• Title/Summary/Keyword: AGING

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Recent Trends on Telomerase Activators, Sirtuin Activators, and Senolytics as a Potential Anti-aging Agent (잠재적인 항노화제로 텔로머레이즈 활성화제, 서르튜언 활성화제, 세노릭틱스에 대한 최신 동향)

  • Kim, Moon-Moo
    • Journal of Life Science
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    • v.30 no.9
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    • pp.819-825
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    • 2020
  • All living organisms exhibit the characteristics of aging, such as skin wrinkle formation, muscle degeneration, cataracts, and hair graying as the number of aged cells increases over time. Senescence, which is known as a key cause of aging, is directly related to the aging of living organisms because cells are aged by external and internal factors and eventually cell proliferation is stopped. Senescence is caused by the gradual shortening of the telomere with cell division, and lifespan is determined by the length of the telomere. Recently, it has been found that the histone deacetylase, which can influence gene expression, is not only involved in yeast but also deeply involved in anti-aging mechanisms in both C. elegans and humans. It was also discovered that old cells play a decisive role in the aging phenomenon, and it has been reported that it is possible to promote the proliferation of young cells and delay aging by removing these senescent cells from the inside. Therefore, in order to develop potential anti-aging agents in the future, research should begin with an in-depth study of telomerase activators, sirtuin activators, and senolytics.

Quality Characteristics of Kochujang Prepared with Maesil (Prunus mume) Extract during Aging (매실추출액 첨가 고추장의 숙성 중 품질특성 연구)

  • Lee, Min-Ji;Lee, Jun-Ho
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.35 no.5
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    • pp.622-628
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    • 2006
  • Kochujang was prepared with various concentrations of Maesil extracts (0, 1, 2, and 5%) and the physicochemical characteristics of Maesil extracts added Kochujang ('Maesil Kochujang') were investigated during aging of 100 days. pH decreased slightly during aging. Titratable acidity, on the other hand, increased with aging, reaching at the highest level at the 40 days of aging and then decreased slowly. The changes of moisture content were complicated in the beginning, but after 60 days it increased slowly. The water activity decreased but salt concentration increased consistently in all samples during aging. L* and a*-values decreased during aging and L*, a*, and b*-values decreased significantly with high amount of Maesil extract in the sample. Soluble solid contents increased slowly while reducing sugar contents increased for up to 40 days and then decreased. Amino nitrogen contents increased steadily after 40 days of aging and they reached at $230.00{\sim}246.00mg%$ upon 100 days of aging.

The Study on the Anti-aging Effects of Mallotus japonicus Bark Extracts (예덕나무 피 추출물의 노화 방지 효과에 관한 연구)

  • Lee Kang Tai;Lee Jeong No;Ahn Gi Woong;Jeong Ji Hean;Jo Byoung Kee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.4 s.48
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    • pp.445-448
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    • 2004
  • Aging is divided into intrinsic aging and photo-aging. Intrinsic aging is naturally occurred as the time passed and photo-aging is induced by the UV radiation of skin. The main reason of aging is the free radicals and the degeneration of the cellular materials by free radicals. In this paper, we checked the anti-aging effects of Mallotus japonicus bark extracts. It has the ability to scavenge free radicals and the SOD like activity. Also, it reduced the cell damage by hydrogen peroxide treatment. Mallotus japonicus bark extracts showed the excellent activity on inhibiting the UV induced cell damage and DNA damage. In conclusion, Mallotus japonicus bark extracts can be used as active ingredients for anti-aging cosmetics.

Effect of Aging Period on Chromatic, Chemical and Organoleptic Properties of Flue-cured Leaf Tobacco (황색종 잎담배의 숙성기간이 색상, 화학성분 및 끽미에 미치는 영향)

  • 정기택;안대진;이종률;제병권
    • Journal of the Korean Society of Tobacco Science
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    • v.26 no.1
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    • pp.27-34
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    • 2004
  • This study was carried out to examinate the effect of aging period on chromatic, chemical and organoleptic characteristics, and to evaluate of optimum aging period for each grade in flue-cured leaf tobacco. The leaf tobaccos were produced in 2000, and threshed, redried and packed in carton box under the current methods. Four grades of processed leaf(A3O, B1O, C1L and D3L) were stored during 24 months(May 10, 2001 to April 31, 2003) in warehouse of Chungju Leaf Tobacco Processing Factory. The leaf tobaccos were sampled at three month intervals for analysis of chromatic, chemical and organoleptic properties. Yellow(b), pH values and total sugar contents of four grades were significantly decreased during the aging. Filling values, tar, nicotine and CO contents of tobacco smoke, and puff number of cigarettes were not significantly changed during the aging. Positive correlation coefficients were significantly observed between taste and irritation of the calculated attributes from contents of volatile oil components in leaf tobacco and those of the panel sensory attributes. The ratio of maximum change in taste attribute was larger than that in irritation attribute during aging. The optimum aging periods estimated by taste for A3O, B1O, C1L and D3L were 17.8, 14.9, 10.8, and 9.8 months, respectively. The thin leaf(Primings and Cutters) undergo satisfactory aging earlier as compared to bodied leaf(Leaf and Tips). The results suggest that decrease of aging period for thin leaf from 18~21 to 9~12 months may be beneficial to save storage cost in flue-cured tobacco.

