• Journal of Life Science
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• v.29 no.7
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• pp.824-835
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• 2019

In recent decades, oncolytic viruses (OVs) have extensively been investigated as a potential cancer drug. Oncolytic viruses have primarily the unique advantage in the fact that they can only infect and destroy cancer cells. Secondary, oncolytic viruses induce the activation of specific adaptive immunity which targets tumor-associated antigens that were hidden during the initial cancer progression. In 2015, one genetically modified oncolytic virus, talimogene laherparepvec (T-VEC), was approved by the American Food and Drug Administration (FDA) for the treatment of melanoma. Currently, various oncolytic viruses are being investigated in clinical trials as monotherapy or in combination with preexistent cancer therapies like immunotherapy, radiotherapy or chemotherapy. The efficacy of oncolytic virotherapy relies on the balance between the induced anti-tumor immunity and the anti-viral response. Despite the revolutionary outcome, the development of oncolytic viruses for the treatment of cancer faces a number of obstacles such as delivery method, neutralizing antibodies and induction of antiviral immunity due to the complexity, variability and reactivity of tumors. Intratumoral administration has been successful reducing considerably solid tumors with no notable side effects unfortunately some tumors are not accessible (brain) and require a systemic administration of the oncolytic viruses. In order to overcome these hurdles, various strategies to enhance the efficacy of oncolytic viruses have been developed which include the insertion of transgenes or combination with immune-modulatory substances.

• 재활복지
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• v.22 no.2
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• pp.127-159
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• 2018

The purpose of this study is to provide the useful reference to establish the system improvement plan that activates the counseling service quality for the disabled parents peer counselors. The qualitative case study method of Yin (2009) has been used to understand and reflect to the system for the experience of field counseling of the peer counselors for the disabled parents. 10 parents peer counselors for the disabled were proportionately sampled and interviewed about their experiences through a FGI and two individual interviews. The result of the study derived from total 87 abstract concepts and 17 categories and personal motivations for participating and changes from the experience are as follows: the effects of counseling are "mutual sympathy toward the same disability," "Identity transformation from nobody to somebody who gives hope," and "another social insurance and social safety network that parents disability make." The barrier facts for the parents peer counseling activation are: "problem of securing the position of the counseling site" and difficulty in finding the client due to lack of awareness and publicity. "The study suggests four programs to upgrade the parents peer counseling: (1) To secure the position of the counseling site, (2) To reestablish the status as a professional counselor. (3) The need of pokicy supplement and support from the government, (4) The expectancy of creating jobs through the conversion of full-time workers.

• Microbiology and Biotechnology Letters
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• v.46 no.4
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• pp.326-333
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• 2018

In this study, we identified methods to improve heat stability and skin permeability of functional protein biopolymers, such as growth factors, enzymes, and peptides. The biopolymers participate in cellular activation and catalytic functions in vivo. Therefore, when applied to cosmetics, their efficacies are expected to be helpful for skin care. However, they have disadvantages that include instability to heat and low skin permeability due to their high molecular weight. To overcome these problems, we searched for a composition that increases heat stability. Stability was improved using a polymeric humectant having a long polyethylene glycol length, compared with a mono-molecular structure humectant. Next, to enhance skin permeation, a permeation enhancing peptide was selected from a phage library. The permeation enhancing peptide can be commonly used to promote the permeation of growth factors, enzymes, and peptides. Screening was performed on the polymeric humectant formulation. One dominant peptide from the modified-screening method was identified. Furthermore, it was confirmed that the permeability of the peptide was better than that of the peptide developed through a screening system based on phosphate-buffered saline. The data indicate that the polymeric humectant formulation will be helpful for increasing the heat stability of protein ingredients and that skin permeability could be increased by a formulation-specific, penetration-enhancing peptide.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.12
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• pp.674-680
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• 2018

