• Korean Journal of Acupuncture
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• 제19권2호
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• pp.35-39
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• 2002

Objective : The purpose of this study was to investigate the Effect of Acupuncture Stimulation of Sohae(H3) and Sobu(H8) Acupoint on Skin Temperature of Sochung Acupint(H9, the end acupoint of Heart Meridian). Sohae and Sobu acupoint has a property of water and fire in the Five agents on Heart Meridian. Methods : Subjects were four healthy oriental medical students volunteers(male, mean age-28). One group(two subjects) received acupuncture on Sohae acupoint(H3) and the other group(two subjects) on Sobu acupoint(H8) while resting. Skin temperature was measured on Sochung acupoint(H9) before, during, and after acupunture stimulation. Each test took 15minutes. The initial 5minutes were definded as BAS(Before Acupuncture Stimulation) period, the following 5minutes as DAS(During Acupuncture Stimulation) period, the last 5minutes as AAS(After Acupuncture Stimulation) period. This test was performed twice in order to increase the statistical authenticity. Results : Our result indicates that acupuncrue stimulation of Sohae acupoint(H3) decreased and Sobu acupoint(H8) increased skin temperature on Sochung acupoint(H9) in the DAS period. The changes remained throughout the AAS period. Our conculusion are that stimulaton of the Water and Fire property-acupoint(H3, H8) on Heart changes the skin temperature on Sochung acupoint on the same Heart Meridian. However this study has no authenticity because it had no regard for many factors effecting on the result and the result of the study was the very reverse of our expectation.

• Korean Journal of Acupuncture
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• 제21권1호
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• pp.29-40
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• 2004

Objectives : The aim of this study was to examine the effects of electroacupuncture(EA) at the $H_7$ (Shinmun) on normal humans using power spectral analysis. Methods : EEG power spectrum exhibit site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity. 32 channel EEG study was carried out in 9 subjects (9 males; age=25,8 years). Results : In alpha band, the power values at Fp2 channels(p<0.05) during the $H_7-acupoint$ treatment significantly were decreased. In beta band, the power values at Fp1, Fp2 channels(p<0.05) during the $H_7-acupoint$ treatment significantly were decreased. In delta and theta band, the power values at the $H_7-acupoint$ treatment significantly was increased than the before-acupuncture treatment. Conclusions : This results suggest that electroacupuncture at the $H_7$ is significantly in beta band of EEG.

• Korean Journal of Acupuncture
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• 제27권1호
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• pp.31-47
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• 2010

Objectives: To investigate the anti-inflammatory effects of cultivated wild ginseng pharmacopuncture in lipopolysaccharide (LPS)-induced inflammatory rat model. Methods: Sprague-Dawley rats were divided into 4 groups; LPS control (n=6), LPS+cultivated wild ginseng pharmacopuncture at CV4 (n=6), LPS+cultivated wild ginseng pharmacopuncture at CV17 (n=6), and LPS+cultivated wild ginseng pharmacopuncture at Ex-HN1 (n=6). Pharmacopuncture (0.1 ml) was given every two days for 4 weeks followed by inflammation induction by peritoneal LPS injection (5 mg/kg). Blood, liver tissue, and peritoneal lavage fluid were taken and proinflammatory cytokines and other related factors were analysed. Results: Compared with the control group, CV4 and Ex-HN1 pharmacopuncture groups significantly attenuated plasma IL-$1{\beta}$, IL-6, and TNF-$\alpha$ increase at 2h and 5h after LPS injection (P<0.05). A significant difference from control group emerged at 5 h for plasma IL10 (P<0.05). For liver cytokines analyzed at 5 h after LPS injection, only CV4 pharmacopuncture group showed significant difference in TNF-$\alpha$ and IL-10 (P<0.05). Blood CD4/CD8 ratio and the phagocytic activities of polymorphonuclear neutrophils were not different from those of control group in all pharmacopuncture groups (P>0.05). CV4 pharmacopuncture significantly attenuated increase of plasma ${NO_3}^-/{NO_2}^-$, Intracellular adhesion molecule-1 (ICAM-1), cytokine-induced neutrophil chemoattractant-1 (CINC-1), and prostaglandin $E_2$ ($PGE_2$) compared with the control group (P<0.05). Monocyte chemoattractant protein-1, $PGE_2$, and CINC-1 level of CV4 pharmacopuncture group was significantly different from those from the control group (P<0.05). Conclusions: These results indicate that cultivated wild ginseng pharmacopuncture at CV4 may have a potent anti-inflammatory effect in an LPS-induced inflammatory rat model.

