• Nuclear Engineering and Technology
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• v.8 no.1
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• pp.9-17
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• 1976

Dosimetrical properties of polycarbonate film for high-level dosimetry of electrons have been examined. Polycartonate film of 0.1mm in thickness was chosen for this purpose. It can cover the dose range of 1.0-130 Mrad and the measurable range can be extended up to 200 Mrad by using calibration curve. The measurement error was within 3.5%. The radiation induced optical density at 330nm shows rapid initial fading of 7-l3n for one day after irradiation at room temperature and subsequent fading rate is very small, about 0.6% per day. The fading depends on the absorbed dose, storage temperature, and wavelengths. The effects of storage time and temperature during and after irradiation of this film are presented. For practical dosimetry, it is necessary to stabilize the induced optical density by storing the irradiated film for a day or by heat treatment at 10$0^{\circ}C$ for an hour.

• Journal of Pharmaceutical Investigation
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• v.9 no.1
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• pp.15-19
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• 1979

The absorption rate of lysino-methylene-ampicillin from the rat small intestine, compared with ampicillin, was determined in vitro and in situ to establish the biopharmaceutical properties of lysino-methylene-ampicillin which is one of the new penicillinase-resistance antibiotics. The half of administered dose was absorbed rapidly within thirty minutes. The water-oil distribution coefficient of lysino-methylene-ampicillin was 0.03 in chloroform versus buffer system with $Na_{2}HPO_{4}-citric$ acid of pH5.2 at $37^{\circ}C$, and its dissolution rate reached the plateau in an hour and then represented 0.6 percent of equilibrium solubility

• Toxicological Research
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• v.17 no.4
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• pp.317-323
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• 2001

The skin penetration rate of methidathion in vitro and pharmacokinetics of methidathion in vivo were studied with male Sprague-Dawley rats by dermal treatment. The in vitro skin penetration rates for Sprague-Dawley rats of methidathion technical (50 mg, 100 ${mu}ell$) and emulsifable concentrate (EC,40mg, 100${mu}ell$) were determined as 18.4 $\mu\textrm{g}$/c $m^2$/h (RSD : 6.5) and 18.5 $\mu\textrm{g}$/c $m^2$/h (RSD : 3.2), respectively. Dose-related systemic exposure (AUC) was observed in rats after dermal treatment. The corresponding AUC, $T_{max}$, $C_{max}$, and $T_{1}$2/ of methidathion in plasma were 1.5$\mu\textrm{g}$.hr/ml, 6 h, 0.10 $\mu\textrm{g}$/ml, and 16 h, for 116mg/kg doses, 3.2 $\mu\textrm{g}$. hr/ml, 8 h, 0.12 $\mu\textrm{g}$/ml, and 23 h, for 232 mg/kg doses and 10 $\mu\textrm{g}$. hr/ml, 12 h, 0.32 $\mu\textrm{g}$/ml, and 20 h, for 1,160 mg/kg doses respectively. The urinary excretion of methidathion, estimated wing an equation derived from the in vitro skin penetration study was 0.24~0.35% of the absorbed dose. The concentration of methidathion in kidney was higher than that in liver. Dose-dependent absorption and excretion of methidathion without saturation was observed under in vivo experimental condition.n.n.

• Journal of the Korean Applied Science and Technology
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• v.15 no.4
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• pp.11-20
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• 1998

The propagation of light radiation in a turbid medium is an important problem that confronts dosimetry of therapeutic laser delivery and the development of diagnostic spectroscopy. Scattered light is measured as a function of the position(distance r, depth z) between the axis of the incident beam and the detection spot. Turbid sample yields a very forward-directed scattering pattern at short range of position from source to detector, whereas the thicker samples greatly attenuated the on-axis intensity at long range of position. The portions of scattered light reflected from or transmitted throughphantom depend upon internal reflectance and absorption properties of the phantom. Monte Carlo simulation method for modelling light transport in tissue is applied. It uses the photon is moved a distance where it may be scattered, absorbed, propagated, internally reflected, or transmitted out of tissue. The photon is repeatedly moved until it either escape from or is absorbed by the phantom. In order to obtain an optimum therapeutic ratio in phantom material, optimum control the light energy fluence rate is essential. This study is to discuss the physical mechanisms determining the actual light dose in phantom. Permitting a qualitative understanding of the measurements. It may also aid in designing the best model for laser medicine and application of medical engineering.

