• International journal of advanced smart convergence
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• v.6 no.1
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• pp.32-38
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• 2017

In Korea, the act for promoting use of the public data has been enforced since 2013. The Key Government 3.0 Strategy was established for providing the public data as an obligation of public authorities for users to use them free of charge. The aim of open public data and using them targeted by the government is creation of a solution for vitalizing the economy by using the public data. However, the reason for low usability and tangible outcomes despite unlimited provision of open government data is as follows. That is, it is essential to address the issue of difficult software technology required to access public data for using the data. However, with the open API method currently provided, the development procedure is not easy even for IT students or specialized software developers. Therefore, strategies for each step ideal for the level of developers are required to vitalize applications based on the public data and developed by ordinary users. Two strategic methods can be used for facilitating the use of public data and applications developed by ordinary users suggested in this paper on the basis of the public data portal organized by the Ministry of the Interior and provided to all ordinary users. That is, they are applications developed in the web browser environment and those developed in the PC environment. They allow ordinary users to develop and distribute applications based on the public data to contribute to enforcing the policy for facilitating the use of public data of the government just with basic training and basic knowledge from the training without using program coding knowledge of open API which requires the knowledge of development professionals.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.252-263
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• 2016

This study considered the factors of city brand reinforcement and city revitalization through a case study of two cities that were successful in revitalizing using a brand strategy. World leading cities are securing city competitiveness through the culture resources, particularly traditional culture, as a key asset to highlight the cities' uniqueness in increasing their value. The Confucianism influence on Korean traditional culture has a valuable content like etiquette, ritual ceremony, food, education, etc. as well as culture heritage in historical architecture. Therefore, it can be used as the city's assets to promote it worldwide. On the other hand, there is difficulty in preserving most Confucianism culture content and the intangible cultural properties have been neglected. This needs to be applied actively to be used on a city brand strategy. This study reviewed the successful case of Andong city in Korea and Qufu city in Sandong, China and suggests ways of raising the cities' brand power.

• Journal of Korea Port Economic Association
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• v.34 no.4
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• pp.39-52
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• 2018

The Seosan-Daesan Port is a representative trade port in Chungnam, and has the sixth largest total cargo throughput and the third largest oil cargo throughput in Korea. However, research on this port's development is lacking relative to that for Busan Port, Incheon Port, and Gwangyang Port, and no study exists that suggests the direction of the development strategy for Seosan-Daesan Port. This study discusses the future role of Seosan-Daesan Port in preparation for a rapidly changing future and the development strategy that should be established. Using the AHP, a development strategy is provided for Seosan-Daesan Port from short/mid-term and long-term viewpoints for three aspects: operation activation, infrastructure construction, and policy support. Operation activation is chosen as the most significant factor from a short/mid-term viewpoint, whereas infrastructure construction is recognized as important from a long-term viewpoint. Specifically, from a short/mid-term viewpoint, sustainable container cargo attraction, multipurpose dock construction, management pier construction, and opening of international passenger ferry lines are important factors while from the long-term viewpoint, hinterland construction, petrochemical industry cluster construction, automobile industry cluster construction, and management improvement system are important. Establishing action plans for each strategy and a cooperative network for sharing goals and strengthening cooperation is necessary.

• The Journal of the Korea Contents Association
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• v.8 no.8
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• pp.206-212
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• 2008

In spite of the element that tourism contents are importance for tourism activation attract attention that I took the culture sightseeing contents development strategy that utilized Ginseng. A basic course of contents development is the element which is well-being to be able to let you increase health and high value-added article development. A development strategy must be accompanied with a story in representative well-being and must develop the contents that can be full of character of multipurpose not a story for an article and in consideration of a last article form and develop feasible contents. Lastly, direct profit and participation must be guaranteed by local inhabitants.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.437-442
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• 2020

Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by active caspase-1. It has been reported that overactivation of the NLRP3 inflammasome contributes to the development and pathology of acne vulgaris. Therefore, inhibiting activation of the NLRP3 inflammasome may provide a new therapeutic strategy for acne vulgaris. In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris. Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1β in primary mouse macrophages and human sebocytes. In a P. acnes-induced acne mouse model, injection of P. acnes into the ears of mice induced acne symptoms such as redness, swelling, and neutrophil infiltration. Topical application of auranofin (0.5 or 1%) to mouse ears significantly reduced the inflammatory symptoms of acne vulgaris induced by P. acnes injection. Topical application of auranofin led to the downregulation of the NLRP3 inflammasome activated by P. acnes in mouse ear skin. These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms. The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome.