Perception on Residential Environment Planning for Seniors among University Students visited Aging Simulation Center (노인을 위한 주거환경계획 의식에 관한 연구 - 노인생애체험센터를 방문한 예비디자이너를 중심으로 -)

  • Shin, Hwa-Kyung;Lee, Yun-Hee;Kim, Young-Joo
    • Proceeding of Spring/Autumn Annual Conference of KHA
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    • 2008.11a
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    • pp.322-326
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    • 2008
  • Due to the rapid increasing in the aged population, it calls for social countermeasures urgently. Especially, there are increasing needs of space environment to support physical and spiritual characteristics of elderly. When designing space environment including house, there are growing consideration for elderly and extending appreciation of aging. The purpose of this study is to investigate the perception on environment planning for the seniors among university students who majoring in Housing & Interior Design and who visited the Aging Simulation Center located in Seoul. The Aging Simulation Center gives a chance of space design to support the elderly based on the experiences of daily living for the designers who design environment for elderly. Questionnaire survey was conducted to obtain data from 93 university students in their 20s majoring in housing and interior design who visited the Aging Simulation Center. The research findings showed that the recognition for design elements of residential environment for the elderly of respondents was changed toward positive way after visiting the Aging Simulation Center. The Aging Simulation Center was an effective educational environment for the preliminary designers to understand aging and the importance of appropriate design for users' needs. That is, aging simulation space can improve recognition of necessity of universally designed environment to support the elderly. Handrails around bathtub and wash basin, stair slope, electric auto-level controlled kitchen counter and kitchen cabinet were especially perceived for the respondents as very essential design elements to support the aged.

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Early Germination Response of Soybean Seed to Accelerated Aging and Low Dose Gamma Irradiation

  • Hwangbo, Jun-Kwon;Kim, Jae-Sung;Lim, Ji-Hyeok;Baek, Myung-Hwa;Chung, Byung-Yeoup;Kim, Jin-Hong
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.49 no.1
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    • pp.25-29
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    • 2004
  • The responses of soybean seeds were evaluated to accelerated aging and gamma irradiation with regard to germination, seed leakage, seed leachate component and dry weight of hypocotyl and primary root of the germinating seed. Accelerated aging significantly reduced the final germination rate while gamma irradiation increased the final germination rate. Furthermore, the interactive effects occurred that the final germination rate of 5-day aged seeds increased considerably in response to 4 Gy of gamma irradiation. The extent to which the electrolyte was leaked from the seeds (conductivity) was significantly affected by accelerated aging and showed a close negative correlation with the germination rate. Gamma irradiation, however, did not significantly affect the electrical conductivity of seed leachate. The accelerated aging significantly increased the concentrations of the particular electrolytes leaked from the seeds while the gamma irradiation did not affect those concentrations. Of the electrolytes leaked from the seeds, Ca and Mg showed relatively lower concentrations while K showed greater concentrations than others. Moreover, N and P showed similar responses to aging treatment. Aging treatment significantly affected dry weight (DW) of hypocotyls and primary root. Also, gamma irradiation decreased DW of hypocotyls and primary root, particularly for 8 Gy associated with 5 days aging treatment. The data were discussed in terms of the relationships of seed vigor with aging treatment and gamma irradiation.

