• Korean Chemical Engineering Research
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• v.47 no.4
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• pp.501-505
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• 2009

In this study, we evaluated the effect of soluble EPCR(Soluble Endothelial Protein C Receptor, sEPCR) on the anti-inflammatory activities by activated protein C(APC) in endothelium. We demonstrated that sEPCR inhibited the barrier protective activity, the inhibition of neutrophils adhesion toward endothelial cells and the inhibition of transendothelial migration by APC in endothelial cells. Interestingly, sEPCR also blocked the mechanism by which APC inhibited the expression of cell adhesion molecules(CAM) by TNF-alpha in endothelial cells. These results suggested that the anti-inflammatory activities of APC was inhibited by sEPCR which blocked the binding motifs of Gla domain of APC to membrane bound EPCR. This finding will provide the important evidence in the development of new medicine for the treatment of severe sepsis and inflammatory diseases and good clue for understanding unknown mechanisms by which APC showed the anti-inflammatory activities in endothelium.

• Journal of Life Science
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• v.22 no.5
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• pp.697-701
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• 2012

Activated protein C (APC) has an anticoagulant effect and a non-hemostatic effect such as regulation of cell metastasis and modulation of inflammation. In this study, we investigated whether APC could modulate apoptosis in cancer cells. Tumor necrosis factor (TNF)-${\alpha}$, cyclohexamide, and FAS markedly induced apoptosis in human renal carcinoma Caki cells. When Caki cells were pretreated with APC, the percentage of death receptor-induced apoptosis did not change. Furthermore, we checked the effect of APC on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human glioma T98G and human breast carcinoma MDA231 cells. APC also had no effect on TRAIL-induced apoptosis in both cell lines. However, pretreatment with APC inhibited combination treatment (kahweol plus TRAIL and kahweol plus melatonin)-induced apoptosis and PARP cleavage in Caki cells. Taken together, our results suggest that APC can modulate anti-cancer therapeutic efficiency.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.177-182
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• 2015

In a MPC(Multi-Pulse Coding) using excitation source of voiced and unvoiced, it would be a distortion of voice waveform. This is caused by normalization of synthesis speech waveform of voiced in the process of restoration. To solve this problem, this paper present APC-MPC of amplitude-position compensation in a multi-pulses each pitch interval in order to reduce distortion of synthesis waveform. Also, I was implemented that the APC-MPC in coding system. And I evaluate the SNRseg of APC-MPC in 8kbps coding condition of convergence system. As a result, SNRseg of APC-MPC was 13.9dB for female voice and 14.3dB for male voice respectively. And so, I expect to be able to this method for cellular phone and smart phone using excitation source of low bit rate.

• Korean Chemical Engineering Research
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• v.44 no.5
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• pp.425-434
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• 2006

The operability and productivity of continuous processes, especially in petrochemical industries have made remarkable improvement during the past twenty years through advanced process control (APC) typified by model-based predictive control. On the other hand, APC have not been actively practiced in industrial batch processes typified by batch polymerization reactors. Perhaps the main cause for this has been the lack of reliable batch process APC techniques that can overcome the unique problems in industrial batch processes. Recently, some noteworthy progress is being made in this area. New high-performance batch process control techniques that can accommodate and also overcome the unique problems of industrial batch processes have been proposed on the basis of iterative learning control (ILC). In this review paper, recent advancement in the batch process APC techniques are presented, with a particular focus on the variations of the so called Q-ILC method, with the hope that they are widely practiced in different industrial batch processes and enhance their operations.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.257.1-257.1
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• 2014

We investigated characteristics of ITO/Ag-Pd-Cu (APC)/ITO multilayer electrodes prepared by direct current magnetron sputtering for use as an anode in organic solar cells (OSCs). To optimize electrical properties of ITO/APC/ITO multilayer, we fabricated the ITO/APC/ITO multilayer at a fixed ITO thickness of 30 nm as a function of APC thickness. Compare to the surface of Ag layer on ITO, the APC had a smooth surface morphology. At optimized APC thickness of 12 nm, the ITO/APC/ITO multilayer exhibited a sheet resistance of $6{\Omega}/square$ and optical transmittance of 84.15% at a wavelength of 550 nm which is comparable to conventional ITO/Ag/ITO multilayer. However, the APC-based ITO multilayer showed a higher average transmittance in a visible region than the Ag-based ITO multilayer. The higher average transmittance of ITO/APC/ITO multilayer indicated the multilayer is suitable anode for organic solar cells with P3HT:PCBM active layer. OSCs fabricated on the optimized ITO/ACP/ITO multilayer exhibited a better performance with a fill factor of 64.815%, a short circuit current of $8.107mA/cm^2$, an open circuit voltage of 0.59 V, and power conversion efficiency (3.101%) than OSC with ITO/Ag/ITO multilayer (2.8%).

