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Comparison of International Guidelines of Dermal Absorption Tests Used in Pesticides Exposure Assessment for Operators

  • So, Jaehwan;Ahn, Junyoung;Lee, Tae-Hee;Park, Kyung-Hun;Paik, Min-Kyoung;Jeong, Mihye;Cho, Myung-Haing;Jeong, Sang-Hee
    • Toxicological Research
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    • v.30 no.4
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    • pp.251-260
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    • 2014
  • The number of farmers who have suffered from non-fatal acute pesticide poisoning has been reported to vary from 5.7% to 86.7% in South Korea since 1975. Absorption through the skin is the main route of exposure to pesticides for farmers who operate with them. Several in vitro tests using the skins of humans or animal and in vivo tests using laboratory animals are introduced for the assessment of human dermal absorption level of pesticides. The objective of this study is to evaluate and compare international guidelines and strategies of dermal absorption assessments and to propose unique approaches for applications into pesticide registration process in our situation. Until present in our situation, pesticide exposure level to operator is determined just using default value of 10 as for skin absorption ratio because of data shortage. Dermal absorption tests are requested to get exposure level of pesticides and to ultimately know the safety of pesticides for operators through the comparison with the value of AOEL. When the exposure level is higher than AOEL, the pesticide cannot be approved. We reviewed the skin absorption test guidelines recommended by OECD, EFSA and EPA. The EPA recommends assessment of skin absorption of pesticides for humans through the TPA which includes all the results of in vitro human and animal and animal in vivo skin absorption studies. OECD and EFSA, employ a tiered approach, which the requirement of further study depends on the results of the former stage study. OECD guidelines accept the analysis of pesticide level absorbed through skin without radioisotope when the recovery using the non-labeled method is within 80~120%. Various factors are reviewed in this study, including the origin of skin (gender, animal species and sites of skin), thickness, temperature and, etc., which can influence the integrity of results.

Production and Economic Factor Analysis for the Low Input Sustainable Agriculture(LISA) of Red Pepper (고추의 LISA 模型開發을 위한 技術${\cdot}$經濟的 要因分析)

  • Hwang, Young-Hyun;Choi, Jung;Kim, Chung-Sil;Kim, Byung-Do
    • Korean Journal of Organic Agriculture
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    • v.7 no.1
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    • pp.35-48
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    • 1998
  • The total amount of dry matter for the green manure crops was great wheat> rye> barley> Italian ryegrass in that order. The green manure crope were verified to have the reducing effect of injury of successive croppingin peper, mainly reducing the occurance of the most important pepper disease, Phytophthora capsisi, and enhancing the pepper quality in the fruit length and diameter. The direct seeding using current commercial pepper variety was proved as not economical one. In the first year of compost application, the growth and yield of red pepper were rather somewhat decreasing compared with those of check plot applied with organic fertilizers. compst application increased the content of organic matter in soil, which suggested compost could be applied for the sustainable purposes. In preference analysis about taking the new technique, the smaller farmer's cultivation area the more they wanted to accept the LISA farming, compared with the conventional one, could be possible to save 12% in the inorganic fertilizer expenses but wasted 412% ant 163% in both organic fertilizer and operator labor expenses, respectively. At the same time, the LISA decreased 15% in production cost but increased 225% and 139% in organic fertilizer quantity and operator labor hours. Since there was a great deal of difference in technological and economic factors from two farming methods, LISA multi-goal decision modeling is further required.

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Study of Selective Cell Drop Scheme using Fuzzy Logic on TCP/IP (TCP/IP에서 퍼지 논리를 사용한 선택적 셀 제거 방식에 관한 연구)

  • 조미령;양성현;이상훈;강준길
    • Journal of the Korea Computer Industry Society
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    • v.3 no.1
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    • pp.95-104
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    • 2002
  • This paper presents some studies on the Internet TCP/IP(Transmission Control Protocol-Internet Protocol) traffic over ATM(Asynchronous Transfer Mode) UBR(Unspecified Bit Rate) and ABR(Available Bit Rate) classes of service. Fuzzy logic prediction has been used to improve the efficiency and fairness of traffic throughput. For TCP/IP over UBR, a novel fuzzy logic based cell dropping scheme is presented. This is referred to as fuzzy logic selective cell drop (FSCD). A key feature of the scheme is its ability to accept or drop a new incoming packet dynamically based on the predicted future buffer condition in the switch. This is achieved by using fuzzy logic prediction for the production of a drop factor. Packet dropping decision is then based on this drop factor and a predefined threshold value. Simulation results show that the proposed scheme significantly improves TCP/IP efficiency and fairness. To study TCP/IP over ABR, we applied the fuzzy logic ABR service buffer management scheme from our previous work to both approximate and exact fair rate computation ER(Explicit cell Rate) switch algorithms. We then compared the performance of the fuzzy logic control with conventional schemes. Simulation results show that on zero TCP packet loss, the fuzzy logic control scheme achieves maximum efficiency and perfect fairness with a smaller buffer size. When mixed with VBR traffic, the fuzzy logic control scheme achieves higher efficiency with lower cell loss.