• Journal of Radiation Industry
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• v.5 no.1
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• pp.69-73
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• 2011

Polyamide 66 (PA66) nanofibers with Triallyl cyanurate (TAC) were obtained by electrospinning of formic acid and chloroform solution. Electron beam irradiation of PA66 nanofiber with and without TAC was carried out over a range of absorbed doses (20~100 kGy) in nitrogen. The characterization of the irradiated PA66 nanofibers and PA66 nanofibers with TAC was done by scanning electron microscopy (SEM), nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA) and universal testing machine (UTM). The results of the SEM image analysis confirmed that the morphology of PA66 nanofibers was not altered by electron beam. The amount of TAC in PA66 nanofiber with TAC was identified by $^1H-NMR$ analysis. The degradation temperature of PA66 nanofibers with TAC at an absorbed dose of 20~100 kGy was higher than the irradiated PA66 nanofiber without TAC. On the other hand, the decreasing rate of modulus of irradiated PA66 nanofibers with TAC was less than PA66 nanofibers.

• Journal of the Korean Society of Radiology
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• v.12 no.4
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• pp.467-474
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• 2018

CBCT is useful for improving the accuracy of the treatment site, but Repeated use increases the exposure dose. In this study, we aimed to provide basic data for dose reduction in CBCT implementation by dataization the simulating and dose reduction effect using shielding substance. Material in this study, Analyzation the photon beam by simulate the CBCT Through MCNPX and then calculate the absorption dose of body organ at shooting moment of thoracic abdominal position as target UF-Revise simulated body. At this time. Dose reduction effects at this time were evaluated according to the texture of materials and presence of shielding materials( lead, antimony, barium, sulfate, tungsten, bismuth). When CBCT was taken without shielding, the dose was calculated to be high in the breast and spine, and the dose in the esophagus and lung was calculated to be low. The doses according to the shield material were calculated as barium sulfate, antimony, bismuth, lead, and tungsten. The shielding rate was the highest in the thymus (73.6%) and the breast (59.9%) compared with the dose reduction according to presence or absence of the shield. However, it showed the lowest shielding rate in lung (2.1%) and spine (12.6%).

• Journal of Korean Neurosurgical Society
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• v.43 no.1
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• pp.26-30
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• 2008

Objective : The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C. Development and verification procedures were described in this article. Methods : The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-$frame^{(R)}$ and $KOPF^{(R)}$ rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images. Results : The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma $Plan^{(R)}$. The dose distributions measured with $GAFCHROMIC^{(R)}$ MD-55 film corresponded to those of Leksell Gamma $Plan^{(R)}$ within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife. Conclusion : A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.

• Analytical Science and Technology
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• v.20 no.6
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• pp.460-467
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• 2007

Dose rate conversion factor was calculated to estimate the absorbed effective annual doses for soils for the beta-rays and gamma-rays, which were emitted from $^{238,235}U$, $^{232}Th$, and $^{40}K$ isotopes. The most recent data of the emitted energies per decay, half-lifes, and branching ratios, which were obtained from National Nuclear Data Center, were used. When this factor and the effective annual doses for the beta-rays and the gamma-rays of natural radioisotopes were compared with those of Aitken, these of $^{238}U$, $^{232}Th$ and $^{40}K$ are estimated to have good agreements but a large difference is shown in this for $^{235}U$. Through the calculations of effective annual doses by using these factor and the measurements of gamma-ray spectra for soils, which were extracted from prehistoric remains (Mansuri) on Osong, Chungchengbuk-do, The annual effective doses were obtained to be 3.8~5.9 mGy/yr. Also, when these doses including decay elements upper Rn were compared with those on all isotopes, the differences within 9~30 % were obtained. The analysis method of the annual effective doses for the beta-rays and the gamma-rays of the natural isotopes of soils was established by this dose rate conversion factor.

