• 제목/요약/키워드: Activity Coefficient

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뇌졸중환자의 반웅크리기 동안에 하지근활성도와 BBS, TUG와의 상관관계 (Correlation Between BBS, TUG and Lower Extremity Muscle Activity during Semi-Squat in Stroke Patients)

  • 박승규;양대중;김제호;정용식
    • 대한임상전기생리학회지
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    • 제9권2호
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    • pp.7-12
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    • 2011
  • Purpose : We studied the correlation between reference voluntary contraction (% RVC) of vastus lateralis (VL) and vastus medialis (VM), Berg balance scale (BBS), and timed-up & go (TUG) test. Methods : We recruited 30 stroke patients from a rehabilitation center at a hospital.? All subjects could walk with or without an assisting device. Subjects were evaluated with % RVC of VL and VM, BBS, and TUG. The data were analyzed using a Pearson correlation coefficient. Results : The % RVC of VL and VM and BBS (p<0.01) showed a significant positive correlation. TUG negatively correlated with % RVC of VL and VM and BBS (p<0.01). Conclusion : Lower extremity muscle activity increases balance and walking ability. We recommend the implementation of lower extremity strength exercises in the rehabilitation of stroke patient.

Chitin의 효소적 가수분해 특성에 대한 속도론적 연구 (Kinetics on the Specificity of Enzymatic Hydrolysis of Chitin)

  • 이은영;김광
    • KSBB Journal
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    • 제13권1호
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    • pp.44-51
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    • 1998
  • Hydrolysis and adsorption reversibility experiments were run for initial enzyme activity of 4.48, 9.65, 11.19 and 17.14U/mL at a temperature 30$^\circ C$. The chitin particle size corresponded to a mean particle diameter of 0.127mm, and the initial concentration of chitin was 10mg/mL. After approximately 2hrs, the enzyme activity remained constant in a speudo-steady state. The amounts in the bulk [E] and the amounts of enzyme adsorbed on the chitin surface [E] are plotted on Lineweaver-Burk plot to yield a linear relationship with a correlation coefficient of 0.99, a slope of 2.79cm$^-1$ and an intercept of 0.08$\textrm{cm}^2$/U. From this parameters, the values of [E$_T$] and $K_E$ were calculated to be 12.5U/cm$^2$ and 34.88U/mL. respectively, Adsorption isotherm of the enzyme on the particles showed a well developed plateau of 1.35$\times$10$^-3$, 4.72$\times$10$^-3$, 4.42$\times$10$^-3$, 8.58$\times$10$^-3$U/cm$^2$ at 30$^\circ C$. To determine the specificity of chitinase for crystalline chitin, the free energy of adsorption was measured, and its was determined as about -14.62~-18.8kJ/mol.

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Occurrence of Glutathione Sulphydryl (GSH) and Antioxidant Activities in Probiotic Lactobacillus spp.

  • Yoon, Yung H.;Byun, Jung R.
    • Asian-Australasian Journal of Animal Sciences
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    • 제17권11호
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    • pp.1582-1585
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    • 2004
  • The antioxidative ability on the basis of reduced glutathione sulphydryl level, the inhibition activities of linoleic acid peroxidation of cell free extract of Lactobacillus spp. and the effects of types of media and growth phase of the cells on the cellular GSH level have been determined. Correlation between reduced glutathione sulphydryl level and antioxidative ability of Lactobacillus spp. was analyzed: Lactobacillus casei HY 2782 contained 25.15 $\mu$mole/g of GSH, the cellular GSH level of L. casei HY 2782 reached maximum after 24 h of cultivation and tended to decrease on further cultivation up to 72 h. There was a significantly higher level of cellular GSH when grown in de Man Rogosa and Sharpe (MRS) broth than in tryptone phytone yeast extract (TPY) broth or bromcresol pruple dextrose (BCP) broth (p<0.05). The antioxidant activity of cell free extract of Lactobacillus spp. have been shown to be significantly different among strains in the inhibition of linoleic acid peroxidation by thiobarbituric acid (TBA) test (p<0.01). L. casei HY 2782 and L. acidophilus ATCC 4356 revealed a high degree of antioxidative effect in linoleic acid oxidation system. Spearmans' rank correlation coefficient between inhibitory activity on linoleic acid peroxidation and cellular GSH levels of Lactobacillus spp. was 0.65, which means a significant positive correlation.

