• 한국농촌건축학회논문집
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• 제20권1호
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• pp.69-76
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• 2018

This study is to research technical measures for improving energy efficiency in the conservation and reuse of historic buildings focused on the recent research trends and case studies of the west. These measures are broadly classified into three types, the passive measures for saving energy and increasing comfort, the most cost-effective energy saving strategies, and the renewable energy sources. Firstly, the passive measures are divided into the elements and systems. The passive elements are awnings and overhanging eaves, porches, shutters, storm windows and doors, and shade trees. There are also the natural ventilation systems such as the historic transoms, roofs and attics to improve airflow and cross ventilation to either distribute, or exhaust heat. Secondly, the most cost-effective energy efficiency strategies are the interior insulation, airtightness and moisture protection, and the thermal quality improvement of windows. The energy efficiency solutions of modern buildings are the capillary-active interior insulation, the airtightness and moisture protection of interior walls and openings, and the integration of the original historic window into the triple glazing. Beyond the three actions, the additional strategies are the heat recovery ventilation, and the illumination system. Thirdly, there are photovoltaic(PV) and solar thermal energy, wind energy, hydropower, biomass, and geothermal energy in the renewable energy sources. These energy systems work effectively but it is vital to consider its visual effect on the external appearance of the building.

• BMB Reports
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• 제32권5호
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• pp.515-520
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• 1999

Incubation of two types of glutamate dehydrogenase isoproteins from bovine brain with the arginine-specific dicarbonyl reagent phenylglyoxal resulted in a biphasic loss of enzyme activity. Reaction of the glutamate dehydrogenase isoproteins with phenylglyoxal caused a rapid loss of 53~62% of the enzyme activities and modification of two residues of arginine per enzyme subunit. Prolonged incubation of the glutamate dehydrogenase isoproteins with phenylglyoxal resulted in the modification of an additional four residues of arginine per enzyme subunit without further loss of the residual activities. Partial protection against inactivation was provided by the coenzyme NADH or substrate 2-oxoglutarate. The most marked decrease in the rate of inactivation was observed by the combined addition of NADH and 2-oxoglutarate, suggesting that the first two modified arginine residues are in the vicinity of the catalytic site. However, inactivation of the glutamate dehydrogenase isoproteins by phenylglyoxal appears to be partial with approximately 40% activity remained after an extended reaction time with excess reagent, suggesting that the modified arginine residues may not be directly involved in catalysis. The lack of complete protection by substrates also suggest the possibility that the modified arginine residues are not directly involved at the active site, and the partial loss of activity by the modification of arginine residues may be due to a conformational change. There were no significant differences between the two glutamate dehydrogenase isoproteins in sensitivities to inactivation by phenylglyoxal, indicating that the microenvironmental structures of the glutamate dehydrogenase isoproteins are very similar to each other.

• 동의신경정신과학회지
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• 제24권3호
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• pp.309-320
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• 2013

Objectives : There is a possibility LRE as remedy in Alzheimer disease (AD), but it's nerve protection effect and mechanism have to be elucidate. In this research, we applied LRE on $A{\beta}_{25-35}$ pre-treated SH-SY5Y cells, to find out the nerve protection effect and mechanism in AD cell model. Methods : We tried to confirm that effect by experimenting with 20, 50, and $100{\mu}g/ml$ concentration of LRE as a medicine. Next experiment, we assessed damage effect which induced $A{\beta}_{25-35}$, known to cause AD, on SH-SY5Y cell. In addition, cellular viability test is executed under $H_2O_2$ treatment condition in a SH-SY5Y cell. Results : 1. In $A{\beta}_{25-35}$ treated SH-SY5Y cell, LRE exhibited an anti-phosphorylation effect about tau protein, JNK, and IKB. 2. LRE prevent nerve cell apoptosis, which indued $A{\beta}_{25-35}$ and oxidative stress, modify JNK engaged synaptic structure and $NF{\kappa}B$ induced p75-neurotrophin receptor polymorphism. Conclusions : We found that LRE prevented oxidative stress-induced cellular destruction, for example, increased SOD activity of $A{\beta}_{25-35}$ treated SH-SY5Y cell and reduced toxicity of oxygen free radical. Consequently, the ingredients of LRE have a role as a catalyzer for $A{\beta}_{25-35}$ clearance and as scavenger for active oxygen free radical.

