• 한국임상수의학회지
• /
• 제29권3호
• /
• pp.263-267
• /
• 2012

4세령의 래브라도 리트리버견이 좌측상악의 종괴의 평가를 위해 내원하였다. 두개부 방사선학적 검사와 컴퓨터 단층촬영검사가 실시되었으며, 그 결과 좌측상악부의 골용해소견을 동반한 연부조직종괴가 확인되었다. 종괴의 적출과 소파술이 시행되었으며, 적출된 종괴는 조직병리학적 검사의뢰되었다. 조직병리학적 검사결과 섬유성 이형성이 동반된 유두종성 에나멜아세포종으로 진단되었다.

• Imaging Science in Dentistry
• /
• 제41권1호
• /
• pp.29-33
• /
• 2011

A 46-year-old man was referred to our hospital for treatment, complaining of swelling on the right mandibular molar region. Radiographic examination revealed a well defined multilocular radiolucent lesion with root resorption of right lower anteriors and molars. Following biopsy, a diagnosis of unicystic ameloblastoma of mural type was made and hemimandibulectomy was performed under general anesthesia. Histopathological examination of the surgical specimen exhibited a unicystic ameloblastoma of luminal, intraluminal, and mural type. Intraluminal proliferation was of plexiform pattern and mural proliferation showed unusual histopathological findings, which revealed follicular, acanthomatous areas coexisted with desmoplastic areas. This mural picture was similar to the so-called 'hybrid lesion of ameloblastoma', whose biological profile is not elicited due to the lack of adequate published reports. Two years follow up till date has not revealed any signs of recurrence.

• Imaging Science in Dentistry
• /
• 제51권2호
• /
• pp.195-201
• /
• 2021

Unusual radiographic findings of intraosseous ameloblastoma have been reported and discussed. In the case discussed herein, cone-beam computed tomography (CBCT) clearly showed many radiographic features that were ambiguous on conventional radiographs, including an ill-defined periphery, extensive superficial buccal extension with minimal lingual extension, obvious bucco-crestal expansion, and multiple triangular (Codman's triangle-like) areas of periosteal reaction. Based on the above-mentioned findings, the differential diagnosis was a long-term infected benign or low-grade malignant lesion. An incisional biopsy was performed, and the histopathologic diagnosis was acanthomatous ameloblastoma. Recurrence of the lesion was clearly detected on CBCT images at 4 and 8 years after surgery. These unusual radiographic findings have never been reported to be associated with ameloblastoma, and thus may contribute to novel concepts in radiographic interpretation in the future. This report also underscores the important role played by CBCT as a comprehensive diagnostic tool and for definite confirmation of recurrence.

• 치과방사선
• /
• 제22권2호
• /
• pp.339-348
• /
• 1992

The purpose of this study was to evaluate the correlationship between histopathologic types of ameloblastoma and their radiographic appearances. The materials for this study consisted of 106 patients diagnosed as ameloblastoma both radiographically and histologically. The obtained results were as follows: 1. The incidence of ameloblastoma in male(60cases, 56.6%) was slightly higher than that in female (46 cases, 43.4%). The average age was estimated as 30.7 years with a range from 6 to 76 years. The second decade revealed the highest rate. 2. 106 ameloblstomas were histopathologically classified as 36 unicystic, 28 plexiform, 20 follicular, 14 acanthomatous, 7 granular cell, and 1 basal cell ameloblastoma. 3. Unilocular, soap-bubble appearance and scalloped margin were the radiographic appearances frequently seen in unicystic ameloblastoma. The predominant radiographic appearance of plexiform ameloblastoma showed unilocular radiolucency with scalloped margin. 4. 19.8%, 21 cases of ameloblastoma in this study showed containing tooth in their tumor mass by radiography. 5. Root resorption occured in 37 cases(34.9%) and tooth displacement in 7 cases(6.6%). Root resorption and tooth displacement occured in same patient were 24 cases(22.6%). 6. Recurrence occured in 21.7% and average year between initial treatment and recurrence were 2 years.

