• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.331-336
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• 2011

The instability of hirsutenone (HST), a potential therapeutic candidate for the treatment of atopic dermatitis (AD) and ovarian carcinoma, is one of the main concerns for the development of drug product. In the present study, aqueous stability of HST was investigated by kinetic analysis, and the effect of several factors covering temperature, nitrogen gas ($N_2$) flushing, and selection of proper antioxidant was compared. Cosolvent system composed of distilled water and methanol (9:1 v/v) was used as a vehicle to dissolve HST at the concentration of $200{\mu}g/mL$. Samples of aqueous solution were prepared under the absence or presence of antioxidants, such as ascorbic acid (AA), sodium edetate (EDTA), and ascorbyl palmitate (AP), and subjected for stability test. The degradation of HST in aqueous solution was followed by the first order kinetics with an extremely short half life of less than a week at room temperature, and was accelerated as the temperature increased. $N_2$ flushing brought a little enhancement in stability compared to control solution, but the effect was insufficient. The addition of AA and EDTA (0.1%) significantly enhanced the stability of HST at $40^{\circ}C$, but the addition of AP (0.01%) was limited due to its water insolubility and revealed no promising result. The stability of HST was increased proportionally by the amount of AA added, showing the difference in degree of stabilization as an order of magnitude. Finally, we conclude that HST was stabilized by the addition of a suitable antioxidant, suggesting AA as the most effective stabilizer.

• Applied Biological Chemistry
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• v.14 no.2
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• pp.131-135
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• 1971

1. L-Tyrosine-${\alpha}$-ketoglutaric transaminase and p-hydroxyphenylpyruvic acid oxidase are distributed in Aspergillus oryzae. 2. L-Tyrosine oxidation in extracts of acetone powder, cell free extract and culture liquid of Aspergillus oryzae cultivated in the shaking culture are considerably accelerated by the addition of ${\alpha}$-ketoglutaric acid and then formation of glutamic acid was identified by chromatography method. 3. The roles of ${\alpha}$-ketoglutaric acid and pyridoxal phosphate have been shown to be an amino group acceptor in a transamination reaction. 4. Enzyme systems of an extracts of acetone powder and cell free extract also rapidly oxidized L-tyrosine and p-hydroxyphenlpyruvic acid to homogentisic acid. 5. The optimum pH for L-tyrosine-${\alpha}$-ketoglutaric acid transaminase was pH values of 6.0 and 6.5, and that for p-hydroxyphenylpyruvic acid oxidase was at pH values of 7.5.

• Journal of Satellite, Information and Communications
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• v.1 no.2
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• pp.56-62
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• 2006

This paper describes the MMIC product qualification of the Ka band satellite transponder for the COMS(Communication, Ocean and Meteorological Satellite). Ka-band active equipment for the COMS communications transponder are being developed by using 12 kinds of MMICs which include low noise amplifiers, medium power amplifiers, frequency mixers, frequency multipliers, RF switch, and HEMT attenuator MMIC, Those MMICs had been fabricated at the MMIC production foundry of northrop Grumman Space Technology (Velocium) which is qualified for space application, and experienced in various space programs during past decades. For the MMIC product qualification, Visual inspection and SEM inspection had been performed, and burn-in test for 240 hours and accelerated life-test for 1000 hours had been done on test fixtures of individual MMIC products at $125^{\circ}C$. Additionally, infrared temperature scanning and finite element simulation were performed to analyze and confirm the channel temperature of semiconductor devices on several representatives of those MMIC products that os one of the most important factors in performance degradation and life reduction.

• Korean Journal of Food Science and Technology
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• v.49 no.6
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• pp.693-698
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• 2017

Turmeric is a yellow food-coloring spice containing curcuminoids, curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BMC), which have several physiological effects. In the present study, the effect of microwave irradiation on the chemical properties, antioxidant activity, and cytotoxicity of turmeric were investigated. Degradation of turmeric pigments was accelerated upon increase in irradiation time or intensity at 405 nm. Residual levels of curcumin, DMC, and BMC after 5 minutes of irradiation at 700 W were 11.3, 34.4, and 71.2%, respectively. Scavenging activities of turmeric pigment against 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH) peroxyl radical and nitrite were enhanced significantly after microwave radiation. However, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity remained unaffected. Cytotoxic activity of turmeric was significantly reduced, and hydrogen peroxide generated from turmeric increased after microwave irradiation. The results obtained indicate that microwave irradiation affects chemical stability and bioactivity of turmeric pigment. Hence, these effects should be considered when processing foods containing turmeric pigments.

• Applied Biological Chemistry
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• v.31 no.1
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• pp.79-85
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• 1988

The effects of herbicides on biochemical processes in soil environment were studied by examining the effects of the chemical structure of each herbicides on soil enzyme activities and pesticides residue revealed when soil treated with urea was incubated at $28{\pm}1^{\circ}C$ for 56 days. The inhibition effects of herbicides on soil enzyme activites in soil decreased in the order of urea group>dinoseb>propanil>diphenyl eter group>acid amide group for urease, and dinoseb>urea group>diphenyl ether group>acid amide group for L-glutaminase and protease, dinoseb>diphenyl ether group>urea group>acid amide group for phosphatase. Herbicides inhibited the activities of soil enzyme in the early stage of treatment but increased the activities of urease, L-glutaminase and protease in the late stage. When herbicides were treated in soil together with urea the degradation of insecticides was accelerated.

