• 한국유기농업학회지
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• 제15권4호
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• pp.339-353
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• 2007

It is important to facilitate consumers' purchases of EAP (Environment-friendly Agricultural Products) for establishing the successful Environment-friendly Agriculture (EA). This study was conducted to evaluate the present state of some potentially influential factors on consumers' purchasing decisions of EAP using Importance- Performance Analysis (IPA). A total of 299 Gwangju citizens participated in the questionnaire survey during September and October, 2007. Urgent improvement efforts are needed for "reliability about the safety of the EAP", "reliability on EAP certification mark", "credibility of EAP producers", and "growth of EA". Respondents also seem to have positive attitudes to EA activation.

• 약학회지
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• 제43권4호
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• pp.481-486
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• 1999

Excessive or long term ingestion of alcohol may cause hepatitis, cirrhosis, hepatic tumor and so on. Aldehyde and active form of free oxygen that are metabolites of alcohol in liver are the cause of liver cell damage. The main system of alcohol metabolism is composed of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450. In connection with in vivo alcohol metabolism, more than one hundred natural products were screened for inhibition or activation of alcohol dehydrogenase. As a results, we found significant inhibition ($IC_50$) of ADH by methanolic extracts of Puerariae Radix ($61.2{\;}\mu\textrm{g}/ml$), Glycyrrhizae Radix ($105.0{\;}\mu\textrm{g}/ml$), Cinnamomi Ramulus ($7.0{\;}\mu\textrm{g}/ml$), Rhei Rhizoma ($36.7{\;}\mu\textrm{g}/ml$), Mori Cortex Radicis ($106.2{\;}\mu\textrm{g}/ml$), Chrysanthemi Flos ($112.2{\;}\mu\textrm{g}/ml$), Erycibes Caulis ($36.7{\;}\mu\textrm{g}/ml$), and Scutellariae Radix ($122.5{\;}\mu\textrm{g}/ml$)

• 조명전기설비학회논문지
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• 제26권4호
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• pp.1-5
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• 2012

By using LED optical devices and improving the efficiency of optical devices as well as lighting apparatus for humans, LED lighting industry puts the purpose of manufacturing the main products related with information, electric, large-sized LCD BLU, automobile, shipbuilding, agriculture, medical treatment, environment, and telecommunications, etc. Moreover, the main products and the industrial lighting products are manufactured with fusion, as the result, LED lighting industry provides various effects as well as sources of technology based on practical use of LED technology in order to develop the industry from the perspective of the lower price, the higher efficiency, the higher function, the deeper reliance. In the future, not only the development of new LED technology but also the fusion and combination of digital IT technologies using wire-wireless communication, sensor, controller, and artificial intelligence will be expected to create new industrial fields.

• Journal of Microbiology and Biotechnology
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• 제7권4호
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• pp.272-277
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• 1997

In the purification of elaiophylin from a culture of Streptomyces hygroscopicus MCY -846, mono- and di-methyl-elaiophylin were obtained through a O-methylation of the hemiketal hydroxy group of elaiophylin. All the three elaiophylins showed cytotoxicity against several human tumor cell lines and murine cell lines. Elaiophylin and monomethyl-elaiophylin also showed antimicrobial activities against gram-positive bacteria and potent inhibitory effects on the activation of B cells by lipopolysaccharide as well as on the proliferation of mouse splenic lymphocytes stimulated by mitogens but dimethyl-elaiophylin did not. This result indicates that elaiophylin and monomethyl-elaiophylin would be strong immunosuppressants. Furthermore this result revealed an interesting structure-activity relationship suggesting that the lack of symmetry and/or the free OH group at C-11 of elaiophylin might be important in conferring biological activities.

