• Proceedings of the Optical Society of Korea Conference
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• 2008.07a
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• pp.151-152
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• 2008

• Clinical and Experimental Pediatrics
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• v.56 no.1
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• pp.19-25
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• 2013

Purpose: Childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), and it has become one of the most common causes of childhood chronic liver diseases which significant as a cause of liver related mortality and morbidity in children in the United States. The development of simpler and easier clinical indices for medical practice is needed to identify advanced hepatic fibrosis in childhood NAFLD instead of invasive method like liver biopsy. FibroScan and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) have been proposed as a simple and noninvasive predictor to evaluate hepatic fibrosis in several liver diseases. APRI could be a good alternative to detect pathologic change in childhood NAFLD. The purpose of this study is to validate the efficacy of APRI for assessing hepatic fibrosis in childhood NAFLD based on FibroScan. Methods: This study included 23 children with NAFLD who underwent FibroScan. Clinical, laboratory and radiological evaluation including APRI was performed. To confirm the result of this study, 6 patients received liver biopsy. Results: Factors associated with hepatic fibrosis (stiffness measurement >5.9 kPa Fibroscan) were triglyceride, AST, alanine aminotransferase, platelet count, APRI and collagen IV. In multivariate analysis, APRI were correlated with hepatic fibrosis (>5.9 kPa). In receiver operating characteristics curve, APRI of meaningful fibrosis (cutoff value, 0.4669; area under the receiver operating characteristics, 0.875) presented sensitivity of 94%, specificity of 66%, positive predictive value of 94%, and negative predictive value of 64%. Conclusion: APRI might be a noninvasive, simple, and readily available method for medical practice to predict hepatic fibrosis of childhood NAFLD.

• Laser Solutions
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• v.11 no.1
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• pp.25-31
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• 2008

The characteristics of femtosecond laser ablation of $Al_2O_3$ for prescision microfabrication are studied experimentally. Specifically, the process time during femtosecond laser drilling of microholes with $sub-100{\mu}m$ diameter are investigated for varying laser fluence, scan speed and beam path designs like trepanning with continuously changed start points. The accumulation of sub-micrometer size particles within the hole and the deterioration of edge clarity and roundness for decreasing hole diameter are examined and through process optimization the microdrilling with good hole quality is achieved using a femtosecond laser system (repetitionrate 1 kHz, wavelength 785 nm, pulse duration 185 fs)

• Journal of the Optical Society of Korea
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• v.19 no.4
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• pp.327-333
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• 2015

This paper reports the fabrication of various micro-lensed single-mode optical fibers through the use of an enhanced peak power $CO_2$ laser beam. The end faces of the optical fibers are exposed to the $CO_2$ laser beam to form convex, concave, and conical shape optical fiber tips. Peak power of the $CO_2$ laser beam was varied from 0.8 W to 1.5 W depending on the shape of the optical fiber tip. We also discover the dependence of the angle of the optical fiber tip on the rotation angle and the number of $CO_2$ laser irradiations. The angle shows an increasing trend with both these parameters. We achieve a wide range of lenticular fibers with end face angle varying from $4.47^{\circ}$ to $8.13^{\circ}$. Furthermore, we investigate the emission pattern of light from the developed micro-lensed fibers. The proposed $CO_2$ laser based optical fiber reshaping technique shows great consistency, and thus is suitable for commercial applications.

• Journal of the Optical Society of Korea
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• v.13 no.1
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• pp.53-59
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• 2009

A chirped-pulse amplification Ti:sapphire laser system has been designed using a 10-Hz 100-TW Ti:sapphire laser to generate 0.1-Hz 0.5-PW laser pulses and optimize their temporal qualities such as temporal contrast and pulse duration. A high-energy booster amplifier to be added is expected to produce an energy above 30 J through the parasitic lasing suppression and the efficient amplification. To improve the temporal contrast of the laser pulses, a high-contrast 1-kHz amplifier system is used as a front-end. A grating stretcher which makes the laser pulse have 1-ns duration is used to prevent optical damages due to high pulse energy during amplification. A grating compressor has been designed with group delay analysis to obtain the recompressed pulse duration close to the transform-limited pulse duration. The final laser pulses are expected to have energy above 20 J and duration below 40 fs.

