• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.28-35
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• 2005

It is now well recognized that the ultimate limit state approach is a much better basis for design and strength assessment of ships and offshore structures since it is difficult to determine the realistic margin of safety using the traditional allowable working stress approach on the basis of linear elastic method solutions together with buckling strengthchecks adjusted by a simple plasticity correction. This paper outlines ALPS theory for ultimate limit state assessment of ship structures. ALPS is a computer software which stands for nonlinear Analysis of Large Plated Structures. Application examples of ALPS program to ultimate limit state assessment of plates, stiffened panels and ship hull girders are presented. A benchmark study is made by a comparison with the ALPS solutions with other methods including class rule formulae, nonlinear finite element methods and experimental results. Future trends on ultimate limit state assessment of ship structures are addresse[1]

• Applied Science and Convergence Technology
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• 제24권6호
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• pp.284-288
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• 2015

Anionic small molecules are hard to penetrate the cell membranes because of their negative charges. Encapsulation of small molecules into liposome particles can provide target specific delivery of them. In our previous study, siRNA could be efficiently encapsulated into liposome particles using an asymmetric preparation method of liposomes. In this study, the same method was applied for encapsulation of small anionic fluorescent chemicals such as calcein and indocyanine green (ICG). More than 90% fluorescent chemicals were encapsulated in the asymmetric liposome particles (ALPs). No intracellular fluorescent signal was observed in the tumor cells treated with the unmodified calcein/ALPs and ICG/ALPs, whereas the surface modification with a cell-penetrating polyarginine peptide (R8 or R12) allows cellular uptake of the ALPs. The results demonstrate that the ALPs encapsulating small anionic drugs will be useful for target-specific delivery after modification of target-specific ligands.

• 농촌계획
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• 제19권2호
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• pp.35-49
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• 2013

The study area is Cheonjang-ri, also called Alps village, making continuous profit after performing Comprehensive Rural Village Development Projects. This study aims to determine the development process of activities about urban and rural interchange and its characteristics for making continuous profit by residents themselves. A focus on thinking about the process is necessary to make activities in order to achieve continuous profits in the underdeveloped rural village by residents themselves. As a result of this study, Alps village has developed new activities, improving problems which are encountered on the development process of activities. And, Alps village has developed new activities by linking them with previous activities. To improve problems, Alps village has made an effort by itself and cooperated with the subject, both inside and outside of the village. This way has been effective for increasing the number of visitors in village. Increasing the number of visitors in village has been effective in making a continuous profit. Also, continuing to make new activities in order to substitute previous activities including problems has been effective to increase profit.

• Korean Journal of Radiology
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• 제24권6호
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• pp.564-573
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• 2023

Objective: To investigate the feasibility of assessing the viscoelastic properties of the brain using magnetic resonance elastography (MRE) and a novel MRE transducer to determine the relationship between the viscoelastic properties and glymphatic function in neurologically normal individuals. Materials and Methods: This prospective study included 47 neurologically normal individuals aged 23-74 years (male-to-female ratio, 21:26). The MRE was acquired using a gravitational transducer based on a rotational eccentric mass as the driving system. The magnitude of the complex shear modulus |G^*| and the phase angle 𝛗 were measured in the centrum semiovale area. To evaluate glymphatic function, the Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) method was utilized and the ALPS index was calculated. Univariable and multivariable (variables with P < 0.2 from the univariable analysis) linear regression analyses were performed for |G^*| and 𝛗 and included sex, age, normalized white matter hyperintensity (WMH) volume, brain parenchymal volume, and ALPS index as covariates. Results: In the univariable analysis for |G^*|, age (P = 0.005), brain parenchymal volume (P = 0.152), normalized WMH volume (P = 0.011), and ALPS index (P = 0.005) were identified as candidates with P < 0.2. In the multivariable analysis, only the ALPS index was independently associated with |G^*|, showing a positive relationship (β = 0.300, P = 0.029). For 𝛗, normalized WMH volume (P = 0.128) and ALPS index (P = 0.015) were identified as candidates for multivariable analysis, and only the ALPS index was independently associated with 𝛗 (β = 0.057, P = 0.039). Conclusion: Brain MRE using a gravitational transducer is feasible in neurologically normal individuals over a wide age range. The significant correlation between the viscoelastic properties of the brain and glymphatic function suggests that a more organized or preserved microenvironment of the brain parenchyma is associated with a more unimpeded glymphatic fluid flow.

• 한국정보통신학회논문지
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• 제16권11호
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• pp.2550-2556
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• 2012

본 논문에서는 노드의 위치정보를 측정함에 있어 거리정보에 기반을 두지 않은 방식(range-free)에서의 라우팅 에너지 효율성을 개선한 ALPS(Ad hoc network Localized Positioning System) 알고리즘을 제안한다. 본 논문에서 제안되는 ALPS 알고리즘은 계층적 클러스터 단위에 소속된 임의의 노드에 대한 위치정보를 RSSI(Received signal strength indication)에 의해 상대적 위치정보를 제공하는 방법이다. 제안된 알고리즘에 따른 위치정보를 사용 할 경우 기존의 DV-hop방식에 따른 노드의 평균 위치정보를 사용한 경우보다 계층적 좌표 방식에 의한 제안된 방식이 보다 최적화된 에너지 소모를 유지할 수 있는 경로 알고리즘을 제공하게 된다. 제공된 알고리즘의 성능 분석을 위해 본 논문에서는 상기 두 가지 방식의 위치정보에 따른 라우팅에서 소모되는 에너지 관계를 비교 하였고, 이로부터 보다 최적화된 에너지 경로 관리가 되는 결과를 보여주었다.

