• 대한후두음성언어의학회지
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• 제10권2호
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• pp.124-129
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• 1999

1) 음성 장애를 호소하지 않는 성악인 50명중 여자는 59% 남자는 50%에서 후두스트로보스코피상 성대 병변이 발견되었다. 2) 성종별로는 소프라노에서 가장 성대 병변의 발생률이 높았다(66.7 %). 3) 최장발성 지속시간은 성악인의 경우 성대 병변에 관계없이 일반 정상인에 비해서 증가되어 있었으며 특히 정상 성대를 가진 여자 성악인에서는 일반인에 비해 통계적으로 의의 있게 증가되어 있었다. 4) 기본진동수, 기본진동수 표준편차, 기본진동수변 이들은 성악인이 일반인에 비해 안정되어 있었고, jitter. PPQ는 성악인이 성대 병변이 있더라도 일반인에 비해 감소되어 있었으며, 특히 남자 성악인에서는 통계적으로 유의하게 감소되어 있었고, Shimmer. APQ 역시 성악인이 성대 병변이 있더라도 일반인에 비해 통계적으로 의의 있게 감소되어 있었다.

• 한국정보통신학회논문지
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• 제6권1호
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• pp.76-82
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• 2002

본 연구에서는 계층적 신경회로망을 사용하여 정상, 후두질환(polyp, nodule, palsy 등), 후두질환 중 성문암 시기별 감별진단이 가능한 후두질환 감별진단 분류기를 구현하였다. 후두질환을 가진 환자군과 정상군, 그리고 성문암의 각 시기별에 해당되는 환자군으로부터 /a/, /e/, /i/, /o/, /u/ 모음에 따른 분류작업을 수행하였다. 각 모음별 분류 실험을 수행한 결과 모든 입력 파라미터에 대해서 /a/모음이 다른 모음에 비해 우수한 분류율을 나타내므로, /a/모음만을 사용하여 후두질환을 감별진단하기 위한 계층적 신경회로망을 구현하였다. 구현된 계층적 신경회로망은 각 계층별로 서로 다른 파라미터들을 적용하여 여러 후두질환을 감별진단하도록 구성되었다.

• 대한후두음성언어의학회지
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• 제24권1호
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• pp.33-40
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• 2013

Background and Objectives:This study is to objectively compare and analyze the acoustic changes in the patients with total thyroidectomy before and after RI therapy. Subjects and Methods:For this study, a total of 50 patients with total thyroidectomy were participated as subjects. Voice samples were obtained at the time of post-operation (Post-OP), before high-dose radioactive iodine therapy (Pre-RIT), and after high-dose radioactive iodine therapy (Post-RIT). Acoustic analysis, the maximum phonation time and K-VHI (Korea-Voice handicap index) were used for subjective evaluation. Results:According to the comparison analysis of the three periods, mFo (Hz) was significantly reduced in all of the vowels /a/ and /i/ as the hormone was discontinued. This can be related to the reduction in vocal range. As thyroid hormone was discontinued, Shim (%) and APQ (%) values, which are the parameters related to the degree of aggressiveness, showed a significant increase in the middle vowel /a/. As thyroid hormone was discontinued, emotional index was significantly decreased in VHI (voice handicap index). Conclusion:These results can be assumed that thyroid hormone suspension is related to the increased changes in the vocal intensity, the increase in noise and the reduction in vocal range. Emotionally, these data can be assumed that the responsive factors of one's own voice disorders were significantly decreased in the patients with vocal handicap.

• 사상체질의학회지
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• 제18권2호
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• pp.55-67
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• 2006

1. Objective & Method The purpose of this study was to objectify the diagnosis of Sasang constitution. 163 children's voices were analyzed with 74 factors using PSSC-2004. 2. Results (1) In male children group, Taeumin's APQ4 was significantly low compared with the others. (2) In male children group, Taeumin's octave 5 & octave 6 were significantly low compared with the others. It was significant distinction between Taeumin and Soeumin at the result of post hoc. (3) In male children group, Taeumin's Time Domain Total Sum / Time Domain Count & Frequency Domain Total Sum / count(0) were significantly low compared with the others. It was significant distinction between Taeumin and Soeumin at the result of post hoc. (4) In male children group, Taeumin's 0k-2k total sum & 2k-4k total sum were significantly low compared with the others. It was significant for distinction between Taeumin and Soeumin at the result of post hoc. (5) In male children group, Taeumin's 2k-4k deviation was significantly low compared with the others. It was significant distinction between Taeumin and Soeumin at the result of post hoc. (6) In male children group, Taeumin's D# Total Energy & F# Total Energy were significantly low compared with the others. It was significant distinction between Taeumin and Soeumin at the result of post hoc. (7) In male children group, Taeumin's D# deviation & F# deviation were significantly low compared with the others. It was significant distinction between Taeumin and Soeumin at the result of post hoc. (8) In female children group, Soyangin's center frequency (7) was significantly high compared with the others. It was significant distinction between Taeumin and Soyangin at the result of post hoc. 3. Coclusion With these results, we got some information for standardization of the clinical diagnosis guideline of Sasang constitutional type classification using PSSC-2004 in the Korean children

• IMMUNE NETWORK
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• 제21권5호
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• pp.34.1-34.16
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• 2021

Sjögren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and eyes. The glandular dysfunction in SS involves not only T cell-mediated destruction of the glands but also autoantibodies against the type 3 muscarinic acetylcholine receptor or aquaporin 5 (AQP5) that interfere with the secretion process. Studies on the breakage of tolerance and induction of autoantibodies to these autoantigens could benefit SS patients. To break tolerance, we utilized a PmE-L peptide derived from the AQP5-homologous aquaporin of Prevotella melaninogenica (PmAqp) that contained both a B cell "E" epitope and a T cell epitope. Repeated subcutaneous immunization of C57BL/6 mice with the PmE-L peptide efficiently induced the production of Abs against the "E" epitope of mouse/human AQP5 (AQP5E), and we aimed to characterize the antigen specificity, the sequences of AQP5E-specific B cell receptors, and salivary gland phenotypes of these mice. Sera containing anti-AQP5E IgG not only stained mouse Aqp5 expressed in the submandibular glands but also detected PmApq and PmE-L by immunoblotting, suggesting molecular mimicry. Characterization of the AQP5E-specific autoantibodies selected from the screening of phage display Ab libraries and mapping of the B cell receptor repertoires revealed that the AQP5E-specific B cells acquired the ability to bind to the Ag through cumulative somatic hypermutation. Importantly, animals with anti-AQP5E Abs had decreased salivary flow rates without immune cell infiltration into the salivary glands. This model will be useful for investigating the role of anti-AQP5 autoantibodies in glandular dysfunction in SS and testing new therapeutics targeting autoantibody production.