• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.916-921
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• 2014

In this paper, an improved small-scaled blade prototype was designed with the flap-driving mechanism classified as an active vibration reduction method, in order to reduce vibratory load in the helicopter. In detail, the previous Active Trailing-Edge Flap based on piezoelectric actuator, called SNUF(Seoul National University Flap), failed to achieve the target value (${\pm}4^{\circ}$) of the flap deflection angle. Therefore, the flap-driving mechanism design was improved, and a new piezoactuator was selected to accomplish the target value of the flap deflection angle in both static and rotating situations.

• Structural Engineering and Mechanics
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• v.33 no.4
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• pp.391-406
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• 2009

Viscoelastic materials store as well as dissipate energy to the thermal domain under deformation. Two efficient modelling techniques reported in literature use coupled (thermo-mechanical) ATF (Augmenting Thermodynamic Fields) displacements and ADF (Anelastic Displacement Fields) displacements, to represent the constitutive relationship in time domain by using certain viscoelastic parameters. Viscoelastic parameters are first extracted from the storage modulus and loss factor normally reported in hand books with the help of Genetic Algorithm and then constitutive relationships are used to obtain the equations of motion of the continuum after discretizing it with finite beam elements. The equations of motion are solved to get the frequency response function and modal damping ratio. The process may be applied to study the dynamic behaviour of composite beams and rotors comprising of several viscoelastic layers. Dynamic behaviour of a composite beam, formed by concentric layers of steel and aluminium is studied as an example.

• Molecules and Cells
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• v.41 no.8
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• pp.705-716
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• 2018

The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. The UPR is characterized by three distinct downstream signaling pathways that promote cell survival or apoptosis depending on the stressor, the intensity and duration of ER stress, and the cell type. Mammalian cells express the UPR transducers IRE1, PERK, and ATF6, which control transcriptional and translational responses to ER stress. Direct links between ER stress and immune responses are also evident, but the mechanisms by which UPR signaling cascades are coordinated with immunity remain unclear. This review discusses recent investigations of the roles of ER stress in immune responses that lead to differentiation, maturation, and cytokine expression in immune cells. Further understanding of how ER stress contributes to the pathogenesis of immune disorders will facilitate the development of novel therapies that target UPR pathways.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.415-418
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• 2006

적응 횡단 필터는 상관 전 처리 기법으로서 실시간 간섭 신호 제거가 가능한 시간 영역 신호처리 기법을 사용한다. 적응 횡단 필터는 협대역 간섭 신호에 좋은 성능을 나타내며, 구현이 용이하고 높은 효율성을 갖는다. 적응 횡단 필터의 구성은 입력 샘플 신호의 지연 탭을 위한 FIR 필터와 전파 간섭 신호의 크기와 주파수를 결정하는 가중치 생성부로 나눌 수 있다. 본 논문에서는 가중치 생성부에 적용 되는 알고리즘 중 상대적으로 연산량이 적은 LMS와 NLMS를 적용한 적응 횡단 필터를 설계하고, GPS 수신기에 적용 하였다. 실제 측정치를 이용한 다양한 실험에 의한 항법 성능 평가를 통하여 NLMS가 LMS보다 좋은 성능을 나타냄을 확인하였다.

• Development and Reproduction
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• v.22 no.1
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• pp.95-104
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• 2018

CREBZF (cAMP-response element binding protein zhangfei) is a member of ATF/CREB family, and which regulates various cellular functions by suppressing major factors with direct interaction. In this study, we have examined the expression of CREBZF on mouse endometrium during uterus estrous cycles and estrogen (E2) treatment. In uterus, CREBZF mRNA expression was higher than other organs and mRNA and protein of CREBZF was increased in proestrus phase and decreased in estrus phase. The expression of CREBZF in 3-weeks old mouse uterus was reduced by E2 injection in endometrium. In addition, the expression of progesterone receptor, a marker of E2 in ovariectomized mice was found to be strongly expressed in stroma, while CREBZF was only expressed in epithelium. Also, we conformed that E2-suppressed CREBZF was restored by co-injection of ICI 182,780, an estrogen receptor antagonist. Overall, these results suggest that CREBZF is regulated by estrogen and involved in ER signaling pathway in mouse uterus.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.11a
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• pp.273-279
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• 2000

Until recently performance requirements for automatic transmission fluids have continued to change to reflect the design changes of automatic transmission. The major purpose for these design changes is to improve the fuel economy and easy driving. To meet recent performance requirements fur automatic transmission the needs for special base oils Bike API Group III and IV base oils become larger. In this paper to evaluate the effects of base oils on performance of automatic transmission fluids formulated with API Group I,II,III and IV and Dexron III and Hereon Type additive package, Brookfield viscosity, oxidation test, SAE No.2 friction test and seal compatibility test were examined. From the test we knew that the use of Croup III and IV base oils in ATF has several benefits in low temperature viscosity, oxidation stability and SAE No.2 friction characteristics.

• Genomics & Informatics
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• v.17 no.1
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• pp.8.1-8.10
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• 2019

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, $NF-{\kappa}B$, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

• Molecules and Cells
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• v.44 no.8
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• pp.569-579
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• 2021

Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced CAP2 expression is mediated through activation of protein kinase C epsilon (PKCε) and the promotor binding of activating transcription factor 2 (ATF2). In addition, we further demonstrated that CAP2 expression promoted epithelial-mesenchymal transition (EMT) through activation of Rac1 and ERK. In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancer cells. Our results shed light on the novel functions of CAP2 in the metastatic process of liver cancer cells.

• ETRI Journal
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• v.44 no.4
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• pp.560-572
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• 2022

H²RDC (heuristic handover based on RCC-DTSK-C), a heuristic algorithm based on a highly interpretable deep Takagi-Sugeno-Kang fuzzy classifier, is proposed for suppressing the mobile heterogeneous networks problem of frequent handover and handover ping-pong in the multibase-station scenario. This classifier uses a stack structure between subsystems to form a deep classifier before generating a base station (BS) priority sequence during the handover process, and adaptive handover hysteresis is calculated. Simulation results show that H²RDC allows user equipment to switch to the best antenna at the optimal time. In high-BS density load and mobility scenarios, the proposed algorithm's handover success rate is similar to those of classic algorithms such as best connection (BC), self tuning handover algorithm (STHA), and heuristic for handover based on AHP-TOPSIS-FUZZY (H²ATF). Moreover, the handover rate is 83% lower under H²RDC than under BC, whereas the handover ping-pong rate is 76% lower.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2000.11a
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• pp.225-228
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• 2000

In this paper, the design for a low noise amplifier with the EM simulation is presented. The ATF36077 pHEMT device is applied to design LNA for U-NII frequency band (5 GHz ～ 6 GHz). The matching networks have been designed by the only open ended stub in order to reduce parasitic effects generated from a via structure. Through EM simulator, the simulation result shows that the linear gain (@5.5 GHz) is over 10 dB, input return loss and output return loss (@ 5.5 GHz) are a below 10 dB respectively, and the 3rd order intercept point is about 17 dBm.