• The Korean Journal of Physiology
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• 제20권1호
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• pp.89-102
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• 1986

It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in the experimental hypertension. But the exact nature of the cause and maintenance of early and late Phase of renal hypertension is still controversial. Increased renin-angiotensin system has been suggested. To clarify the altered renin-angiotensin system in the early phase of two kidney one clip Goldblatt hypertension(2K1C GH), experiments were carried out in the rats of 3,7, and 14 days of 2K1C GH rats, sham-operated, and control rats. Responses of the plasma renin activity to the intravenous infusion of L-isoproterenol were dose-dependent. Responses of the plasma renin activity to the intravenous L-isoproterenol in 2K1C GH rats were not different from sham-operated control rats. Hypotensive responses of the 2K1C GH rats were not different from sham-operated rats. Suppression by intravenous infusion of angiotensin II of plasma renin activity showed a dose-dependent manner. Suppression by angiotensin ll of plasma renin activity was attenuated or abolished in the early phase of 2K1C GH rats. Intravenous infusion of arginine vasopressin(AVP) showed a dose-dependent suppression of plasma renin activity, Attenuated responses by AVP of plasma renin activity were noticed in the early phase of 2K1C GH rats. These results suggest that the altered renin-angiotensin system in the early phase of the two kidney one clip Goldblatt hypertension may be caused by failure of the short loop negative feedback control mechanism.

• 전자공학회논문지SC
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• 제44권5호
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• pp.30-37
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• 2007

수질 감시를 위한 물벼룩 활동량 측정을 실시간으로 측정하는 하드웨어를 구현 하였다. 물벼룩은 수질 감시에 빈번히 시용하는 살아있는 생물학적 센서라고 할 수 있다. 물벼룩은 수질이 오염이 되면 활동량의 변화가 나타나기 때문에 물벼룩의 활동량을 감시함으로서 해당 수질의 독성 물질의 유입을 즉각 확인할 수 있다. 물벼룩의 활동량 조사는 기존의 방법은 LED를 이용한 발광부와 Photo TR.을 이용한 수광부를 사용하는 방법이 있으나 물벼룩이 빛에 민감하게 반응하고 측정 대상인 물벼룩을 기준에 두고 2 개의 장치(발광부와 수광부)를 두는 불편한 점이 있었다. 본 논문은 기존의 방식을 대체하기 위해 CCD 카메라를 사용한다. CCD 카메라의 영상처리를 위해 이미지 버퍼에 저장한 후 컴퓨터나 DSP를 사용하여 소프트웨어로 일괄 처리를 하는 것이 아니라 실시간으로 하드웨어로 처리하는 시스템을 구현하였다. 그리고 구현된 하드웨어로 수질 경보를 위한 원격 모니터링 임베디드 시스템을 구축하였다.

• 정보처리학회논문지D
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• 제13D권5호
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• pp.749-754
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• 2006

최근 들어 경쟁력 향상을 위해 많은 기업들이 기간 정보 시스템을 도입하여 운영하고 있는 추세이다. 도입된 정보 시스템의 활용도를 향상시키기 위해서는 정보 시스템 사용 현황을 실시간으로 모니터링/분석할 수 있는 체계를 갖추는 것이 필수적인데 현재 대부분의 기업 정보 시스템들은 이러한 체계적인 모니터링 기능을 제공하고 있지 않고 있는 실정이다. 본 연구에서는 이를 위해 정보활동 모니터링 (IAM: Information Activity Monitoring) 프레임워크를 제안하고 이를 실사례를 통해 그 유용성을 보인다. IAM은 기업 내의 중요한 정보 처리 활동을 실시간으로 모니터링하고 분석하여 그 결과를 사용자에게 피드백 하는 행위라고 정의되며 기업의 정보 처리 행위에 관한 4가지 주요한 시각 (업무 프로세스, 데이터, 사용자/조직, IT 시스템)에 관한 요약 정보를 제공한다. 제안된 '정보활동 모니터링' 기능은 항공기 부품을 생산하는 기업의 설계/생산 통합 정보 시스템의 한 모듈로 개발되어 운영되고 있으며 이러한 기능은 특히 정보 시스템 도입의 필요성에는 공감하나 지속적인 운영에 필요한 인력과 시간이 부족한 중소기업의 정보 시스템 활용도 향상을 위한 필수적인 기능이라 판단된다.

