• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1073-1076
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• 2015

Background: To explore the relationship between CXCR4, CD133 co-expression and clinicopathological features as well as prognosis of patients with phase II~III colon cancer. Materials and Methods: Forty-nine paraffin-embedded samples of tumor tissue and epithelial tissue adjacent to cancer were collected from patients with colon cancer undergoing radical surgery in Baotou Cancer Hospital from January, 2010 to June, 2011. CXCR4 and CD133 expression was detected using immunohistochemistry and its relationship with clinicopathological features and the 3-year survival rate was analyzed. Results: In the tumor tissue and colonic epithelial tissue adjacent to cancer, the positive expression rates of CXCR4 were respectively 61.2% (30/49) and 8.16% (4/49), while those of CD133 being 36.7% (18/49) and 6.12% (3/49). CXCR4 and CD133 expression in tumor tissue was not related to patient age, gender, primary focal sites, tumor size, TNM staging, histological type, tumor infiltration depth and presence or absence of lymphatic metastasis, but CXCR4 and CD133 co-expression was associated with TNM staging and lymphatic metastasis. The 3-year survival rate of patients with CXCR4 and CD133 co-expression was 27.3% (3/11), and that of the remainderwas 76.3% (29/38), the difference being significant ($X^2=7.0206$, p=0.0081). Conclusions: CXCR4 and CD133 co-expression may be a risk factor for poor prognosis of patients with stage II~III colon cancer.

• 대한예방한의학회지
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• 제28권1호
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• pp.31-42
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• 2024

Objective : In order to understand the changes in domestic approval regulations applicable to traditional Korean medical device companies, this article will explain the major amendments 「Regulation on Medical Device Approval Report Review, etc.」 from 2005 to the present on a year-by-year basis, and provide a counter plan to the recent changes in approval regulations. Methods : We analysed the changes in approval regulatory amendments related to the traditional Korean medical devices from 2005 to the present. Results : The Ministry of Food and Drug Safety is continuously improving medical device approval regulations to ensure the global competitiveness of domestic medical devices and contribute to the improvement of public health. Recent major approval regulatory amendments include the establishment of a review system for software medical devices and digital therapeutics, the recognition of real world evidence materials, the introduction of a biological evaluation of medical devices within a risk management process and a medical device approval licence renewal system. Conclusions : It is expected that the range of medical devices available to Korean medicine doctors will continue to expand in the future through the provision of non-face-to-face medical services and the development of advanced and new medical devices, as well as wearable medical devices and digital therapeutics. In order to increase the market entry potential of traditional Korean medical devices that incorporate advanced technologies such as digital technology and AI-based diagnosis and prediction technology, it is urgent that the government provide significant support to traditional Korean medical device companies to improve approval regulatory compliance.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5177-5182
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• 2012

Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.

• 한국과학교육학회지
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• 제44권3호
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• pp.231-248
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• 2024

본 연구에서는 오픈소스 소프트웨어와 인공지능 문서 분류 모델인 한국어 Sentence-BERT로 고등학교 1학년 통합과학 질문-답변 챗봇을 제작하고 2023학년도 1년 동안 독립형 서버에서 운영했다. 챗봇은 Sentence-BERT 모델로 학생의 질문과 가장 유사한 질문-답변 쌍 6개를 찾아 캐러셀 형태로 출력한다. 질문-답변 데이터셋은 인터넷에 공개된 자료를 수집하여 초기 버전을 구축하였고, 챗봇을 1년 동안 운영하면서 학생의 의견과 사용성을 고려하여 자료를 정제하고 새로운 질문-답변 쌍을 추가했다. 2023학년도 말에는 총 30,819개의 데이터셋을 챗봇에 통합하였다. 학생은 챗봇을 1년 동안 총 3,457건 이용했다. 챗봇 사용 기록을 빈도분석 및 시계열 분석한 결과 학생은 수업 중 교사가 챗봇 사용을 유도할 때 챗봇을 이용했고 평소에는 방과 후에 자습하면서 챗봇을 활용했다. 학생은 챗봇에 한 번 접속하여 평균적으로 2.1~2.2회 정도 질문했고, 주로 사용한 기기는 휴대폰이었다. 학생이 챗봇에 입력한 용어를 추출하고자 한국어 형태소 분석기로 명사와 용언을 추출하여 텍스트 마이닝을 진행한 결과 학생은 과학 질문 외에도 시험 범위 등의 학교생활과 관련된 용어를 자주 입력했다. 학생이 챗봇에 자주 물어본 주제를 추출하고자 Sentence-BERT 기반의 BERTopic으로 학생의 질문을 두 차례 범주화하여 토픽 모델링을 진행했다. 전체 질문 중 88%가 35가지 주제로 수렴되었고, 학생이 챗봇에 주로 물어보는 주제를 추출할 수 있었다. 학년말에 학생을 대상으로 한 설문에서 챗봇이 캐러셀 형태로 결과를 출력하는 형태가 학습에 효과적이었고, 통합과학 학습과 학습 목적 이외의 궁금증이나 학교생활과 관련된 물음에 답해주는 역할을 수행했음을 확인할 수 있었다. 본 연구는 공교육 현장에서 학생이 실제로 활용하기에 적합한 챗봇을 개발하여 학생이 장기간에 걸쳐 챗봇을 사용하는 과정에서 얻은 데이터를 분석함으로써 학생의 요구를 충족할 수 있는 챗봇의 교육적 활용 가능성을 확인했다는 점에 의의가 있다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2015년도 춘계학술대회
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• pp.299-301
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• 2015

