• 한국시스템다이내믹스연구
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• 제16권2호
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• pp.5-32
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• 2015

Last year, a disastrous accident happened on the sea. Car ferry Se-wol which was on its way from In-cheon to Je-ju sank in the middle of the western sea. 304 passengers were drowned at the sea in the accident. There were no passengers who were waiting on board ship rescued in the accident. This study is to review the pattern of decision making in the middle of saving a life, right after Se-wol was about to sink. The starting point of this study is decision making on the rescue by rescue corps with no expert knowledge at the initial stage. When it comes to saving victims, there was no expert on rescue on the sea. Failure in rescue at Se-wol disaster lets us find a vicious circle of positive feedback loop. Experts with no experience act like well-qualified persons. Unqualified persons(leaders) have no expertise. Those who pretend to be expert occupy the important post in the hierarchy. It means we could not accumulate expertise of know-how in rescue division. That's why a vicious circle of positive feedback is formed in areas of disasters. It is necessary to train experts in Government Organizations to weaken the vicious circle of positive feedback.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.1
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• pp.259-262
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• 2003

The surface electronic state of rutile $TiO_2$, which is an oxide semiconductor and has a wide band gap of 3.1 $\sim$ 3.5 eV, was calculated by DV-$X_{\alpha}$ method, which is a sort of the first principle molecular orbital method and uses Hartre-Fock-Slater approximation. The $[Ti_{15}O_{56}]^{-52}$ cluster model was used for the calculation of bulk state and the $[OTi_{11}O_{34}]^{-24}$ model for the surface state calculation. After calculations, the energy level diagrams and the deformation electron density distribution map were compared in both models. As results, it was identified that the surface energy levels are found between the valence and conduction band of bulk $TiO_2$ on the surface area. The energy values of these surface-induced levels are lower than conduction band of bulk $TiO_2$ by 0.1 $\sim$ 1 eV. From this fact, it is expected that the surface energy levels act as donar levels in n-type semiconductor.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제1회 추계심포지움 and 제2회 생리분자과학연구센터워크숍
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• pp.28-33
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• 1993

Regulation of nerve growth factor (NGF)-induced neuronal differentiation by GTPase activating protein(GAP) and its mechanism were investigated in rat pheochromocytoma cell line, PCl2. Overexpression of GAP caused the delay in the onset of neurite outgrowth of PCl2 eel Is in response to NGF. GAP has been known to inhibit p21$\^$ras/, the activated form of which induces neuronal differentiation. Therefore, the activity of p21$\^$ras/ was compared in control cells and cells overexpressing GAP indirectly by measuring the activities of B-Raf and MAP kinase that are known to be positively regulated by p21$\^$ras/. Surprisingly, NGF-induced activities of these two proteins were the same in control eells and GAP-overexpressing cells. Activities of Trk, PLC-r and SMC that act at a site upstream to p21$\^$ras/ in NGF signal transduction pathway were not also affected by GAP overexpression. Interestingly, however, the extent of tyrosine phosphorylation of SNT was found to be remarkably low in cells overexpressing GAP. It has been shown previously that neurotrophins and not mitogens induce SNT tyrosine phosphorylation in PCl2 cells. Thus it is possible that the timing of NGF-induced neuronal differntiation may be in part regulated by SNT and the slower onset of neurite outgrowth in cells overexpressing GAP may be through the inhibition of SNT by GAP.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2009년도 특별 Symposium
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• pp.3-12
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• 2009

특허맵 (Patent Map, 특허동향조사)이란 특정 기술분야에 대한 국내외 특허출원 및 등록현황에 대한 자료를 여러 기준으로 상세하게 분석한 후, 이를 사용목적에 맞게 가공하여 이해하기 쉽게 작성한 자료로 기술의 추이와 특허동향이나 현황을 쉽게 파악할 수 있도록 도표, 기호, 그림 등 다양한 형태로 표현한 것이다. 연구자나 기업들의 R&D와 사업은 연구나 사업의 실패 확률을 줄이기 위해 특허맵, 특허동향조사를 필수적으로 활용한다. 특허동향조사를 활용함으로써 다음의 이점을 제공받을 수 있는데, 즉 연구개발방향의 설정에 활용할 수 있고, 중복연구 및 특허분쟁을 미연에 방지할 수 있다. 또한, 경쟁자의 동향을 용이하게 파악할 수 있으며, 기술개발 추이를 파악하여 미래예측이 가능하다. 이러한 활용을 통해 연구개발 예산을 효율적으로 사용할 수 있게 된다. 또한, 특허맵이나 특허동향조사가 활용되는 시점은 연구기획단계에서부터, 연구개발단계, 비즈니스단계 및 특허소송에 이르기까지 전 과정, 즉 R&D부터 그 활용단계에까지 필수적으로 필요한 도구(tool)라 할 것이다. 본 발표에서는 줄기세포분야에 대한 국내외 특허동향을 조사해 보았다. 국내에서는 2000년 이후부터 관련 기술의 급격한 출원을 보이고 있으며, 서울대, 고려대, 제론, 위스콘신 등 국내외 대학이 주요 출원이었다. 또한, 출원현황을 통한 국내 연구 분야의 활성도는 성체줄기세포가 배아줄기세포에 비하여 월등히 앞서 있음을 파악할 수 있다. 특히, 역분화와 관련된 기술도 국내에 약 10건 정도가 검색되었으며 주로 해외 출원인이 주를 이루고 있다. 해외의 경우, 약 6,800여 건을 검색하였으며 미국에서의 출원이 가장 두드러지고 있다. 특허출원의 추이는 국내와 유사하게 2000년 이후에 급격히 증가되었으며 국내보다 2년 앞선 2004년에 최고의 출원량을 보이고 있다. 주요 출원인으로는 OLYMPUS, GENRO, OSIRIS, JAPAN SCIENCE & TECHNOLOGY, ACT, SYSTEMIX 등의 순서임을 확인할 수 있었다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.915-916
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• 2014

