• Journal of the Korean Wood Science and Technology
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• v.19 no.4
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• pp.18-26
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• 1991

This study was carried out to examine not only the effect and the process of activation of aluminum sulfate for the manufacture of PB and MDF, but also application of the activation treatment to PB and MOF made with MDI adhesive. The results were as follows: 1. For the manufacture of PB, activating effect did not take place Because the low moisture content of 30% in the process of activation treatment made probably insufficient activation. It needs to examine higher moisture content for the uniform and enough activation same as that of MOF. 2. In the case of MOF, Activating effect was excellent, it showed not only better results of MOR 48%, MOE 29%, IB 60% than those of the control but also better dimensional stability. 3. Application of alum activation to the PB and MDF made with MDI adhesive yielded no effects. Maybe it was the reson that the curing mechanism of MDI is different. 4. Modifing the wood surface was the oxidation and wettability was not the variable limiting glueline performance. It is necessary to make a more study about activating reaction.

• Food Science and Biotechnology
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• v.14 no.2
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• pp.200-206
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• 2005

Effect of quercetin on NO production and regulation mode of quercetin on oxidative stress, $NF{\kappa}B$ activation, and iNOS expression, possible mechanisms of NO suppression in LPS-stimulated macrophages were investigated. Treatment of RAW 264.7 cells with quercetin significantly reduced lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production dose-dependently ($IC_{50}$, $9.2\;{\mu}M$). Expression of iNOS and specific DNA binding activities of nuclear factor kB ($NF{\kappa}B$) were significantly suppressed by quercetin pretreatment. Quercetin reduced thiobarbituric acid-reactive substances (TBARS) accumulation, enhancing GSH level and antioxidant activities of enzymes, such as superoxide dismutase (SOD) and catalase. These results demonstrate quercetin may ameliorate inflammatory diseases by suppressing NO production through inhibition of iNOS expression, $NF{\kappa}B$ transactivation, and oxidative stress, which may be mediated partially by antioxidative effect of quercetin. Thus, quercetin appears to be used as a potential therapeutic agent for treating LPS-induced inflammatory processes.

• Archives of Pharmacal Research
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• v.26 no.7
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• pp.511-515
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• 2003

Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

• Journal of Navigation and Port Research
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• v.36 no.5
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• pp.401-407
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• 2012

The purpose of this study was to examine the preferences to yacht tourism and perceptions to importance of yacht tourism industry's activation strategies from consumers perspectives. In order to such a purpose, this study employed survey methodology with a total of 300 visitors to yacht facility and beach located in B metropolitan city. With 265 usable questionnaires, data collected were analyzed using descriptive statistics such as frequency, percentage, mean and standard deviation. Accordingly, following findings were derived from current study. First, 32% of participants had yacht tourism experiences and more than 64% of them had willing to purchase yacht tourism products in the future, which indicates optimistic increases in yacht tourism demand. In addition, amount of willingness to pay for yacht tourism was less than 100 thousand Won per day. Second, the most preferred product was a yacht training and experience program, and preferred time for yacht tourism was weekend and or vacation with the period of one day or one night and two days. The main motivation was to spend leisure time and enjoyment with accompanying persons of family or friend members. Third, consumers' restriction factors included high expenditures, time consuming and lack of various yacht tourism products but their selection attributes included low expenditures, associated tourism products and quality of yacht tourism products. Finally, the most important activation strategies included the development of yacht tourism products, building yacht tourism conditions and establishing marketing strategies, but the least important activation strategies from consumers views included policies, experts and facilities.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.519-527
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• 2017

Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative disorders. Balanophonin, a natural neolignoid from Firmiana simplex, has been reported to have anti-inflammatory and anti-cancer effects. In this study, we aimed to evaluate the anti-neuroinflammatory effects and mechanism of balanophonin in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of balanophonin. The results indicated that balanophonin reduced not only the LPS-mediated TLR4 activation but also the production of inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), $Interleukin-1{\beta}$ ($IL-1{\beta}$), and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), in BV2 cells. Balanophonin also inhibited LPS-induced inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX2) protein expression and mitogen activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAPK. Interestingly, it also inhibited neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells. In conclusion, our data indicated that balanophonin may delay the progression of neuronal cell death by inhibiting microglial activation.

