• 핵의학기술
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• 제16권1호
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• pp.86-90
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• 2012

Rb-82를 이용한 PET 검사는 심근 관류의 임상적 평가에 중요한 역할을 한다고 알려져 있다. 그러나 PET/CT의 dead time 때문에 count value와 방사능농도 사이의 직선성이 유지되지 않는다면 데이터를 획득할 때 좌심실 입력 함수가 과대평가되어 심근관류가 과대평가될 수 있다. 본 연구에서는 리스트 모드에서 획득한 PET data에서 방사능농도에 따른 count value의 직선성을 평가하였다. Biograph 40 True Point PET/CT를 이용하여 직경 12 cm, 길이 10.5 cm의 cylindrical phantom에 F-18 333 MBq과 물 800 mL를 채우고 7반감기동안 10min frame/bed로 리스트 모드를 이용하여 획득하였다. Raw data는 OSEM (order: 4, subsets: 8)과 FBP (Gaussian filter FWHM 5 mm) 알고리즘을 이용하여 재구성하였다. Sinogram 정보에서 prompt counts, net true counts, random counts를 측정하였다. 재구성 된 phantom 영상에 ROI를 설정하여 총 계수와 background를 측정하고 background correction을 사용하여 count value를 측정하여 직선성을 평가하였다. 리스트 모드를 이용하여 sinogram에서 측정된 prompt counts는 방사능농도에 비례하여 증가하였다. 낮은 방사능농도에서 net true counts와 random counts는 방사능농도에 따라 증가하였다. 높은 방사능농도에서는 net true counts의 증가율이 점차 감소되었고, 반면에 random counts의 증가율은 증가하였다. 그리고 OSEM과 FBP 알고리즘으로 재구성된 영상에서 측정한 count value의 차이는 없었고 방사능농도에 비례하여 count value가 증가하고 직선성이 유지되었다. Biograph 40 True Point PET/CT scanner는 재구성된 영상에서 낮은 방사능농도뿐만 아니라 높은 방사능농도(~416.25 kBq/mL)에서도 측정 된 count value와 방사능농도 사이의 직선성이 유지되는 것을 보여주었다. 따라서 실험에서 사용한 PET/CT scanner는 Rb-82, N-13, O-15, F-18을 이용한 heart dynamic PET study에서데이터의 정량적 분석에 유용할 것으로 판단된다.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.154-160
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• 2018

본 논문은 공과대학에서 인공지능 교과목에 문제중심학습(PBL : Problem-Based Learning) 활용을 위하여 PBL 문제를 개발하여 수업에 적용하고 PBL 효과를 확인하는데 목적을 두었다. 현대 산업사회에서는 협동 학습 능력, 자율적인 학습능력, 통합지식 활용 능력, 창의 문제해결 능력을 갖춘 인재를 필요로 하고 있다. 대학은 사회에서 요구하는 인재를 양성하기 위해 학습자들에게 문제해결능력 향상과 협동학습의 기회를 제공해 주어야 한다. PBL 활동은 이러한 실천을 위한 적합한 학습방법이다. 연구대상은 '인공지능'교과목을 수강한 H대학 2학년 학생 37명이었으며, PBL수업은 15주에 5개의 PBL문제를 적용하였다. 학생들은 주어진 문제의 PBL 활동이 끝날 때마다 성찰일지를 작성하여 제출하였으며, 5번째 PBL문제의 활동이 끝난 후에 강의 평가지를 작성하였다. 연구 결과는 학습내용에 대한 이해(86.48%), 협동학습에 대한 이해(94.59%), 실제적 경험(75.67%), 문제해결력(89.18%), 프리젠테이션 스킬(97.29%), 창의성 향상(81.08%), 지식획득 능력(86.48%), 의사소통 능력 향상(97.29%), 통합지식 활용 능력(78.37%), 자기주도적 학습 능력(86.48%), 자신감(97.29%)과 같은 다양한 PBL의 효과를 경험한 것으로 나타났다. 학생들은 이 PBL 학습 활동은 현대 산업사회에서 요구하는 미래의 유능한 엔지니어로서의 전문성을 기를 수 있는 중요한 방법이라고 인식하였다.