• Journal of the Korean Society of Radiology
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• v.13 no.4
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• pp.539-546
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• 2019

Liver biopsy is invasive and it is a risk of complications. Nevertheless, liver biopsy is gold standard for predicting liver fibrosis. To compensate for these shortcomings, in this study, the liver fibrosis stage was divided using Fibroscan(R) in 200 chronic hepatitis C patients. And, the usefulness and cut-off values of fibrosis index based on four factors(FIB-4), AST to platelet ratio index(APRI) and AST/ALT ratio(AAR) calculated as serum tests were investigated by analyzing ROC curve. As a result, using FIB-4 and APRI rather than AAR is appropriate for evaluation of liver fibrosis. And using APRI to predict significant Fibrosis(F2) and FIB-4 is considered useful for predicting cirrhosis(F4). By applying the advantages of the serum based liver fibrosis marker, which are convenient and repeatable, liver fibrosis follow-up term can be reduced, and furthermore, the prevalence of liver cirrhosis and hepatocellular carcinoma(HCC) can be reduced.

• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.115-122
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• 2008

Purpose : To evaluate the correlation between the radiological non-invasive hepatic fibrosis index (RNHFI), as determined by SPIO-enhanced MRI, and the laboratory non-invasive hepatic fibrosis index. Materials and Methods : Patients (99 total: 61 men and 38 women; mean age: 58 years) who underwent SPIO-enhanced MRI (1.5T) during 5 years included. These patients were subdivided into a liver cirrhosis group (LCG) and a non-liver cirrhosis group (non-LCG). Using PACS view, we measured the RNHFI (mean standard deviation of hepatic signal intensity (SD), noise-corrected coefficient of variation (CV)) of three ROIs in the liver parenchyma by SPIO-enhanced MRI. The laboratory non-invasive hepatic fibrosis index (AST-platelet ratio index (APRI)) of all patients was calculated from the laboratory data. We compared the RNHFI and APRI of LCG with those of non-LC group using Student's t-test. A bivariate correlation was performed to investigate the relationship between the RNHFI and APRI in the LCG. Results : For the LCG, mean values of SD and CV by SPIO-enhanced MRI were $10.3{\pm}3.7$ and $0.19{\pm}0.08$, respectively. For the non-LCG, mean values of SD and CV were $6.5{\pm}1.6$ and $0.08{\pm}0.05$, respectively. The mean APRI of the LCG and the non- LCG were $2.04{\pm}1.7$ and $0.32{\pm}0.32$, respectively. The RNHFI and APRI were significantly different between both groups (p<0.05). For the LCG, the bivariate correlation between SD and APRI revealed a statistically significant positive correlation (r=0.5, p<0.001). In both groups, there was no statistically significant correlation between CV and APRI. Conclusion: A measurement of SD can be a simple and useful method for the evaluation of hepatic fibrosis.

• Proceedings of the Optical Society of Korea Conference
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• 2009.02a
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• pp.441-442
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• 2009

• Proceedings of the Optical Society of Korea Conference
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• 2009.10a
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• pp.227-228
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• 2009

• Korean Journal of Veterinary Research
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• v.11 no.2
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• pp.157-161
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• 1971

This experiment was undertaken in order to investigate whether chicken can serve as a carrier for swine lungworm, Metastrongylus apri. The results abtained are summerized as follows: All chickens which were fed the infective larvae of M. apri, in the form of infected earthworm (Eisenia foctida) excreted appreximately 4.4 to 5.4 percent of the infective larvae in their feces between 2 to 10 hours after dosing. The larval excretion was marked especially during the first 2 hours. A few (0.10~0.12%) larvae were detected from the intestinal wall of chickens by pepsin-digestion method on a day after dosing, but no further migration or development of the larvae was observed. The larvae which had passed through the digestive tract of chickens retained their viability and produced characteristic lungworm disease when inoculated to guineapigs. From these results, it may he concluded that the chicken can serve as a carrier for the infective larvae of M. apri.