• 혜화의학회지
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• 제28권2호
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• pp.41-47
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• 2019

Objectives : Atopic dermatitis is an irritable skin disease accompanying rash and itching leading to impaired skin barrier. ATO-ALL is an ethanol extract of natural products comprising 12 herbs and effective on atopic dermatitis. In this study, we aimed to propose that the effect of ATO-ALL on skin regeneration in human keratinocyte cell line, HaCaT cells. Methods : To evaluate the skin regenerating effects of ATO-ALL, scratch wound healing assay, bromodeoxyuridine (BrdU) assay, and propidum iodide (PI) assay were performed using cultured HaCaT cell line. Result : Scratch wound healing assay showed that ATO-ALL was able to enhance the gap filling activity more than 2-fold at 7 ppm concentration compared with control group. BrdU assay demonstrated that ATO-ALL treatment increased the de novo cell proliferation in a dose-dependent manner. Finally, PI assay indicated that the cell cycle of HaCaT cells was modulated by ATO-ALL treatment. Conclusions : These results suggested that ATO-ALL may have skin regenerating effects by increasing cell proliferation via cell cycle regulation. Taken together, ATO-ALL is supposed to have a potential on regeneration of damaged skin or functional disease including atopic dermatitis.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 추계학술대회 논문집
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• pp.1132-1137
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• 2008

Automatic Operation based on ATO (Automatic Train Operation) is necessary for driverless Light Rail Transit business. When this kind of driverless LRT operation plan is made, TPS (Train Performance Simulation) is traditionally simulated at all-out mode and coasting mode based on manual operation. Commercial schedule speed equals to all-out speed minus $9{\sim}15%$ make-up margin. Coasting mode TPS simulation is also run at commercial schedule speed to calculate run time and energy consumption. But TPS based on manual operation should make an improvement on accuracy in case of driverless LRT operation Plan. In this paper, new fast mode TPS simulation using ATO pattern is proposed and show near actual ATO result. The actual ATO pattern can be accurately simulated with the introduction of 4 parameters such as commercial braking rate, jerk, station stop profile and grade converted distance. Normal mode TPS simulation for commercial schedule speed can be designed to have fast mode trip time plus 3 seconds/km margin recommended by korean standard LRT specification.

• 한국항공운항학회지
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• 제28권4호
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• pp.182-186
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• 2020

As all flight training institutions in Korea were approved by the Ministry of Land, Infrastructure and Transport (MOLIT) as aviation training organizations (ATO), safety management based on the Aviation Safety Management System (SMS) became mandatory. However, even though safety management using SMS has become mandatory, the performance of aviation safety voluntary report, which is the core of the system, remains low compared to other countries. The current address of SMS, a ATO, is like a watermill without water. The present study is to find out why voluntary aviation safety reports, which is equivalent to water from waterwheel, is underperforming and to suggest ways to revitalize it.

• 한국항해항만학회지
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• 제44권4호
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• pp.347-353
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• 2020

항로표지는 선박에게 위치정보 등 다양한 정보를 제공함으로써 해양사고 예방 및 해양환경 보호 등에 기여하고 있다. 이러한 항로표지의 중요성을 인식하여 무역항을 입출항하는 선박에 톤당 24원의 항로표지이용료가 징수되고 있다. 그러나 24원의 항로표지이용료는 1999년에 책정된 이후 현재까지 유지되어 오고 있는 반면, 해운 및 항만 4.0 시대변화에 따라 자율운항 선박 및 스마트 항만운영 등을 위한 항로표지의 새로운 역할에 대한 수요는 점점 증가하고 있다. 따라서 본 연구의 목적은 이러한 해운 및 항만산업의 변화에 따른 적정한 항로표지이용료의 추정에 있으며, 이를 위해 평택청을 대상으로 총괄원가를 회수하는 방법을 도입하였다. 항로표지이용료 추정은 연도별 및 누적환산 연도별 2가지와 항로표지이용료 징수대상이 무역항 이용 선박임으로 평택청의 항로표지를 전체와 대상 항로표지로 구분한 총 4가지 경우로 추정하였다. 추정결과 평택청의 항로표지이용료는 53.78-71.62원(2019년 기준)으로 현재 24원보다 29.78-47.62원이 높게 추정되어 인상이 필요하였다. 이러한 연구결과는 항로표지의 역할을 고려한 관련 예산 운영과 정책 운용에 유용한 기초자료로 활용될 수 있을 것이다.

