• Journal of Korean Society for Quality Management
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• v.46 no.3
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• pp.509-522
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• 2018

Purpose: The purpose of this study was to propose more accurate mathematical model which can represent result of government quality assurance activity, especially corrective action and flaw. Methods: The collected data during government quality assurance activity was represented through histogram. To find out which distributions (Poisson distribution, Zero-Inflated Poisson distribution) could represent the histogram better, this study applied Pearson's correlation coefficient. Results: The result of this study is as follows; Histogram of corrective action during past 3 years and Zero-Inflated Poisson distribution had strong relationship that their correlation coefficients was over 0.94. Flaw data could not re-parameterize to Zero-Inflated Poisson distribution because its frequency of flaw occurrence was too small. However, histogram of flaw data during past 3 years and Poisson distribution showed strong relationship that their correlation coefficients was 0.99. Conclusion: Zero-Inflated Poisson distribution represented better than Poisson distribution to demonstrate corrective action histogram. However, in the case of flaw data histogram, Poisson distribution was more accurate than Zero-Inflated Poisson distribution.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.301-309
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• 2006

The main purpose of this study is to derive a regression equation that predicts the individual differences in activity energy expenditure (AEE) using accelerometer during different types of activity. Two subject groups were recruited separately in time: One is a homogeneous group of 94 healthy young adults with age ranged from $20\sim35$ yrs. The other subject group has a broad spectrum of physical characteristics in terms of age and fat ratio. 226 adolescents and adults of age ranged from $12\sim57$ yrs and fat ratio from $4.1\sim39.7%$ were in the second group. The wireless 3-axis accelerometers were developed and carefully fixed at the waist belt level. Simultaneously the total calorie expenditure was measured by gas analyzer. Each subject performed walking and running at speeds of 1.5, 3.0, 4.5, 6.0, 6.5, 7.5, and 8.5 km/hr. A generalized sensor-independent regression equation for AEE was derived. The regression equation was developed fur walking and running. The regression coefficients were predicted as functions of physical factors-age, gender, height, and weight with multivariable regression analysis. The generalized calorie estimation equation predicts AEE with correlation coefficient of 0.96 and the average accuracy of the accumulated calorie was $89.6{\pm}7.9%$.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.225-231
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• 2003

To search and development a new material with superior melanogenesis inhibitory activity, the bioactivities (obs. pl$_{50}$) of alkyl-3,4-dihydroxybenzoyl esters and N-alkyl-3,4-dihydroxybenz-oyl amides as substrate molecules were measured in mouse melanoma cells. And also, we have studied that 3-D QSARs (3 dimensional Quantitative Structure-Activity Relationships) between molecular interaction field of substrates and the bioactivities were analyzed using CoMFA (Comparative Molecular Field Analyses) method. When cross-validation value (q$^2$) is 0.68 at 3 components, the Pearson correlation coefficient ($r^2$) is 0.900. From the basis on the findings, the model was appeared by the contour map such as steric field and electrostatic field relationships between quantitative structure and the bioactivity of the various substrate derivatives. Measured bioactivities (obs. pl$_{50}$) of unknown compounds are very similar to predicted activity (pred. pl$_{50}$) according to the CoMFA model. As the results of prediction, we could conclude that the bioactivities were increased by creation of R$_1$ substitution of 5,5-dime-thylhexoxy, 6,6-dimethylheptyl, 1-amino-6,6-dimethylheptyl group etc and R$_2$ substitution of hydroxy, methyl, methoxy group etc.p etc.

• The Korean Journal of Ecology
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• v.18 no.4
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• pp.503-512
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• 1995

The present paper describes partial results of the study on the activities of microbes in the soil of Quercus mongolica forest from July, 1994 to April, 1995. To determine the relationship between structure and function of soil microbial ecosystem, the author investigated the seasonal change of physical environmental factors, microbial population and soil enzyme activities. The changes of pH was not significant and the temperature of surface soil was 2℃ higher than lower soil through out the year. Moisture contents (％) of soil samples ranged from 7.64％ to 42.11％. However, soils of site 3 at Mt. Komdan in which vegetation is successional have higher moisture content than the others. The bacterial population increased in summer, but continuously decreased in autumn and winter, and then reincreased again in spring. Bacterial population of surface soil was higher than those of 30 cm depth all the year round. Dehydrogenase activity (DHA) was about two-fold higher throughout in surface soil compared to those of lower soil. And the correlation coefficient between DHA and bacterial population size was 0,713, It was suggested that DHA could be used as a primary index of soil microbial population and activity in soil ecosystem.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• v.23 no.1
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• pp.1-11
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• 1995

Thermospheric neutral winds and temperatures have been collected from the ground-based Fabry-Perot interferometer (FPI) at Thule Air Base ($76.5^{\circ}N{\;}69.0^{\circ}W$), Greenland since 1985. The thermospheric observations are obtained by determining the Doppler characteristics f the [OI] 6300 ${\AA}$ emissions of atomic oxygen. The FPI operates routinely during the winter season, with a limitation in the observation by the existence of clouds. For this study, data acquired from 1985 to 1991 were analyzed. The neutral wind measurements from these long-term measurements are used to investigate the influence of solar cycle variation on the high-latitude thermospheric dynamics. These data provide experimental results of the geomagnetic polar cap are also compared with the predictions of two semiempirical models : the vector spherical harmonics (VSH) model of Killeen et al. (1987) and the horizontal wind model (HWM) of Hedin et al. (1991). The experimental results show a good positive correlation between solar activity and thermospheric wind speed over the geomagnetic polar cap. The calculated correlation coefficient indicates that an increase of 100 in F10.7 index corresponds to an increase in wind speed of about 100 m/s. The model predictions reveal similar trends of wind speed variation as a function of solar activity, with the VSH and HWM models tending to overestimate and underestimate the wind speed, respectively.