충남지역 치위생(학)과 학생의 여가활동인식과 대학생활만족의 관계 (Correlation between the perception towards leisure activities and satisfaction with campus life in dental hygiene students in the Chungcheongnam-do area)

  • 유진아;장종화
    • 한국치위생학회지
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    • 제17권4호
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    • pp.647-656
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    • 2017
  • Objectives: The purpose of the study was to examine the correlation between leisure activity recognition and campus life satisfaction of dental hygiene students in the Chungnam area. Methods: A self-reported questionnaire was completed by 494 dental hygiene students at eight universities from January 11 to January 29, 2016. The questionnaire used a five point Likert scale to measure campus life satisfaction and perception towards leisure activities. Data were analyzed with descriptive statistics of variables, independent t-test, one way ANOVA, and Pearson's correlation coefficient analysis. Results: The mean for satisfaction with campus life and perception towards leisure activities were 3.15 and 3.73, respectively, wich were both higher than the average. The campus life satisfaction of facilities, study, life showed positive correlations with leisure activity recognition. Conclusions: Perception towards leisure activities was associated with satisfaction with campus life. These results suggest that university authorities should encourage students to use active leisure time such as by establishing leisure programs and club activities in order to improve students' awareness of leisure activities and encourage them to make the most of university life.

A Study of Stroke Patients' Leisure Activities and Quality of Life

  • Paek, Hyun Hee;Seo, Eun Jin;Kim, Jeong Ja
    • 국제물리치료학회지
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    • 제5권2호
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    • pp.764-771
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    • 2014
  • This study was conducted in order to examine relationship between stroke patients' degree of satisfaction with leisure and quality of life according to their leisure activity types and whether they conducted leisure activities. A direct survey was performed from April 8 to May 3, 2013 on 92 inpatients and outpatients who received occupational therapy at hospitals located in Jeonju and Gunsan. A frequency analysis was carried out in order to look at the general characteristics of the subjects, their degree of participation in leisure activities, and their degree of satisfaction with leisure activities. A Pearson's coefficient was used to examine relationship between their degree of satisfaction and quality of life according to participation in leisure activities. Their degree of satisfaction according to participation in leisure activities was significantly higher when they took part in leisure activities such as handicraft activities, sports activities, or travel or tourism activities than when they did not perform any leisure activities. Their quality of life according to participation in leisure activities was higher when they conducted sports activities, outing activities, or tourism activities than when they did not. There was significant correlation between their degree of satisfaction with leisure and quality of life according to leisure activities.

영광 원자력발전소 주변해역 표층퇴적물의 입도와 원소분포 특성 (Characteristics of Particles Size and Element Distribution in the Coastal Bottom Sediments in the Vicinity of Youngkwang Nuclear Power Plant)

  • 은고요나
    • 자원환경지질
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    • 제33권3호
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    • pp.195-204
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    • 2000
  • order to investigate physical characteristics and element concentrations of sediments, coastal bottom sediments were collected at 20 stations in the vicinity of Youngkwang Nuclear Power Plant. After air drying of samples in the laboratory. article size distribution was examined by Master sizer (X-350F), radio-activity by HPGe ${\gamma}$-spectrphotometer, and element concentrations by ICP-AES and AAS. According to particle size analysis , sediments are mainly composed of silt fraction weith 23% of sand, 65% of silt and 12% of clay on average. Most sediments are derived from muddy environment that silt dominates with the characteristics of 5.3${\varsigma}$ mean particle size, poorly sorted, very fine skewed and lepto-kurtic. Only two sediments are well sorted with sandy silt owing to wind, winnowing action, tide and current andits complex reactions. Element concentrations in the coastal bottom sediments are relatively high at finer sediment and show significant relationship with grain size. Index of geoaccumulation by heavy metals at every sampling station is classified as practically unpolluted. The radioactivities of the sediments were measured for 15 isotope elements, and 2 elements of K-40 and Cs-137 were detected in most sediments. The K-40 is the natural nuclide and the artificial nuclide of Cs-137 was thought to be derived from the fallout of past nuclear weapon test. The results of correlation coefficient between grain size and radioactivity shows that the activity of Cs-137 significantly increases in finer grain.

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Adenosine Kinase Inhibitor Design Based on Pharmacophore Modeling

  • Lee, Yun-O;Bharatham, Nagakumar;Bharatham, Kavitha;Lee, Keun-Woo
    • Bulletin of the Korean Chemical Society
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    • 제28권4호
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    • pp.561-566
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    • 2007
  • Adenosine kinase (AK) is a ubiquitous intracellular enzyme, which catalyzes the phosphorylation of adenosine (ADO) to adenosine monophosphate (AMP). AK inhibitors have therapeutic potential as analgesic and antiinflammatory agents. A chemical feature based pharmacophore model has been generated from known AK inhibitors (26 training set compounds) by HypoGen module implemented in CATALYST software. The top ranked hypothesis (Hypo1) contained four features of two hydrogen-bond acceptors (HBA) and two hydrophobic aromatics (Z). Hypo1 was validated by 124 test set molecules with a correlation coefficient of 0.905 between experimental and estimated activity. It was also validated by CatScramble method. Thus, the Hypo1 was exploited for searching new lead compounds over 238,819 chemical compounds in NCI database and then the selected compounds were screened based on restriction estimated activity and Lipinski's rules to evaluate their drug-like properties. Finally we could obtain 72 new lead candidates and the two best compound structures from them were posted.