The Investigation on Thermal Aging Characteristics of Oil-Paper Insulation in Bushing

  • Liao, Rui-jin;Hu, En-de;Yang, Li-jun;Xu, Zuo-ming
    • Journal of Electrical Engineering and Technology
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    • v.10 no.3
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    • pp.1114-1123
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    • 2015
  • Bushing is the key link to connect outer and inner insulating systems and also the essential electric accessory in electric power system, especially in the high voltage engineering (AC 1000kV, DC 800kV). This paper presented the experimental research of thermal aging characteristic of oil-paper insulation used in bushing. A thermally accelerated aging experiment at 90℃ was performed. The bushing models containing five layers of paper were sealed into the aging vessels and further aged for 250 days. Then several important parameters associated with the aging were observed and evaluated. The results showed that the degree of polymerization (DP) of papers gradually decreased. The DP values of outermost layer and middle layer fit well into the second-order kinematic model and first-order kinematic model, respectively. Less deterioration speed of the inter-layer paper than outer layer was confirmed by the variation of DP. Hydrolysis was considered as the main cause to this phenomenon. In addition, the logarithm of the furfural concentrations in insulation oil was found to have good linear relationship with DP of papers. Interestingly, when the aging time is about 250 days and DP is 419, the aging process reaches an inflection point at which the DP approaches the leveling off degree of polymerization (LODP) value. Both tanδ and acid number of oils increased, while surface and volume resistivity of papers decreased. The obtained results demonstrated that thermal aging and moisture absorbed in papers brought great influence to the degradation of insulating paper, leading to rapid decrease of DP and increase of the tanδ. Thus, the bushing should be avoided from damp and real-time monitoring to the variation of tanδ and DP values of paper is an effective way to evaluate the insulation status of bushing.

Effects of Thermal Aging of Natural Rubber Bearing on Seismic Performance of Bridges (천연고무받침의 열 노화가 교량 내진성능에 미치는 영향)

  • Oh, Ju;Jung, Hie-Young
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.3
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    • pp.855-864
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    • 2013
  • The dynamic characteristics of natural rubber bearings, which are used as isolator, are dependent on the main rubber's dynamic behaviors and nonlinear properties. Rubber materials tend to undergo an aging process under the influence of mechanical or environmental factors, so they inevitably end up facing damage. A main cause of aging like this is known to be oxidization, which occurs through the heat of reaction at high temperatures. Accordingly, in this study an accelerated thermal aging test was carried out in order to compare the characteristic values of the bearings before and after thermal aging occurs. As a result of this experiment, it was found that a thermal aging phenomenon could have some effects on shear stiffness, energy absorption, and equivalent damping coefficients of the bearings. Furthermore, a deterioration in the dynamic properties of the natural rubber bearings caused by the thermal aging was applied to an actual bridge and then the effects of such thermal aging on the seismic performance of the bridge were also compared and analyzed based on numerical analysis. As a result of this analysis, it was found that the changes in the basic properties of the natural rubber bearings caused by the thermal aging bring only a minor effect on the seismic performance of bridges.

Aging Workforce and Organizational Innovation: Curvilinearity and the Moderating Role of Age Diversity (고령화와 조직 혁신: 비선형성과 연령 다양성의 조절효과)

  • Park, Jisung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.6
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    • pp.440-446
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    • 2018
  • This study examines the contrasting effects of an aging workforce on organizational innovation and the moderating role of age diversity. By utilizing a knowledge-based view, this study asserts that an aging workforce can contribute to organizational innovation to some degree due to accumulated firm-specific knowledge and experiences as well as various social networks within and outside the firm. On the contrary, as the portion of an aging workforce increases, the negative effect of the aging workforce on organizational innovation can overwhelm the positive effects because of the limitations of new knowledge creation. In addition, this study explores the effect of age diversity to moderate the relationship between aging workforce and organizational innovation.Empirical findings showed that an aging workforce and organizational innovation had an inverted-U relationship, and age diversity moderated this curvilinear relationship as this study predicted. These theoretical arguments and empirical findings highlight the necessity to explore the complex effects of an aging workforce on organizational innovation as well as additional factors influencing the relationship between aging workforce and firm innovation.

AMOLED Aging Chamber Signal Generation and Heating System (AMOLED 에이징 챔버 신호 생성 및 가열 시스템)

  • Lee, Byungkwon;Cho, Kwanghee;Jung, Hoekyung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.6
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    • pp.861-866
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    • 2018
  • In OLED (Organic Light-Emitting Diode) manufacturing, the aging process increases the manufacturing efficiency and measures the correction value to correct the aging. The correction value for correcting the aging of the OLED can be applied to the driving signal. The OLED aging process measures the current after outputting the light for a predetermined time according to the preset driving signal and temperature. In the OLED manufacturing process, aging is applied for non-uniformity by deposition and temperature. This time has little effect on OLED efficiency reduction. Heating devices and signal generation systems are required to create the conditions necessary for aging. The results measured by the heating system and signal generation system can be used as a basis for evaluating power requirements, uniformity and efficiency in OLED manufacturing. In this paper, we propose and implement a configuration for interlocking the driving signal generation and heating system for practical OLED aging correction.