• Journal of Haehwa Medicine
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• v.28 no.2
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• pp.41-47
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• 2019

Objectives : Atopic dermatitis is an irritable skin disease accompanying rash and itching leading to impaired skin barrier. ATO-ALL is an ethanol extract of natural products comprising 12 herbs and effective on atopic dermatitis. In this study, we aimed to propose that the effect of ATO-ALL on skin regeneration in human keratinocyte cell line, HaCaT cells. Methods : To evaluate the skin regenerating effects of ATO-ALL, scratch wound healing assay, bromodeoxyuridine (BrdU) assay, and propidum iodide (PI) assay were performed using cultured HaCaT cell line. Result : Scratch wound healing assay showed that ATO-ALL was able to enhance the gap filling activity more than 2-fold at 7 ppm concentration compared with control group. BrdU assay demonstrated that ATO-ALL treatment increased the de novo cell proliferation in a dose-dependent manner. Finally, PI assay indicated that the cell cycle of HaCaT cells was modulated by ATO-ALL treatment. Conclusions : These results suggested that ATO-ALL may have skin regenerating effects by increasing cell proliferation via cell cycle regulation. Taken together, ATO-ALL is supposed to have a potential on regeneration of damaged skin or functional disease including atopic dermatitis.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1132-1137
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• 2008

Automatic Operation based on ATO (Automatic Train Operation) is necessary for driverless Light Rail Transit business. When this kind of driverless LRT operation plan is made, TPS (Train Performance Simulation) is traditionally simulated at all-out mode and coasting mode based on manual operation. Commercial schedule speed equals to all-out speed minus $9{\sim}15%$ make-up margin. Coasting mode TPS simulation is also run at commercial schedule speed to calculate run time and energy consumption. But TPS based on manual operation should make an improvement on accuracy in case of driverless LRT operation Plan. In this paper, new fast mode TPS simulation using ATO pattern is proposed and show near actual ATO result. The actual ATO pattern can be accurately simulated with the introduction of 4 parameters such as commercial braking rate, jerk, station stop profile and grade converted distance. Normal mode TPS simulation for commercial schedule speed can be designed to have fast mode trip time plus 3 seconds/km margin recommended by korean standard LRT specification.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.28 no.4
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• pp.182-186
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• 2020

As all flight training institutions in Korea were approved by the Ministry of Land, Infrastructure and Transport (MOLIT) as aviation training organizations (ATO), safety management based on the Aviation Safety Management System (SMS) became mandatory. However, even though safety management using SMS has become mandatory, the performance of aviation safety voluntary report, which is the core of the system, remains low compared to other countries. The current address of SMS, a ATO, is like a watermill without water. The present study is to find out why voluntary aviation safety reports, which is equivalent to water from waterwheel, is underperforming and to suggest ways to revitalize it.

• Journal of Navigation and Port Research
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• v.44 no.4
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• pp.347-353
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• 2020

Aids to Navigation (AtoN) contribute to preventing marine accidents and protecting marine environment by providing various information such as location information etc. to ships. Recognizing the importance of the AtoN, a 24 won of the AtoN service fee is charged for ships entering and leaving international trade ports. However, while the 24 won of the AtoN service fee has been maintained since its establishment in 1999, the demand for new roles of the AtoN service for autonomous shipping and smart port operations, etc. has gradually increasing with the change of shipping and port 4.0. Thus the purpose of this study was to estimate the appropriate level of the AtoN service fee in accordance with such changes in the shipping and port industries. To accomplish this, a method of recovering the total cost was introduced to the PROOF (Pyeongtaek Regional Office of Ocean and Fisheries). It is estimated that there are four cases in which estimation of the AtoN service fee is estimated in two cases year by year and conversion year, the AtoNs of PROOF are classified into the all and part of a ship using the trade port. As a result of the estimation, the AtoN service fee of PROOF is estimated at 53.78-71.62 won (as of 2019), and 29.78-47.62 won is higher than the today at 24 won. The results of this study can be used as useful basic data for the operation of budgets and policy management considering the role of the AtoN.

