• 한국광학회:학술대회논문집
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• 한국광학회 2008년도 하계학술발표회 논문집
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• pp.151-152
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• 2008

• Clinical and Experimental Pediatrics
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• 제56권1호
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• pp.19-25
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• 2013

Purpose: Childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), and it has become one of the most common causes of childhood chronic liver diseases which significant as a cause of liver related mortality and morbidity in children in the United States. The development of simpler and easier clinical indices for medical practice is needed to identify advanced hepatic fibrosis in childhood NAFLD instead of invasive method like liver biopsy. FibroScan and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) have been proposed as a simple and noninvasive predictor to evaluate hepatic fibrosis in several liver diseases. APRI could be a good alternative to detect pathologic change in childhood NAFLD. The purpose of this study is to validate the efficacy of APRI for assessing hepatic fibrosis in childhood NAFLD based on FibroScan. Methods: This study included 23 children with NAFLD who underwent FibroScan. Clinical, laboratory and radiological evaluation including APRI was performed. To confirm the result of this study, 6 patients received liver biopsy. Results: Factors associated with hepatic fibrosis (stiffness measurement >5.9 kPa Fibroscan) were triglyceride, AST, alanine aminotransferase, platelet count, APRI and collagen IV. In multivariate analysis, APRI were correlated with hepatic fibrosis (>5.9 kPa). In receiver operating characteristics curve, APRI of meaningful fibrosis (cutoff value, 0.4669; area under the receiver operating characteristics, 0.875) presented sensitivity of 94%, specificity of 66%, positive predictive value of 94%, and negative predictive value of 64%. Conclusion: APRI might be a noninvasive, simple, and readily available method for medical practice to predict hepatic fibrosis of childhood NAFLD.

• 한국레이저가공학회지
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• 제11권1호
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• pp.25-31
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• 2008

The characteristics of femtosecond laser ablation of $Al_2O_3$ for prescision microfabrication are studied experimentally. Specifically, the process time during femtosecond laser drilling of microholes with $sub-100{\mu}m$ diameter are investigated for varying laser fluence, scan speed and beam path designs like trepanning with continuously changed start points. The accumulation of sub-micrometer size particles within the hole and the deterioration of edge clarity and roundness for decreasing hole diameter are examined and through process optimization the microdrilling with good hole quality is achieved using a femtosecond laser system (repetitionrate 1 kHz, wavelength 785 nm, pulse duration 185 fs)

• Journal of the Optical Society of Korea
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• 제19권4호
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• pp.327-333
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• 2015

This paper reports the fabrication of various micro-lensed single-mode optical fibers through the use of an enhanced peak power $CO_2$ laser beam. The end faces of the optical fibers are exposed to the $CO_2$ laser beam to form convex, concave, and conical shape optical fiber tips. Peak power of the $CO_2$ laser beam was varied from 0.8 W to 1.5 W depending on the shape of the optical fiber tip. We also discover the dependence of the angle of the optical fiber tip on the rotation angle and the number of $CO_2$ laser irradiations. The angle shows an increasing trend with both these parameters. We achieve a wide range of lenticular fibers with end face angle varying from $4.47^{\circ}$ to $8.13^{\circ}$. Furthermore, we investigate the emission pattern of light from the developed micro-lensed fibers. The proposed $CO_2$ laser based optical fiber reshaping technique shows great consistency, and thus is suitable for commercial applications.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.53-59
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• 2009

A chirped-pulse amplification Ti:sapphire laser system has been designed using a 10-Hz 100-TW Ti:sapphire laser to generate 0.1-Hz 0.5-PW laser pulses and optimize their temporal qualities such as temporal contrast and pulse duration. A high-energy booster amplifier to be added is expected to produce an energy above 30 J through the parasitic lasing suppression and the efficient amplification. To improve the temporal contrast of the laser pulses, a high-contrast 1-kHz amplifier system is used as a front-end. A grating stretcher which makes the laser pulse have 1-ns duration is used to prevent optical damages due to high pulse energy during amplification. A grating compressor has been designed with group delay analysis to obtain the recompressed pulse duration close to the transform-limited pulse duration. The final laser pulses are expected to have energy above 20 J and duration below 40 fs.

