• 반도체디스플레이기술학회지
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• 제15권2호
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• pp.61-65
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• 2016

Facial feature detection is a fundamental function in the field of computer vision such as security, bio-metrics, 3D modeling, and face recognition. There are many algorithms for the function, active shape model is one of the most popular local texture models. This paper addresses issues related to face detection, and implements an efficient extraction algorithm for extracting the facial feature points to use on iOS platform. In this paper, we extend the original ASM algorithm to improve its performance by four modifications. First, to detect a face and to initialize the shape model, we apply a face detection API provided from iOS CoreImage framework. Second, we construct a weighted local structure model for landmarks to utilize the edge points of the face contour. Third, we build a modified model definition and fitting more landmarks than the classical ASM. And last, we extend and build two-dimensional profile model for detecting faces within input images. The proposed algorithm is evaluated on experimental test set containing over 500 face images, and found to successfully extract facial feature points, clearly outperforming the original ASM.

• International Journal of Control, Automation, and Systems
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• 제4권5호
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• pp.660-667
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• 2006

This paper presents a novel region-based snake method for vessel segmentation. According to geometric shape analysis of the vessel structure with different scale, an efficient statistical estimation of vessel branches is introduced into the energy objective function, which applies not only the vessel intensity information, but also geometric information of line-like structure in the image. The defined energy function is minimized using the gradient descent method and a new region-based speed function is obtained, which is more accurate to the vessel structure and not sensitive to the initial condition. The narrow band algorithm in the level set framework implements the proposed method, the solution of which is steady. The segmentation experiments are shown on several images. Compared with other geometric active contour models, the proposed method is more efficient and robust.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 D
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• pp.2798-2800
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• 2003

Active contour models(called Snakes) are methods for the image segmentation. Many researchers have developed snake algorithms and then published such as GVF, GGF snake. In this paper, we present a pre-process for GGF snake algorithm. This process removes noise so that snakes can flow smoothly. In experiment, we compared a image removed noise with a image corrupted by noise. In result, the pre-process produced a good image for GGF Snake and is necessary.

• 디지털융복합연구
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• 제12권7호
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• pp.239-245
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• 2014

본 논문에서는 얼굴의 전체적인 특징(윤곽선, 얼굴크기, 눈, 코) 분석에 기반을 둔 가중치 주름 검출 방법을 제안한다. 첫째 입력된 영상에서 능동적 외향 방법을 이용하여 얼굴의 전체적인 주요 성분을 검출하게 되는데, 크게 형태 기반과 외향 방법으로 구성되어 있다. 이것은 얼굴 모델을 학습하고, 학습된 모델을 기반으로 새로운 영상에서 얼굴을 정합할 때 사용된다. 두 번째로는 영상에서 얼굴과 배경을 분리하고, 얼굴에서 주름 확률이 가장 큰 곳 네 곳을 선정하여 주름 가중치를 높게 부과하다. 마지막으로 가중치를 부여한 관심 영역에 대해서 캐니에지 알고리즘을 적용하여 주름을 검출하게 된다. 제안한 알고리즘은 다양한 종류의 영상을 사용하여 실험 하였으며, 실험결과 대부분의 영상에서 높은 성능의 얼굴 및 주름 검출 결과를 보였다.

• 통합자연과학논문집
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• 제8권4호
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• pp.273-284
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• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• 통합자연과학논문집
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• 제8권2호
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• pp.89-98
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• 2015

Chemoattractant receptor homologous molecule expressed on Th2 cells (CRTh2) is a G-protein coupled receptor targeted for inflammatory diseases such as asthma, allergic rhinitis and atopic dermatitis. In this study, pharmacophore modeling and comparative molecular field analysis (CoMFA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Five highly active compounds were used for generation of pharmacophore models using GASP module. The best pharmacophore model was selected and used as template for the alignment of compounds which was used for CoMFA analysis. The best predictions obtained for CoMFA was $q^2=0.545$, $r^2=0.756$. The predictive ability of the model was investigated using 15 test set compounds. Contour maps suggested that presence of bulky substituents at $5^{th}$ position of benzene ring connected to suphur atoms attached to imidazol ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Bulletin of the Korean Chemical Society
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• 제31권5호
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• pp.1355-1360
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• 2010

In order to search new inhibitors against farnesyl protein transferase (FPTase), a series of 2,3-bis-benzylidenesuccinaldehyde derivatives (1-29) were synthesized and their inhibition activities ($pI_{50}$) against FPTase were measured. From based on the reported results that the inhibitory activities of dimers 2,3-bis-benzylidenesuccinaldehydes were higher than those of monomers cinnamaldehydes, 3D-QSARs on FPTase inhibitory activities of the dimers (1-29) were studied quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. The statistical qualities of the optimized CoMFA model II ($r^2{_{cv.}}$= 0.693 and $r^2{_{ncv.}}$= 0.974) was higher than those of the CoMSIA model II ($r^2{_{cv.}}$ = 0.484 and $r^2{_{ncv.}}$ = 0.928). The dependence of CoMFA models on chance correlations was evaluated with progressive scrambling analyses. And the inhibitory activity exhibited a strong correlation with steric factors of the substrate molecules. Therefore, from the results of graphical analyses on the contour maps and of predicted higher inhibitory active compounds, it is suggested that the structural distinctions and descriptors that contribute to inhibitory activities ($pI_{50}$) against FPTase will be able to applied new inhibitor design.