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The Study on User's Continuance Intention of Traceability System between Agricultural and Marine Products (식품 유형간 이력추적시스템의 지속사용의도에 미치는 영향에 관한 연구)

  • Lee, Seung-Yook;Park, Hyeon-Suk
    • Journal of Distribution Science
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    • v.14 no.4
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    • pp.67-79
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    • 2016
  • Purpose - Over recent years, we have concerned about safety and quality on food products because of delivery complexity. The dependence of foreign food products escalate supply of products. And there are often negligent accident of marine and agricultural products. Therefore, the complexity increases the importance of safety on food and information quality for consumers. In spite of the interest augmentation of various interested parties, there is decrease in reliability and effectiveness, if it would be established without the right directivity. For the study, we tried to examine the first considerations the point of - view in service environment and information quality with accepting and diffusing the Traceability System. Then, we tried to verify the relationships between the factors of TS and the determinants of behavior decision. Next, we made efforts to find the mutual relationship among distributors, producers, consumers and the other prerequisite factors from the point of view in service environment and information quality in order to operate effectively the information perspective and system. Research design, data, and methodology - For the purpose of this study, the samples of consumers were targeted to Traceability System, and 661 people have been investigated. Through theoretical discussion of previous research, nine hypotheses were established, the influence of Continuous User Intention in TS. In order to test the hypotheses, a survey had conducted for 661 consumers as opinion leaders in their 20s-60s as data, and structural equation modeling was used. The difference analysis between Agricultural and Marine Products in TS; SPSS 22.0 and AMOS 22.0 were used for statistical analysis. Results - The major findings from this study were as follow; all factors of information quality excluding completeness and a social-impact had effects on the ease of use; all factors excluding understand ability in information quality and a social-impact had effects on the usefulness; completeness and social-impact had effects on perceived value; the ease of use had effects on usefulness and perceived value; usefulness had effects on perceived value and the intention of continuous use. From the results of different analysis, the CPLT(Completeness) factor has positive effects on Easy of USE and PV(Perceived Value) strongly in agricultural products. On the other hand, Social Duty has positive effects on Easy of Use strongly in marine products. Conclusion - In the age of information overflowing, TS will be a burden for users if it places too much emphasis upon accessibility. To accept and diffuse TS safely, therefore, Information System should be settled first into initial market formation. In addition, if TS elements are considered in conjunction with information factors and user environment, the acceptance and diffusion of TS would make synergy effect, even better. That is, this study contributes to the acceptance and diffusion of Traceability System. Accordingly, information quality will be settled into initial market formation. Also, social-impact element will be considered in conjunction with information quality's factors, and it will make synergy effect.

Yeoheon's Spirit of Humanities and the Genealogy of his Prose (여헌(旅軒)의 인문(人文) 정신(精神)과 산문(散文)의 계보(系譜))

  • Ahn, Se-hyun
    • (The)Study of the Eastern Classic
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    • no.41
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    • pp.61-90
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    • 2010
  • In this paper, I focused on analyzing Yeoheon Chang Hyeon-gwang's literary theory and his prose in the genealogy of Confucian scholars in Chosun. Through this study, I would like to examine the trend of concentrating on 16th century when we treat the literary tendency of Confucian scholars. With this goal, I tried to seek the direction which was pursued by Confucian scholars who lived during the 17th century. Yeoheon tried to construct the spirit of humanities cosmically as an aim of his life, study, and literature. And he had a new understanding of human independence by suffering from Japanese invasion in the late of 16th century. He insisted that only human can realize the spirit of humanities on a cosmic base. He also thought that the morality(道) could be settled only by literature(文). We may interpret this concept as a progressive idea about literature comparing to the former Confucian scholars. On the other hands, Yeoheon tried to accept the literary theory of former scholars such like Park Young, Cho Sik, and Seong Woon who embraced Taoism. Yet he erased the color of Taoism in the field of topic, and he also tried to keep his distance from them in the field of literary form. This concept actually came from Lee Hwang's opinion, while Yeoheon tried to rouse scholar's independence. Through above, we may realize that the Confucian scholars of 17th century were not just imitators of 16th century. They tried to examine the former study and also tried to renew the theory.