• Applied Chemistry for Engineering
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• v.30 no.2
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• pp.178-185
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• 2019

Three spherical quaternary composites composed of metal/metal oxide/high explosive/oxidizer were prepared by a crystallization/agglomeration process. From the characteristics of composites by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), the shortening of the decomposition zone of high explosives in the quaternary composite was observed, which may be attributed to the autocatalytic reaction caused by $ClO_2$ or HCl which are ammonium perchlorate (AP) degradation products. The activation energy analysis showed that the activation energy abruptly decreases at the end of the decomposition zone of high explosives, and it was considered to be caused by $HNO_2$ which is common in decomposition products of high explosives. The activation energy predicted from complex pyrolysis results by the distributed activation energy model (DAEM) showed much better in accuracy than those by model-fitting methods such as Kissinger-Akahira-Sunose and Flynn-Wall-Ozawa models.

• International journal of advanced smart convergence
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• v.1 no.2
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• pp.59-63
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• 2012

The mVoIP service is the technology which focuses on the wireless data service as the IP network having the transmission rate of 100 Mbps classes on the high-speed middle of movement through the WiFi, WiBro and 3G mobile radio communication network, and etc. and is developed. Since 2010, the mVoIP (mobile VoIP) service shows the rapid growth due to 4G-LTE service seriously disclosed from July with the Smart phone and 2,011 it begins to be rapidly popularized. In this research, additionally the mVoIP service industry activation plan is presented with the trends of technology development including the chip-set/module/terminal, etc. based upon local and foreign market trend searchlight through the market demand analysis. The mVoIP service downloads App to the mobile apparatus and or can provide the service as the software through the WiFi network. Therefore, the change which is large in the products development aspect is to be have no. Expected to is being provided as the added service in the case of 4G-LTE as a matter of course, the service deployment where it is based on the market principle and demand needs is needed.

• International Commerce and Information Review
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• v.7 no.1
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• pp.283-307
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• 2005

The research was carried out at the electronic Gw-mart located at Gangwon province. The secondary data and the various other reference materials were used for the research. This research brings forth the concrete activation plan for the activation of an electronic market in the Gangwon province. So, the activation plan for an e-market at Gang won can be done in six ways, first result of the undertaken research achieved in six ways- first, concentration has to be laid on the internet portal sites, second, the local sites should be well connected with the shopping mall facilities, third, a trustworthy shopping mall has to be established by maintains the product quality and quantity, fourth, a visible distinction should be made between the various products, fifth, the division of labor must be specified and a provisions should be made for a efficient after service.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.195.3-196
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• 2003

In this study, we investigated the molecular pathways targeted by platycodin D, which could involve apoptosis in immortalized human keratinocytes (HaCaT). We demonstrated that platycodin D-mediated apoptosis of HaCaT cells exhibited representative features, including DNA fragmentation, caspase-3, caspase-8 activation, and upregulation of Fas and FasL expression, but not p53 activation. To investigate the events involved in activation-induced FasL upregulation, we have examined mRNA accumulation, protein expression, and NF-$\kappa$B activity to elucidate transcription level in the HaCaT cell line treated with platycodin D. (omitted)

• Archives of Pharmacal Research
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• v.24 no.3
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• pp.202-206
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• 2001

The effects of various sedative cyclopeptides and peptide alkaloids from the Zizyphus species on calmodulin-dependent $Ca^{2+}$ -ATPase and phosphodiesterase were Investigated. Calmodulin-induced activation of $Ca^{2+}$-ATPase was strongly inhibited by sanjoinine-A dialdehyde (IC_{50}$, 2.3$\mu\textrm{m}$), -Ah1 (IC_{50}$, 4.0$\mu\textrm{m}$), -A (IC, 4.6$\mu\textrm{m}$), and -G2 (IC_{50}$, 7.2$\mu\textrm{m}$), while calmodulin-induced activation of phosphodiesterase was strongly inhibited by both deachuine- S10 (IC_{50}$, 4.9$\mu\textrm{m}$) and sanjoinine-D (IC_{50}$, 9.0$\mu\textrm{m}$). The inhibitory activity of the various cyclopeptides and peptide alkaloids on $Ca^{2+}$-ATPase was found to correlate well with their Sedative activity.