• 대한약침학회지
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• 제13권2호
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• pp.5-12
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• 2010

본 연구의 목적은 자하거약침액의 항산화기능에 관련한 생리활성을 보기 위하여 대한약침학회에서 제공받은 자하거 약침액을 시료로 사용하였다. 총 폴리페놀 함량은 자하거 약침액 원액에서 24.641 mg/L로 이는 산수유 등과 같은 약용식물과 비슷한 수준의 함량이다. 자하거약침액원액에서 DPPH radical 소거능과 Superoxide dismutase(SOD) 유사활성 측정은 각각 49.4%, 50.87%였다. 또한 ABTS radical 소거능과 Nitrite radical 소거능(pH1.5)에서는 각각 50.01%, 52.8%로 ABTS radical과 Nitrite radical 소거능이 우수하였다. 본 실험결과로볼 때, 자하거 약침액은 항산화능력은 뛰어난 것으로 사료된다. 하지만 현재 자하거 약침액과 관련된 실험이 부족한 실정이기 때문에 앞으로 이에 관련된 더 많은 연구가 필요하다고 생각된다.

• Korean Journal of Acupuncture
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• 제26권3호
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• pp.55-68
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• 2009

Objectives : To investigate the anti-inflammatory effects of Scutellaria baicalensis Georgi pharmacopuncture in lipopolysaccharide (LPS)-induced inflammatory rat model. Methods : Sprague-Dawley rats were divided into 4 groups; LPS control (n=6), LPS+Scutellaria baicalensis Georgi pharmacopuncture at BL23 (n=6, BL23), LPS+Scutellaria baicalensis Georgi pharmacopuncture at CV12 (n=6, CV12), and LPS+Scutellaria baicalensis Georgi pharmacopuncture at GV4 (n=6, GV4). Pharmacopuncture was given every two days for 4 weeks followed by inflammation induction by intraperitoneal LPS injection (5mg/kg). Blood, liver tissue, and peritoneal lavage fluid were taken and proinflammatory cytokines and other related factors were analysed. Results : For proinflammatory cytokines, CV12 pharmacopuncture group was significantly different compared with the control group in plasma IL-$1{\beta}$, IL-6, TNF-$\alpha$, and IL-10 5 h after LPS injection (P<0.05). For plasma IL-$1{\beta}$ and IL-6, CV12 pharmacopuncture group also showed significant difference at 2 h compared with the control (P<0.05). GV4 pharmacopuncture group was significantly different compared with the control at 5 h in plasma IL-$1{\beta}$, IL-6, and TNF-$\alpha$ and at 2 h in IL-10 (P<0.05). Liver cytokines were analyzed at 5 h after LPS injection; only CV12 pharmacopuncture group showed significant difference in IL-$1{\beta}$ (P<0.05) and others including IL-6, TNF-$\alpha$, and IL-10 had no difference compared with the control group. CD4/CD8 ratio and the phagocytic activities of polymorphonuclear neutrophils were not different from those of control group in all pharmacopuncture groups (P>0.05). Plasma NO3-/NO2- and intracellular adhesion molecule-1 of CV12 pharmacopuncture group were significantly lower than that of the control group (P<0.05). In the plasma concentration of prostaglandin E2, all 3 pharmacopuncture groups had significantly lower values than that of the control group (P<0.05), but there was no difference among pharmacopucnture groups. Monocyte chemoattractant protein-1 and cytokine-induced neutorphil chemoattractant-1 in peritoneal lavage fluid was significantly decreased in CV12 pharmacopuncture group compared with the control group (P<0.05). Conclusions : These results indicate that Scutellaria baicalensis Georgi pharmacopuncture at CV12 may have a potent anti-inflammatory effect in an LPS-induced inflammatory rat model.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.39-51
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• 2009

