• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1085-1091
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• 2014

Matrix metalloproteinases (MMPs) are a family of zinc dependent extracellular matrix (ECM) remodelling endopeptidases having the ability to degrade almost all components of extracellular matrix and implicated in various physiological as well as pathological processes. Carcinogenesis is a multistage process in which alteration of the microenvironment is required for conversion of normal tissue to a tumour. Extracellular matrix remodelling proteinases such as MMPs are principal mediators of alterations observed in the microenvironment during carcinogenesis and according to recent concepts not only have roles in invasion or late stages of cancer but also in regulating initial steps of carcinogenesis in a favourable or unfavourable manner. Establishment of relationships between MMP overproduction and cancer progression has stimulated the development of inhibitors that block proteolytic activity of these enzymes. In this review we discuss the MMP general structure, classification, regulation roles in relation to hallmarks of cancer and as targets for therapeutic intervention.

• 대한안전경영과학회지
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• 제17권1호
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• pp.45-52
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• 2015

The purpose of this investigation is to enhance the survival rate of patients by transporting them to the hospital within the golden hour through the operational improvement of emergency dispatch instruction. To this end, problems and improvements of current operating system were derived by carrying out a survey against paramedics of Incheon city in 2012 and analyzing the current emergency dispatch instruction. This study analyzed the emergency activity daily reports for one year from January 1 through December 31, 2012 and researched the consciousness of 119 emergency medical technician. According to the analysis of the survey, there were no meaningful differences in the on-site arrival times per triage. Therefore, the item of 'Emergency Classification' specified in the emergency dispatch instruction needs to be integrated in the scheme of "triage". Also, the feedbacks of the emergency action log and the emergency dispatch instruction are necessary for 'duty for operation' to review the adequacy to the severity after the end of emergency operation. Finally, the improvement of the system for the continuous communication between the paramedics and the command staff is necessary. This improvements as stated above are expected to contribute to raise survival rate of patients.

• 가정과삶의질연구
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• 제11권1호
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• pp.159-175
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• 1993

The purpose of this study was to find out the psychological distance through semantic app-roach perceived by adolescent child in the subtypes of 'Extrem Family' dysfunctional families by classification of Olson and his associates ' Circrumplex Model. The subjects of this research were 1072 abolescents living in Seoul. Korea The survey methods were questionnaires including FACES II and The Psychological Distance Scale. Data were analyzed by means of the statistics of frequency percentage arithematic mean standard devia-tion crosstabs and one way-anova. The major findings are as follows: 1) The levels of family cohesion family adaptibility and the psychologival distances with father mother and siblings perceived by adolescent were high. 2) The most of subject's families belonged to 'Balanced Family' in the types of family system ' Extreme Family' type showed the lowest frequency and the main subtypes of it that had the highest frequency were 'Enmeshed Chaotic Family' ' Disengaged Rigid Family' 3) While adolescents of 'Enmeshed Chaotic Family' perceived most closely with other family members. those of 'Disengated Rigid Family' most distantly totally and in evaluation potency and activity three subfactors in psychological distance. 4) There were differences of unit points in subfactors of psychological distances with other family members perceived by adolescents according to the types of family system. While the points of 'Enmeshed Chaotic Family' were the highest those of 'Disengaged Rigid Family' were the lowest. 5) While 'Enmeshed Chaotic Family' were located most closely 'Disengaged Rigid Family' were located most distantly in the mutual distances and direct distances among family concepts on semantic space.

• 천문학회보
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• 제39권2호
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• pp.43.1-43.1
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• 2014

We report on the optical spectroscopic analysis of a Low Luminosity Quasi Stellar Objects (LLQSOs) sample at $z{\leq}0.06$ based on the Hamburg/ESO QSO survey (HES). To better relate the low-redshift Active Galactic Nucleus (AGN) to the QSO population it is important to study samples of the latter type at a level of detail similar to that of the low-redshift AGN. Powerful QSOs, however, are absent at low redshifts due to evolutionary effects and their small space density. Our understanding of the (distant) QSO population is, therefore, significantly limited by angular resolution and sensitivity. The LLQSOs presented here offer the possibility to study the faint end of this population at smaller cosmological distances and, therefore, in greater detail. This, in turn, provides information about the key ingredients with respect to fueling and feedback of QSOs, and their relative importance/strength. Here, we present results of the analysis of visible wavelength spectroscopy provided by the HES and the 6 Degree Field Galaxy Survey (6dFGS). Interesting differences in the taxonomy of the sources having both types of spectra have been noticed and will be discussed.

• 한국보육지원학회지
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• 제11권5호
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• pp.91-111
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• 2015

본 연구에서는 유아가 오감을 이용한 벼 관찰활동을 통해 유아의 과학과정기술이 어떻게 변화하는지 살펴보고자 실시되었다. 연구참여자는 경기도 오산시에 소재한 Y어린이집에 재원중인 만3세 유아 10명이었다. 유아의 과학과정기술의 변화를 살펴보기 위하여 Spradley(1980)의 참여관찰 분석과정을 최정열(2000)이 수정 보완한 분석과정을 사용하였다. 분석자료에는 유아 인터뷰 자료, 유아관찰일지, 교사 관찰기록 등이 사용되었다. 연구결과 오감을 이용한 벼 관찰활동은 유아의 과학과정기술에 긍정적인 효과가 있는 것으로 나타났다. 유아는 초기에 비해 후기로 갈수록 벼에 대해 예측하기, 관찰하기, 분류하기, 비교하기, 측정하기 능력이 향상되었다. 본 연구결과는 유아의 과학적 사고 신장을 위한 교수방법의 기초자료로 활용될 수 있을 것이다.