• 대한본초학회지
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• 제31권4호
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• pp.79-85
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• 2016

Objectives : The aim of this study is to investigate anti-atopic dermatitis effect using ato-tang.Methods : Ato-tang was external treatment to NC/Nga mice for 4 weeks, where atopic dermatitis was induced by DNCB at 1% and 0.4% for 3 weeks. Atopic dermatitis index score was measured using eye observation and picture evaluation. The histopathological change of dorsal skin was observed by hematoxylin and eosin (H&E) staining. Cytokines including IL-4, IL-5 and IL-13 were measured by Luminex or reverse transcriptase polymerase chain reaction (RT-PCR) analysis and immunoglobulin E (IgE) was measured by ELISA reader.Results : The dorsal skin of Ato-tang group showed decrease in erythema, pruritus, dry skin, edema, excoriation, erosion and lichenification level through naked eye observations. Immunoglobulin cell infiltration and the thickness of epidermis were significantly decreased in the dorsal skin compared to control. Production of Th2 cytokines (IL-4, IL-5, IL-13) and IgE level in serum were all significantly decreased, in comparison with control. In addition, mRNA expression level of Th2 cytokines (IL-4, IL-5, IL-13) in spleen was decreased, in comparison with control.Conclusion : The results indicated that external treatment of ato was improved skin barrier function in the symptoms of atopic dermatitis disease. Also, atopic dermatitis factors where cytokine as well as immunoglobulin E in serum and mRNA expression were decreased, respectively, in comparison with control. Therefore, we suggest that ato could be effectively used as a external therapeutic drug based on atopic dermatitis factors.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.579-587
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• 2008

Promotion of the line no.2 in Seoul Metro was changing from the existing signaling facilities for ATS(Automatic Train Stop) vehicles to the up-to-date signaling facilities for ATO(Automatic Train Operation). But, in consequence of conducting a trial run after being equipped with the ATO signaling facilities, the matter related to mix-operation with the existing ATS signaling facilities appeared. The operation of the existing ATS signaling system in combination with the ATO signaling system has made improper working related to frequency recognition of the ATS On-board Computerized Equipment. This obstructs operation of a working ATS vehicle. That is, as barring operation of an ATS vehicle that should proceed, it may make the proceeding ATS vehicle stop suddenly and after all, it will cause safety concerns. In this paper, we designed a wayside track occupancy detector that previously prevents improper working related to frequency recognition of the ATS On-board Computerized Equipment by gripping classification and working processes of operating trains throughout transmission of local signaling information from the existing facilities, which does not need to change or replace the existing signaling facilities. Furthermore, we described general characteristics of the wayside track occupancy detector and modeled the IFC(InterFace Contrivance) device and the logical circuit recognizing signal information. Then, we made an application program of PLC(programmable Logic Computer) based on the stated model. We, in relation to data transfer method, used the frame in TCP/IP transfer mode as the standard, and we demonstrated that ATO transmission frequency is intercepted.

• Archives of Pharmacal Research
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• 제29권6호
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• pp.503-507
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• 2006

Flavonoids are known as natural anti-inflammatory agents. In this investigation, an anti-inflammatory potential of new topical preparation (SK Ato $Formula^{\circledR}$) containing flavonoid mixtures from Scutellaria baicalensis Georgi roots and Ginkgo biloba L. leaves with an extract of Gentiana scabra Bunge roots was evaluated in an animal model of chronic skin inflammation. Multiple 12-O-tetradecanoylphorbol-13-acetate treatments for 7 consecutive days on ICR mouse ear provoked a chronic type of skin inflammation: dermal edema, epidermal hyperplasia and infiltration of inflammatory cells. When topically applied in this model, this row formulation $(5-20\;{\mu}L/ear/treatment)$ reduced these responses. Furthermore, it inhibited prostaglandin $E_2$ generation (17.1-33.3%) and suppressed the expression of proinflammatory genes, cyclooxygenase-2 and $interleulin-1{\beta}$ in the skin lesion. Although the potency of inhibition was lower than that of prednisolone, all these results suggest that Ato $Formula^{\circledR}$ may be beneficial for treating chronic skin inflammatory disorders such as atopic dermatitis.