목적 : 신맥 혈위 자극이 뇌활성화 변화에 미치는 영향에 있어 자침 시술자간의 재현성을 fMRI 영상을 통해 평가하고자 하였다. 방법 : 본 연구는 건강한 성인 남자 15명을 대상으로 실시하였으며, 15명의 피험자 중 7명은 각각 2회 방문하였으며, 두 시술자에 의해 침을 맞고 총 4개의 데이터를 얻었다. 나머지 8명은 1회 방문하여 두 시술자에게 침을 맞아 2개씩의 데이터를 얻어 총 44개의 fMRI 데이터를 얻었다. 실험자간의 차이를 줄이기 위해 자침의 깊이와 회전, 강도 등을 동일하게 하였으며, 우측 신맥혈에 자침하였다. 침에 의해 활성화되는 영역을 확인하기 위해 블록디자인을 사용하여 fMRI를 촬영하였다. 결과 : 다른 날에 실시한 같은 시술자내의 재현성은 24 %, 같은 날 실시한 다른 시술자간의 재현성은 64 % 로, 다른 시술자간의 재현성이 서로 다른 날 실시한 같은 시술자내의 재현성보다 높게 나타났다. 결론 : 침을 이용한 fMRI의 실험에서 시술자에 의한 차이 외에도 실험하는 날짜의 차이, 피험자 인체의 생리적인 변화 등에 의한 차이가 크다는 것을 본 실험을 통하여 확인하였다. 그리고 자침의 깊이와 회전, 자극의강도 등을 동일하게 함으로써 다른 시술자간의 재현성을 높일 수 있다는 것을 확인했다. 추후 침실험에 있어서 여러 변수들에 의한 차이를 극복하고 재현성을 높일 수 있는 방법에 관한 더욱 심도 있는 연구가 필요하다.

• Korean Journal of Acupuncture
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• 제19권1호
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• pp.7-13
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• 2002

1. 천궁약침액은 1${\times}$에서 15.1%의 cytochrome P4501A1 저해효과를 나타냈으며 그 억제효과는 약침액의 농도가 높을수록 증가하였다. 2 천궁약침액은 benzo[a]pyrene과 세포의 DNA 결합을 유의성있게 억제시켰다. 이상의 결과를 종합해 볼때 천궁약침액은 효과적으로 cytochrome P4501A1 효소를 저해했으며, 발암물질과 DNA의 결합을 억제시켜 외부 물질 또는 대사물에 의해 일어날 수 있는 돌연변이와 암 발생을 억제할 것으로 사료된다.

• Journal of Acupuncture Research
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• 제22권1호
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• pp.91-97
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• 2005

2004 년 3월 9일부터 5월 15일까지 경희의료원 침구과 외래를 내원하여 8주간 연구과정을 마친 환자 29명의 환자를 관찰하여 뜸치료 전, 후의 파킨슨병 증상의 호전도를 여러 임상 척도를 이용하여 살펴 본 결과를 다음과 같이 보고하는 바이다. 1. UPDRS 점수는 침치료 전, 4주 후, 8주 후 각각 $35.41{\pm}22.98$, $31,93{\pm}23.44$, $30.75{\pm}24.55$로 나타나 통계적으로 매우 유의한 차이가 있었다 (p<0.01). 2. HY stage의 변화는 4주후(p=0.046)에는 유의한 변화가 있으나, 8주후에는 (0.063) 유의한 변화가 없었다. 3. Schwab과 England에 의한 ADL의 변화는 4 주후, 8주후 모두 유의한 변화가 없었다(p>0.05). 4. FOCQ의 변화는 치료 4주후에는 유의한 차이가 있었으나(p=0.05) 8주 후에는 유의한 차이가 없었다(p=0.13) 5. 뜸치료를 통해 환자에게서 파킨슨병 임상척도의 변화 외에 움직임의 유연성이나, 덜 피로함과 같은 다양한 변화가 나타났다.