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.12
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• pp.25-30
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• 2007

In this paper, we proposed a new burst-mode optical transmitter structure which is suitable for high data rate operation such as Gb/s operation. With this structure we made a 1.25Gb/s burst-mode optical transmitter including a digitally controlled APC circuit for EPON systems using commercial 0.8m BiCMOS technology. It well functioned at 1.25Gb/s and showed good eye patterns with 53.3ps jitter, 191ps rise time and 258ps fall time. To characterize the APC function we measured optical output power as increasing external voltage VREF. The optical power is linearlyproportional to VREF at the rate of 0.293mW/V.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.5
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• pp.427-436
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• 2023

Mitotic arrest deficient 2 like 2 (Mad2L2, also known as Mad2B), the human homologue of the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares high sequence homology with Mad2, the mitotic checkpoint protein. Previously, we demonstrated the involvement of Mad2B in the cisplatin-induced DNA damage response. In this study, we extend our findings to show that Mad2B is recruited to sites of DNA damage in human cancer cells in response to cisplatin treatment. We found that in undamaged cells, Mad2B exists in a complex with Polζ-Rev1 and the APC/C subunit Cdc27. Following cisplatin-induced DNA damage, we observed an increase in the recruitment of Mad2B and Cdc20 (the activators of the APC/C), to the complex. The involvement of Mad2B-Cdc20-APC/C during DNA damage has not been reported before and suggests that the APC/C is activated following cisplatin-induced DNA damage. Using an in vitro ubiquitination assay, our data confirmed Mad2B-dependent activation of APC/C in cisplatin-treated cells. Mad2B may act as an accelerator for APC/C activation during DNA damage response. Our data strongly suggest a role for Mad2B-APC/C-Cdc20 in the ubiquitination of proteins involved in the DNA damage response.

• Journal of the Korean Data and Information Science Society
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• v.19 no.4
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• pp.1219-1231
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• 2008

The main object of this paper is to develop a leave-one-out(LOO) bound of all pairwise comparison error correcting output codes (APC-ECOC). To avoid using classifiers whose corresponding target values are 0 in APC-ECOC and requiring pilot estimates we developed a bound based on mean misclassification probability(MMP). It can be used to tune kernel hyperparameters. Our empirical experiment using kernel mean squared estimate(KMSE) as the binary classifier indicates that the bound leads to good estimates of kernel hyperparameters.

• Korean Journal of Food Science and Technology
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• v.41 no.5
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• pp.515-521
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• 2009

The DEFT (direct epifluorescent filter technique)/APC (aerobic plate count) test was utilized to screen powdered Ramen soup samples (RS-1, RS-2) whether or not they have been microbial-decontaminated. The initial microbial loads of commercially-packaged samples were log DEFT 6.46 (RS-1) and 7.05 (RS-2), but the viable bacterial counts were log APC 2.74 (RS-1) and 1.95 (RS-2), respectively; this finding showed that they have been already decontaminated by methods other than irradiation. The same samples were then subjected to gamma irradiation at 0, 5 and 10 kGy in order to evaluate the microbial and physicochemical changes during post-irradiation storage for 6 months under room conditions ($10{\pm}3^{\circ}C$). The DEFT count was constant in irradiated samples even at different doses, but APC decreased with dose increases; this implies that the log DEFT/APC increased in a linear fashion with dose. No coliforms, yeasts and molds were detected in any of the samples, whereas the initially detected aerobic bacteria ($5.49{\times}10^2CFU/g$) were inactivated by 5 kGy or more and no growth was observed during the subsequent storage period. The pH of RS-1 was reduced by irradiation (p<0.01), but increased (p<0.01) with increasing storage time. Irradiation induced a reduction in volatile basic nitrogen (VBN), whereas an increase in thiobarbituric acid (TBA) values was observed. The storage time proved more influential than irradiation up to 10 kGy in terms of changes in the VBN and Hunter’s color values of powdered Ramen soups.

• Journal of the Korean Society for information Management
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• v.31 no.3
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• pp.249-270
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• 2014

OA journal publishing has steadily increased its relative share of all scholarly journal articles by about 20%-30%. The 'Gold' OA, often preferred by readers, refers to journal articles which are more widely available through the journal's web site immediately. This study analyzed funder and university's policy for paying APCs in implementing a Gold OA. In recent years there have been a number of attempts in the UK and Europe to stimulate more systematic arrangements for paying APCs, leading funders have clearly established arrangements in place. Also OA fund made by major universities in North America provides publisher with APCs. On the other hand, it is still in early stages in paying with gold OA requirements from Korean funders and universities. The funders have a 'Green' OA policy, such as upload the article accepted version to their online platform. Although it varies by field, many Korean authors are publishing in international journals. Their articles' impacts would rise when they are published as gold OA. Therefore, funders and universities need to pay attention to gold OA publishing and set up subsidies for APCs which are required by OA or hybrid journal publishers.