• Proceedings of the Korean Nuclear Society Conference
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• 1996.05c
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• pp.98-104
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• 1996

핵분열 생성물 방출량을 계산하는 모델들에 대한 비교 분석을 위해 GAPCON-THERMAL-2 Revision 2 (GT2R2) 코드를 이용하여 Beyer-Hann , Beyer-Hann with NRC High Burnup Correction, ANS5.4와 Modified ANS5.4 핵분열 생성물 방출 모델들을, RISO-M2-2C 핵연료봉의 실험결과와 비교하였다. Beyer-Hann 모델은 실험결과보다 낮게 예측한반면 ANS5.4 모델은 실험결과 보다 높게 예측하였다. 한편 NRC High Burnup Correction을 한 Beyer-Hann 모텔과Modified ANS5.4 모델은 실험 결과와 비슷한 방출비를 예측하였다. 이러한 결과를 확인하기 위해 국부적인 핵연료 온도와 연소도를 검토한 결과 ANS5.4 모델이 .Modified ANS5.4 모델보다 온도와 연소도에 따라 더 민감한 반응을 보이고 있으며, Beyer-Hann 모텔은 연소도 영향이 없이 각 온도 영역에서 일정하였고, Beyer-Hann with NRC High Burnup Correction 모델은 20,000MWd/MTU 연소도 이상영역에서 연소도 영향을 보이고 있다.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05c
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• pp.139-144
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• 1996

핵분열 생성물 방출량을 계산하는 모델들에 대한 비교 분석을 위해 GAPCON-THERMAL-2 Revision 2 (GT2R2) 코드를 이용하여 Beyer-Hann , Beyer-Hann with NRC High Burnup Correction, ANS5.4와 Modified ANS5.4 핵분열 생성물 방출 모델들을, RISO-M2-2C 핵연료봉의 실험결과와 비교하였다. Beyer-Hann 모델은 실험결과보다 낮게 예측한반면 ANS5.4 모델은 실험결과 보다 높게 예측하였다. 한편 NRC High Burnup Correction을 한 Beyer-Hann 모델과 Modified ANS5.4 모델은 실험 결과와 비슷한 방출비를 예측하였다. 이러한 결과를 확인하기 위해 국부적인 핵연료 온도와 연소도를 검토한 결과 ANS5.4 모델이 Modified ANS5.4 모델보다 온도와 연소도에 따라 더 민감한 반응을 보이고 있으며, Beyer-Hann 모델은 연소도 영향이 없이 각 온도 영역에서 일정하였고, Beyer-Hann with NRC High Burnup Correction 모델은 20,000MWd/MTU 연소도 이상영역에서 연소도 영향을 보이고 있다.

• BMB Reports
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• v.29 no.3
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• pp.230-235
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• 1996

The interaction of ${\alpha}-ketoglutarate$ dehydrogenase complex (${\alpha}-KGDC$) with a hydrophobic fluorescent probe [1,1'-bi(4-aniline)naphthalene-5,5'-disulfonic acid] (bis-ANS) was studied. The punfied ${\alpha}-KGDC$ was potently inhibited by bis-ANS with an apparent half maximal inhibitory concentration ($IC_{50}$) of 9.8 ${\mu}m$ at pH 8.0. The catalytic activities of both the E1o and E2o subunits were predominantly inhibited while that of the E3 component was hardly affected. The binding of bis-ANS to the enzyme caused a marked enhancement and blue shift from 523 nm to 482 nm in the fluorescence emission spectrum. The dissociation constant ($K_d$) and the number of binding sites (n) were calculated to be 0.87 mM and 158, respectively. Allosteric regulators such as purine nucleotides and divalent cations further increased the fluorescence intensity of the $bis-ANS-{\alpha}-KGDC$ binary complex. These data suggest that the binding of these allosteric regulators to ${\alpha}-KGDC$ may cause the conformational changes in the enzyme and that bis-ANS could be used as a valuable probe to study the interaction of the multi-enzyme complex and its allosteric regulators.

• Journal of Pharmaceutical Investigation
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• v.19 no.2
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• pp.71-79
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• 1989