• Korean Journal of Acupuncture
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• 제21권1호
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• pp.175-199
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• 2004

Objectives : To study acupuncture and moxibution treatments for stomatopathy( aphthae, oral ulceration, mycolic stomatitis, halitosis, thirst, bitter) the ancient and the present literatures were reviewed. Methods : We've got compared and analyzed 55 kinds of literatures. Results and Conclusions : 1. The acupuncture meridians used frequently for stomatopathy were $Su-yangmy\bar{o}ng-Taejang-ky\bar{o}ng(LI),\;Chok-yangmy\bar{o}ng-Wi-Ky\bar{o}ng(S),\;Immaek-Ky\bar{o}ng(CV)$. 2. The acupoints used frequently for aphthae were $Sungjang(CV_{24}),\;Yomchon(CV_{23}),\;Hapkok(LI_4),\;Nogung(P_8),\;Chok-samni(S_{36}),\;Hyopko(S_6),\;Sugu(GV_{26})$. 3. The acupoints used frequently for oral ulceration were $Hapkok(LI_4),\;Nogung(P_8),\;Chok-samni(S_{36}),\;Kokchi(LI_{11}),\;Sotaek(SI_1),\;Pisu(B_{20}),\;Wisu(B_{21}),\;Samgan(LI_3),\;Yomchon(CV_{23}),\;Chichang(S_4)$. 4. The acupoints used frequently for mycolic stomatitis were $Hapkok(L_4),\;Chichang(S_4),\;Hyopko\;(LI_4),\;Sungjang(CV_{24}),\;Samumgyo(SP_6)$. 5. The acupoints used frequently for halitosis were $Naejong(S_{44}),\;Chok-samni(S_{36}),\;Chung-wan\;(CV_{12}),\;Sang-wan(CV_{13}),\;Hawan(CV_{10}),\;Kongson(SP_4),\;Wisu(B_{21}),\;Nogung(P_8),\;Sugu(GV_{26}),\;Sungjang(CV_{24})$. 6. The acupoints used frequently for thirst were $Sosang(L_{11}),\;Sangyang(LI_1),\;Sotaek(SI_1),\;Kwanch'ung(TE_1),\;Ch'\bar{o}kt'aek(L_5),\;T'ae-gye(K_3),\;Kokt'aek(P_3),\;Sugu(GV_{26}),\;Samgan(LI_3),\;Igan(LI_2),\;T'aech'ung(Liv_3),\;Sojangsu(B_{27})$. 7. The acupoints used frequently for bitter were $Yangn\bar{u}ngch'\bar{o}n(G_{34}),\;Hy\bar{o}njong(G_{39}),\;Kwanch'ung(TE_1),\;Tamsu(B_{19}),\;Chokkyu\bar{u}m(G_{44}),\;Y\bar{o}n-gok(K_2),\;Shinmun(H_7),\;Chok-Samni(S_{36})$.

• Korean Journal of Acupuncture
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• 제39권1호
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• pp.8-15
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• 2022

Objectives : Saam acupuncture is one of the indigenous therapeutic modalities in traditional Korean medicine. In this study, the neuroprotective effect of Saam acupuncture of kidney tonification was investigated using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Methods : Twelve-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP at 24-h intervals for 5 days and acupuncture stimulation at LU8, KI7, SP3 and KI3 was performed once a day for 12 days from the first MPTP injection. The pole test and the rotarod test were performed to evaluate motor function, and dopaminergic neuronal survival in the substantia nigra (SN) and striatum was evaluated using tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration caused behavioral impairment and dopaminergic neuronal death in the nigrostriatal pathway. Whereas the Saam acupuncture treatment alleviated the MPTP-induced motor dysfunction and dopaminergic neuronal death in the SN and striatum. Conclusions : Saam acupuncture of kidney tonification can alleviate the MPTP-induced motor dysfunction and dopaminergic neuronal death in the nigrostriatal pathway, suggesting a possible role for acupuncture in the treatment of Parkinson's disease.