• 한국콘텐츠학회논문지
• /
• 제14권9호
• /
• pp.556-566
• /
• 2014

목적 : 경혈, 침구 온톨로지의 연계율을 높이기 위한 연구를 시행하였다. 방법 : 혈성(효능) 용어와 치법 용어를 최소 의미 단위로 분해하여 상호 연계하였다. 결과 : 혈성(효능)과 치법의 연계가 증가함에 따라 경혈, 침구 온톨로지 간 연계성이 증가하였으며, 확장 연계되는 프로퍼티의 수와 프로퍼티 간 노드의 수도 증가하였다. 결론 : 혈성(효능) 용어와 치법 용어의 최소 의미 단위로의 연계를 통해 온톨로지의 연계율이 개선되고 이에 따라 온톨로지의 활용성이 제고될 수 있음을 알 수 있었다.

• 대한한의학원전학회지
• /
• 제26권3호
• /
• pp.127-139
• /
• 2013

Objectives : In the traditional oriental medicine, efforts to utilize the knowledge system so called Ontology have been achieved for systemic researches and efficient propagation of knowledge on oriental medicine. So far, in Korea, studies on drug ontology, pathological ontology, Cold Damage ontology and diagnostic ontology had been implemented, however, any development of ontology in the field of Acupuncture &, Moxibustion has not been achieved. Methods : We used Microsoft Access to collect terms in ZhenJiuJiaYiJing. The terms are related to human body area and structure. And then we built relationship of 'part of' and 'criterion of acupuncture point location' between the terms. Result & Conclusions : The terms used to explain acupuncture points in order to describe the position of acupuncture point name in ZhenJiuJiaYiJing were 8 words concerning different name of acupuncture point(穴名) 109, body part name(人體部位名稱) 150, meridian(經脈) 6 and structure(構造物).

• 대한한의학원전학회지
• /
• 제25권4호
• /
• pp.105-113
• /
• 2012

Objectives : Acquiring information from symptoms is one of the important method to gain clinically available information in korean medicine. Therefore, up to now, study of symptom terms was frequently implemented in promotion of various information project. In data extraction methods using symptom information from DB, information search using synonym and method using ontology is studied and utilized. However, considering concept of symptom has essential information of appeared body area and phenomenon we think that extending synonym and ontology relationship in symptom terms can be useful for search and set to this study. Methods : We collect terms relevant to human body area and structure described in Donguibogam. Synonymous relationship between collected terms is organized. Relationship between collected terms is build to human-body-knowledge table which has form of Concept+Relation+Concept. Type of relationship is limited on a range of expressing content about parts of human body. Result & Conclusion : Search condition is generated automatically using relationship of the upper area in knowledge table contents. Information of next and previous acupuncture point, upper and lower acupuncture point, left and right acupuncture point can be searched using information of acupuncture point location, order, relative position in area, direction in knowledge table contents.

• 대한한의학회지
• /
• 제37권3호
• /
• pp.87-96
• /
• 2016

Objectives: Through this study, it would be expected to compare the characteristics of medicinal and acupuncture treatment. Method: Ontology DB of traditional Korean medicine has been used comparing medicinal and acupuncture treatment. Terms of the efficacy and the method of treatment were divided to predicate and object. And two groups were compared through contrasting the frequency of occurrence of significant words. Results: Predicates utilized more in medicinal treatment are the character ryeom[斂], go[固], pa[破], nae[內], and tu [透]. Predicates utilized more in acupuncture treatment are the character so[疏], jo[調], and seo[舒]. Object utilized more in acupuncture treatment is the character gi[氣]. Object utilized more in medicinal treatment is the character jeong[精]. Conclusions: In terms about the efficacy of acupuncture, there are many expressions associated with Qi[氣]. But expressions associated with Jing[精] are rare compare to medicinal treatment. There is a difference in language that represents the efficacy between medicinal and acupuncture treatment. In addition, there are some terms about efficacy that are not shared with each other due to the differences in disease treatment and the different branches of the two theories.

• Journal of Acupuncture Research
• /
• 제37권2호
• /
• pp.128-135
• /
• 2020

Background: Classical acupuncture is being used in the treatment of rheumatoid arthritis (RA). To explore the biological response to acupuncture, a network-based analysis was performed on gene expression data collected from an animal model of RA treated with acupuncture. Methods: Gene expression data were obtained from published microarray studies on blood samples from rats with collagen induced arthritis (CIA) and non-CIA rats, both treated with manual acupuncture. The weighted gene co-expression network analysis was performed to identify gene clusters expressed in association with acupuncture treatment time and RA status. Gene ontology and pathway analyses were applied for functional annotation and network visualization. Results: A cluster of 347 genes were identified that differentially downregulated expression in association with acupuncture treatment over time; specifically in rats with CIA with module-RA correlation at 1 hour after acupuncture (-0.27; p < 0.001) and at 34 days after acupuncture (-0.33; p < 0.001). Functional annotation showed highly significant enrichment of porphyrin-containing compound biosynthetic processes (p < 0.001). The network-based analysis also identified a module of 140 genes differentially expressed between CIA and non-CIA in rats (p < 0.001). This cluster of genes was enriched for antigen processing and presentation of exogenous peptide antigen (p < 0.001). Other functional gene clusters previously reported in earlier studies were also observed. Conclusion: The identified gene expression networks and their hub-genes could help with the understanding of mechanisms involved in the pathogenesis of RA, as well understanding the effects of acupuncture treatment of RA.

• 동의생리병리학회지
• /
• 제27권6호
• /
• pp.705-709
• /
• 2013

We in this paper proposed a distinction method to compare objects in the Korean medicine ontology. Comparing same and different information between two objects, two scenarios to use our system were designed and implemented. One is the distinction of formulas, medicinal materials, and acupuncture points and the other is the distinction of effects, treatments, and symptoms. To compare objects easily, the decomposition of effects and treatments and the processing of medicinal materials were provided. Also, information of each object was shown through the link to the semantic search system. Our distinction method and system could be helpful to compare and distinct two objects in the diagnosis systems or search systems of Korean medicine information.

• Korean Journal of Acupuncture
• /
• 제41권1호
• /
• pp.7-15
• /
• 2024

Objectives : This study aimed to predict the effectiveness and potential of Schizonepeta tenuifolia as an anticancer treatment for non-small cell lung cancer through network-based pharmacology and cellular experiment. Methods : To identify the major bioactive compounds in Schizonepeta tenuifolia, we used the Traditional Chinese Medicine Systems. The target genes for the cancer treatment were selected using the UniProt database and the networked using Cytoscape. We performed functional enrichment analysis based on the Gene Ontology Biological Process and Kyoto Encyclopedia of Genes and Genomes Pathways to predict the mechanisms. To investigate the effect of Schizonepeta tenuifolia on lung cancer cell growth, we treated A549 cells, a lung cancer cell line, with different concentrations of the drug and used the MTT assay for cell viability. Results : Research has shown that the most effective mechanism of active compounds from Schizonepeta tenuifolia is through the pathway of cancer. The results of the network pharmacology analysis indicate that Schizonepeta tenuifolia has potential medicinal value as an adjuvant in anticancer treatment. The concentration-dependent inhibition of cell viability was observed on A549 cells. Furthermore, synergistic anticancer activity with Doxorubicin was also observed. Conclusions : Through a network pharmacological approach, Schizonepeta tenuifolia was predicted to have potential as an anticancer agent, and its efficacy was experimentally demonstrated using A549 cells. These findings suggest that Schizonepeta tenuifolia is a promising candidate for future research.