• Korean Journal of Pharmacognosy
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• v.25 no.1
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• pp.35-40
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• 1994

Aqueous extreact of fresh ginseng (AFG) was examined for the antigenicity in Hartley guinea pigs in comparision with ovalbumin (OVA). When guinea pigs were sensitized with AFG emulsified with complete Freund's adjuvant (CFA), these animals showed negative reactions in active systemic anaphylaxis (ASA), active cutaneous anaphylaxis (ACA) and passive cutaneous anaphylaxis (PCA) tests and passive hemagglutination (PHA) reaction. On the contrary, when guinea pigs were sensitized with OVA emulsified with CFA as positive controls, these animals disclosed positive reactions in ASA, ACA and PCA tests and PHA reaction. From these results, AFG was considered not to possess antigenic properties in guinea pigs. In addition, the dose levels of AFG empolyed in the present experiment were confirmed not to suppress immune reactions.

• Journal of The Korean Astronomical Society
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• v.29 no.spc1
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• pp.239-240
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• 1996

Precise masses, radii, and luminosities from eclipsing binaries and colour-magnitude diagrams for open clusters are classic tools in empirical tests of stellar evolution models. We review the accuracy and completeness required for such data to discriminate between current models and describe some recent. results with implications for convection theory.

• Advances in nano research
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• v.13 no.1
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• pp.63-75
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• 2022

The nonlinear dynamic behavior of a nonuniform small-scale nonlocal beam is investigated in this work. The nanobeam is theoretically modeled using the nonlocal Eringen theory, as well as a few of Von-nonlinear Kármán's theories and the classical beam theory. The Hamilton principle extracts partial differential equations (PDE) of an axially functionally graded (AFG) nano-scale beam consisting of SUS304 and Si₃N₄ throughout its length, and an elastic Winkler-Pasternak substrate supports the tapered AFG nanobeam. The beam thickness is a function of beam length, and it constantly varies throughout the length of the beam. The numerical solution strategy employs an iteration methodology connected with the generalized differential quadratic method (GDQM) to calculate the nonlinear outcomes. The nonlinear numerical results are presented in detail to examine the impact of various parameters such as nonlinear amplitude, nonlocal parameter, the component of the elastic foundation, rate of cross-section change, and volume fraction parameter on the linear and nonlinear free vibration characteristics of AFG nanobeam.

• Steel and Composite Structures
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• v.42 no.5
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• pp.599-615
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• 2022

In the present paper, the numerical dynamic analysis of a functionally graded nano-scale nonuniform tube was investigated according to the high-order beam theory coupled with the nonlocal gradient strain theory. The supposed cross-section is changed along the pipe length, and the material distribution, which combines both metal and ceramics, is smoothly changed in the pipe length direction, which is called axially functionally graded (AFG) pipe. Moreover, the porosity voids are dispersed in the cross-section and the radial pattern that the existence of both material distribution along the tube length and porosity voids make a two-dimensional functionally graded (2D-FG) truncated conical pipe. On the basis of the Hamilton principle, the governing equations and the associated boundary conditions equations are derived, and then a numerical approach is applied to solve the obtained equations.

• Steel and Composite Structures
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• v.42 no.5
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• pp.649-655
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• 2022

In presented paper, moving load problem of simply supported axially functionally graded (AFG) beam is investigated under temperature rising based on the first shear beam theory. The material properties of beam vary along the axial direction. Material properties of the beam are considered as temperature-dependent. The governing equations of problem are derived by using the Lagrange procedure. In the solution of the problem the Ritz method is used and algebraic polynomials are used with the trivial functions for the Ritz method. In the solution of the moving load problem, the Newmark average acceleration method is used in the time history. In the numerical examples, the effects of material graduation, temperature rising and velocity of moving load on the dynamic responses ofAFG beam are presented and discussed.

• Toxicological Research
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• v.27 no.2
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• pp.125-131
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• 2011

