• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2003년도 춘계공동학술대회
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• pp.1085-1092
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• 2003

Proposed in this paper is a standard-compliant business process modeling tool which is based on the UML(Unified Modeling Language) activity diagram and produces an XPDL(XML Process Definition Language) file as an output. The XPDL is a standard process definition exchange format by WfMC(Workflow Management Coalition). To develop an UML/XPDL-based modeling tool, the mapping of modeling elements between activity diagram and XPDL format is conducted after the detailed analysis of each modeling specification. As a result of this mapping, it is revealed that modeling elements of each activity diagram and XPDL must be expanded. So new modeling elements are identified and added to each specification. Based on this mapping, the prototype system is developed, and the usefulness of the developed system is shown through the case study.

• Journal of Advanced Marine Engineering and Technology
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• 제32권5호
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• pp.768-774
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• 2008

In many areas of speech signal processing such as automatic speech recognition and packet based voice communication technique, VAD (voice activity detection) plays an important role in the performance of the overall system. In this paper, we present a new feature parameter for VAD which is the product of energy of the signal and the difference of two types of entropies. For this end, we first define a Mel filter-bank based entropy and calculate its difference from the conventional entropy in frequency domain. The difference is then multiplied by the spectral energy of the signal to yield the final feature parameter which we call PEED (product of energy and entropy difference). Through experiments. we could verify that the proposed VAD parameter is more efficient than the conventional spectral entropy based parameter in various SNRs and noisy environments.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.543-550
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• 2007

This study is for an effective response as the pre-stage for railway agencies to prepare the rail road kind based emergency response standard operation procedures when the emergency event occurs. Accordingly, I would like to increase the utility in helping the railroad employees to make their decisions. And that is possible through suggesting them to make computerized Emergency situation based activity and Emergency response that is individual based. And of course all of this procedure would be based on the emergency event categorized response scenario.

• Journal of Construction Engineering and Project Management
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• 제5권4호
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• pp.12-15
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• 2015

Size of building has a direct relationship with building cost, energy use and space maintenance cost. Therefore, minimizing building size during a project development is of paramount importance against such wastes. However, incautious reduction of building size may result in crowded space, and therefore harms the functionality despite the fact that building is supposed to satisfactorily support users' activity. A well-balanced design solution is, therefore, needed at an optimum level that minimizes building size in tandem with providing sufficient space to maintain functionality. For such design, architects and engineers need to be informed accurate and reliable space-use information. We present in this paper a conceptual framework of an agent-based space-use prediction simulation system that provides individual level space-use information over time in a building in consideration of project specific user information and activity schedules, space preference, ad beavioural rules. The information will accordingly assist architects and engineers to optimize space of the building as appropriate.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.349-352
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• 2015

Size of building has a direct relationship with building cost, energy use and space maintenance cost. Therefore, minimizing building size during a project development is of paramount importance against such wastes. However, incautious reduction of building size may result in crowded space, and therefore harms the functionality despite the fact that building is supposed to satisfactorily support users' activity. A well-balanced design solution is, therefore, needed at an optimum level that minimizes building size in tandem with providing sufficient space to maintain functionality. For such design, architects and engineers need to be informed accurate and reliable space-use information. We present in this paper a conceptual framework of an agent-based space-use prediction simulation system that provides individual level space-use information over time in a building in consideration of project specific user information and activity schedules, space preference, ad beavioural rules. The information will accordingly assist architects and engineers to optimize space of the building as appropriate.

• 한국축산식품학회지
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• 제33권5호
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• pp.565-571
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• 2013

An enzyme ${\beta}$-galactosidase or ${\beta}$-galactohydrolase [EC3.2.1.23], commonly called lactase, mediates galacto-oligosaccharide (GOS) synthesis under conditions of high substrate concentrations. Also, lactase hydrolyzes ${\beta}$($1{\rightarrow}4$) lactose into glucose and galactose, the latter is successively transferred to free lactose to make various oligosaccharides via transgalactosylation. GOS is non-digestible to human digestive enzymes and has been used as a functional prebiotics. Among the 24 lactic acid bacteria (LAB) strains used, Lactobacillus paracasei YSM0308 was selected based on its exhibition of the highest ${\beta}$-galactoside hydrolysis activity, and the crude lactase was prepared for examination of reaction conditions to affect the GOS synthesis. Lactase activity was measured with a spectrophotometer using ONPG (o-nitropheyl ${\beta}$-D-galactopyranoside) method. Lactase activity was not detected in the culture supernatant and was mostly present in the cell pellet after centrifugation. Activity of the crude lactase preparation ranges from102 to 1,053 units/mL, with the highest activity determined for L. paracasei YSM0308. Optimal conditions for GOS synthesis are as follows: concentration of whey powder, pH, temperature, and time were 30%, pH 6.5-7.0, $30^{\circ}C$, and 4 h, respectively. The final GOS concentration was 19.41% (w/v) by the crude YSM0308 lactase, which was obtained from strain YSM0308 grown in the 10% (w/v) reconstituted whey-based medium.