• 한국대기환경학회지
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• 제33권3호
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• pp.217-232
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• 2017

An Eulerian-Lagrangian hybrid modeling system to analyze physical and chemical processes during the transport of air parcels was developed. The Backward-tracking Model Analyzer (BMA) was designed to take advantages of both Eulerian and Lagrangian modeling approaches. Simulated trajectories from the National Oceanic and Atmospheric Administration HYSPLIT model were combined with the US Environmental Protection Agency Community Multi-scale Air Quality (CMAQ)-simulated concentrations and additional diagnostic analyses. In this study, we first introduced a generalized methodology to seamlessly match polylines (HYSPLIT) and threedimensional polygons (CMAQ), which enables mass-conservative analyses of physio-chemical processes of transporting air parcels. Two applications of the BMA were conducted: (1) a long-range transport case of pollutant plume across the Yellow Sea using CMAQ Integrated Process Rate analyses, and (2) a domestic circulation of pollutants within (and near) the South Korea based on the sulfate tracking analyzer. The first episode demonstrated a secondary formation of nitrate and ammonium during the transport over the Yellow Sea while sulfate is mostly transported after being formed over the China, and the second episode demonstrated a dominant impact of boundary condition with active sulfate formation from gas-phase oxidation near the Seoul Metropolitan Area.

• Journal of Ginseng Research
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• 제37권1호
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• pp.80-86
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• 2013

Korean red ginseng has been shown to possess a variety of biological activities. However, little is known about antiviral activity of ginsenosides of Korean red ginseng. Here, we investigated the protective effect by oral administration of various ginsenosides on the lethal infection of haemagglutinating virus of Japan (HVJ) in mice. In a lethal infection model in which almost all mice infected with HVJ died within 15 days, the mice were administered orally (per os) with 1 mg/mouse of dammarane-type (ginsenoside-Rb1, -Rb2, -Rd, -Re, and -Rg2) or oleanolic acid-type (ginsenoside-Ro) ginsenosides 3, 2, and 1 d before virus infection. Ginsenoside-Rb2 showed the highest protective activity, although other dammarane-type and oleanolic acid-type ginsenosides also induced a significant protection against HVJ. However, neither the consecutive administration with a lower dosage (300 ${\mu}g$/mouse) nor the single administration of ginsenoside-Rb2 (1 mg/mouse) was active. In comparison of the protective activity between ginsenoside-Rb2 and its two hydrolytic products [20(S)- and 20(R)-ginsenoside-Rg3], 20(S)-ginsenoside-Rg3, but not 20(R)-ginsenoside-Rg3, elicited a partial protection against HVJ. The protective effect of ginsenoside-Rb2 and 20(S)-ginsenoside-Rg3 on HVJ infection was confirmed by the reduction of virus titers in the lungs of HVJ-infected mice. These results suggest that ginsenoside-Rb2 is the most effective among ginsenosides from red ginseng to prevent the lethal infection of HVJ, so that this ginsenoside is a promising candidate as a mucosal immunoadjuvant to enhance antiviral activity.

• Journal of Radiation Protection and Research
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• 제22권3호
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• pp.219-226
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• 1997

환경시료 및 Swipe시료에서 방출되는 감마선을 측정 분석하기 위하여 극저준위 백그라운드 감마선 측정시스템을 설치하였다. 본 측정시스템은 백그라운드를 저감하기 위해 극저방사능 물질로 구성된 수동적 차폐방법, 우주선 영향을 차단하기 위한 역동시 측정법, 그리고 공기중 방사성 핵종인 라돈가스를 시스템 내부에서 제거하는 방법 등을 적용하고 있다. 적용된 백그라운드 저감법에 대한 성능시험 결과, 실험실 조건의 백그라운드 준위가 관심 대상 에너지 영역($50\;keV{\sim}2\;MeV$)에서 $10^{-2}$ order 정도로 저감되었다. 그리고 미신고 핵활동을 탐지하기 위한 관심 대상 핵종의 감마선 에너지 영역에서 평가된 시스템의 최소검출하한(MDA)값은 환경시료 분석에 적합한 것으로 평가되었다. 그러나 저에너지 영역에서는 여전히 우주선에 의한 중성자 영향이 백그라운드 요인으로 작용하고 있는 것으로 분석되었다.

• 대한전자공학회논문지SP
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• 제41권5호
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• pp.99-109
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• 2004

본 논문에서는 웹 로봇과 핑거프린팅 기법을 이용하여 인터넷에 배포되어 있는 이미지 콘텐츠를 자동으로 수집하고 원구매자를 식별하는 기법을 소개한다. 핑거프린팅 기법은 워터마킹 기법의 확장 기술로 구매자의 정보를 콘텐츠에 삽입/추출하는 저작권보호 기법의 하나이다. 콘텐츠 내에 삽입된 핑거프린트는 콘텐츠를 식별하는 식별자의 역할을 할 뿐만 아니라 원 구매자의 정보도 가지고 있어서 콘텐츠의 저작권 보호에도 활용된다. 본 논문에서는 이미지 검색 엔진과 핑거프린팅 기법을 혼합한 능동적 콘텐츠 추적 시스템을 제안한다. 제안된 시스템은 콘텐츠가 배포되기 전에 원 구매자의 정보를 핑거프린트로 삽입하고 구매기록을 저장한다. 배포된 콘텐츠는 웹 로봇에 의해 자동으로 수집되고 동시에 핑거프린트 정보가 추출되어 서버에 저장된다. 콘텐츠의 식별은 추출된 핑거프린팅 정보와 배포 시점에 저장된 판매기록을 비교하여 이루어진다.