The structure of knowledge intended to 'you(游)': case on the 『Dohwaguenmungi』 and 『Limchungochi』 ('유(游)'의 원리로 구성되는 화의(畵意)의 구조 연구 서설 - 『도화견문지(圖畵見聞誌)』, 『임천고치(林泉高致)』를 중심으로 -)

  • Son, Bo Mee
    • (The)Study of the Eastern Classic
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    • no.41
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    • pp.445-476
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    • 2010
  • In this essay I aimed to analyze the concept of cultivation in east asian aesthetics. Most people regarded traditional asian paintings as an artwork that was obviously an artwork by artists. Moreover, they emphasized the cultivation of artists in their creation and used to accept the concept of cultivation which means cultivating one's mind. Generally speaking, to cultivate one's mind meant enlarging one's ethical behavior and he or she became a better person. And in creation, it meant considering all things more deeply. In this point of view, it was too vague to notice the meaning. What is an accurate meaning of cultivate artist's mind? What was the relation between creation and cultivation? In confucian philosophy, the concept of cultivation had two meanings. One was to enlarge one's ethical behavior and the other was to improve one's knowledge about things. The knowledge implied all of the one's experiences about things. Thus, the knowledge meant what he communicated with under his surroundings and created. In this perspective, to analyze the case of "Dohwaguenmungi" and "Limchungochi", cultivation was related to 'you(游)' and 'jing(精)'. It implied all of the artist's efforts to make communication with his objects deeper and wider, at last, he created his own meaning about object that he experienced. Therefore, I suggest that when we use the concept of cultivation in the context of creation, it should be used as the meaning related with improving one's knowledge about things.

Christina Rossetti's Maude : Self-Abnegation and Self-Expression of a Victorian Poet (크리스티나 로제티의 『모드』 : 빅토리아 시대 시인의 자기 단념과 자기표현)

  • Ha, Myungja
    • Cross-Cultural Studies
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    • v.25
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    • pp.391-420
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    • 2011
  • Christina Rossetti's novella Maude displays Tractarian influences in terms of Holy Eucharist, Puseyism, and the doctrine of Reserve. Tractarianism is High Church revival movement of nineteenth century. In the story a teenage girl, Maude went through hard time receiving Holy Eucharist due to self-consciousness and internal guilt according to Puseyism. She felt guilty when she enjoyed worldly things and outward beauty. Due to guilt Maude refused to receive Holy Communion, which is complete connection to God. Her cousin, Agnes suggested that in refusing Holy Communion Maude is following her own will not God's will. Later Maude overcame Puseyite thought of self-hatred and reconciled with her identity as a poet and a woman. Maude oscillates between concealing and revealing, secrecy and truth, sincerity and affectation, and modesty and display. Her marvelous poetic talent makes people praise her but she withholds private feelings and attempts to divert attention from herself. Like Maude herself, the meaning of her poems is at times reserved and withheld. This tendency goes with the doctrine of Reserve in Tractarianism. The doctrine of Reserve utilizes indirect methods to reveal divine attributes because finite human being can not accept infinite God. The doctrine of Reserve sees to it that the expression will be veiled, indirect, subdued and self-effacing. Rossetti adapts a poetic method of Reserve when Maude has anxiety over 'display and poetry' and generates the reticence, secrecy, mystery, renunciation, modesty and detachment. According to Mary Arseneau, by veiling and expressing herself through symbols she can rise above the self and employ the phenomenal to suggest a noumenal reality. Thus the poetry becomes an expression of longing for the divine. The poem "Three Nuns" exemplifies Maude's maturity and gradual progress in the relationship with God. Rossetti suggests the vision full of hopes and promises of reuniting with God. In conclusion, in some sense, authoritative and conservative Tractarianism affects Rossetti both ways. On the one hand, it makes Rossetti abnegate herself and leads her to asceticism, on the other hand, it makes Rossetti express her faith in God and write amazing devotional poems such as "Three Nuns". A poem within the poem has three voices that are in perfect harmony. In the poem the first and second nun show hesitation to fully commit to God's will and the desire for the world prevents them from having heavenly joy. Third nun reveals spiritual maturity and sings new life in God where their hopes and joys begin. Rossetti expresses the procedure of spiritual growth through the poem "Three Nuns". For Rossetti, self-abnegation and self-expression both are involved in the doctrine of Reserve, Puseyism and Holy Communion.