• Analytical Science and Technology
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• v.31 no.5
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• pp.179-184
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• 2018

Diphencyprone (DPCP) is frequently used as a compounded preparation in dermatology for the treatment of alopecia and recalcitrant warts based on the immune reaction of skin allergy. However, DPCP is a non-recognized agent in Pharmacopoeia, because there are no criteria or analytical method for quality control of its powder and formulation. DPCP is unstable under light irradiation because as it easily decomposes to diphenylacetylene (DPA). This study aims to develop a simultaneous HPLC analytical method for analyzing DPCP and DPA in the raw materials and compounded preparation. The method required a C18 column ($250{\times}4.6mm$, $5{\mu}m$) at $40^{\circ}C$ with a mobile phase of (A) 0.01 M phosphoric acid in water and (B) acetonitrile at UV 220 nm. DPA conversion to DPCP in the powder and compounded preparations was accelerated after light exposure for 60 min. In addition, this resulted in different patterns depending on the wavelength of light and the formulation. That is, DPCP in compounded preparation was more unstable than that in the powder. However, the DPCP formulation in amber bottles was observed to remain stable, although the measured concentrations of DPCP were somewhat different from the nominal concentration of the compounded preparations. The control of the exact concentration is required for effective disease treatment, depending on the state of the patient. In conclusion, these results will be useful for the recognition of DPCP in Pharmacopoeia and new DPCP formulation development to prevent photodecomposition.

• Journal of the Korean Magnetics Society
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• v.3 no.3
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• pp.229-233
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• 1993

The effects of differential partial pressures of oxygen during sputtering on the magnetic and recording characteristics of magneto-optical disks were investigated. Different flows of oxygen were deliberately introduced into the sputtering chamber to have a variety of partial pressures of oxygen during sputtering. A residual gas analyzer was employed to monitor the oxygen peak before, during, and after sputtering and to estimate the reacted oxygen amount. Most of the oxygen introduced into the chamaber was reacted during sputtering. As the partial pressure of oxygen increased, the oxygen content of the TbFeCoCr film increased also. The oxygen appeared to be bound as Tb-O, effectively decreasing the magnetically active Tb content of the film The coercivity decreased but the squareness of the Kerr hysteresis loops was still excellent. The perpendicular anisotropy was not significantly affected by oxygen amount. The carrier-to-noise ratio, includi!1g the write power sensitivity and bias field sensitivity did not change too much with oxygen content in the film The disks sputtered with oxygen showed better bias field sensitivity with lower write power threshold than the disk sputtered without oxygen, due to high demagnetization during domain formation. No significant degradation of coercivity for the disk sputtered oxygen was observed during an accelerated aging test.

• Journal of the Korea Concrete Institute
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• v.18 no.5 s.95
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• pp.667-675
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• 2006

Concrete is much more easily damaged by various parameters than by the only one and performance reducing mechanism grows more complicated in that condition. In addition, the factors which really act in concrete structure tend to be activated in turn and the degradation of concrete is very rapidly progressed. The purpose of this study is to evaluate the properties of polymer cement mortars under combined cures. The polymer cement mortars are prepared with various polymer types, polymer-cement ratios and cement-fine aggregate ratio, and tested for compressive and flexural strengths, accelerated carbonation, chloride ion penetration and acid resistance test, and freezing-thawing test. The properties of polymer cement mortars under combined cures is discussed. From the test results, polymer cement mortars have superior strengths compared with plain cement mortar under combined cures. The strengths of polymer cement mortars are markedly increased at curing condition II and V, however strengths are not improved at curing condition I and IV irregardless of polymer types. The carbonation and chloride ion penetration depths of polymer cement mortars tend to decrease in curing conditions, III-C, IV-B, V-A order, and decrease with increasing polymer cement ratios. It is concluded that polymer cement ratio of 10 to 15% are considered optimum for the preparation of such polymer cement mortars.

• Journal of the Korean Institute of Gas
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• v.2 no.4
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• pp.42-46
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• 1998

Miniaturized specimen technology Permits mechanical behavior to be determined using a minimum volume of material. The technology is useful in case of not collecting a large amount of materials from industrial equipments. Five kinds of accelerated degradation materials were prepared by isothermal aging heat treatment at $630^{\circ}C$. Three kinds of specimens were prepared for impact testing. In order to increase plastic constraint of subsize specimen, side-groove was introduced. Results between subsize and full size impact testing were compared. Size effects correlations were developed for the impact properties of turbine rotor material. These correlations successfully predict the ductile brittle transition temperature (DBTT) of full size Charpy impact specimens based on subsize specimen data.

• Journal of the Korean Recycled Construction Resources Institute
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• v.4 no.1
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• pp.10-18
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• 2016

RC(Reinfored Concrete) structures exposed to carbonation in urban city have durability degradation with extended service life and cracks in concrete causes a local accelerated carbonation. In the present work, crack effect on carbonation depth is investigated and the service life of RC structure is evaluated considering cracks from early age and time-dependent cracks based on the previous field investigation. DFP(Durability Failure Probability), safety index, and the related service life are calculated considering the time to crack width reaches to maximum crack width(0.3mm). The results with time effect on crack width show lower DFP and longer service life, which seems to be reasonable compared with conservative results from crack effect from initial stage. Furthermore, crack effect is evaluated to be insignificant on DFP and service life. The technique with time-dependent crack effect on carbonation can be effectively used for RC structure containing cracking in use.