• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3791-3794
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• 2012

CD44v, especially splice variants containing exon v6, has been shown to be related closely to development of different tumors. High levels of CD44v6/v7 have been reported to be associated with invasiveness and metastasis of many malignancies. The objective of this study was to detect expression of CD44v6-containing variants in patients with acute promyelocytic leukemia (APL) and evaluate the potential of CD44v6/v7 for risk stratification. Reverse transcription polymerase chain reaction (RT-PCR) followed by PCR product purification, ligation into T vectors and positive clone sequencing were used to detect CD44 v6-containing variant isoforms in 23 APL patients. Real-time quantitative PCR of the CD44v6/v7 gene was performed in patients with APL and in NB4 cells that were treated with all-trans retinoic acid (ATRA) or arsenic trioxide ($As_2O_3$). Sequencing results identified four isoforms (CD44v6/v7, CD44v6/v8/v10, CD44v6/v8/v9/v10, and CD44v6/v7/v8/v9/v10) in bone marrow mononuclear cells of 23 patients with APL. The level of CD44v6/v7 in high-risk cases was significantly higher than those with low-risk. Higher levels of CD44v6/v7 were found in three patients with central nervous system relapse than in other patients inthe same risk group. Furthermore, in contrast to ATRA, only $As_2O_3$ could significantly down-regulate CD44v6/v7 expression in NB4 cells. Our data suggest that CD44v6/v7 expression may be a prognostic indicator for APL.

• International Journal of Highway Engineering
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• v.5 no.1 s.15
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• pp.11-18
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• 2003

Road roughness, as the key factor influencing not only drivers' ride quality and safety but also pavement deterioration, is one of the most important pavement performance indicator to be evaluated by users' subjective assessment. For this reason, a specific number of the pavement roughness has been adopted to monitor the condition of a road for pavement management systems and to evaluate the quality of newly constructed sections, however, none of the unified methodology was internationally accepted. In Korea highway network, road roughness has been used mainly to evaluate newly placed pavement by using 7.6m CP (California Profile meter) to calculate PrI (Profile Index). But this instrument is manually operated to measure road profiles by traffic closure and their interpretation depends on personal bias. Therefore, problems arisen from the manually operated instrument will be overcome by using the APL (Longitudinal Profile Analyzer) which can be operated in the speed of 80km per hour. A study was conducted to correlate the relation from both concrete and asphalt pavement between IRI (measured by APL) and PrI (measured by 7.6m CP). Test results showed that there was a good correlation between IRI and PrI.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2004.10a
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• pp.243-255
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• 2004

• Korean Management Science Review
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• v.32 no.4
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• pp.81-96
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• 2015

This paper models knowledge diffusion on an inter-organizational network. Based on literatures related to knowledge diffusion, the model considers critical factors that affect diffusion behavior including nodal property, relational property, and environmental property. We examine the relationships among network structure, knowledge search, and diffusion performance. Through a massive simulation runs based on the agent-based model, we find that the average path length of a network decreases a firm's cumulative knowledge stock, whereas the clustering coefficient of a firm has no significant relationship with the firm's knowledge. We also find that there is an interaction effect of network structure and the range of knowledge search on knowledge diffusion. Specifically, in a network of a larger average path length (APL) the marginal effect of search conduct is significantly greater than in that of a smaller APL.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4301-4305
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• 2014

Tanshinone IIA is a pharmacologically active ingredient extracted from Danshen, a Chinese traditional medicine. Its molecular mechanisms are still unclear. The present study utilized computational approaches to uncover the potential targets of this compound. In this research, PharmMapper server was used as the inverse docking tool andnd the results were verified by Autodock vina in PyRx 0.8, and by DRAR-CPI, a server for drug repositioning via the chemical-protein interactome. Results showed that the retinoic acid receptor alpha ($RAR{\alpha}$), a target protein in acute promyelocytic leukemia (APL), was in the top rank, with a pharmacophore model matching well the molecular features of Tanshinone IIA. Moreover, molecular docking and drug repurposing results showed that the complex was also matched in terms of structure and chemical-protein interactions. These results indicated that $RAR{\alpha}$ may be a potential target of Tanshinone IIA for APL. The study can provide useful information for further biological and biochemical research on natural compounds.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1483-1486
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• 2006

We describe the contrast enhancement of images using an APL(Average Picture Level) in an AC-PDP. A CEC(Contrast Enhancement Curve) determined by the APL was applied to enhance the contrast of images depending on the dominant gray levels. The most effective advantage of the proposed method is that it is easier to adjust the dynamic ranges to be enhanced with good quality and implement in a hardware system. The simulation result shows that the proposed method enhanced the contrast of given images significantly and kept the original brightness except the specific area of them compared to the HE(Histogram Equalization).

