• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 춘계학술대회
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• pp.114-114
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• 2008

• Asian-Australasian Journal of Animal Sciences
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• 제10권1호
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• pp.75-78
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• 1997

Season is very important as it defines the contemporaries for sire and cow evaluation. An attempt is made for defining season for animal model evaluation of Sahiwal animals, using 1,227 records from 730 cows. Cows were required to have a lactation length of 305-days. Ten different combinations of months for two, four, five or other seasons were tried. The other fixed effect in the model was age defined within parity. The random effects were permanent environment and animal's breeeding value along with the residual effects. A single trait animal model was used where all known relationships of an animal were incorporated in a relationship matrix. The error variance from the fitted model decreased as the number of year-season combinations increased, indicating a month-year model to be more appropriate. This, on the other hand, decreased the number of contemporaries for certain subclasses to a minimum of one, making the bull comparisons invalid. Use of a two season scenario, with winter (November through February) and summer (March through October) was better than the other combinations in terms of error variance of the fitted model and the number of lactations represented in any year-season subclass.

• Asian-Australasian Journal of Animal Sciences
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• 제30권8호
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• pp.1074-1080
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• 2017

Objective: The growth, carcass and retail cut yield records on 1,428 Hanwoo steers obtained through progeny testing were analyzed in this study, and their heritability and genetic relationships among the traits were estimated using animal models. Methods: Two different models were compared in this study. Each model was fitted for different fixed class effects, date of slaughter for carcass traits and batch of progeny test live measurement traits, and a choice of covariates (carcass weight in Model 1 or backfat thickness in Model 2) for carcass traits. Results: The differences in body composition among individuals were deemed being unaffected by their age at slaughter, except for carcass weight and backfat thickness. Heritability estimates of body size measurements were 0.21 to 0.36. Heritability estimates of retail cut percentage were high (0.56 from Model 1 and 0.47 from Model 2). And the heritability estimates for loin muscle percentage were 0.36 from Model 1 and 0.42 from Model 2, which were high enough to consider direct selection on carcass cutability traits as effective. The genetic correlations between body size measurements and retail cut ratio (RCR) were close to zero. But, some negative genetic correlations were found with chest girths measured at yearling (Model 1) or at 24 months of age or with chest widths. Loin muscle ratio (LMR) was genetically negatively correlated with body weights or body size measurements, in general in Model 1. These relationships were low close to zero but positive in Model 2. Phenotypic correlation between cutability traits (RCR, LMR) and live body size measurements were moderate and negative in Model 1 while those in Model 2 were all close to zero. Conclusion: Therefore, the body weights or linear body measurements at an earlier age may not be the most desirable selection traits for exploitation of correlated responses to improve loin muscle or lean meat yield.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.571-571
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• 2007

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.572-572
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• 2007

• Asian-Australasian Journal of Animal Sciences
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• 제10권1호
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• pp.70-74
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• 1997

Data on 2,571 lactation records of Nili-Ravi buffaloes from four institutional herds and four field recording centers were analyzed under an animal model to see the effect of season definition on the error variance of the fitted model. Herd-year-season(HYS) was the main fixed effect along with permanent environment, breeding value and residuals as the random effects. All known relationships among the animals were considered. The error variance differed for various HYS combinations. It was minimum when then months were not grouped into seasons. The four or Five season scenarios were better than the two season scenarios. The average number of lactations represented in a HYS combination varied widely from 6 to 28. Very few subclasses for a given HYS combination warrants the use of fewer seasons for animal model evaluation of buffaloes.

• BMB Reports
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• 제48권2호
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• pp.68-80
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• 2015

G protein-coupled receptors (GPCRs) are a large class of transmembrane receptors categorized into five distinct families: rhodopsin, secretin, adhesion, glutamate, and frizzled. They bind and regulate 80% of all hormones and account for 20-50% of the pharmaceuticals currently on the market. Hundreds of GPCRs integrate and coordinate the functions of individual cells, mediating signaling between various organs. GPCRs are crucial players in tumor progression, adipogenesis, and inflammation. Several studies have also confirmed their central roles in embryonic development and stem cell maintenance. Recently, GPCRs have emerged as key players in the regulation of cell survival, proliferation, migration, and self-renewal in pluripotent (PSCs) and cancer stem cells (CSCs). Our study and other reports have revealed that the expression of many GPCRs is modulated during the generation of induced PSCs (iPSCs) or CSCs as well as during CSC sphere formation. These GPCRs may have crucial roles in the regulation of self-renewal and other biological properties of iPSCs and CSCs. This review addresses the current understanding of the role of GPCRs in stem cell maintenance and somatic reprogramming to PSCs or CSCs.