• 대한화장품학회지
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• 제34권2호
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• pp.109-115
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• 2008

기질 화합물로써 $3{\beta}$-hydroxy-12-oleanen-28-oic acid 유도체들의 치환기($R_1{\sim}R_4$)가 변화함에 따른 protein tyrosine phosphatase(PTP)-1B의 저해활성에 관한 비교 분자장 분석(CoMFA) 모델을 유도하고 정량적으로 검토하였다. 최적의 CoMFA F1 모델은 가장 높은 예측성과 상관성($r^2_{cv.}=0.654$ 및 $r^2_{ncv.}=0.995$)을 나타내었다. 저해활성에 관한 CoMFA장 기여비율(%)의 순서는 입체장(53.0%), 정전기장(36.2%) 및 소수성장(10.8%) 이었다. 등고도 분석 결과로부터 저해활성은 기질 분자 내 $R_4$-치환기에 의존적이었으며 특히 melanin 저해활성이 높은 새로운 화합물(P1 및 P2)이 예측되었다.

• Geomechanics and Engineering
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• 제16권4호
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• pp.435-448
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• 2018

In order to make reliable earthquake-resistant design of civil engineering structures, one of the most important considerations in a region with high seismicity is to pay attention to the local soil condition of regions. It is aimed in the current study at specifying dynamic soil characteristics of Kirikkale city center conducting the 1-D equivalent linear and non-linear site response analyses. Due to high vulnerability and seismicity of the city center of Kirikkale surrounded by active many faults, such as the North Anatolian Fault (NAF), the city of Kirikkale is classified as highly earthquake-prone city. The first effort to determine critical site response parameter is to perform the seismic hazard analyses of the region through the earthquake record catalogues. The moment magnitude of the city center is obtained as $M_w=7.0$ according to the recorded probability of exceedance of 10% in the last 50 years. Using the data from site tests, the 1-D equivalent linear (EL) and nonlinear site response analyses (NL) are performed with respect to the shear modulus reduction and damping ratio models proposed in literature. The important engineering parameters of the amplification ratio, predominant site period, peak ground acceleration (PGA) and spectral acceleration values are predicted. Except for the periods between the period of T=0.2-1.0 s, the results from the NL are obtained to be similar to the EL results. Lower spectral acceleration values are estimated in the locations of the city where the higher amplification ratio is attained or vice-versa. Construction of high-rise buildings with modal periods higher than T=1.0 s are obtained to be suitable for the city of Kirikkale. The buildings at the city center are recommended to be assessed with street survey rapid structural evaluation methods so as to mitigate seismic damages. The obtained contour maps in this study are estimated to be effective for visually characterizing the city in terms of the considered parameters.

• Journal of Applied Biological Chemistry
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• 제53권4호
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• pp.225-231
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• 2010

기질분자로서 polyhydroxy 치환된 2-phenyl-l,4-benzopyrone 유도체(Flavones)(1-25)들의 hydroxyl 치환기($R_1-R_9$)가 변화함에 따른 Tyrosinase(PDB ID: oxy-form; 1WX2)에 대한 저해활성을 이해하기 위하여 분자도킹과 3차원적인 정량적 구조활성관계 (3D-QSARs: CoMFA 및 CoMSIA)가 연구되었다. 그 결과, 통계적으로 CoMFA 1 및 CoMSIA 1 모델이 가장 양호한 3D-QSARs 모델이었다. 또한, 순차 혼합화 분석결과로부터 CoMSIA 1 모델($dq^2'/dr_{yy'}^2$=1.009 및 $q^2$=0.511)이 우연상관성에 저촉되지 않는 최적화 모텔이었으며 최적화된 CoMSIA 1 모델의 tyrosinase에 대한 저해활성은 기질분자의 정전기장(51.4%)에 의존적이었다. Tyrosinase의 반응점에 대한 3D-QSAR 모델의 등고도는 수용체로서 tyrosinase과 저해제로서 2-phenyl-l,4-benzopyrone 기질분자 사이의 새로운 상호작용 관계를 이해하는 계기가 되었다. 그러므로 이 결과들은 새로운 잠재적인 tyrosinase 저해제의 최적화에 적용될 수 있을 것이다.