• 한국전문물리치료학회지
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• 제22권2호
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• pp.30-40
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• 2015

Robot-assisted rehabilitation therapy has been used to increase physical function in post-stroke patients. The aim of this meta-analysis was to identify whether robot-assisted gait training can improve patients' functional abilities. A comprehensive search was performed of PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Academic Search Premier (ASP), ScienceDirect, Korean Studies Information Service System (KISS), Research Information Sharing Service (RISS), Korea National Library, and the Korean Medical Database up to April, 2014. Fifteen eligible studies researched the effects of robot-assisted gait training to a control group. All outcome measures were classified by International Classification of Functioning, Disability, and Health (ICF) domains (body function and structures, activity, and participation) and were pooled for calculating the effect size. The overall effect size of the robot-assisted gait training was .356 [95% confidence interval (CI): .186~.526]. When the effect was compared by the type of electromechanical robot, Gait Trainer (GT) (.471, 95% CI: .320~.621) showed more effective than Lokomat (.169, 95% CI: .063~.275). In addition, acute stroke patients showed more improvement than others. Although robot-assisted gait training may improve function, but there is no scientific evidence about the appropriate treatment time for one session or the appropriate duration of treatment. Additional researchers are needed to include more well-designed trials in order to resolve these uncertainties.

• 근관절건강학회지
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• 제20권1호
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• pp.22-30
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• 2013

Purpose: The International Classification of Functioning, Disability and Health (ICF) model was proposed by the World Health Organization for enhancing interdisciplinary communication. The purpose of this study was to examine the functional status of acute stroke patients using ICF core sets-short form. Methods: A set of 15 ICF items on functional status was used by nurses for their daily nursing assessment on functional status in 44 acute stroke patients in a university hospital. Results: The highest level of function was "consciousness", while the lowest was "defecation". Compared with functional status on the first day, consciousness, ingestion, language (mental), and defecation functions were significantly improved on the 14th day. However, there was no significant changes in items on activity and participation or environmental functions. Conclusion: These findings suggest that the function-specific nursing interventions for acute stroke patients need to be developed. Future research needs to test the usefulness of ICF items as an measurement tool.

• The Journal of Korean Physical Therapy
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• 제29권3호
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• pp.115-121
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• 2017

Purpose: The aim of this study was to investigate applicability of the GMFM-88 in planning intervention for CP children. Specifically, this study assessed functional improvement after a four-week GMFM-88 item-based training in CP children divided into three age groups (${\leq}24$ months, 25-48 months, and >48 months) and five levels of the gross motor function classification system (GMFCS). Methods: Subjects were 264 children with CP (mean age 32.90 months) recruited from one CP clinic. The GMFM-88 item-based training was planned for each child, after an interview with its caregiver. To investigate functional improvement after the intervention, minimum important difference (MID) and MID proportion for the change in scores of GMFM-88 were calculated. Results: The GMFM-88 scores increased after the interventions in all three age groups (p<0.05). In particular, children with CP aged ${\leq}24$ months and at the GMFCS level II showed greater functional improvement after training. Conclusion: This study found that the GMFM-88 item-based training would be used to plan activity-oriented intervention both in clinic and home in each CP child.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 춘계학술대회 논문집
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• pp.673-679
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• 2005

Urban conditions such as underground facilities and ambient noises due to cultural activity restrict the application of conventional geophysical techniques in general. We used the linear array microtremor technique which uses these noises as strong energy source. The result parameter of the survey is shear wave velocity profile which had been applied as an fundamental information for the determination of the rock support type in tunnel design. This study was the first case in Korea which utilized a surface geophysical technique yielding successful result in urban area especially under the existing rail ways. The quantitative relation between the shear wave velocity from this method and the rock mass rating(RMR) determined from the inspection of the cores recovered from the same boreholes showed high statistical relationship. These correlations were then used to relate the shear-wave velocity to RMR along the entire profile.

• Journal of Photoscience
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• 제8권2호
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• pp.61-66
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• 2001

Using maize green- and white-leaf tissue, we have examined the effect of various chemicals on cytoplasmic leakage with respect to the light requirement or chloroplast targeting for their activities. Oxyfluorfen, oxadiazon, diuron, and paraquat, which are known as representative herbicides acting on plant chloroplasts, caused the electrolyte leakage only in the green tissues, whereas 2, 4-dinitrophenol, rose bengal (singlet oxygen producing chemical) and methyl-jasmoante (senscence-stimulating chemical) play a role both in green- and white-tissue. Benzoyl(a) pyrene, generating superoxide radical upon light illumination, functions only in white tissues. Tralkoxydim, metsulfuron-methyl and norflurazon showed no effect in two tested plant samples. In terms of light requirement in electrolyte leakage activity, diuron, oxyfluorfen, oxadiazon, rose bengal, and benzoyl(a) pyrene absolutely require the light for their functions, but other chemicals did not. based on these results, we could classify into four different response types according to whether chemicals require light or chlroplasts for their action. This classification is likely to be applied to simply and rapidly identify the requirement of light and chlroplasts for the actions of chemicals, thereby it makes easy to characterize many new herbicides that their action mechanisms are unclear, and to elucidate the mode of action of them.