The Problem of Plato's Space (플라톤의 공간 문제)

  • Kim, Yoon-dong
    • Journal of Korean Philosophical Society
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    • v.145
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    • pp.195-215
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    • 2018
  • Plato said that our cosmos was created from the union of nous and $anank{\bar{e}}$ in Timaeus. In addition to this, 'the third kind', namely $ch{\bar{o}}ra$, exists already with genesis before the birth of the cosmos. Plato explains this $ch{\bar{o}}ra$ with several metaphors. That is, 'receptacle', 'mother', 'gold', 'space', 'place' etc. From Aristotle to contemporary scholars, generally three types of interpretations are presented. First, $ch{\bar{o}}ra$ is a kind of a 'void.' Secondly, $ch{\bar{o}}ra$ is Aristotle's $prot{\bar{e}}$ $hyl{\bar{e}}$. Thirdly, $ch{\bar{o}}ra$ has two aspects of space and matter. I will accept the third opinion. Plato's $ch{\bar{o}}ra$ has both a spatial aspect and material aspect. $Ch{\bar{o}}ra$ is a place that accommodates all sensible things in itself. On the other hand, $ch{\bar{o}}ra$ seems to be a mother who nourishes sensible things like a child. In this, Plato lacks a logical consistency. The research of $ch{\bar{o}}ra$ can not deviate from the limits of $eik{\bar{o}}s$ logos.

Artists or Educators? : A Phenomenological Study on the Collective Identity of Future Arts & Culture Education Instructors (ACEIs) (예술가인가 교육가인가?: 문화예술교육사 국가자격증 취득희망자의 정체성에 관한 현상학적 연구)

  • Kim, InSul;Park, ChilSoon;Cho, Hyojung
    • Review of Culture and Economy
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    • v.17 no.2
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    • pp.185-216
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    • 2014
  • It has been two years since the national certificate of Arts & Culture Education Instructor(ACEI) was implemented the 2012 amendment to the Arts & Culture Education Act. Separate from the initial policy goals, students who attend the program to achieve ACEI certificate share various expectations, motivations and intents. The purpose of the research is to understand the collective identity of future ACEIs to evaluate the initial policy implementation during the period when the collective professional identity has not been fully formed yet. This research studies the data that were collected from 172 students who were attending one of the official ACEI institutes in Seoul area. As one of qualitative research methods, Questionnaire Method was employed to conduct this phenomenological study. James E Marcia's theory provides the theoretical framework for the data analysis of this study. The research results indicate that many students'identity status are between Identity Diffusion and Moratorium, which raises concerns for both arts and cultural fields as well as the policy success. Therefore, this research will relate these findings to the larger arts and culture infrastructure in order to better prepare them as arts and cultural professionals and also to stress the importance of the job market development and social environment that can accept them.

Schiller's 'Beautiful Soul' and Kant and Shaftesbury ("실러의 칸트 수용과 '아름다운 영혼' 그리고 샤프츠베리")

  • Kim, Joo-whee
    • Journal of Korean Philosophical Society
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    • v.148
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    • pp.101-128
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    • 2018
  • While there are various opinions about the relationship of Schiller's thought and Kant's, it is undeniable that Schiller owes much to Kant. What distinguished Schiller from other Weimar thinkers at his time, such as Goethe, Herder and Wieland, was that unlike them Schiller accepted Kant's project of critical philosophy. In fact, Schiller did not just accept it, but tried to interpret and formulate anew the relation of beauty and morality and some other aesthetical-ethical ideals on the basis of the new philosophy. Schiller's famous project of 'aesthetic education of mankind' itself is the product of such an endeavor. In this work we follow the history of Schiller's acceptance of Kant's critical philosophy and ruminate over its implications. And then, we'll show that Schiller's 'beautiful soul' in Grace and Dignity (1793), which is often suggested to be a proof of Schiller's conflict with Kant, was understood on the basis of Kant's moral theory. In this part of the work, we compare Schiller's ideal of the 'beautiful soul' and Shaftesbury's ethical thought, which is often presumed to be its background. From this comparison we'll be able to see that there is a considerable disparity, despite apparent similarities, between Schiller's and Shaftesbury's ethical ideals, which is due to their respective philosophical sources, that is neo-platonic metaphysics and Kant's critical philosophy.