• 산학경영연구
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• 제18권1호
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• pp.59-79
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• 2005

최근들어 전세계는 지속적인 기술혁신과 경제성장을 바탕으로 대량소비를 추구하고 있으며 이러한 과정에서 환경파괴는 가속화되고 있다. 기업활동의 핵심인 산업활동 및 서비스의 증가는 이에 수반되는 제품 생산을 위하여 원자재의 취득에서부터 최종제품의 제조 및 폐기과정까지의 전과정에서 환경오염물질을 배출하고있다. 동시에 다량의 원자재를 사용함으로 인하여 자원소모를 촉진시키고 있으며, 그 결과 지속가능한 개발에 장애요인이 되고 있다. 이에 환경보전을 위한 기업의 책임이 강조되고 있다. 그린라운드에 대비해야 하는 기업은 단순히 최종제품을 제조하여 판매하는 일뿐만 아니라 원료취득과 사용후의 폐기처리까지를 포함하는 제품의 전과정에 걸쳐 발생되는 환경영향을 고려하지 않으면 않되게 되었다. 국제적으로는 ISO의 TC207에서 전과정평가(Life Cycle Assessment : LCA) 기법이 표준화되고 있으며, 국내의 여러 기업에서 전과정평가 기법을 습득하여 기업활동에 적용하려는 작업이 활발히 진행되고 있다. 최근의 교토의정서 발효와 ISO 14000 시리즈 정비는 국가간 또는 기업간 경쟁에 새로운 생존원칙을 제시하고 있다. 또한 개개의 제품에 대한 전과정평가는 단일 제품에 대한 경쟁력 향상뿐만 아니라 기업 전체의 이미지에도 큰 영향을 줄 것이다. 따라서 본 연구는 향후 기업의 운명을 좌우할 수 있는 전과정평가 기법에 대한 이론적 고찰과 그 기법을 이용하여 제품의 환경친화성 평가 및 미래에 경쟁력 있는 제품개발을 위한 몇 가지 사례를 살펴보고자 한다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.75-75
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• 2020

Potatoes were first introduced outside the Andes region four centuries ago, and have become an integral part of much of the world's food. Potatoes were first introduced into Europe in the 16th century and Korea in the early 19th century. Potatoes have a short growing season, high production per unit area, relatively strong environmental adaptability, and are cultivated in more than 130 countries around the world. It is the world's fourth-largest crop, following rice, wheat, bean and maize. In the nutritional aspects, potatoes contain abundant vitamins and minerals, as well as an assortment of phytochemicals such as carotenoids and natural phenols. Due to the high content of potato functional compounds, it has known that potatoes are effective in the prevention of various human diseases. In particular, the potato contains a large amount of polar compounds, including the saponin in the polar compounds, and the physiological activity of the saponins, such as immunity enhancement, antioxidant and anti-inflammatory is known. In this study, the antioxidative activity of polar compounds from five potatoes was examined by cell based anti-oxidation assay. The smallest amount of ROS(Reactive oxygen species) was generated when the compound was derived from 'Haryung' and 'hongyoung' and strong SOD(Superoxide dismutase) activity was observed in 'Sumi' and 'Jayoung'. The results of this study reveal the antioxidative effect of polar compounds extracted from various kind of potatoes, which will enable the acquisition of new bioactive candidates and the establishment of new profit generation models for farmers

• The Journal of Korean Physical Therapy
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• 제15권2호
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• pp.75-84
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• 2003

The purpose of this study was to review of mechanism and application methodology about mental practice. The mental practice is symbolic rehearsal of physical activity in the absence of any gross muscular movements. Human have the ability to generate mental correlates of perceptual and motor events without any triggering external stimulus, a function known as imagery, Practice produces both internal and external sensory consequences which are thought to be essential for learning to occur, It is for this reason that mental practice, rehearsal of skill in imagination rather than by overt physical activity, has intrigued theorists, especially those interested in cognitive process. Several studies in sport psychology have shown that mental practice can be effective in optimizing the execution of movements in athletes and help novice learner in the incremental acquisition of new skilled behaviors. There are many theories of mental practice for explaining the positive effect In skill learning and performance. Most tenable theories are symbolic learning theory, psyconeuromuscular theory, Paivio's theory, regional cerebral blood flow theory, motivation theory, modeling theory, mental and muscle movement nodes theory, insight theory, selective attention theory, and attention-arousal set theory etc.. The factors for influencing to effects of mental practice are application form, application period, time for length of the mental practice, number of repetition, existence of physical practice.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.249-254
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• 2008

The present study was undertaken to determine whether hypoxia influences on the agonist-induced vascular smooth muscle contraction and, if so, to investigate the related mechanism. The measurement of isometric contractions using a computerized data acquisition system was combined with molecular experiments. Hypoxia significantly inhibited fluoride-induced contraction regardless of endothelial function, but there was no relaxation on thromboxane $A_2$ mimetic U-46619-induced contraction suggesting that other pathway such as $Ca^{2+}$ entry or thin filament regulation was not affected. In addition, hypoxia significantly decreased fluoride-induced increase of phospho-myosin-targeting subunit of myosin light chain phosphatase (pMYPT1). Interestingly, hypoxia didn't inhibit significantly phenylephrine-induced contraction suggesting that myosin light chain kinase (MLCK) activity or thin filament regulation is less important on the hypoxia-induced vasorelaxation in the denuded muscle than Rho-kinase activity. In conclusion, this study provides the evidence and possible related mechanism concerning the vasodilation effect of hypoxia on the agonist-specific contraction in rat aortic rings regardless of endothelial function.