• Biomolecules & Therapeutics
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• 제13권3호
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• pp.174-180
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• 2005

Antigen presenting cells (APCs), dendritic cells (DCs) and macrophages, playa critical role not only in the initiation of immune responses, but also in the induction of immune tolerance. In an effort to regulate immune responses through the modulation of APC function, we searched for and characterized APC function modulators from natural products. Bifidobacterium pseudocatenulatum SPM1204 (SPM1204) isolated from feces of healthy Korean in the age of 20s was used in this experiment. DCs and macrophages were cultured in the presence of supernatants of SPM 1204 and then examined for their activities for the presentation exogenous antigen in association with major histocompatibility complexes (MHC) and macrophage activation. SPM1204 increased class I MHC-restricted presentation of exogenous antigen (cross-presentation) in a DC cell line, DC2.4 cells. The RAW 264.7 cell line was used to test the nonspecific effect of immune reinforcement of SPM1204 as a source of biological regulating modulator for the macrophage activation, include nitric oxide (NO) production and cytokine production. Results showed that the production of NO, tumor necrosis factor (TNF)-$\alpha$, interleukin 1 (IL-1)-$\beta$ and morphological changes in macrophages were largely affected by SPM1204 in a dose-dependent manner. Our results demonstrated that SPM1204 promote cross-presentation of dendritic cells as well as the induction of NO, TNF-$\alpha$ production, and activation of macrophage.

• 한국산학기술학회논문지
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• 제14권2호
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• pp.977-982
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• 2013

다양한 종류의 지방산 아실 체인으로 치환된 Cellulose mixed esters(CME)는 재생 가능한 bio-based 폴리머이다. 셀룰로오스 에스터는 생분해성 고분자로써, 분해되지 않는 석유계 플라스틱을 대체할 미래 고분자 소재이다. 본 연구에서는 개질 실험에 앞서 alpha 셀룰로오스를 $40^{\circ}C$의 증류수에 2시간동안 activation하였다. Water-activated 셀룰로오스와, 다양한 불포화 지방산, 무수 아세트산을 $120^{\circ}C$의 lithium chloride/N,N-dimethylacetamide (LiCl/DMAc)용매에서 5시간동안 반응시켜 CME를 합성했다. 세척과 감압을 반복한 후, TGA, FT-IR, 1H-NMR과 FE-SEM를 통해 특성을 관찰하였고, water activation이 셀룰로오스의 수산기 치환에 미치는 영향에 대하여 조사하였다.

• 동의생리병리학회지
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• 제25권3호
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• pp.459-465
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• 2011

The nuclear factor of activated T cells (NFAT) protein induces transcriptions of cytokine genes including IL-2 for T-cell activation. Normally activation of NFAT is important to induce immune responses but excessive NFAT activation provokes immunopathological reactions such as autoimmunity, transplant rejection, and inflammation. Thus, for the treatment of autoimmune diseases drugs repressing the activation of NFAT have been searched. In this study, immnunosuppressive effects of Rosa chinensis Jacq. extracts identified as a potent NFAT inhibitor from a natural product library were examined. NFAT reporter assay, MTS assay, real time PCR, IL-2 ELISA, MLR, and FACS (Fluorescent Activated Cell Sorting) were used to measure inhibitory immunocyte activities of Rosa chinensis Jacq. The variety of natural products have been screened and some were found to show inhibitory activities against the NFAT transcription factor. Among them, extract of Rosa chinensis Jacq. showed an strong inhibitory effect on the activation of NFAT without affecting cell viability. Levels of IL-2 transcripts as well as IL-2 protein were decreased with treatment of Rosa chinensis Jacq. extract. In addition, immunosuppressive activity of Rosa chinensis Jacq. extract was exhibited in the mixed leukocytes reaction. The increasement of CD4+CD25+ (Treg) immunocyte was also detected in the analysis using FACS after applying Rosa chinensis Jacq. extract. Immunosuppressive effects of the Rosa chinensis Jacq. extracts were clearly demonstrated in the present study. In addition, Rosa chinensis Jacq. extract also positively affected regulatory T cell induction. Further investigations in particular on purification of single substance responsible for the immunosuppressive effects from the extract and analysis on possible actions of the extract in interfering cell signaling and cytokine production will be needed.

