• Journal of Sericultural and Entomological Science
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• v.50 no.1
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• pp.20-26
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• 2012

In this study, silk gland powder of silkworm were investigated to see the possibility for baby powder cosmetics materials. To test possibility as a baby powder cosmetics, total content rate of amino acids, DPPH free radical scavenging assay, MTT assay, and clinical trial were done. According to the result of the analysis of the amino acids of silk gland powder, serin (26.77%) content was the highest and asparatic acid (15.47%), and glycine (9.62%) were followed. DPPH free radical scavenging activity of silk gland powder was lower than vitamin C by 82.3% and 97%, respectively, which is relatively good. Moisture effect were increased in silk gland powder compared to control cosmetics by 50%. Also, silk gland powder was classified as a practically non-irritating material based on the score 0.05 of primary irritation index. Thus, these results suggest that silk gland powder of silkworm may have beneficial properties as a material for baby powder cosmetics.

• The Korean Journal of Pesticide Science
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• v.8 no.2
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• pp.95-102
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• 2004

The present study was conducted to test and evaluate estrogenic effect of 17 pesticides including benomy1 and carbaryl, being suspected as endocrine disrupting chemicals. For estrogenic effect examination, luciferase assay were achieved with human ovarian cancer cell, BG1Luc4E2. Estrogenic effects of cypermethrin, dicofol, endosulfan, esfenvalerate, and fenvalerate were observed at the concentration of $10^{-5}$ M by estrogen receptor binding assay. Relative luciferase potency and relative luciferase effects compared with $10^{-10}$ M 17 $\beta$-estradiol were $10^{-5}$, 56% for dicofol, and $10^{-5}$, 72% for endosulfan, respectively. Estimated maximum daily intake for pesticides was calculated from maximum residue limit of agricultural commodity and food consumption was 1.2298 mg/person. Theoretically calculated blood estrogen level from dietary intake for pesticides based on MRL in Korea, 3.075 ng/L was equivalent to 15% of estrogen concentration in normal blood, but practical monitoring data, 0.01938 ng/L was equal to 0.09693% of estrogen concentration in normal blood.

• Science of Emotion and Sensibility
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• v.12 no.4
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• pp.373-380
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• 2009

This study tried to investigate how three levels of arousal affect performance of a 3-back task. Ten university male (age $25.7{\pm}1.5$) and ten female (age $24.5{\pm}1.8$) students participated in this experiment. Using pictures selected from a group test, three levels of arousal, i.e. tensed, neutral, and relaxed emotions, were induced. Each subject was run through the procedure three times, once for each arousal level. The procedure consisted of six phases for each arousal condition Rest 1(2 min), Picture 1(presenting emotion arousing photos for 2 min), 3-back task 1(2 min), Picture 2(presenting emotion arousing photos for 2 min), 3-back task 2(2 min), and Rest 2(2 min). Skin conductance level(SCL) of electrothermal activity was also measured during all phases of the experiment. The accuracy rate of 3-back task performance was the highest at a neutral emotional state, followed by relaxed and then tensed emotional state. There was no difference in reaction time(RT) among the three levels of arousal. SCL was the highest at a tensed emotional state, followed by neutral emotional state and then relaxed emotional state. Based on the results, it could be inferred that tension, induced by stimuli unrelated to cognitive tasks, decreases the ability to perform cognitive tasks.

• Journal of Music and Human Behavior
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• v.6 no.1
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• pp.55-80
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• 2009

The objective of this study was to improve the self-expression of children through Orff activities. In this study, three (3) children from D day care center in Seoul who demonstrated withdrawn behaviors were chosen as research subjects, based on a self-expression test score of 50 points. The activities were conducted for 6 weeks, totaling fourteen (14) sessions, with each session being scheduled for forty (40) minutes. Across 14 sessions, the researcher conducted, analyzed and compared the self-expression scale of subjects, measured during the third and the last session. The researcher then qualitatively analyzed verbal and non-verbal self-expression behaviors of subjects by video recording the session. The analysis results shown by the study are as follows. First, the results of a quantitative analysis of the self-expression scale showed significant changes in self expression. Furthermore, the results of a qualitative analysis of verbal self-expression showed positive changes in self-perception and an increase in feelings of independence and activity than that of initial sessions.

• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.201-207
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• 2006

Acetaminophen (paracetamol), a para-aminophenol derivative, has analgesic and antipyretic properties and weak anti-inflammatory activity. The purpose of the present study was to evaluate the bioequivalence of two acetaminophen tablets, $Tylenol^{\circledR}$ ER (Janssen Korea Ltd.) and Tylicol ER (Hana Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of acetaminophen from the two acetaminophen formulations in vitro was tested using KP VIll Apparatus II method with pH 1.2 buffer solution. Twenty six healthy male subjects, $22.8{\pm}1.99$ years in age and $65.6{\pm}8.03$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 650 mg as acetaminophen was orally administered, blood samples were taken at predetermined time intervals and the concentrations of acetaminophen in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar in pH 1.2 buffer solution. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Tylenol^{\circledR}$ ER, were 2.84, 1.89 and -1.36% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log $0.987{\sim}log$ 1.08 and log $0.944{\sim}log$ 1.17 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Tylicol ER tablet was bioequivalent to $Tylenol^{\circledR}$ ER tablet.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.215-221
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• 2002

Cephradine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequivalence of two cephradine capsules, Cefradine Yuhan (YuHan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, $23.10{\pm}2.90$ years in age and $67.69{\pm}8.04\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephradine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AVC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of 1og(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.02)\;and\;log(0.88){\sim}log(1.13)\;for \;AVC_t\;and\;C_{max},\;respectively)$. The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g., \;-17.54{\sim}7.78\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.