사물 인터넷 시대에 들어서면서 센서 네트워크는 더욱 주목을 받고 있다. 라즈베리파이는 작고 기능이 많아 센서 네트워크로 사용 시 인터넷 프로토콜을 사용하여 센서 노드로 동작이 가능하며, 하둡 클러스터 네트워크 구성이 가능하다. 본 논문에서는 5대의 라즈베리파이를 사용하여 실험적인 하둡 센서 네트워크 테스트베드 상의 5개의 노드를 가진 맵리듀스 하둡 소프트웨어 프레임워크를 구성하였다. 다양한 파라미터를 변경해가면서 네트워크 아키텍쳐를 분석하여 효율성, 자원분배, 처리속도를 비교하였다. 테스트 워크로드로는 지지벡터머신 기계학습을 사용하였고, 실험 결과 라즈베리파이는 센서 네트워크 노드로서 위치측정을 위한 분산 컴퓨팅 노드의 역할을 충분히 수행하였다.

• 천문학회보
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• 제43권2호
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• pp.33.3-34
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• 2018

Galaxy clusters contain a diffuse component of stars outside galaxies, that is observed as intracluster light (ICL). Since the ICL abundance increases during various dynamical exchanges of galaxies, the amount of ICL can act as a measurement tool for the dynamical stage of galaxy clusters. There are two prominent ICL formation scenarios; one is related to the brightest cluster galaxy (BCG) major mergers, and the other to the tidal stripping of galaxies. However, it is still under debate as to which is the main ICL formation mechanism. In this study we improve on earlier observational constraints of the ICL origin, by investigating it in a massive fossil cluster at z~0.47. Fossil clusters are believed to be dynamically matured galaxy clusters which have dominant BCGs. Recent simulation studies imply that, BCGs have assembled 85~90% of their mass by z~0.4 (e.g., Contini et al. 2014). Thus our target is an optimal test bed to examine the BCG-related scenario. Our deep images and Multi-Object Spectroscopic observations of the target fossil cluster (Gemini North 2018A) allow us to extract the ICL distribution, ICL color map and ICL fraction to cluster light. We will present a possible constraint of the ICL origin and discuss its connection to the BCG and the host galaxy cluster.

• 영어영문학
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• 제54권4호
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• pp.443-459
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• 2008

This paper examines the discourse of masturbation in modern England and aims to re-draw the map of male sexuality related to such issues as nation, empire, family, and economy. It argues that the discourse of masturbation in modern England reflects national anxieties for the future of empire and an economic concern for unproductive sexual behavior, which were the main factors to transform masturbation into "solitary vice." The anxieties about empire and British dominance were constituted as the core of the anti-masturbation discourse on the boys. The imperial destiny was regarded to depend on the protection of the middle- and upper-class boys from the harmful psychological and physiological effects of masturbation represented in Lawrence's "The Rocking-Horse Winner." In the case of a single male, the concern for masturbation is constructed as a concern about economy, family, and human solidarity. As seen in Eliot's Silas Marner, the act of masturbation was condemned as the fulfillment of illegitimate sexual desire outside the familial sphere and a commercial economy, and thus without the possibility of human community. Silas Marner and Meredith's The Ordeal of Richard Feverel show the ways of reconstituting sexual others as normalized subjects: Boys were forced to be asexual through the regime of surveillance; and a single male was required to enroll in a remedial course on familial respectability.