• Journal of Korean Dental Science
• /
• 제11권2호
• /
• pp.86-91
• /
• 2018

Ameloblastomaa are odontogenic benign tumors with epithelial origin, which are characterized by slow, aggressive, and invasive growth. Most ameloblastomas occur in the mandible, and their prevalence in the maxilla is low. A 27-year-old male visited our clinic with a chief complaint of the left side nasal airway obstruction. Three-dimensional computed tomography showed left maxillary sinus filled with a mass. Except for the perforated maxillary left edentulous area, no invaded or destructed bone was noted. The tumor was excised via Le Fort I osteotomy. The main mass was then sent for biopsy and it revealed acanthomatous ameloblastoma. The lesion in the left maxillary sinus reached the ethmoidal sinus through the nasal cavity but did not invade the orbit and skull base. The tumor was accessed through a Le Fort I downfracture in consideration of the growth pattern and range of invasion. The operation site healed without aesthetic appearances and functional impairments. However, further long-term clinical observation is necessary in the future for the recurrence of ameloblastoma. Conservative surgical treatment could be the first choice considering fast recovery after surgery and the patient's life quality.

• 한국임상수의학회:학술대회논문집
• /
• 한국임상수의학회 2009년도 추계학술대회
• /
• pp.236-236
• /
• 2009

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제18권1호
• /
• pp.144-152
• /
• 1996

저자는 desmoplastic ameloblastoma의 문헌 고찰 및 일례의 치험례를 통하여 이 병소의 독특한 임상, 방사선학적 및 병리조직학적 소견을 보고하는 바이다. 1. 임상적 특징으로는 매우 드물게 발생하며, 일반적인 법랑모세포종에 비해 상악 및 악골의 전방부에 호발한다. 2. 방사선학적 특징으로는 경계가 불명확한 방사선 투과상의 병소로, 방사선 불투과상이 혼재되어 나타나 오히려 섬유골화병소와 유사하다. 3. 병리조직학적 특징으로 종양상피도는 압축되어져 모양이 불규칙하고 가장자리세포층은 일반적인 원주세포대신 입방체 또는 편평세포로 이루어져 있고 중심부는 방추형이나 다각형의 세포들이 특징적으로 나타나며 극세포화가 관찰된다. 이들은 교원섬유가 풍부한 결합조직 형성을 동반한다. 4. 재발률은 일반적인 법랑모세포종과 유사할 것으로 사료된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제31권4호
• /
• pp.316-321
• /
• 2005

Ameloblastoma is the most common odontogenic tumor of the jawbones, but the origin of this tumor has been remained to be unproven. Cytokeratins (CKs) are specific intermediate filament of epithelial cells, and vimentin is expressed in mesenchymal cells. The immunohistochemical detection of different CKs and vimentin has made it easier to know the origin of tumor. Paraffin-embedded tissue sections from 15 ameloblastomas and 1 ameloblastic carcinoma were used for immunohistochemical evaluation of CK 7, 8, 13, 14, 19 and vimentin. Their expression is evaluated in different tumor cells, which are observed in different type of tumors. In the follicular and reticular subtype, central stellate cells of tumor nests expressed CK 8, 14, 19 and peripheral columnar cells expressed CK 14. CK 7, and 13 were not expressed. Vimentin was detected in fibrous stroma around tumor nest, not in tumor cells. The tumor cells of ameloblastic carcinoma expressed CK 7, 14 and 19, but CK 8 was more weakly stained than that in ameloblastoma. Central stellate cells and peripheral columnar cells of acanthomatous subtype showed same expression pattern with others. Meta plastic squamous cells expressed CK 8, 14, 19 and keratinizing squamous cells expressed CK 13, 19. CK 7 and vimentin were not detected in tumor cells and vimentin was expressed in fibrous stroma. Most of the tumor cells of ameloblastoma showed CK 14 and CK 19 and did not express CK 7 and vimentin. These findings were similar to the immunophenotype of dental lamina. And these results will be beneficial to differential diagnosis of odontogenic tumors and other kind of tumors arising at the oral cavity.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제29권4호
• /
• pp.199-205
• /
• 2003