• 한국균학회지
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• 제31권2호
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• pp.103-113
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• 2003

국내의 가지과 작물에서 분리한 Alternaria 25 균주를 공시하여 분생포자의 형태적 특징을 조사하였고 A. solani와 A. tomaotphilad의 대표균주와 비교하였다. 분리균주 중 형태적으로 구별되는 몇 균주들과 대표균주를 공시하여 감자, 토마토, 가지, 고추에 대한 병원성 검정을 실시하였다. 대표균주를 포함한 Alternaria 17개 균주를 공시하여 ITS 영역과 histone h3 유전자의 염기서열분석, URP (universal rice primer)에 의한 핵산지문분석을 실시하였다. Alternaria 균주들은 분생포자의 형태적 특징에 의하여 A. tomaotophila(ATO), A. solani(ASO) 및 미동정의 Alternaria sp.(ASP)의 group으로 나눌 수 있었고 A. solani(ASO)는 분생포자 부리(beak)의 특징에 의하여 다시 ASO(1)과 ASO(2)의 2 type으로 나눌 수 있었다. ATO와 ASO 균주들은 실험에 사용한 감자, 토마토, 가지, 고추에 모두 병원성이 있었고 ATO 균주는 특히 토마토에 강한 병원성이 있었으나, ASP 균주는 감자에만 병원성이 있었다. 이 연구에서 사용한 molecular marker중 ITS와 histon H3 유전자의 염기서열 분석은 4개의 형태적 group을 명확히 구분할 수 없었지만, URP-PCR 핵산지문분석법은 이들 group을 명확히 구분할 수 있었다. 분생포자의 형태, 병원성검정, 분자생물학적 특징을 종합할 때 토마토 겹무늬병에 관여하는 A. tomatophila는 감자겹둥근무늬병에 관여하는 A. solani와 뚜렷이 구분할 수 있었다. 또한 감자에서 분리한 Alternaria sp.(ASP)는 A. solani(ASO)와 형태적으로 유사하였지만 분생포자의 폭이 두껍고 부리(beak)가 작다는 점에서 ASO와 구별되었으며 가지과 작물에서 보고된 바 없는 신종으로 추정되었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 추계학술대회 논문집
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• pp.1264-1269
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• 2008

We designed a track circuit of Tag in-tag out type that can be used for light rails and monorails. This method is called RFID-Tag and it literally uses RFID-Tag and replaces a fixed track circuit and implements a moving block. The distance between RFID-Tags is set to the length of a train and thus a train is always in contact with one of the tags. A train runs in RFID-Tag in -RFID-Tag out type at all times and the distance between trains can be precisely controlled through the application of a moving block combined with the basic principle of a fixed block, which enables the continuous speed control and enhances the satisfaction of passengers. When constructing a track circuit using RFID-Tag the Tag in-tag out brings us the cost reduction and is more economical than the existing fixed track circuit in that sense and easy for installation and maintenance. The wireless communication between onboard and wayside makes the continuous control possible and can improve the control capacity of ATP/ATO by the implementation of a moving block on top of a fixed one.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.175-175
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• 2010

Transparent conducting oxide (TCO) films are widely used as transparent conducting thin film material for application in various fields such as solar cells, optoelectronic devices, heat mirrors and gas sensors, etc. Recently the increased utilization of many transparent electrodes has accelerated the development of inexpensive TCO materials. Indium tin oxide (ITO) film is well-known for TCO materials because of its low resistivity, but there is disadvantage that it is too expensive. ZnO film is cheaper than ITO but it shows thermally poor stability. On the contrary, antimony-doped tin oxide films (ATO) are more stable than TCO films such as Al-doped zinc oxide (AZO) and ITO. Moreover, SnO2 film shows the best thermal and chemical stability, low cost and mechanical durability except the poor conductivity. However, annealing is proved to improve the conductivity of ATO film. Therefore, in this work, antimony (6 wt%) doped tin oxide films to improve the conductivity were deposited on 7059 corning glass by RF magnetron sputtering method for the application to transparent electrodes. In general, of all TCO films, glass is the most commonly selected substrate. However, for future development in flexible devices, glass is limited by its intrinsic inflexibility. In this study, we report the growth and properties of antimony doped tin oxide (ATO) films deposited on PES flexible substrate by using RF magnetron sputtering. The optimization process was performed varying the sputtering parameters, such as RF power and working pressure, and parameter effect on the structural, electrical and optical properties of the ATO films were investigated.