• 간호행정학회지
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• 제8권1호
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• pp.17-29
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• 2002

The purpose of this study was to examine the application of the Activity-based Costing(ABC) system to analyze the cost of nursing services in the delivery room in a major medical center.The results of this study are as follows;1. In order to calculate the cost of nursing activities, 67 activities of staff nurses on a delivery room were identified and classified as direct nursing activities(45.2%), the indirect activities(32.1%), general management activities(13.9%) and others(8.8%).2. Nursing cost in the delivery room was classified into activity cost(29.9%) and common cost(70.1%). Activity cost involved direct activity cost of staff nurses. The common costs were categorized into indirect activity & general management cost of staff nurses, management cost of the head nurse and activity cost of assistants.3. The final cost objects of nursing services in the delivery room were nursing service for women who had normal vaginal deliveries and nursing service for women who had preterm labor.The total cost of nursing service for a woman who had a normal vaginal delivery was 165,710 won (100.0%). The cost incurred through direct activity cost of staff nurses(58,242 won, 35.1%), indirect activity & general management cost of staff nurses (55,643 won, 33.6%), management cost of head nurse (16,211 won, 9.8%), activity cost of assistants (35,614 won, 21.5%).If the number of days of hospitalization was presumed to be 14 days, the total cost of nursing service for woman who had preterm labor would be 1,845,901 won (100.0%). The cost incurred by direct activity cost of staff nurses in the activity cost (341,349 won, 18.5%), indirect activity & general management cost of staff nurses in the common cost(779,002 won, 42.2%), management cost of head nurse(226,954won, 12.3%), activity cost of assistants in the common cost(498,596 won, 27.0%).In this study, the cost of the nursing services in the delivery room was calculated based on the ABC system. The results of this study showed that resources are assigned to the nursing activities in the delivery room and the mechanisms for assigning the cost of activities for nursing services.

• 생명과학회지
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• 제20권6호
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• pp.853-860
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• 2010

DevSR two-component system은 Mycobacterium smegmatis의 redox sensing에 관련된 주요한 regulatory system이다. DevSR system은 DevS histidine kinase와 DevR response regulator로 구성되어 있다. 저산소 조건에서 DevS histidine kinase는 활성화되어 DevR response regulator를 인산화 시키고, 인산화된 DevR response regulator는 DevR regulon의 transcriptional activator로 작용한다. DevS의 kinase activity는 DevS의 N-terminal에 위치한 GAF domain에 존재하는 heme의 ligand-binding state에 의해 결정된다. 본 연구에서는 C-terminal kinase domain의 redox-responsive cysteine (C547)이 DevS kinase activity의 redox-dependent control과 연관이 있음을 밝혔다. 산소가 존재할 때, C547 residue 사이의 disulfide bond의 형성은 DevS kinase activity를 불활성화 시킨다. $\beta$-mercaptoethanol과 dithiothreitol과 같은 환원제를 이용하여 산화된 DevS를 환원시켰을 때, DevS kinase activity가 복원된 것이 관찰되었다. 또한, C547을 alanine으로 치환했을 때, M. smegmatis의 DevS의 sensory 기능을 부분적으로 손상되는 것이 complementation 실험을 통해 in vivo 상에서 증명되었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.861-864
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• 2011

Since national GHG reduction target by 2020 has been presented in Korea, the role of railroad has been reinforced within transport system due to the allocation of reduction target into sector. So, it is necessary to manage activity data systematically for the calculation of GHG emission in railroad. Now, the activity data of diesel consumption for NIR(National Inventory Report) are provided from oil supply and demand statistics. On the other hands, the activity data collected directly from railroad operating companies are used for GHG & Energy Target Management Act. This study aimed to assess the GHG emissions using two kinds of activity data related to the diesel consumption of railroad in 2009 and 2010. As a result, GHG emissions based on oil supply and demand statistics was 636 thousands ton $CO_{2e}$, but the activity data collected from railroad operating companies showed 649 thousands ton $CO_{2e}$ in 2009. Also, the gap of $CO_{2e}$ emission was increased in 2010. These trends were caused because oil supply and demand statistics included total diesel sales volume during 1 year and the activity data collected from railroad operating companies were the amount of diesel consumption only at railcar operation and maintenance step. In conclusion, it is important to develop the management and verification system of activity data with high reliability to substitute oil supply and demand statistics in railroad sector.