• 기술사
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• 제45권2호
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• pp.28-32
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• 2012

The European Alps face a number of major threats - from habitat loss to pollution, from mass tourism to the impacts of climate change. The European alpine climate has changed significantly during the past century, with temperatures increasing more than twice the global average. This makes alpine mountains especially vulnerable to changes in the hydrological cycle and decreases in snow and glacier cover, which are already occurring. In winter, artificial snow-making is currently the most widespread strategy to extend and supplement natural snow cover and secure winter tourism. Artificial snow-making is not only very costly, but also has knock-on effects such as increased water consumption and energy demand or ecological damage, which may lead to negative externalities. The European Alps facing the challenge of changing climate and anthropogenic pressures.

• 한국토양동물학회지
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• 제5권1호
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• pp.39-46
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• 2000

The distribution and some properties of alkaline phosphatase (ALP) were investigated in the midgut of the earthworm, Eisenia andrei. The ALP activity appeared to be highly polarized toward the luminal side of epithelium, with minor ALP activity in chloragogue tissue. The epithelial and chloragogeneous tissues contained approximately 85 and 15% of total intestinal ALP activity, respectively. The optimal temperature was approximately 37$^{circ}C$ and isoelectricpoint was estimated to be 4. The treatment of neuraminidase and PtdIns-PLC failed to change the migration rate of ALPs. Also, these ALPs appeared to have a wide range of substrate specificity. The relationship between the properties and physiological significances of the midgut ALPs in Eisenia andrei was discussed.

• 한국미생물·생명공학회지
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• 제17권5호
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• pp.489-493
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• 1989

쥐 하이브리도마 Alps 25-3를 이용하여 무혈청 배지 KM3의 각 성분이 세포증식과 항체생성에 미치는 영향을 조사하여 무혈청 배지를 최소화한 KMS를 결정하였다. Alps 25-3에 영향을 미치는 것으로 조사된 transferrin, ethanolamine 그리고 BSA만을 혼합하여 결정한 KMS를 다른 쥐 하이브리도마인 A4W, KW 그리고 HCGK에 적용시켰다. KM5를 KM3와 비교하였을 때 세포증식과 항체생산이 거의 동일한 양상을 보였다. 그러나 혈청배지와 비교하여 보면 최고 세포농도는 50-90%, 최종 단일클론항체의 농도는 85-100%의 수준을 보였다. 본 연구의 결과로 쥐 하이브리도마 세포를 무혈청 배지에서 배양시킬 때 필수적으로 첨가기어야 하는 성분들이 조사되었으므로 대량배양에 응용하거나 대사를 연구하는데 유용하게 이용되어지리라 본다.

• 전자공학회논문지A
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• 제31A권3호
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• pp.53-67
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• 1994

This paper describes the design of a high-level synthesis system. SODAS-VP. which automatically generates hardwares executing operation sequences in pipelined fashion.Target architecture and clocking schemes to drive pipelined datapath are determined, and the handling of pipeline hazards which degrade the performance of pipeline is considered. Partitioning of an operation into load, operation, and store stages, each of which is executed in partitiones control step, is performend. Pipelinecl hardware is generated by handling pipeline hazards with internal forwarding or delay insertion techniques in partitioning process and resolving resource conflicts among the partitioned control steps with similarity measure as a priority function in module allocation process. Experimental results show that SODAS-VP generates hardwares that execute faster than those generated by HAL and ALPS systems. SODAS-VP brings improvement in execution speed by 17.1% and 7.4% comparing with HAL and ALPS systems for a MCNC benchmark program, 5th order elliptical wave filter,respectively.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2004년도 가을 학술발표회 논문집
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• pp.110-117
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• 2004

The aim of a benchmark study is carried out nine methods are employed for ULS analysis which implicitly predict the ultimate strength of aluminium stiffened panels under axial compression. For this purpose, DNV PULS, experimental and numerical data on the ultimate strength of panels were collected. Comparison of these experimental / numerical, DNV PULS / numerical, results with theoretical solutions by the candidate methods is performed. Also it's compared that ALPS/ULSAP program is based on closed-form formula for the ULS of plates and grillages under axial compression. It is considered that ALPS/ULSAP methodology provides quite accurate and reasonable ULS calculations by a comparison with more refined FEA. Comparison of these experimental data, numerical, computational software results with the simplified solutions obtained by the candidate methods is then performed. The model uncertainties associated with the candidate methods are studied in terms of mean bias and COV (i.e., coefficient of variation) against experiments and numerical solutions, and the relative performance of the various methods is discussed.