Background and Objectives The representative mucin genes in the human airway are MUC5AC and MUC5B, which are regulated by several inflammatory and anti-inflammatory substances. Triptolide (TPL), udenafil, betulinic acid, changkil saponin, and glucosteroid are some of the many anti-inflammatory substances that exist. TPL is a diterpenoid compound from the thunder god vine, which is used in traditional Chinese medicine for treatment of immune inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. However, the effects of TPL on mucin expression of human airway epithelial cells have yet to be reported. Hence, this study investigated the effect of TPL on lipopolysaccharide (LPS)-induced MUC5AC and MUC5B expression in human airway epithelial cells. Subjects and Method The NCI-H292 cells and the primary cultures of human nasal epithelial cells were used to investigate the effects of TPL on LPS-induced MUC5AC and MUC5B expression using real-time polymerase chain reaction, enzyme immunoassay, and Western blot. Results TPL significantly decreased the LPS-induced MUC5AC and MUC5B mRNA expression and protein production. TPL also significantly decreased the nuclear factor-kappa B (NF-kB) phosphorylation. Conclusion These results suggest that TPL down regulates MUC5AC and MUC5B expression via inhibition of NF-kB activation in human airway epithelial cells. This study may provide important information about the biological role of triptolide on mucus-secretion in airway inflammatory diseases and the development of novel therapeutic agents for controlling such diseases.

• Journal of IKEEE
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• v.22 no.4
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• pp.1226-1229
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• 2018

We investigated the improvement of surface roughness and states after high temperature annealing using reduced-graphene oxide (r-GO) capping layer on ion-implanted 4H-SiC epitaxial layer. The specification of the 4H-SiC wafer grown on n-type $4^{\circ}$ off-axis 4H-SiC was $10{\mu}m$-thick and n-type epitaxial layer with a dose of $1.73{\times}10^{15}cm^{-2}$. The $n^+$ region were formed by multiple nitrogen ion-implantations and r-GO capping layer was produced by spray coating method. AFM measurements revealed that RMS value of the sample capped with r-GO was tenfold decrease compared to the sample without r-GO capping. The improvement of surface states was also verified by the improvement of leakage current level.

• Journal of Korea Port Economic Association
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• v.35 no.2
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• pp.1-20
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• 2019

This study aims to establish a method for activating Korean ship finance through an analysis on the development of Chinese ship finance market, which has grown rapidly in recent years. It focuses on its main institutions, laws and policies, strengths and weaknesses, market share, and development status. Because 80.7% of South Korea's economy depends upon foreign trade and 99.7% of the South Korea's traded volume is transported by ships, shipping has assumed an important role in Korean economy. However, since the global financial crisis, Korean shipping and shipbuilding industry has been facing difficulties and Hanjin, the biggest Korean shipping company, went bankrupt in 2017. One of the key aspects of the competitiveness of the shipping and shipbuilding industry is acquiring competitive shipping assets; therefore, stable and smooth supply of ship finance is crucial for the development of the shipping and shipbuilding industry. Given this background, the study analyzed how the Chinese ship finance market has grown rapidly in the past 30 years and identified the problems, strengths, and weaknesses of the Chinese ship finance. The analysis on the status of the Chinese ship finance market is expected to suggest a direction for establishing methods for activating the Korean ship finance market, which is facing scarcity of finance, even as the global ship finance market has remained depressed since the global financial crisis. Although this study focused exclusively on the Chinese market, future research can draw conclusions from a comparative analysis that includes the Japanese ship finance market; the conclusions obtained would contribute to the establishment of long-term policies and plans for Korean ship finance.

• Korean Journal of Applied Biomechanics
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• v.31 no.2
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• pp.133-139
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• 2021

Objective: This study aims to verify the conventional deadlift motions using by two different grips, thereby elucidating the grounds for effective training methods that can minimize the risk of injury. Method: Total of 18 healthy young adults were recruited for this study (age: 25.11±2.19 yrs., height: 175.67±5.22 cm, body mass: 78.5±8.09 kg, 1-RM: 125.75±19.48 kg). All participants were asked to perform conventional deadlift with two types of grips which are overhand grip (OG) and underhand grip (UG). In each grip, participant perform the deadlift with 50% and 80% of the pre-measured 1-RM. A 3-dimensional motion analysis with 8 infrared cameras and 3 channels of EMG was performed in this study. A two-way ANOVA (group × load) with repeated measure was used for statistical verification. The significant level was set at α=.05. Results: There were significant differences in grip type and weight on the right shoulder joint, and only significant difference in grip on the left shoulder joint (p<.05). The hip joint ROM was significantly increased as the weight increased in both types of grips on phase 1, while the ROM of hip joint was significantly decreased as the weight increased only in the case of OG on phase 2 (p<.05). In case of the OG, as the weight, increased significantly increased L1 ROM and L3 ROM were revealed on phase 1 and phase 2, respectively (p<.05). Moreover, as the weight increased, UG revealed significantly decreased L5 ROM on phase 1, while both grips showed significantly increased ROM on phase 2 (p<.05). In addition, the erector spinae and the biceps femoris, which are synergist for the motion, showed a significant difference in both types of grip according to the weight (p<.05). The muscle activity ratio of gluteus maximus/biceps femoris showed a significant difference only in the UG according to the weight (p<.05). Conclusion: In conclusion, beginners might be suggested to use the UG for maintaining the neutral state of the lumbar spine and focus on the gluteus maximus muscle, which is the main activation muscle. For the experts, it may recommend alternative use of the OG and UG according to the training purpose to minimize the compensation effect.