• Journal of Radiation Protection and Research
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• 제25권4호
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• pp.197-205
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• 2000

실리콘 PIN 다이오드 검출기를 이용하여 전자선량계(PED)를 설계 및 제작하고, 전자신호회로의 성능과 방사선 검출 반응특성을 평가하였다. 전자회로의 성능검사에서는 방사선에 의한 검출기의 신호가 신호처리회로에서 양호하게 출력되었으며, $^{137}Cs$ 감마 방사선을 이용한 방사선조사 시험결과 선량계의 반응도 및 분산계수는 각각 1.85 cps/$Gy{\cdot}h^{-1}$ 및 19.3%로 측정되어 전자선량제의 성능기준을 만족하는 것으로 나타났다. 본 전자선량계의 시작품은 향후 전자회로의 성능향상과 작동 프로그램을 보완 및 개선함으로써 개인 방사선 모니터링에 활용될 것으로 기대된다.

• The Plant Pathology Journal
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• 제16권3호
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• pp.130-136
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• 2000

Differences in physiological and biochemical responses between sensitive and tolerant rice cultivars to ozone were investigated to develop reliable indications of early ozone damage. Three Korean local rice cultivars -sen-sitive cultivar Dongjin (DJ), moderately tolerant cultivar Hwayeong (HY) and tolerant cultivar Ilmee (IM) were exposed to ozone at the concentrations of 100 nl $\textrm{l}^{-1}$ or 200 nl $\textrm{l}^{-1}$ , 8 h per day for 10 days in a controlled-environment fumigation chamber. The rice cultivars seemed to be endurable to ozone stress at the concentration of 100 nl $\textrm{l}^{-1}$ which is frequently monitored during the growing season in summer. However, severe damage was induced and differential sensitivity was clearly noted among the rice cultivars at the higher ozone concentration. Activation of the glutathion (GR) -ascorbate peroxidase (APX) cycle was likely to be responsible for protection of rice plants against ozone exposure, relating difference in sensitivity of rice cultivars to ozone. Photosynthetic activity appeared to be one of sensitive responses, for which chlorophyll fluorescence and leaf greenness can together provide a very reliable index, a degree of photosynthetic damages by ozone. Formation of malondialdehyde (MDA) was also considered as an indication that can differentiate cultivars sensitivity to ozone. However, the changes in polyamines and total phenolics were not consistent with exposed ozone concentrations and/or ozone sensitivity of the cultivars. The behavior of polyamines and phenolics in the damaged plants at high ozone levels could be interpreted as an indication of ozone injury rather than activation of additional protection mechanisms scavenging active oxygen species formed by ozone. Several responses triggered by ozone could explain the differential sensitivity of the rice cultivars and be used as reliable indications of relative ozone damage to rice plant.

• KSBB Journal
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• 제18권6호
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• pp.517-521
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• 2003

본 연구에서는 절대적 호기성인 Vitreoscilla가 지닌 FeSOD의 특성을 밝히고자 paraquat와 iron을 사용하여 실험하였다. Vitreoscilla에서 FeSOD의 활성도는 초산화 음이온을 생성하는 paraquat에 대해 커다란 영향 없이 일정하게 발현되었다. 이 결과는 Vitreoscilla는 호기적인 물질대사 동안 생성되어지는 초산화 음이온에 대해 방어할 수 있을 만큼 충분한 FeSOD를 평상시 지니고 있음을 의미한다. 또한 다른 요소에 의한 FeSOD의 발현 가능성이 고려되어졌다. 보조 인자인 Fe 를 처리한 결과 활성도가 증가됨을 알 수 있었다. 이는 CN-resistant respiration을 증가시키는 초산화 음이온에 대한 조절 기작과는 달리 apoenzyme 상태가 보조 인자인 금속 이온 (Fe)에 의해 holoenzyme 상태로 전환되었음을 의미한다. PQ와 Fe를 함께 처리하였을 경우, FeSOD의 증가는 PQ에 의해서 생성된 초산화 음이온에 의해 apo 상태에서 hole 상태로 FeSOD의 활성이 증진되는 synergism effect로 설명되어진다. 결론적으로 metalloenzyme인 SOD의 경우는 이런 전환이 활성 속도를 제한하거나 조절할 수도 있는 posttranslational 수준의 조절 기작이 존재함을 알 수 있었다.