• 한국방사선학회논문지
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• 제13권4호
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• pp.539-546
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• 2019

간조직 생검은 침습적이며, 합병증의 위험을 동반함에도 불구하고 간섬유화의 정도를 예측하는 표준 진단법으로 적용된다. 이러한 단점을 보완하기 위해 본 연구에서는 만성 C형간염 환자 200명을 대상으로 Fibroscan(R)을 이용하여 간섬유화 등급을 나누고, ROC 곡선을 측정하여 혈청학적검사로 계산되는 FIB-4, APRI, AAR의 유용성과 실질적인 Cut-off value를 알아보고자 하였다. 그 결과 간섬유화 평가를 위해 AAR을 적용하는 것보다는 APRI, FIB-4를 이용하는 것이 적절할 것으로 생각되며, 경한 섬유화 등급을 예측하기 위해서는 APRI, 간경변군인 F4등급에는 FIB-4를 사용하는 것이 유용하다고 판단된다. 혈청학적 간섬유화 표지자의 간편하고 반복 측정이 가능하다는 장점을 이용해 간 섬유화의 경과 관찰 기간을 줄일 수 있으므로 나아가 간경변과 간암의 유병률을 감소시킬 수 있을 것으로 사료된다.

• Investigative Magnetic Resonance Imaging
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• 제12권2호
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• pp.115-122
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• 2008

목적: SPIO-enhanced MRI상에서 얻은 radiological non-invasive hepatic fibrosis index (RNHFI)와 AST/혈소판 비(AST to platelet ratio index, APRI)간의 상관관계를 알아보고자 하였다. 대상 및 방법: 5년동안 SPIO-enhanced MRI를 시행받은 환자들을 대상으로 하였다. 환자들을 간경변 집단과 비(非)간경변 집단으로 분류했다. PACS를 이용, 각 환자의 SPIO-enhanced MRI에서 RNHFI (간실질 신호강도 표준편차의 평균(SD), 잡음교정 변이계수(CV))를 산출했고, 각 환자의 실험실 검사 결과를 이용, APRI를 산출했다. Student's t-test를 이용하여 두 집단간의 RNHFI와 APRI의 차이를 비교했다. 각 집단에서, RNHFI와 APRI간의 이변량 상관분석을 시행했다. 결과: 간경변 집단에서, SD, CV의 평균은 각각 $10.3{\pm}3.7$, $0.19{\pm}0.08$였다. 비간경변 집단에서, SD, CV의 평균은 각각 $6.5{\pm}1.6$, $0.08{\pm}0.05$였다. 두 집단의 평균 APRI는 각각 $2.04{\pm}1.7$, $0.32{\pm}0.32$였다. RNHFI와 APRI는 두 집단 사이에서 의미 있는 차이를 보였다 (p<0.05). 간경변 집단에서, SD와 APRI는 양의 상관관계를 보였다 (r=0.5, p<0.001). 결론: SD값이 간섬유화의 간단하고 유용한 예측 인자가 될 수 있을 것으로 기대된다.

• 한국광학회:학술대회논문집
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• 한국광학회 2009년도 동계학술발표회 논문집
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• pp.441-442
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• 2009

• 한국광학회:학술대회논문집
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• 한국광학회 2009년도 창립 20주년기념 특별학술발표회
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• pp.227-228
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• 2009

• 대한수의학회지
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• 제11권2호
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• pp.157-161
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• 1971

This experiment was undertaken in order to investigate whether chicken can serve as a carrier for swine lungworm, Metastrongylus apri. The results abtained are summerized as follows: All chickens which were fed the infective larvae of M. apri, in the form of infected earthworm (Eisenia foctida) excreted appreximately 4.4 to 5.4 percent of the infective larvae in their feces between 2 to 10 hours after dosing. The larval excretion was marked especially during the first 2 hours. A few (0.10~0.12%) larvae were detected from the intestinal wall of chickens by pepsin-digestion method on a day after dosing, but no further migration or development of the larvae was observed. The larvae which had passed through the digestive tract of chickens retained their viability and produced characteristic lungworm disease when inoculated to guineapigs. From these results, it may he concluded that the chicken can serve as a carrier for the infective larvae of M. apri.