• The Journal of the Acoustical Society of Korea
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• v.25 no.2E
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• pp.60-68
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• 2006

High-frequency bistatic scattering measurements from a corrugated surface were made in an acoustic water tank. First the azimuthal scattering pattern was measured from an artificially corrugated surface which has varying impedance. The corrugated surface was installed both transverse to the direction of incident wave and longitudinal to the direction of incident wave. The angle between the corrugated surface and the direction of the incident wave was about $45^{\circ}$. Second, the scattering strengths were measured from the flat sediment and the corrugated sediment. A critical angle of about $37^{\circ}$ was calculated in the acoustic water tank. The measurements were made at three fixed grazing angles: $33^{\circ}$ (lower than critical angle), $37^{\circ}$ (critical angle), and $41^{\circ}$ (higher than critical angle). The scattering angle and the grazing angle are equal in each measurement. Frequencies were from 50 kHz to 100 kHz with an increment of 1 kHz. The corrugated sediment was made transverse to the direction of the incident wave. The first measurement indicates that the scattering patterns depend on the relations between the corrugated surface and the direction of the incident wave. In the second measurement, the data measured from the flat sediment were compared to the APL-UW model and to the NRL model. The NRL model's output shows more favorable comparisons than the APL-UW model. In case of the corrugated sediment, the model and the measured data are different because the models used an isotropic wave spectrum of sediment roughness in the scattering calculations. The isotropic wave spectrum consists of $w_2$ and ${\gamma}_2$. These constants derived from sediment names or bulk size. The model which used the constants didn't consider the effect of a corrugated surface. In order to consider a corrugated surface, the constants were varied in the APL-UW model.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7893-7895
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• 2015

Background: Acute promyelocytic leukemia (APL) is a distinctive clinical, biological and molecular subtype of acute myeloid leukemia. However, data from Pakistan are scarce. Therefore we reviewed the demographic and clinical profile along with risk stratification of APL patients at our center. Materials and Methods: In this descriptive cross sectional study, 26 patients with acute promyelocytic leukemia were enrolled from January 2011 to June 2015. Data were analyzed with SPSS version 22. Results: The mean age was $31.8{\pm}1.68years$ with a median of 32 years. The female to male ratio was 2:1.2. The majority of our patients had hypergranular variant (65.4%) rather than the microgranular type. The major complaints were bleeding (80.7%), fever (76.9%), generalized weakness (30.7%) and dyspnea (15.38%). Physical examination revealed petechial rashes as a predominant finding detected in 61.5% followed by pallor in 30.8%. The mean hemoglobin was $8.04{\pm}2.29g/dl$ with the mean MCV of $84.7{\pm}7.72fl$. The mean total leukocyte count of $5.44{\pm}7.62{\times}10^9/l$; ANC of $1.08{\pm}2.98{\times}10^9/l$ and mean platelets count were $38.84{\pm}5.38{\times}10^9/l$. According to risk stratification, 15.3% were in high, 65.4% in intermediate and 19.2% in low risk groups. Conclusions: Clinico-epidemiological features of APL in Pakistani patients appear comparable to published data. Haemorrhagic diathesis is the commonest presentation. Risk stratification revealed predominance of intermediate risk disease.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.71-81
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• 2007

Objective : In this study, herbal medicine(GJE, Gardenia jasminoides Ellis; HCT, Houttuynia cordata Thunb.; CIL, Chrysanthemum indicum Linne; PMS,Paeonia moutan Sims, P. subfruticosa Makino; APL, Agrimonia pilosa Ledebour) were screened for their inhibitory activities against Tyrosinase and PMA plus A23187-induced $TNF-{\alpha}$, IL-6, IL-8 productions in HMC-1 cells to reveal their skin -whitening and anti-allergic effect. Method : To investigate Tyrosinase inhibition we treated Mushroom Tyrosinase(Fluka, 93898) $10{\mu}{\ell}$ and 7.5mM Tyrosine (Sigma, T3754) $20{\mu}{\ell}$ with 80% ethanol medicine extracts. Then we observed 96well micro plate extinction at 490nm. In the next experiment, to investigate Anti-allergic effect we blended cultured Human Mast Cells(HMC-1) with medicine extracts. We treated the blended solution with Phorbol 12-myristate 13-acetate(PMA) and A23187, then observed $TNF-{\alpha}$, IL-6, IL-8 by ELISA (enzyme-linked immunosorbent assay) at 450nm. Results : In inhibiting Tyrosinase the results are as follows. 1. We observed 22% inhibition of Mushroom Tyrosinase at $500{\mu}g/m{\ell}$ concentration of GJE extracts. 2. We also could observe that the decreased Mushroom Tyrosinase activities in HCT, CIL extracts. In inhibiing $TNF-{\alpha}$, IL-6, IL-8 productions in HMC-1 cells the results are as follows. 1. Of the extracts examined, HCT, PMS, APL extracts showed over 50% inhibitions of Cytokines at $200{\mu}g/m{\ell}$ concentration. 2. In particular, APL extracts showed the best inhibitory effect on Cytokine productions in a dose-dependent manner. Conclusion : These results suggest that GJE extracts contributes to the anti melanin activities and represent a potential source of whitening agent. Thus these herbal medicines suggest novel drugs on anti-allergic effects.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.4
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• pp.760-763
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• 2001

Five commercial salt-fermented shrimps contained 29.8~48.3% of salt 3.5%~7.3% of total nitrogen and 0.3~0.7g/100g of amino-nitrogen respectively. The average peptide length(APL) of five commercial salt-fermented shrimps ranged from 10.1 to 15.0. Sample B and E showed longer APL than the others with the values of 15.0 and 14.4 respectively. Protease activity showed the large differences in five samples from 17 unit to 232 unit ; sample C showed the highest protease activity with 232 unit while sample D and E were relatively lower with 17 unit and 18 unit respectively. The chitinase activities which can hydrolyze chitin the one of components on outer layer of shrimp ranged from 14.4 unit to 171 unit. Sample E had the highest chitinase activity as 171 unit but sample B showed the lowest activity with 14.4 unit. Chitooligosaccharides of five commercial salted-fermented shrimps were consisted of monoglucosamine diglucosamine and triglucosamine.