• 지능정보연구
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• 제4권1호
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• pp.115-131
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• 1998

Customer service process is one of the most important processes in today's competitive business environment. Among the various activities of customer service process, equipment malfunction diagnosis activity should be performed fast and accurately. When a customer calls the service center and reports the observed symptoms, he/she describes them in layman's terms. Therefore, the customer-reported symptoms have not been considered helpful information for service representatives. However, in order to perform diagnosis activity fast and accurately, we need to make use of the customer-reported symptoms actively. In this research, we developed three systems called R-EMD (Rule-based Equipment Malfunction Diagnostic system), C-EMD (Case-based Equipment Malfunction Diagnostic system) and R&C-EMD (Rule & Case-based Equipment Malfunction Diagnostic system), each of which diagnoses equipment malfunctions using the customer-reported symptoms. R&C-EMD is a hybrid system that utilizes both rule-based and case-based technologies. The diagnosis rules used in R&C-EMD and R-EMD were not acquired from service manuals or interviews with service representatives. Rater, we extracted them directly from the past diagnosis cases based on symptoms' frequencies. By this way, we were able to overcome the knowledge acquisition bottleneck. Using the real 100 malfunction diagnosis cases, we evaluated the performances of R&C-EMC, R-EMD and C-EMD in terms of speed and accuracy. In diagnosis time, R&C-EMD took longer than R-EMD and shorter than C-EMD. However, R&C-EMC was the best in accuracy.

• 대한전기학회논문지:시스템및제어부문D
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• 제55권11호
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• pp.495-501
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• 2006

Diagnostics of unborn baby is mainly aimed at prediction and detection of occurrence of intrauterine hypoxia. Consequences resulting from fetal hypoxia appear in its heart activity. In this study, we have developed a new non-invasive system for fetal hypoxia diagnosis which provides systolic time interval(STI) parameters on the basis of analysis of electrical and mechanical heart activity together. For this we have worked on 1) the proper lead system for the acquisition of abdominal ECG, 2) the independent component analysis based signal processing and fetal ECG separation, 3) the development of a hardware which consists of an abdominal ECG amplifying module and an ultrasound module and 4) the detection of characteristic points of FECG and Doppler signal and the extraction of diagnostic parameters. The developed system was evaluated by the clinical experiments in which 33 subjects were participated. The acquired STI by the system were distributed within the ranges from the well-established invasive results of other researchers. From this, we can conclude that the developed non-invasive fetal hypoxia diagnosis system is useful.

• Mycobiology
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• 제51권3호
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• pp.169-177
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• 2023

To further explore the molecular mechanism of triterpenoid biosynthesis and acquire high-value strain of Sanghuangporus baumii, the Agrobacterium tumefaciens-mediated transformation (ATMT) system was studied. The key triterpenoid biosynthesis-associated gene isopentenyl diphosphate isomerase (IDI) was transformed into S. baumii by ATMT system. Then, the qRT-PCR technique was used to analyze gene transcript level, and the widely targeted metabolomics was used to investigate individual triterpenoid content. Total triterpenoid content and anti-oxidant activity were determined by spectrophotometer. In this study, we for the first time established an efficient ATMT system and transferred the IDI gene into S. baumii. Relative to the wild-type (WT) strain, the IDI-transformant (IT) strain showed significantly higher transcript levels of IDI and total triterpenoid content. We then investigated individual triterpenoids in S. baumii, which led to the identification of 10 distinct triterpenoids. The contents of individual triterpenoids produced by the IT2 strain were 1.76-10.03 times higher than those produced by the WT strain. The triterpenoid production showed a significant positive correlation with the IDI gene expression. Besides, IT2 strain showed better anti-oxidant activity. The findings provide valuable information about the biosynthetic pathway of triterpenoids and provide a strategy for cultivating high-value S. baumii strains.

• International Journal of Vascular Biomedical Engineering
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• 제1권1호
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• pp.3-12
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• 2003

Ultrasonic pulsed Doppler velocimetry has become a standard international method of classifying carotid disease. Because the measured angle adjusted velocity increases as the Doppler angle increases, examinations should be performed at a convenient standard Doppler examination angle. An angle of 60 degrees is achievable throughout most examinations. Multiple Doppler viewing angles allow the acquisition of velocity vectors during the cardiac cycle, revealing the complex velocity patterns. Ultrasonic velocimetry (whether Doppler or time domain) is based on changes in the phase of the ultrasound echo. Other examinations can be done based on the echo phase. Slow motions of organs such as the brain can be used to monitor changes in edema. Measurements of tissue strain due to the pulsatile filling of the arterioles. This plethysmographic imaging method can display differences in tissue perfusion because of different tissue types and changes in autonomic activity.