• The Korea Journal of Herbology
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• v.31 no.4
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• pp.79-85
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• 2016

Objectives : The aim of this study is to investigate anti-atopic dermatitis effect using ato-tang.Methods : Ato-tang was external treatment to NC/Nga mice for 4 weeks, where atopic dermatitis was induced by DNCB at 1% and 0.4% for 3 weeks. Atopic dermatitis index score was measured using eye observation and picture evaluation. The histopathological change of dorsal skin was observed by hematoxylin and eosin (H&E) staining. Cytokines including IL-4, IL-5 and IL-13 were measured by Luminex or reverse transcriptase polymerase chain reaction (RT-PCR) analysis and immunoglobulin E (IgE) was measured by ELISA reader.Results : The dorsal skin of Ato-tang group showed decrease in erythema, pruritus, dry skin, edema, excoriation, erosion and lichenification level through naked eye observations. Immunoglobulin cell infiltration and the thickness of epidermis were significantly decreased in the dorsal skin compared to control. Production of Th2 cytokines (IL-4, IL-5, IL-13) and IgE level in serum were all significantly decreased, in comparison with control. In addition, mRNA expression level of Th2 cytokines (IL-4, IL-5, IL-13) in spleen was decreased, in comparison with control.Conclusion : The results indicated that external treatment of ato was improved skin barrier function in the symptoms of atopic dermatitis disease. Also, atopic dermatitis factors where cytokine as well as immunoglobulin E in serum and mRNA expression were decreased, respectively, in comparison with control. Therefore, we suggest that ato could be effectively used as a external therapeutic drug based on atopic dermatitis factors.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.579-587
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• 2008

Promotion of the line no.2 in Seoul Metro was changing from the existing signaling facilities for ATS(Automatic Train Stop) vehicles to the up-to-date signaling facilities for ATO(Automatic Train Operation). But, in consequence of conducting a trial run after being equipped with the ATO signaling facilities, the matter related to mix-operation with the existing ATS signaling facilities appeared. The operation of the existing ATS signaling system in combination with the ATO signaling system has made improper working related to frequency recognition of the ATS On-board Computerized Equipment. This obstructs operation of a working ATS vehicle. That is, as barring operation of an ATS vehicle that should proceed, it may make the proceeding ATS vehicle stop suddenly and after all, it will cause safety concerns. In this paper, we designed a wayside track occupancy detector that previously prevents improper working related to frequency recognition of the ATS On-board Computerized Equipment by gripping classification and working processes of operating trains throughout transmission of local signaling information from the existing facilities, which does not need to change or replace the existing signaling facilities. Furthermore, we described general characteristics of the wayside track occupancy detector and modeled the IFC(InterFace Contrivance) device and the logical circuit recognizing signal information. Then, we made an application program of PLC(programmable Logic Computer) based on the stated model. We, in relation to data transfer method, used the frame in TCP/IP transfer mode as the standard, and we demonstrated that ATO transmission frequency is intercepted.

• Archives of Pharmacal Research
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• v.29 no.6
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• pp.503-507
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• 2006

Flavonoids are known as natural anti-inflammatory agents. In this investigation, an anti-inflammatory potential of new topical preparation (SK Ato $Formula^{\circledR}$) containing flavonoid mixtures from Scutellaria baicalensis Georgi roots and Ginkgo biloba L. leaves with an extract of Gentiana scabra Bunge roots was evaluated in an animal model of chronic skin inflammation. Multiple 12-O-tetradecanoylphorbol-13-acetate treatments for 7 consecutive days on ICR mouse ear provoked a chronic type of skin inflammation: dermal edema, epidermal hyperplasia and infiltration of inflammatory cells. When topically applied in this model, this row formulation $(5-20\;{\mu}L/ear/treatment)$ reduced these responses. Furthermore, it inhibited prostaglandin $E_2$ generation (17.1-33.3%) and suppressed the expression of proinflammatory genes, cyclooxygenase-2 and $interleulin-1{\beta}$ in the skin lesion. Although the potency of inhibition was lower than that of prednisolone, all these results suggest that Ato $Formula^{\circledR}$ may be beneficial for treating chronic skin inflammatory disorders such as atopic dermatitis.