• 한국음향학회지
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• 제39권4호
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• pp.286-291
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• 2020

본 논문에서는 템포 기반의 음악 분류와 센서 기반의 인간 행동 인식을 통한 음악을 추천하는 시스템을 제안한다. 제안하는 방식은 템포 기반의 음악 분류를 통해 음악 파일을 색인하고, 인식된 행동에 따라 적합한 음악을 추천한다. 정확한 음악 분류를 위해 변조 스펙트럼 기반의 동적 분류기와 멜 스펙트로그램 기반의 시퀀스 분류기가 함께 사용된다. 또한, 간단한 스마트폰 가속도계, 자이로스코프 센서 데이터가 심층 스파이킹 신경망에 적용되어 행동 인식 성능을 향상시킨다. 마지막으로 인식된 행동과 색인된 음악 파일의 관계를 고려한 매핑 테이블을 통해 음악 추천이 수행된다. 실험 결과는 제안된 시스템이 음악 플레이어가 있는 실제 모바일 장치에 사용하기에 적합하다는 것을 보여준다.

• BMB Reports
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• 제47권8호
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• pp.451-456
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• 2014

Parthenolide, a natural product derived from Feverfew, prevents septic shock and inflammation. We aimed to identify the effects of parthenolide on the RANKL (receptor activator of $NF-{\kappa}B$ ligand)-induced differentiation and bone resorbing activity of osteoclasts. In this study, parthenolide dose-dependently inhibited RANKL-mediated osteoclast differentiation in BMMs, without any evidence of cytotoxicity and the phosphorylation of p38, ERK, and $I{\kappa}B$, as well as $I{\kappa}B$ degradation by RANKL treatment. Parthenolide suppressed the expression of NFATc1, OSCAR, TRAP, DC-STAMP, and cathepsin K in RANKL-treated BMMs. Furthermore, parthenolide down-regulated the stability of c-Fos protein, but could not suppress the expression of c-Fos. Overexpression of NFATc1 and c-Fos in BMMs reversed the inhibitory effect of parthenolide on RANKL-mediated osteoclast differentiation. Parthenolide also inhibited the bone resorbing activity of mature osteoclasts. Parthenolide inhibits the differentiation and bone-resolving activity of osteoclast by RANKL, suggesting its potential therapeutic value for bone destructive disorders associated with osteoclast-mediated bone resorption.

• Interdisciplinary Bio Central
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• 제3권1호
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• pp.5.1-5.5
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• 2011

Introduction: Many signal transduction pathways mediate cell's behavior by regulating expression level of involved genes. Abnormal behavior indicates loss of regulatory potential of pathways, and this can be attributed to loss of expression regulation of downstream genes. Therefore, function of pathways should be assessed by activity of a pathway itself and relative activity between a pathway and downstream genes, simultaneously. Results and Discussion: In this study, we suggested a new method to assess pathway's function by introducing concept of 'responsiveness'. The responsiveness was defined as a relative activity between a pathway itself and its downstream genes. The expression level of a downstream gene as a function of an upstream pathway activation characterizes disease status. In this aspect, by using the responsiveness we predicted potential progress in cancer development. We applied our method to predict primary and metastatic status of melanoma cancer. The result shows that the responsiveness-based approach achieves better performance than using gene or pathway information alone. The mean of ROC scores in the responsiveness-based approach was 0.90 for GSE7553 data set, increased more than 40% compared to a gene-based method. Moreover, identifying the abnormal regulatory patterns between pathway and its downstream genes provided more biologically interpretable information compared to gene or pathway based approaches.

• 지역사회간호학회지
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• 제27권4호
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• pp.299-308
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• 2016

Purpose: The purpose of this study was to develop a positive psychology-based and character strengths-integrated activity program for elders living alone in rural areas, and then to examine the effectiveness of the program. Methods: A quasi-experimental pre- and post-test design with a nonequivalent control group was used. The participants included 59 elders in total, of whom 30 were assigned to the experimental group and 29 to the control group. positive psychology-based and character strengths-integrated activity program for elders consists of sixty-minute sessions held twice per week during 6 weeks, hence 12 sessions in total. Results: There were significant differences between the experimental and control groups in depression, vitality and life satisfaction (all p<.001). Conclusion: The positive psychology-based and character strengths-integrated activity program for elders living alone in rural areas is effective in that it decreased the degree of depression and increased the vitality and life satisfaction in the participants.