2015. 04. 20.부터 2톤 이상 AIS를 설치한 유선을 관제대상으로 지정 고시(연안 해상교통 관제운영에 관한 고시)되면서 전국적으로 유선 보유척수가 가장 많은 통영 연안VTS에서 유선 관제 시행 중 도출된 문제점들에 대한 개선책을 모색하고 보다 더 효율적이고 안전한 관제를 통해 유선해양사고 방지 및 신속한 상황대처로 안전한 바다 조성에 이바지하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1483-1486
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• 2012

Objective: To determine the characteristics of oligoclonal bands that are frequently detected by serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE) after stem cell transplantation. Methods: We retrospectively analyzed 56 patients with multiple myeloma (MM) undergoing transplantation, and standard immunofixation electrophoresis was used to identify and quantify paraproteins. Results: The median follow-up was 35 months (range, 10-76months) and 21 patients relapsed. Twelve (25.0%) demonstrated oligoclonal bands after a median time 1.4 months (range, 1-3months), with a median duration of 5.8 months (range, 1-15months). The majority patients with oligoclonal bands had normal quantities of immunoglobulins and the one year event free survival (EFS) was 92%, even higher than for patients without OBs (P=0.002). Conclusion: Oligoclonal bands frequent develop post-transplantation in MM cases. In the vast majority of patients, they may not represent relapsed disease, and more likely represent a transient phenomenon representing recovery of impaired immunoglobulin production.

• 한국식품영양학회지
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• 제5권2호
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• pp.123-131
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• 1992

This study was designed to find out the effects of aerobic exercise on the serum lipids in the middle-aged women. The effects of aerobic dancing on serum total cholesterol(TC), triglyceride(TG) and HDL-cholesterol (HDL-C) were studied in eight sedentary women(control group) and twenty seven aerobic exercising women(aerobic group) , aged 35∼45%. Aerobic exercising subjects were divided into 3 group; 2 to 3 months exercising group(Al), 4 to 10 months exercising group(AH), over 1 year exercising group(AIII) according to the periods of exercise. The serum lipid levels of aerobic exercising groups(AI, AII, AIIII) were compared with those of control group. The results statistically analyzed were summarized as follows : 1) The serum TG levels of aerobic groups decreased very significantly compared with those of control group(p< 0.001) and tended to be lower with the increase in aerobic periods. But there were no significant differences among aerobic groups by ANOVA. 2) The serum TC levels of aerobic groups decreased compared with those of control group and tended to be lower with the increase of aerobic periods. But there were no significant differences among groups. 3) Serum HDL-cholestrol level of A I group was elevated significantly compared with that of control group and significant difference was observed according to the aerobic periods : AR group exhibited higher serum HDL-cholesterol values than AH group, and AH group higher than A I group.

• 한국정보통신학회논문지
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• 제8권4호
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• pp.782-786
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• 2004

무선랜은 유선랜의 대안으로 개발되어 제한된 공간의 특수한 분야에서 사용였다. 그러나, 최근 들어 다양한 분야에서 그 이용이 시도되고 있다. 최근 5년간에 발생한 해양사고의 주된 유형은 CMDSS협약에 의해 관리되는 대형 선박과 이에 의하여 관리되지 못하는 5톤 미만의 소형선박과의 충돌등이며, 그 원인이 소형선박의 영세성으로 안전통신 시설이 도입되지 못하고 있는 실정이므로 본 연구에서는 최근들어 항만내의 해양사고를 줄이고자 도입이 되고 있는 AIS와 유사한 기능을 할 수 있으며 사용자 측면에서의 저가형 시스템을 제안하였다.

• The Journal of Asian Finance, Economics and Business
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• 제8권12호
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• pp.51-61
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• 2021

If one is looking for an organization that will be responsive to community needs, stimulate economic growth, and raise people's income, cooperatives should be an obvious choice (Calkins & Ngo, 2005; Larocque et al., 2002). This paper investigates whether the households' income is affected by the access to cooperatives for the case of Phong Dien district, Can Tho city of Vietnam. Data used are directly collected from 250 households that are both participating (120 observations) and not participating in the cooperatives in Truong Long, Tan Thoi, Nhon Ai and Nhon Nghia communes. By using the Probit model, the findings show that there are three statistically significant factors affecting the ability of farm households to participate in the cooperatives at the 1 percent level including land area, distance to market center, and education level. In addition, the PSM model analysis suggests that the average income of cooperative members is significantly higher than that of non-members, about 40.880 million VND/year at the significance level of 1 percent. The empirical results imply that being a cooperative member is a significant contributory factor toward an increase in household income. Based on the research findings, several recommendations to improve the households' income are proposed.

• 디지털산업정보학회논문지
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• 제18권1호
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• pp.37-45
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• 2022

With the development of the 4th industry, big data using AI is being used in many areas of our lives, and the importance of data is increasing accordingly. In particular, as various services using personal information appear and hacking attacks that exploit them appear in various ways, the importance of personal information management is increasing. Personal information must be managed safely even when collecting, retaining, using, providing, and destroying personal information, and the rights of information subjects must be protected. In this paper, an analysis was performed on the notification of usage history during the protection of the rights of information subjects using the MyData model. According to the Personal Information Protection Act, users must be periodically notified of the use of personal information, so we notify each individual of the use of personal information through e-mail or SNS once a year. It is difficult to understand and manage which company use my personal information. Therefore, in this paper, a personal information usage history notification system model was proposed, and as a result of performance analysis, it is possible to provide the controllability, availability, integrity, source authentication, and personal information self-determination rights.