• Korean Journal of Adult Nursing
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• v.17 no.3
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• pp.400-410
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• 2005

Purpose: The purpose of this study is to examine the relationship between the living arrangement, life satisfaction and depression in the elderly. Method: The subjects consisted of 371 elderly who has at least one adult child classifying two groups(living with children and not living with children). The data were collected by a structured questionnaire that included general characteristics, Geriatric Leisure Activity Scale, Geriatric Life Satisfaction Scale, Geriatric Depression Scale, from March to December, 2004. The collected data were analyzed by SPSS program including descriptive statistics, ${\chi}^2-test$, t-test, Pearson Correlation Coefficient and Hierarchical Regression. Result: In hierarchical regression, the elders who live with their children showed more life satisfaction than elders who lived by themselves. However, living arrangement showed no effect on the level of depression of the elderly parents. Significant leisure activity interaction effect was found on the depression among the elderly: The elderly with no leisure activity reported lower levels of depression when they lived with their adult child. Conclusion: It is necessary to explore further the various relationship among living arrangement and life satisfaction of the elderly, their preferences and expectations regarding inter-generational obligations and living arrangements.

• Analytical Science and Technology
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• v.8 no.3
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• pp.371-374
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• 1995

An organic germanium compound, Ge-132, was reported to have interferon inducer activity, anti-tumor activity and anti-viral activity. ICP, AA and colorimetry methods were used for the determination of germanium in Ge-132. However these methods have a problem that they only give an information on the total amount of germanium element, and consequently Ge-132 connot be distinguished form toxic inorganic Ge compounds. To overcome this problem, ion chromatography was used to analyze Ge-132. Ge-132 was separated on Ionpac AS4A column with 1.3mM $Na_2B_4O_7$ buffer(pH=9.2) solution as an eluent and detected by the conductivity detector. Correlation coefficient of the calibration curve was 0.999 and the detection limit measured at S/N ratio of 3 was 50pmol. This method was applicable to the analysis of Ge-132 raw material and Ge-132 preparations.

• Bulletin of the Korean Chemical Society
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• v.25 no.10
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• pp.1513-1520
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• 2004

We investigate a series of synthesized ${\beta}$-methoxyacrylate analogues for their 3D QSAR & HQSAR against Magnaporthe grisea (Rice Blast Disease). We perform the three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) studies, using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) procedure. In addition, we carry out a two-dimensional Quantitative Structure-Activity Relationship (2D-QSAR) study, using the Hologram QSAR (HQSAR). We perform these studies, using 53 compounds as a training set and 10 compounds as a test set. The predictive QSAR models have conventional $r^2$ values of 0.955 at CoMFA, 0.917 at CoMSIA, and 0.910 at HQSAR respectively; similarly, we obtain cross-validated coefficient $q^2$ values of 0.822 at CoMFA, 0.763 at CoMSIA, and 0.816 at HQSAR, respectively. From these studies, the CoMFA model performs better than the CoMSIA model.

• Journal of Pharmaceutical Investigation
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• v.27 no.2
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• pp.125-131
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• 1997

Ethoxycarbonyloxyethyl ester of ceftezole (CFZ-ET) was synthesized as a prodrug by esterification of ceftezole (CFZ) with ethoxycarbonyloxyethyl chloride and was confirmed by spectroscopic analyses. CFZ-ET was more lipophillic than CFZ as assessed by n-octanol and water partition coefficients at various pH. CFZ-ET itself did not show any microbiological activity in vitro, but showed substaintial microbiological activity after oral administration of CFZ-ET, indicating that CFZ-ET is converted to microbiologically active metabolite, probably CFZ, in the body. When CFZ-ET was incubated in blood, liver and intestine homogenates of rabbits, liver homogenate showed the fastest conversion of CFZ-ET. CFZ-ET appears rapidly metabolized in the liver when given orally due to the hydrolysis of the ester to CFZ, the parent drug of CFZ-ET. In vivo metabolism of CFZ-ET to CFZ was confirmed in rabbit by HPLC analysis. CFZ-ET were higher than those in the serum samples taken after oral administration of equivalent amount of CFZ. Oral bioavailability of CFZ-ET was 1.5-fold higher than that of CFZ in rabbits because of enhanced lipophilicity and absorption. Based on these findings, CFZ-ET appears useful as a prodrug of CFZ to improve the oral bioavailability of CFZ.

• Journal of Home Health Care Nursing
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• v.26 no.1
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• pp.72-80
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• 2019

Purpose: This study aimed to measure health-related quality of life (HRQoL) and investigate the relevant factors for middle aged women using the 2014 Korea Health Panel data. Methods: The Korea Health Panel data 2014 were collected from February to August 2014 by the Korea Institute for Health and Social Affairs and the National Health Insurance Corporation and included 2,075 people who responded to the questionnaire. Using SPSS WIN program, the data were analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression analysis. Results: Limited activity was the most influential factor for the health-related quality of life of middle-aged women. For health behavior, the factors affecting HRQoL were drinking, sleeping time, and physical activity. For physical health, factors affecting HRQoL were vision problems, eating problems, and hearing problems. For mental health, the factors affecting HRQoL were suicidal impulse, stress, and frustration. Conclusion: These results indicated that to improve HRQoL for middle-aged women, limited activity and suicidal impulses should be addressed.