• 한국의상디자인학회지
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• 제19권2호
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• pp.1-14
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• 2017

The consumption trend of fashion in modern industrial society is developing from the rapid changes, and the lifespan of fashion products becomes shorter due to the various industrial wastes. Due to the attitude change caused by the ethical consumption consciousness and environment awareness, the up-cycle fashion products got to receive attention, and it is in the limelight as a new trend to realize the sustainable fashion products in the domestic and foreign fashion. The purpose of this study lies in drawing the expression characteristics by investigating and analyzing the cases of each type on the fashion bag products of up-cycle brand, and contributing to the diversification of product family fitting to the characteristics of fashion bag product of up-cycle brand, systematic strategies of up-cycle fashion products, and activation of up-cycle fashion market. In research methods, the theatrical researches were conducted centered the relevant domestic literature materials, preceding papers, etc., which ran paralleled with the actual case analysis study. Through the preceding research and websites related to selected products, websites of up-cycle companies, relevant books, related articles, etc., the expression characteristics of up-cycle fashion bag products were drawn. The results of this study are as follows: First, as it has the feature of historicality, the designs can be created by containing the designer's story, story of materials, and consumer's story. Second, since it has the characteristic of sustainability, the application of manufacturing process and materials, extension of product life, conversion of original material's function, etc. can be sustainable. Third, as it's a trait of scarcity, all products may be produced by hand, and it can have the specialty which the original materials have. Fourth, since it has an eco-friendly trait, even while saving the original materials, the aesthetic needs could be met according to the consumers' continuous demand.

• 보건행정학회지
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• 제20권4호
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• pp.126-138
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• 2010

Objectives : The purpose of this study is to evaluate the effects of assistive products usage on activity of daily living for the beneficiary older adults people in Korean long-term care insurance system. The study subjects were divided to assistive products users and non-users among the beneficiary older adults based on Korean long-term care insurance system to compare function improvement of the activity of daily living. Methods : In national wide 12 community elderly care center enrolled the National Health Insurance Corporation, The numbers of 281 beneficiary older adults(long-term care Grade I: 66, Grade II: 58, Grade III: 157) participated in this study. This survey assessment tool for activity of daily living was used the long-term care assessment instrument of the physical functions in the law of Korean long-term care insurance. The function items of Activity of daily living were included in clothing, washing, tooth brushing, bathing, eating, posture converting, stand sitting, move sitting, out of room, using toilet, controlling of stool, controlling of urine, washing hair. According to independence to complete dependence functioning level, remarks pointed 1 to 3 points. The data were analyzed by chi-square, two-way anova using SPSS V. 12.0. Results : The results appeared that the mean score of the functions in activity of daily living of assistive products users was a 27.60, and that of non-users was a 30.66. Assistive products were not effected in Grade I and II recipients, but that effected in Grade III recipients. Conclusion : Preparing for activation of assistive products based Korean long-term care insurance system, the result application as follows is possible. The usage of assistive products could improve the function of daily living activity in older adults. Related to Grade III beneficiary elderly people were improved function in activity of daily living by using assistive products, it is necessary to extend coverage the non-eligible elderly people in Korean long-term care insurance system.

• 한국식품위생안전성학회지
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• 제13권4호
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• pp.355-359
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• 1998

식물중에서 배당체 일종인 saponins을 다량 함유한 시호(Bupleurum falcatum)로부터 생체 조절 기능을 갖는 유효성분을 분리하여 혈소판 활성화 작용을 통하여 뇌심혈관계 질환 연구에 이용하고자 시호 용매 분획물에서 분리 및 동정한 Saikosapini을 thronbin, collagen, arachidonic acid 등의 효능제(agonist)와 세포의 $Ca^{2+}$ 의존성을 비교연구하였다. 시호 용매추출물 중에 acetone 추출물이 혈소판 응집작용이 강하며, 그 유효성분을 분리 및 동정한 saikosaponin a와 d는 C16 위치에 각각 ${\alpha}와\;{\beta}$형의 OH기를 갖는 이성체로, saikosapnin d가 a보다 강한 응집작용을 갖는 구조활성관계를 나타내고 있다. 각 효능제에 따라서 혈소판 활성화에 대한 세포의 $Ca^{2+}$ 의존성은 thrombin > colagen $\geq$ PAF>PMA> arachidonic acid $\geq$ Ionophore A23187순으로 나타났다. 시호 추출물 및 saikosaponin의 혈소판 활성화 작용은 기존 효능제와 다른 세포의 $Ca^{2+}$의존성을 나타내는 것으로 사료된다.