• 한국사회정책
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• v.19 no.3
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• pp.149-183
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• 2012

This article aims to analyze main features of activation policy and compare major programmes in terms of their impact on employment performances in Korea. Since the introduction of National Basic Living Security Act in 2000, a series of activation policies have been in place for social assistance recipients, low-income employees, and youth unemployed by means of providing tailored employment and social services via in-depth counselling and case management. These activation policies carry both enabling and demanding elements: requiring programme participation in exchange for public assistance benefit receipts on the one hand, and providing various social services to remove barriers to employment through case management on the other hand. Therefore, it merits attention to analyze how various features of activation programmes affect employment outcomes, the effectiveness of delivery system and policy instruments as well. In analyzing employment outcomes of activation policy of which main characteristics lie in provision of employment and social services, this article points out the features and policy instruments of the activation policy that contribute to labor market entry of public assistance recipients and low income employees. In addition, it also delineates the determinants of exit from benefit receipts. Results from statistical analysis show that activation policy with intense employment service helps both benefit recipients and low income employees enter into the labor market at a faster rate. However, tailored social service provision enables social assistance recipients to exit from benefit receipts. These results suggest theoretical and policy relevant implication in regards to redesigning the delivery mechanisms and service instruments of activation policy.

• Journal of Radiation Protection and Research
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• v.42 no.3
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• pp.141-145
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• 2017

Background: The concrete walls inside the vaults of cyclotron facilities are activated by neutrons emitted by the targets during radioisotope production. Reducing the amount of radioactive waste created in such facilities is very important in case they are decommissioned. Thus, we proposed a strategy of reducing the neutron activation of the concrete walls in cyclotrons during operation. Materials and Methods: A polyethylene plate and B-doped Al sheet (30 wt% of B and 2.5 mm in thickness) were placed in front of the wall in the cyclotron room of a radioisotope production facility for pharmaceutical use. The target was Xe gas, and a Cu block was utilized for proton dumping. The irradiation time, proton energy, and beam current were 8 hours, 30 MeV, and $125{\mu}A$, respectively. To determine a suitable thickness for the polyethylene plate set in front of the B-doped Al sheet, the neutron-reducing effects achieved by inserting such sheets at several depths within polyethylene plate stacks were evaluated. The neutron fluence was monitored using an activation detector and 20-g on de Au foil samples with and without 0.5-mm-thick Cd foil. Each Au foil sample was pasted onto the center of a polyethylene plate and B-doped Al sheet, and the absolute activity of one Au foil sample was measured as a standard using a Ge detector. The resulting relative activities were obtained by calculating the ratio of the photostimulated luminescence of each foil sample to that of the standard Au foil. Results and Discussion: When the combination of a 4-cm-thick polyethylene plate and B-doped Al sheet was employed, the thermal neutron rate was reduced by 78%. Conclusion: The combination of a 4-cm-thick polyethylene plate and B-doped Al sheet effectively reduced the neutron activation of the investigated concrete wall.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.11
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• pp.911-918
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• 2014

In this paper, a selective activation strategy of cohesive elements using user subroutine UMPC was studied as an efficient solution for the added compliance problem in cohesive zone model crack propagation analyses. The cohesive elements were inserted between every bulk elements in region where cracks were expected to initiate and propagate, but initially not activated by tying the cohesive nodes using multi-point constraints. During analyses, the cohesive elements for which specified criterion was met were selectively activated by releasing the constraints. The effect of initial cohesive stiffness and the release criterion on the crack propagation behavior was carefully investigated.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.597-605
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• 2014

As a result of analysis on the related materials for looking into the plan for activation of regional economy through attraction of off-season training team that Daejeon is currently pushing ahead, Daejeon is lacking in training facilities as compared to other cities and climatic conditions such as temperature, wind and rainfall were not specially advantageous than other cities. Therefore, it is considered necessary for Daejeon to install an exclusive team capable of assuming full charge of attraction of off-season training teams within the region and build a cooperative system among schools, companies and associations, and provide the most advanced medical and athletic performance improvement service to attract off-season training teams.

• BMB Reports
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• v.53 no.3
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• pp.133-141
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• 2020

The epidermal growth factor receptor (EGFR), a member of the ErbB family (EGFR, ErbB2, ErbB3 and ErbB4), plays a crucial role in regulating various cellular responses such as proliferation, differentiation, and survival. As a result, aberrant activation of EGFR, mostly mediated through different classes of genomic alterations occurring within EGFR, is closely associated with the pathogenesis of numerous human cancers including lung adenocarcinoma, glioblastoma, and colorectal cancer. Thus, specific suppression of oncogenic activity of mutant EGFR with its targeted drugs has been routinely used in the clinic as a very effective anti-cancer strategy in treating a subset of tumors driven by such oncogenic EGFR mutants. However, the clinical efficacy of EGFR-targeted therapy does not last long due to several resistance mechanisms that emerge in the patients following the drug treatment. Thus, there is an urgent need for the development of novel therapeutic tactics specifically targeting mutant EGFR with the focus on the unique biological features of various mutant EGFR. Regarding this point, our review specifically emphasizes the recent findings about distinct requirements of receptor dimerization and autophosphorylation, which are critical steps for enzymatic activation of EGFR and signaling cascades, respectively, among wildtype and mutant EGFR and further discuss their clinical significance. In addition, the molecular mechanisms regulating EGFR dimerization and enzymatic activity by a key negative feedback inhibitor Mig6 as well as the clinical use for developing potential novel drugs targeting it are described in this review.