Complex formation of water-soluble polyparacyclophanes bearing two diphenylmethane or two diphenyl ether skeletons with l-anilinonaphthalene-8-sulfonate (ANS) and 2-p-toluidinylnaphthalene-6-sulfonate (TNS) was investigated quantitatively to develop useful host compounds comparing with ${\alpha}\;-\;and\;{\beta}-cyc1odextrins$$({\alpha}-\;and\;{\beta}-CyDs$) in aqueous solution. Benesi-Hildebrand type analysis of the fluorescent intensity showed that the dissociation constants (Kd) of paracyclophane-ANS complexes were $1.55\;{\times}\;10^{-4}M$ for 1,6,20,25-tetraaza[6.1.6.1]paracyclophane(CPM 44) and $1.23\;{\times}\;10^{-4}M$ for 1,7,21,27-tetraaza[7.1.7.1]paracyclophane (CPM 55), and those of paracyclophane-TNS complexes were $6.99\;{\times}\;10^{-6}M$ for CPM 44 and $6.23\;{\times}\;10^{-5}M$ for CPM 55, in 1:1 molar ratio. On the other hand, the Kd values of 1,7,21,27-tetraaza-14,34-dioxa[7.1.7.1]paracyclophane (CPE 55)-ANS, 1,8,22,29-tetraaza-15,36-dioxa[8.1.8.1]paracyclophane (CPE 66)-ANS, CPE 55-TNS, CPE 66-TNS complexes were $1.75\;{\times}\;10^{-3}M$, $3.07\;{\times}\;10^{-3}M$, $3.75\;{\times}\;10^{-3}M$ and $2.15\;{\times}\;10^{-3}M$, respectively. On the contrary, the Kd values of ${\alpha}-CyD-ANS$, ${\beta}-CyD-ANS$, ${\alpha}-CyD-TNS$ and ${\beta}-CyD-TNS$ complexes were found to be $3.98\;{\times}\;10^{-2}M$, $1.05\;{\times}\;10^{-2}M$, $1.38\;{\times}\;10^{-2}M$ and $3.52\;{\times}\;10^{-4}M$, respectively. These results mean that the complexation of CPMs with ANS or TNS is by 5.6-1,975 fold stronger than that for ${\alpha}-or\;{\beta}-CyDs$, and the complex formation of CPEs with ANS or TNS is nearly same as or somewhat stronger than that for ${\alpha}-or\;{\beta}-CyDs$. From the Kd values determined at different temperatures, thermodynamic parameters were calculated and the complexation was found to be a spontaneous exothermic reaction. The effects of pH on Kd values of CPM 44-ANS, and CPM 55-ANS complexes were negligible in the range of pH 1.2-1.8. However, the Kd values of these complexes increased significantly with increasing ionic strength.

• Korean Journal of Food Science and Technology
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• v.25 no.5
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• pp.571-575
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• 1993

Effect of surface hydrophobicity of soybean peptides on serum cholesterol in rats was investigated. Soybean protein(ISP), casein(CNP), and their peptic hydrolyzates fractionated by acid precipitations (SHT, SH8, SH6, SH4, CHT, CH6, CH5, CH4) were fed to rats and the concentration of serum cholesterol and the fecal steroid excretion were measured. And surface hydrophobicities of the peptide fractions were measured by determining by the ANS flourescence intensity and SDS binding capacity. It was found that the higher the surface hydrophobicity of peptides was, the more the fecal steroids excreted(r=0.801) and the lower the concentration of serum cholesterol became(r=-0.868). However, there was no relationship between SDS surface hydrophobicity and fecal steroids or serum cholesterol. ANS surface hydrophobicity of soybean protein was increased by enzymatic hydrolysis. These results suggest that high surface hydrophobicity of peptides formed during digestion is responsible for the hypocholestrolemic effect of soybean protein through the hydrophobic interaction between the peptides and bile salts in rats.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.8 no.1
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• pp.29-38
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• 1978

The purpose of this study is to obtain the enshortening and elongation rate of image in orthopantomograph. The subjects were consisted of 15 dry skulls attached with radiopaque materials on each anatomical points. The length measurements were performed between two points on dry skull, and between two points on film. The results are as follows: 1. The enshortening and elongation rate between two anatomical points (1) ANS↔infraorbital foramen (left:+1.3%, right:+0.7%) (2) ANS↔maxillary tuberosity(left:-11.7%, right:-14.3%) (3) Zygomatic arch length(left:-4.8%, right:-8.9%) (4) first molar↔infraorbital foramen (left:+19.8%, right:+24%) (5) inter-infraorbital foramen length(-21.4%) (6) inter-first molar length (-31.8%) (7) inter-mental foramen length(+1.4%) (8) mental foramen↔mandible angle (left:+3.3%, right:+3.3%) (9) mental foramen↔lingula(left:+8.2%, right:+3.3%) (10) mental foramen↔condyle head(left:+5.2%, right:+4.5%) (11) mandible↔condyle head (left:+15.4%, right:+16.4%) 2. The closer the object is to the occlusal plane and the median line, the smaller it appears.