The p53 protein was discovered in 1979 as cellular 53-kD nuclear phosphoprotein bound to the large transforming antigen of SV40 virus. $P21^{WAF1/CIP1}$, which has been described as the critical downstream mediator of p53, is known to suppress DNA replication and arrest the G1 cell cycle by quaternary complex with cyclin D, cyclin-dependent kinase(CDK) and proliferating cell nuclear antigen(PCNA). In these days, some studies shows that the p21 can be induced by independent pathways. There are various reports about the expression of p21 (67%.82.4%) in oral squamous cell carcinoma. But these studies are mostly done in malignant tumor not in benign tumor. So we decided to study the expression of p21 in ameloblastoma and the relationship between p53 and p21 as a downstream mediator of p53 in ameloblastoma. We investigated the expression of p21 and p53 with the method of immunohistochemistry. We selected 30 cases of ameloblastoma tissue blocks (acanthomatous type: 5 cases, follicular type: 8 cases, plexiform type: 17 cases) imbedded in paraffin. We used 30 cases of normal gingival tissues and 30 cases of squamous cell carcinoma tissues (SCC) respectively and compared their results with those of ameloblastoma. We made slides with the streptavidin-biotin methods and used monoclonal antibody DO-7 (Novocastra, Newcastle, United Kingdom) as p53 antibody and monoclonal antibody M7202 (DAKO, California, U.S.A.) as p21 antibody. We used Pearson's correlation coefficient to analyse the relationship. The results were as follows: 1. p21 was expressed in ameloblastoma about 30% and this is lower than that of normal gingiva and SCC. 2. In normal gingiva and ameloblastoma, p21 expression was correlated with p53 expression. 3. In SCC, p21 were expressed about 83.3% and this is more than that of p53. But there was no correlation between p21 and p53 expression. We confirmed p21 expression and relation with p53 in ameloblastoma. But, to confirm the function of p21, more studies about p21 expression in malignant ameloblastoma and ameloblastic carcinoma are needed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제33권5호
• /
• pp.535-542
• /
• 2007

Ameloblastoma, a benign tumor of odontogenic type, represents 10% of all tumors of the jaw. It is localized in the mandible(80%) and in the maxilla(20%). In every case, the selection of the surgical treatment must consider some fundamental elements, including the age and general state of health the clinicopathological variant, and the localization and extent of the tumor. This study was invested the clinicopathological findings of 23 patients with ameloblastoma which had been diagnosed by biopsy during the period of 1987 to 2005 at Chonnam National University Hospital. And it contained the statistical analysis according to the treatment methods and the clinicopathological findings such as sex, age, location, chief complaints, duration, radiographic findings, histologic findings, treatment methods. The results obtained are were follows. The age of patient ranged from 10 to 91 years(means, 35.9 years) at biopsy. Thirteen(57%) of the 23 subjects were males, and 10(43%) were females. Twenty(87%) of the 23 ameloblastomas were located in the mandible. Swelling was the most common symptom and was experienced by 20(87%) patients. Radiographically, 11(48%) of the 23 tumors were unilocular with a well-demarcated border and 12(52%) were multilocular. The most common histologic pattern was plexiform and acanthomatous rather then follicular. Conservative treatment was performed 7 cases(30%), radical treatment 11 cases(48%), and combined treatment 5 cases(22%). Follow-up period ranged from 2.1 years to 22 years(mean 5.1 years). Based on the above results, surgical excision after marsupialization was found to be useful as a preliminary treatment of the large cystic ameloblastoma in children and adolescents. On the contrary, the lesion with a soap bubble appearance, the one with ineffective marsupialization was subjected to extensive excision of the tumor with a wide margin of normal bone.