• Journal of radiological science and technology
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• v.30 no.3
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• pp.213-219
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• 2007

The purpose of this study is to evaluate shielding effect of radiation protector for interventional radiologists in procedures by measuring inside and outside of radiation protector. In this study, we measured the radiation dose of 4 interventional radiologists during TACE and PTBD procedure for 4 month(2005.05-2005.09). Absorbed dose were measured by TLD placed underneath and over radiation protector such as Goggle, Thyroid protector, Apron and placed on the 4th finger of Hand. In addition, we measured background radiation dose in the control room using TLD. During TACE procedure, using 0.07 mmPb Goggle decreased average 53.8% of radiation dose rate in continuous fluoroscopic mode and decreased average 77.6% of radiation dose rate in pulse fluoroscopic mode. Using 0.5 mmPb Thyroid protector decreased average 88.9% of radiation dose rate in continuous fluoroscopic mode and decreased average 92.8% in pulse fluoroscopic mode. During PTBD procedure, using 0.07 mmPb Goggle decreased radiation dose rate average 62.7%, 87.9% by 0.5 mmPb Thyroid protector, 90.5% by 0.5 mmPb Apron. The average fluoroscopic time of PTBD was 6.14 min. shorter than TACE procedure, but radiation exposure dose rate of PTBD was 3 times higher in total body dose, and 40 times higher in hand dose rate than TACE. Interventional radiologists must wear thicker protector recommended over 0.5 mmPb. Also, they must use lead Goggle during interventional procedure. Abdomen dose decreased average 38.4% by drawing a lead curtain under the patient's table, therefore, they must draw a lead curtain to shield scattering ray. Radiation exposure dose decreased average 59.0% by using pulse fluoroscopic mode. So radiologists would better use pulse fluoroscopic mode than continuous fluoroscopic mode to decrease exposure dose.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.207-215
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• 2024

This study focuses on measuring the levels of naturally occurring radioactivity in the soil of Swabi, Khyber Pakhtunkhwa, Pakistan, as well as the associated health hazard. Thirty (30) soil samples were collected from various locations and analyzed for ²²⁶Ra, ²³²Th, and ⁴⁰K radioactivity levels using a High Purity Germanium detector (HPGe) gamma-ray spectrometer with a photo-peak efficiency of approximately 52.3%. The average values obtained for these radionuclides are 35.6 ± 5.7 Bqkg^-1, 47 ± 12.5 Bqkg^-1, and 877 ± 153 Bqkg^-1, respectively. The level of ²³²Th is slightly higher and ⁴⁰K is 2.2 times higher than the internationally recommended limit of 30 Bqkg^-1 and 400 Bqkg^-1, respectively. Various parameters were calculated based on the results obtained, including Radium Equivalent (Ra_eq), External Hazard (H_ex), Absorbed Dose Rate (D), Annual Gonadal Equivalent Dose (AGDE), Annual Effective Dose Rate, and Excess Lifetime Cancer Risk (ELCR), which are 170.3 ± 24 Bqkg^-1, 0.46 ± 0.06 Bqkg^-1, 81.4 ± 2.04 nGy h^-1, 582 ± 78.08 µSvy^-1, 99.8 ± 13.5 µSv Gy^-1, and 0.349 ± 0.04, respectively. These values are below the limits recommended by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) in 2002. This study highlights the potential radiation threats associated with natural radioactivity levels in the soil of Swabi and provides valuable information for public health and safety.