• The Korean Journal of Mycology
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• v.31 no.2
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• pp.103-113
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• 2003

Twenty five isolates of Alternaria were obtained from various solanaceous crops in Korea. For all isolates, morphological characteristics of the conidia were determined and compared with those of representative isolates of A. solani and A. tomatophila. A selection of the isolates and the representative Alternaria isolates were evaluated for Pathogenicity to potato, tomato, egg plant and red pepper. Molecular characteristics of 17 isolates of Alternaria inculding the representative isolates were determined using sequence analysis of IRS rDNA and histone H3 gene, and URP-PCR analysis. Based on morphological characteristics, the isolates from the solanaceous crops were grouped as identical or very similar to either A. tomatophila (ATO), A. solani (ASO), and unidentified Alternaria sp. (ASP). Isolates of ASO were moderately pathogenic to all the solanaceous crops tested, but ATO isolates were highly pathogenic to tomato and the ASP isolate was pathogenic only to potato. Among the molecular markers used in this study, the URP-PCR analysis was found to be appropriate for taxonomic resolution of these species. Based on the conidial morphology, pathogenicity test and molecular characteristics, A. tomatophila (early blight of tomato) could be distinguished from A. solani (early blight of potato), and the Alternaria sp. (ASP) from potato, which was closely related to ASO in conidial morphology, was considered as a new species.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1264-1269
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• 2008

We designed a track circuit of Tag in-tag out type that can be used for light rails and monorails. This method is called RFID-Tag and it literally uses RFID-Tag and replaces a fixed track circuit and implements a moving block. The distance between RFID-Tags is set to the length of a train and thus a train is always in contact with one of the tags. A train runs in RFID-Tag in -RFID-Tag out type at all times and the distance between trains can be precisely controlled through the application of a moving block combined with the basic principle of a fixed block, which enables the continuous speed control and enhances the satisfaction of passengers. When constructing a track circuit using RFID-Tag the Tag in-tag out brings us the cost reduction and is more economical than the existing fixed track circuit in that sense and easy for installation and maintenance. The wireless communication between onboard and wayside makes the continuous control possible and can improve the control capacity of ATP/ATO by the implementation of a moving block on top of a fixed one.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.175-175
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• 2010

Transparent conducting oxide (TCO) films are widely used as transparent conducting thin film material for application in various fields such as solar cells, optoelectronic devices, heat mirrors and gas sensors, etc. Recently the increased utilization of many transparent electrodes has accelerated the development of inexpensive TCO materials. Indium tin oxide (ITO) film is well-known for TCO materials because of its low resistivity, but there is disadvantage that it is too expensive. ZnO film is cheaper than ITO but it shows thermally poor stability. On the contrary, antimony-doped tin oxide films (ATO) are more stable than TCO films such as Al-doped zinc oxide (AZO) and ITO. Moreover, SnO2 film shows the best thermal and chemical stability, low cost and mechanical durability except the poor conductivity. However, annealing is proved to improve the conductivity of ATO film. Therefore, in this work, antimony (6 wt%) doped tin oxide films to improve the conductivity were deposited on 7059 corning glass by RF magnetron sputtering method for the application to transparent electrodes. In general, of all TCO films, glass is the most commonly selected substrate. However, for future development in flexible devices, glass is limited by its intrinsic inflexibility. In this study, we report the growth and properties of antimony doped tin oxide (ATO) films deposited on PES flexible substrate by using RF magnetron sputtering. The optimization process was performed varying the sputtering parameters, such as RF power and working pressure, and parameter effect on the structural, electrical and optical properties of the ATO films were investigated.