• Journal of the Korea Convergence Society
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• v.11 no.12
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• pp.177-186
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• 2020

Entrepreneurship education has been emphasized worldwide and the number of universities that open related subjects have been increasing. K University, located in Gyeonggi-do, was selected as one of the leading universities in entrepreneurship in 2014, and has continued to grow quantitatively by providing support and education related to entrepreneurship on and off campus. In addition, major issues in entrepreneurship education were derived by conducting written or face-to-face interviews and advisory meetings with instructors, field experts, and education demanders for environmental analysis. Based on this, three major tracks(venture start-up, entrepreneurship convergence, and social venture activation) were derived, and major competency and learning goals for each track were presented. On the other hand, in order for this study to be more effectively accepted, it is necessary to present the objectives of each track, the capabilities pursued, and the courses that help students' progress. Therefore, in the future research, it is necessary to design and present the goals for each track, the curriculum road map, and the detailed curriculum of the convergence major, and at the same time, research to match the appropriate teaching method for each newly opened subject will be required to increase educational effectiveness.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.1
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• pp.9-18
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• 2021

Recently, the rapid proliferation, introduction, and application of the fourth industrial revolution technology has emerged as a trend in the construction market. Building Information Model (BIM) technology is a multidimensional information system that forms the basis of the fourth industrial revolution technology. The river sector utilizing this information-based system is also being actively reviewed, for example, the current measures for maintenance. In recent years, active research and current work should be done to reflect the need for river experts to introduce BIM into the river field. In addition, the development of tools and support software for establishing various information systems is essential for the activation of facility maintenance information systems reflecting advanced technology and to establish and operate management plans. A study on the maintenance of river facilities involves using existing drawings to build a three-dimensional (3D) information model, check the damage utilizing it, and inform it, and utilize it as the data for maintenance reinforcement. This study involved determining a method to build a river facility without the existing information system and using the property maintenance information with 3D modeling to provide a more effective and highly utilized management plan to check maintenance operations and manage damages.

• Journal of Industrial Convergence
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• v.18 no.6
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• pp.61-73
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• 2020

The purpose of this study was to categorize conflict resolution by exploring the conflict experiences of the elderly who participate in jobs for the elderly to create an elderly-friendly village. This study applied grounded theory, a qualitative research method, For data collection, a FGI was conducted by sampling 5 elderly job participants in ◯◯-dong, ◯◯-gu, Seoul. The data were analyzed according to the paradigm model of Strauss & Corbin(1998). As a result of the analysis, causal conditions were social, economic, psychological and physical motivations for participation and contextual conditions were economic difficulties, social disconnection, and differences in life experiences influenced the initiation of conflict. The core phenomena were conflict initiated by 'the difference between experience and role' and 'the difference in psychosocial relationship skills', and the intervention condition were the activation of interpersonal relationships through communication to resolve the conflict, social integration through the use of capabilities, It appeared as a regular social activities. The interaction strategy emerged as a strategy for resolving conflict for senior citizen jobs through education, mutual support for building trust, and successful senior-friendly village program operation. The consequences, it was found that job conflicts for the elderly were alleviated by finding one's life, activating community exchanges, increasing a sense of achievement, and growing a sense of community. In conclusion, the conflict resolution types for senior citizens were classified into educational solution type, mutual support solution type, and success experience solution type.