• The Korean Journal of Pesticide Science
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• v.10 no.2
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• pp.138-148
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• 2006

Two bacteria were isolated from the continuously pesticide-used soil under plastic film house and upland condition. The degradation test of several pesticides by the selected bacteria, B59 and B71, were conducted. The degradation rates for 6 pesticides, procymidone, chlorothalonil, ethoprophos parathior, alachlor and pendimethalin, in medium by the isolates were 21.1% to 53.2% higher than non-inoculated medium. Under shaking culture condition, 90% to 95% of procymidone was degraded after 21 days treatment. Parathion was degraded in the range of 60% to 100% by B71 and B59, respectively. Otherwise 70% of alachlor was degraded by the two isolated bacteria during same period. The pH was not significantly affected for degradation of pesticides. The bacterial strains, B59 and B71 was identified as Acinetobacter sp. and as Pseudomonas sp. based on morphological, biochemical and physiological characteristics, and identity and similarity of automatic identification system, Biolog and MIDI.

• Korean Journal of Applied Biomechanics
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• v.18 no.4
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• pp.109-114
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• 2008

The purpose of this study was to estimate the energy expenditure simply and practically during physical activities. The physical activity is quantified by the integration of the accelerometer signals obtained from the triaxial accelerometer attached at the waist level of the human body. To find a relationship between energy expenditure and accelerometer data, 6 male and 5 female subjects walked and ran on the treadmill with speeds of 1.5, 3.0, 4.5, 6.0, 6.5, 7.0, and 8.5 km/hr. Each subject performed walking at the speed lower than 6.0 km/hr and running at the speed higher than 6.5 km/hr. Actual energy expenditure was determined by a continuous direct gas analyzer. Two predictive equations of walking and running mode for energy expenditure which includes gender, body mass index(BMI) and data from accelerometer were developed using multiple regression analysis. The correlation coefficients and coefficients of determination between the estimated and measured energy expenditure were R=0.936, R2=0.876 and R=0.881, R2=0.776 in walking and running mode, respectively. For further study, experiments on a larger scale of test subjects are essential for acquiring more reliable results.

• Journal of the Korean Society of Groundwater Environment
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• v.1 no.1
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• pp.33-50
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• 1994

The Hydrogeologic data of 455 water wells comprising geologic log and aquifer test were analyzed to determine hydrogeologic characteristics of the Cheju island. The groundwater. of the Cheju island is occurred in unconsolidated pyroclastic deposits and crinker interbedded in highly jointed basaltic and andesic rocks as high level, basal and parabasal types under unconfined condition. The average transmissivity and specific yield of the aquifer are at about 29,300㎡/day and 0.12 respectively, The total storage of groundwater is estimated about 44 billion cubic meters. Average annual precipitation is about 3,390 million ㎥ among which average recharge is estimated for 1,494 million ㎥ being equivalent 44.1% of total annual precipitation with 638 million ㎥ of runoff and 1,256 million ㎥ of evapotranspiration. Based on groundwater budget analysis, the sustainable yield is about 620 million ㎥(41% of annual recharge)and rest is discharging into the sea. The geologic logs of recently drilled thermal water wells indicate that very low-permeable marine sediments(Sehwa-ri formation) composed of loosely cemented sandy silt derived from mainly volcanic ashes at the 1st stage volcanic activity of the area is situated at the 120${\pm}$68m below sea level. Another low-permeable sedimentary rock called Seogipo-formation which is deemed younger than the former marine sediment is occured at the area covering north-west and western part of the Cheju island at the ${\pm}$70m below sea level. If these impermeable beds art distributed as a basal formation of fresh water zone of the Cheju island, the most of groundwater in the Cheju island will be para-basal type. These formations will be one of the most important hydrogeologic boundary and groundwater occurences in the area.

• Korean Journal of Weed Science
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• v.17 no.1
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• pp.52-58
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• 1997

Rice (Oryza sativa L.) contains water-soluble substances that inhibit the germination of Echinochloa crus-galli. This study investigated the allelopathic potential of rice in which rice had been grown with E. crus-galli in the field. Extracts of forty-seven rice varieties were screened for allelopathic potential in the laboratory. Double distilled water was used as a control. Based on the germination percentage, the varieties may be classified in the following order of decreasing inhibition : Namweon(36%) and Gyehwa(38%) hulls extracts and Sambaeg(43%) and Seoan(46%) leaves extracts. In the comparison of allelopathic activity test between leaves and hulls extracts, hulls extracts contain more allelopathic toxic substances. In the effect of concentration treatment on the six levels of extract solutions(3, 6, 12, 25, 50, 100%, v/v) germination percentage was significantly inhibited as the extract concentration increased. The highest concentration(100%) caused the greatest reduction in E. crus-galli. Allelopathic potential effects were significantly different among the various varieties and between '94 and '95 year extracts. The results indicate that there are genetic differences among varieties for allelopathic potentiality on E. crus-galli. Allelopathic potential in the ecological aspects can be decided through variety selection.