• Archives of Pharmacal Research
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• 제28권8호
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• pp.892-896
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• 2005

In order to isolate substances that inhibit the hemolytic activity of human serum against eryth-rocytes, we have evaluated whole plants of the Orostachys japonicus species with regard to its anti-complement activity, and have identified its active principles following activity-guided isolation. A methanol extract of the O. japonicus, as well as its n-hexane soluble fraction, exhibited significant anti-complement activity on the complement system, which was expressed as total hemolytic activity. A bioassay-guided chromatographic separation of the constituents resulted in the isolation of three known compounds 1-3 from the active n-hexane fraction. The structure of these compounds were analyzed, and they were identified as hydroxyhopanone (1), $\beta-sitosteryl-3-O-\beta-D-glucopyranosyl-6'-O-palmitate$ (2), and $\beta-sitosteryl-3-O-\beta-D-glucopyranoside$ (3), respectively. Of these compounds, compound 2 exhibited potent anti-complement activity $(IC_{50}=1.0\pm0.1{\mu}M)$ on the classical pathway of the complement, as compared to tiliroside $(IC_{50}=76.5\pm1.1{\mu}M)$, which was used as a positive control. However, compounds 1 and 3 exhibited no activity in this system.

• 산업경영시스템학회지
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• 제29권4호
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• pp.65-74
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• 2006

This research tried to grasp present condition of domestic corporation's society contribution activity and grope desirable direction of society contribution activity hereafter. As analysis result, establishment of the responsible department or human power in charge for society contribution activity is insufficient, and depend on contribution activity of simple donation than to administer program directly, result of contribution activity is not linked with corporation's purpose or result and practical use of network with similar organization for society contribution was proved by low. Desirable direction of domestic corporation society contribution activity is as following hereafter based on analysis result. First, corporation must put in good order inside system with an establishment of the responsible department for society contribution, security of human power in charge and introducing education program for training specialist. Second, corporation must select specific field with capacity that corporation is holding and improve result of society contribution activity as concentrated investment. Third, corporation must construct network with various similar groups and organizations including NPO/NGO and heighten consummativeness of society contribution activity through mutual interchange and cooperation.

• 한국철도학회논문집
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• 제8권2호
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• pp.161-169
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• 2005

In this paper, we provide safety requirements and advices to guarantee the safety of an interface in a level crossing system which is an interface between the conventional facilities and the new ATP (Automatic Train Protection) system, as well as we accomplish a safety management for the facilities of a country that has a different standard with already standardized ATP system. The system model has been made based on a safety activity of the international standard, and then a tolerance of a risk by the safety activity through PHA (Preliminary Hazard Analysis) has been analyzed. finally we achieved HIA (Hazard Identification and Analysis) for the assumptions that have been produced from a operating scenario and a functional interface. Thus, the safety requirements for the interface has been provided from the safety plan of HIA, and we showed the safety activity to guarantee the system safety through HIA which was depend on the design.

• 한국컴퓨터정보학회논문지
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• 제21권12호
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• pp.81-89
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• 2016

In this paper, we design and implement a mouse movement measurement system using an infrared sensor called MAMS (Mouse Activity Measurement System). Unlike existing systems, MAMS can measure movements between IREDs. MAMS is removable allowing convenient portability and is also low cost. MAMS automatically measures mouse activity during a pre-set time interval. Since the measured data can be easily stored in a computer system, it is much simpler and more efficient than the Ugo 47420 model. Moreover, MAMS can be used in medical and veterinary field to eliminate manual observations.