Through the present study, we produced a monoclonal antibody against aflatoxin B1 (AFB1) using AFB1-carboxymethoxylamine BSA conjugates. One clone showing high binding ability was selected and it was applied to develop a direct competitive ELISA system. The epitope densities of AFB1-CMO against BSA and KLH were about 1 : 6 and 1 : 545, respectively. The monoclonal antibody (mAb) from cloned hybridoma cell was the IgG1 subclass with ${\lambda}$-type light chains. The $IC_{50}s$ of the monoclonal antibody developed for AFB1, AFB2, AFG1 and AFG2 were 4.36, 7.22, 6.61 and 29.41 ng/ml, respectively, based on the AFB1-KLH coated ELISA system and 15.28, 26.62, 32.75 and 56.67 ng/ml, respectively, based on the mAb coated ELISA. Cross-relativities of mAb to AFB1 for AFB2, AFG1 and AFG2 were 60.47, 65.97 and 14.83% in the AFB1-KLH coated ELISA, and 59.41, 46.66 and 26.97% in the mAb coated ELISA, respectively. Quantitative calculations for AFB1 from the AFB1-Ab ELISA and AFB1-Ag ELISA ranged from 0.25 to 25 ng/ml ($R^2$ > 0.99) and from 1 to 100 ng/ml ($R^2$ > 0.99), respectively. The intra- and inter-assay precision CVs were < 10% in both ELISA assay, representing good reproducibility of developed assay. Recoveries ranged from 79.18 to 91.27%, CVs ranged from 3.21 to 7.97% after spiking AFB1 at concentrations ranging from 5 to 50 ng/ml and following by extraction with 70% methanol solution in the Ab-coated ELISA. In conclusion, we produced a group specific mAb against aflatoxins and developed two direct competitive ELISAs for the detection of AFB1 in feeds based on a monoclonal antibody developed.

• Structural Engineering and Mechanics
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• v.40 no.4
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• pp.583-594
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• 2011

In the present study, free vibration of an axially functionally graded (AFG) pile embedded in Winkler-Pasternak elastic foundation is analyzed within the framework of the Euler-Bernoulli beam theory. The material properties of the pile vary continuously in the axial direction according to the power-law form. The frequency equation is obtained by using Lagrange's equations. The unknown functions denoting the transverse deflections of the AFG pile is expressed in modal form. In this study, the effects of material variations, the parameters of the elastic foundation on the fundamental frequencies are examined. It is believed that the tabulated results will be a reference with which other researchers can compare their results.

• Structural Engineering and Mechanics
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• v.66 no.6
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• pp.703-711
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• 2018

In this paper is studied the effect of considering the theory of Timoshenko in the vibration of AFG beams that support ground masses. As it is known, Timoshenko theory takes into account the shear deformation and the rotational inertia, provides more accurate results in the general study of beams and is mandatory in the case of high frequencies or non-slender beams. The Rayleigh-Ritz Method is employed to obtain approximated solutions of the problem. The accuracy of the procedure is verified through results available in the literature that can be represented by the model under study. The incidence of the Timoshenko theory is analyzed for different cases of beam slenderness, variation of its cross section and compositions of its constituent material, as well as different amounts and positions of the attached masses.

• Journal of the Korean Society of Safety
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• v.11 no.4
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• pp.84-89
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• 1996

The Oxidation of aflatoxin $G_1$ ($AFG_1$) with ozone in chloroform solvent gave the stable ozonide into ozonization of the double bond in the terminal furan ring, and this reaction have been carried out for 3hr at -78. 5$^{\circ}C$. The chloroform solvent was removed in a stream of nitrogen and the residue was separated by elution chromatography(EC). The structure of this compound have been identified by using MS, $^1H-NMR$, $^l3C-NMR$ and I. R spectroscopy, respectively. This compound was formed the normal stable AFG$_1$-ozonide into spontaneous rearrangement after unstable ozonide according to sigmatropic rearrange ment dependent upon cyclo addition by ozone.

• Steel and Composite Structures
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• v.34 no.4
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• pp.511-524
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• 2020

In this research, a simple four-variable trigonometric integral shear deformation model is proposed for the static behavior of advanced functionally graded (AFG) ceramic-metal plates supported by a two-parameter elastic foundation and subjected to a nonlinear hygro-thermo-mechanical load. The elastic properties, including both the thermal expansion and moisture coefficients of the plate, are also supposed to be varied within thickness direction by following a power law distribution in terms of volume fractions of the components of the material. The interest of the current theory is seen in its kinematics that use only four independent unknowns, while first-order plate theory and other higher-order plate theories require at least five unknowns. The "in-plane displacement field" of the proposed theory utilizes cosine functions in terms of thickness coordinates to calculate out-of-plane shear deformations. The vertical displacement includes flexural and shear components. The elastic foundation is introduced in mathematical modeling as a two-parameter Winkler-Pasternak foundation. The virtual displacement principle is applied to obtain the basic equations and a Navier solution technique is used to determine an analytical solution. The numerical results predicted by the proposed formulation are compared with results already published in the literature to demonstrate the accuracy and efficiency of the proposed theory. The influences of "moisture concentration", temperature, stiffness of foundation, shear deformation, geometric ratios and volume fraction variation on the mechanical behavior of AFG plates are examined and discussed in detail.