• International Journal of Computer Science & Network Security
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• 제22권11호
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• pp.77-86
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• 2022

The destructive impact of contagious diseases outbreaks on all life facets necessitates developing effective solutions to control these diseases outbreaks. This research proposes an end-to-end, data-driven platform which consists of multiple modules that are working in harmony to achieve a concrete goal: early detection of contagious diseases outbreaks (i.e., epidemic diseases detection). Achieving that goal enables decision makers and people in power to act promptly, resulting in robust prevention management of contagious diseases. It must be clear that the goal of this proposed platform is not to predict or forecast the spread of contagious diseases, rather, its goal is to promptly detect contagious diseases outbreaks as they happen. The front end of the proposed platform is a web-based dashboard that visualizes diseases outbreaks in real-time on a real map. These outbreaks are detected via another component of the platform which utilizes data mining techniques and algorithms on gathered datasets. Those gathered datasets are managed by yet another component. Specifically, a mobile application will be the main source of data to the platform. Being a vital component of the platform, the datasets are managed by a DBMS that is specifically tailored for this platform. Preliminary results are presented to showcase the performance of a prototype of the proposed platform.

• The Korean Journal of Physiology and Pharmacology
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• 제8권6호
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• pp.339-344
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• 2004

Recent data have shown the importance of oxidative stresses in the pathogenesis of inflammatory bowel disease, crohn's disease and ulcerative colitis. $H_2O_2$, reactive oxygen species (ROS) donor, has been reported to act as a signaling molecule involved in a variety of cellular functions such as apo/ptosis and proliferation. In the present study, we investigated viability of cultured ileal smooth muscle cells (ISMC) after stimulation with $H_2O_2$. Trypan blue method revealed that the cell viability of ISMC treated with 1 mM $H_2O_2$ was not different from that of controls at up to 2 h time point, while treatment of ISMC with 1 mM $H_2O_2$ for 48 h finally induced significant decrease in the cell viability. Therefore, we evaluated whether $H_2O_2$ was capable of ERKs activation in ISMC for the short-term exposure and examined whether tyrosine kinase was involved in the process of ERK activation by $H_2O_2$ in ISMC. We also investigated the effects of $H_2O_2$ on activation of SAPK/JNK and p38 MAP kinase in ISMC. Thus, ISMC were cultured and exposed to $H_2O_2$, and western blot analysis was performed with phosphospecific MAP kinase antibodies. Robust activation of ERK occurred within 30 min of 1 mM $H_2O_2$ treatment. $H_2O_2-induced$ ERK activation was attenuated by a tyrosine kinase inhibitor, genistein, indicating that tyrosine kinase was probably involved in the ERK activation by $H_2O_2$. $H_2O_2$ was a moderate activator of SAPK/JNK, while p38 MAP kinase was not activated by $H_2O_2$. We suggest that ERK activation induced by short-term $H_2O_2$ treatment plays a critical role in cellular protection in the early stage of response to oxidative stress. The present study suggests the necessity of identification of MAPK signaling pathways affected by ROS, since it could ultimately elucidate cellular consequences involved in initiation and perpetuation of intestinal tissue damage in the diseases such as crohn's disease and ulcerative colitis, resulted from excessive ROS.

• 한국지역지리학회지
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• 제2권2호
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• pp.159-171
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• 1996

본 연구는 심각해지는 토지문제를 해결하기 위해 최근에 시행되고 있는 여러가지 토지제도들이 효과적으로 운용되도록 지가를 정확히 산정하고자 하는 움직임에 대한 기초 연구로서, 다른 토지이용에 비해 월등 높은 지가를 보이고 중은 범위에서도 그 변동폭이 큰 상업지를 택하여, 상업지지가의 지역적 차이가 왜 발생하는지 알아보고자 하였다. $1989{\sim}1996$ 동안의 상업지역의 확산은 시 외곽에 빠르게 조성되고 있는 고밀도 아파트 단지를 배후지로 하여 주요 간선도로변을 따라 활발하게 이루어지고 있는 반면, 도심부는 영세한 부지규모 및 노후화한 건물들로 말미암아 급변하고 있는 상업환경의 변화에 능동적으로 대응하지 못하므로서 지가하락 현상을 보이고 있다. 상업지지가와 관련이 있으리라고 예상되는 6개 변수를 이용하여 중다희귀분석을 적용한 결과 보행자 통행량과 도심으로부터의 거리 등 두 변수가 상업지지가 변화량의 65% 정도를 설명해 주었다. 설명되지 않은 35%의 해명을 위해 잔차분석을 행한 결과 도심부의 과소예측, 시 외곽의 과대 예측을 읽을 수 있었는데 이는 광주시의 단핵구조적 특성의 반영일 뿐만 아니라 이 모델이 갖고 있는 한계이다.