• Journal of Biomedical Engineering Research
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• v.28 no.4
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• pp.503-511
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• 2007

Heart rate variability(HRV) is the clinical consequence of various influences of the autonomic nervous system(ANS) on heart beat. HRV can estimate the potential physiologic rhythm from the interval between consecutive beats(RR interval or HRV data), but cardiovascular system governed by ANS is in relation to respiration and autonomic regulation. It is known as RSA representing respiration-related HR rhythmic oscillation. Because the mechanism linking the variability of HR to respiration is complex, it has so far been unknown well. In this paper, we tried to evaluate 5-min RR interval segments under control of respiration in order to find out a proper respiration rate that can estimate the ANS function. 10 healthy volunteers were included to evaluate 5-min HRV data under 4 different respiration-controlled environments; 0.03Hz, 0.1Hz, 0.2Hz, and 0.4Hz respiration. HRV data were analyzed both in the frequency and the time domain, with cross-correlation coefficient(cross-coeff.) for HRV and respiration signal. The results showed maximum cross-coeff. of 0.84 at 0.1 Hz and minimum that of 0.16 at 0.4Hz respiration. Cross-coeff was decreased at a faster rate from 0.1Hz respiration. All mean SDNN, RMSSD, and pNN50 of time domain measures were 108.7ms, 71.85ms, and 28.47%, respectively, and LF, HF, and TP of frequency domain measures were $12,722ms^2,\;658.8ms^2$, and $7,836.64ms^2$ at 0.1Hz respiration, respectively. In conclusion, 0.1Hz respiration was observed to be very meaningful from time domain and frequency domain analysis in relation to respiration and autonomic regulation of the heart.

• Horticultural Science & Technology
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• v.28 no.4
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• pp.672-677
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• 2010

A duplex PCR method was developed to detect a transformation vector pSPB130 used in the development of a genetically modified (GM) rose plant. To detect a GM rose plant, the anthocyanin synthase ($ANS$) was used as an endogenous reference gene of rose in PCR detection. The primer pair RHANS-KF/KR producing 107 bp amplicon was used to amplify the $ANS$ gene and no amplified product was observed in any of the 9 different plants used as a template. The primer pair GMRH-KF/KR was designed to amplify the junction sequence between 35S promoter and flavonoid 3',5'-hydroxylase ($F3^{\prime}5^{\prime}H$) gene in pSPB130. The detection limit of the duplex PCR method is approximately 0.5%. This result indicates that this duplex PCR method could be useful for monitoring unauthorized GM rose in Korea.

• The korean journal of orthodontics
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• v.22 no.1
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• pp.179-203
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• 1992

This study was designed to analyze nasal respiratory patency and its correlation with skeletal components in growing children with anterior crossbite. The subjects consisted of 40 control patients, 24 nose breathers with anterior crossbite and 18 mouth breathers with anterior crossbite. The mean age was 11.4 years in the control group, 10.1 years in nose breathing group and 9.5 years in mouth breathing group. The results were as follows, 1. In anterior cross bite group, and nasal respiratory airflow rates (N.R.A.R.) was significantly lower than that of control group regardless of nasal decongestants application. 2. The N.R.A.R. of mouth breathers with anterior crossbite in male group was significantly lower than that of mouth breathers, but increased to the level of control group after nasal decongestants application. But in female group, the N.R.A.R. was significantly lower in mouth breathing group at both conditions. 3. Mouth breathing group showed smaller anterior vertical nasal cavity height (ANS-ANS'), lower upper anterior facial height ratios (N-sp'/N-Me) and higher maxillary occlusal plane ratios (OL-ML/ML-NL) than those of nose breathing group with anterior crossibte. 4. Items showing nasal height (ANS-ANS', PNS-PNS'), anterior upper facial height (N-sp') was were strongly correlated with N.R.A.R. at 150 pascal in inspiration. But item showing maxillary occlusal plane ratios (OL-ML/ML-NS) was negatively correlated with N.R.A.R. at 150 pascal in inspiration. 5. There were forward tongue position in mouth breathing group, but it was not significantly correlated with N.R.A.R. at 150 pascal in inspiration.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.10a
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• pp.429-436
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• 1997

운전원 훈련용 시뮬레이터의 국산화 개발계획에 따라 영광 원자력 3,4호기 발전소 운전원 훈련용 시뮬레이터가 국내 최초로 개발되었다. STK(space and time kinetics)와 RETACT (Real Time Advanced Core and Thermohydraulics)코드를 이용하여 영광 3,4호기 시뮬레이터의 실시간 NSSS 모델을 생성하였다. 생성된 모델의 검증(Verification Validation)을 위해 정상상태(Steady State)에서의 주요인자들이 ANS3.5의 오차범위이내임을 확인하였다. 과도상태(Transient)의 검증을 위해 터빈정지 과도상태와 주증기 관파열(Main Steam Line Rupture)사고를 실제 발전소 시험 데이터 및 성능해석 코드(NPA)를 이용하여 분석한 결과와 비교하였다. 비교 결과 기준발전소의 반응과 큰 차이 없이 운전원 훈련용 시뮬레이터의 규격인 ANS 3.5를 잘 만족함을 확인 할 수 있었다.