Seta Flash 밀폐식 장치를 이용한 Water-Methanol과 Water-Ethanol계의 인화점 측정 (The Measurement of Flash Point of Water-Methanol and Water-Ethanol Systems Using Seta Flash Closed Cup Tester)

  • 하동명;박상훈;이성진
    • 한국화재소방학회논문지
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    • 제29권2호
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    • pp.39-43
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    • 2015
  • 인화점은 액체 혼합물의 화재와 폭발의 위험성을 특징짓는 주된 성질이다. 인화점은 가연성 액체에 불꽃이 가해졌을 때 점화가 발생하는 가장 낮은 온도로 정의된다. Seta flash 밀폐식 장치를 이용하여 이성분계 수용성 혼합물인 water-methanol계와 water-ethanol계의 인화점을 측정하였다. Wilson 식과 UNIQUAC 식과 같은 활동도 모델식을 활용한 방법을 이용하여 인화점을 계산하였다. 이 계산치와 라울의 법칙에 의한 계산치를 비교하였다. 그 결과, 활동도 계수 모델식에 의한 계산치가 라울의 법칙에 의한 계산치 보다 측정값에 보다 근접하였다.

세프테졸 피발로일옥시메칠 에스텔의 합성 및 생물약제학적 연구 (Synthesis and Biopharmaceutical Studies of Ceftezole Pivaloyloxymethyl ester, a Novel Prodrug of Ceftezole)

  • 김가나;박용채;이진환
    • Journal of Pharmaceutical Investigation
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    • 제25권4호
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    • pp.323-330
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    • 1995
  • Ceftezole pivaloyloxymethyl ester(CFZ-PV) was synthesized to improve oral absorption and bioavailability of parent drug by esterification of ceftezole(CFZ) with chloromethyl pivalate. The successful synthesis of CFZ-PV was conformed by spectroscopic analysis. Partition coefficient studies showed that CFZ-PV is more lipophillic than CFZ. The pharmacokinetic characteristics of CFZ-PV and CFZ were compared following oral administrations of these compounds to rabbits. The amount of CFZ in plasma was determined with an HPLC method. The ester compound (prodrug) was not detected in plasma following oral administration of CFZ-PV, and although CFZ-PV had not microbiological activity in vitro, the plasma taken after oral administration of CFZ-PV had microbiological activity. From above observations, it was noted that CFZ-PV is rapidly hydrolyzed to CFZ in the body. And the oral absorption of CFZ-PV was increased by yielding 2-fold bioavailability rather than CFZ. Therefore, CFZ-PV could be a novel prodrug of CFZ which can improve the oral bioavailability of CFZ.

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Relative contribution of geomagnetic and CO2 effects to global temperature anomaly

  • Kim, Jinhyun;Moon, Yong-Jae
    • 천문학회보
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    • 제41권1호
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    • pp.79.3-80
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    • 2016
  • We have investigated the correlation analysis between global temperature anomaly and two main factors: geomagnetic activity (aa index) of Earth external factor and CO2 of Earth internal factor. For this, we used NOAA Global Surface Temperature anomaly (Ta) data from 1868 to 2015. The aa index indicates the geomagnetic activity measured at two anti-podal subauroral stations (Canberra Australia and Hartland England) and the CO2 data come from historical ice core records and NOAA/ESRL data. From the comparison between (Ta) and aa index, we found several interesting things, First, the linear correlation coefficient between two parameters increases until 1985 and then decreases rapidly. Second, the scattered plot between two parameters shows a boundary of the correlation tendency (positive and negative correlation) near 1985. A partial correlation of (Ta) and two main factors (aa index, CO2) also shows that the geomagnetic effect (aa index) is dominant until about 1985 and the CO2 effect becomes much more important after then. These results indicate that the CO2 effect become very an important factor since at least 1985. For a further analysis, we simply assume that Ta = Ta(aa)+Ta(CO2) and made a linear regression between (Ta) and aa index from 1868 to 2015. A linear model is then made from the linear regression between energy consumption (a proxy of CO2 effect) and Ta-Ta(aa) since 1985. Our results will be discussed in view of the prediction of global warming.

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