• Journal of Animal Science and Technology
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• 제55권5호
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• pp.359-365
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• 2013

단형질 개체모형을 이용한 육종가 추정프로그램의 해를 구하는 컴퓨터 프로그램을 포트란 언어를 이용하여 자체개발하였고, 프로그램은 자료기반으로 반복적으로 계산을 해 나가는 간접법을 이용한 것으로 일반적인 알고리즘으로 프로그램을 개발하고 이의 효율을 개선한 개선알고리즘으로 프로그램을 개발하여, 두 프로그램 간 효율을 비교하였다. 기존의 전통적인 알고리즘은 순차적인 반복문을 이용하여 자료를 읽고 기록하는 방법이며, 새로운 알고리즘은 효과별로 LHS를 직접 작성하여 추정하는 방법을 사용하였다. 개발된 두 가지 프로그램으로 육종가를 추정하고, 그 추정 값이 정확하게 평가되었는지 알아보기 위하여 기존에 개발되어 사용되고 있는 BLUPF90 (Misztal, 2007)과 MTDFREML (Boldman 등, 1999)과 비교하여 보았다. 서로 다른 프로그램으로 추정된 육종가간의 상관은 전체 항목에서 99% 이상 고도의 상관이 나타났으며, 프로그램 추정치 간의 높은 상관으로 볼 때 Model I, Model II는 정확하게 개발되었고 평가된 것을 확인할 수 있었다. Solution이 수렴 될 때까지의 반복횟수는 Model I은 2,568 round, Model II는 1,038 round로 수렴되어 Model II가 Model I보다 작은 반복횟수에서 수렴이 된 것을 확인할 수 있었으며, 수렴속도는 Model I은 256.008초, Model II는 235.729초로 Model II가 Model I 보다 약 10% 정도 개선된 것을 확인할 수 있었다. 개발된 프로그램을 기존 D/B와 연계한다면 농가 및 지자체 등에 지속적인 개량 정보를 제공할 수 있으며, 농가 단위 암소 유전능력평가로 암소개량을 도모할 수 있을 것이라 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제22권1호
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• pp.57-71
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• 2009

Crop-livestock mixed farming systems depend on the efficiency with which nutrients are conserved and recycled. Home-grown forage is used as animal feed and animal excretions are applied to cultivated crop lands as manure. The objective of this study was to develop a mixed farming system model for dairy cattle in Japan. The model consisted of four sub-models: the nutrient requirement model, based on the Japanese Feeding Standards to determine requirements for energy, crude protein, dry matter intake, calcium, phosphorus and vitamin A; the optimum diet formulation model for determining the optimum diets that satisfy nutrient requirements at lowest cost, using linear programming; the herd dynamic model to calculate the numbers of cows in each reproductive cycle; and the whole farm optimization model to evaluate whole farm management from economic and environmental viewpoints and to optimize strategies for the target farm or system. To examine the model' validity, its predictions were compared against best practices for dairy farm management. Sensitivity analyses indicated that higher yielding cows lead to better economic results but higher emvironmental load in dairy cattle systems integrated with forage crop production.

• 농업과학연구
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• 제43권4호
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• pp.595-602
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• 2016

In pigs, individuals in the same pen may show aggressive behavior toward each other, such as tail biting. Such social interactions among pen mates may considerably affect their welfare and performance, both in negative and positive ways. The present study was conducted to investigate social genetic effects on days to 90 kg using data from 12,208 Duroc and Yorkshire pigs that were born between 2008 and 2012. Heritability was estimated using the five following animal models: a basic model with direct heritable effects only (Model 1), a social model with direct and social heritable effects (Model 2), a model accounting for covariance between direct and social heritable effects (Model 3), and two models considering a dilution factor with direct and social heritable effects (Models 4 and 5). The optimal model to represent Duroc pigs was Model 1 which only uses direct heritable effects. Direct heritability (0.21) was higher than total heritability (0.09) and covariance was negative. Model 2 was evaluated as the optimum model for Yorkshire pigs. Yorkshire data showed that total heritability (0.5) was twice as high as direct heritability (0.25) and covariance was positive. Our results suggest that the efficiency of social effects differed among breeding lines. Further research on social effects related to breeds by group size would clarify which is the most efficient selection method that accounts for social genetic effects.