in posture, 10m walk test. The improved results were compared before and three weeks after mediation interventions. Conclusions: Frequency manual therapy and pelvic floor muscle exercise is thought to be an efficient way of patients with acute lumbar sprain.

• 한방재활의학과학회지
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• 제25권3호
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• pp.127-136
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• 2015

Objectives This study was carried out to investigate the clinical effects of Korean medical treatment on acute peroneal nerve palsy caused by prolonged immobilization. Methods One patient with acute peroneal nerve palsy was treated with various korean medical techniques such as acupuncture, moxibustion, cupping and herbal medicine, bee-venom acupuncture for 12 weeks. Manual Muscle Test, Range of motion, Numerical Rating Scale, Ankle-hindfoot scale, Digital infrared thermographing imaging system were used to evaluate treatment effect. Results After treatment, all the scales mentioned above were improved significantly. Conclusions This result showed that Korean medical treatment is effective on acute peroneal nerve palsy caused by prolonged immoblization.