• 생물정신의학
• /
• 제22권3호
• /
• pp.140-148
• /
• 2015

Objectives The aim of this study is to investigate the correlation between degenerative changes in brain [i.e., global cortical atrophy (GCA), medial temporal atrophy (MTA), white matter hyperintensities (WMH)] and neurocognitive dysfunction in Korean patients with Alzheimer's disease. Methods A total of 62 elderly subjects diagnosed with Alzheimer's disease were included in this study. The degenerative changes in brain MRI were rated with standardized visual rating scales (GCA or global cortical atrophy, MTA or medial temporal atrophy, and Fazekas scales) and the subjects were divided into two groups according to the degree of degeneration for each scale. Cognitive function was evaluated with Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) and several clinical features, including apolipoprotein E ${\varepsilon}4$ status, lipid profile and thyroid hormones, were also examined. Chi-square test and Fisher's exact test were performed to analyze the relationship between the degree of cerebral degeneration and neurocognitive functions. Results Demographic and clinical features, except for the age, did not show any significant difference between the two groups divided according to the degree of cerebral degenerative changes. However, higher degree of GCA was shown to be associated with poorer performance in verbal fluency test, word list recall test, and word list recognition test. Higher degree of MTA was shown to be associated with poorer performance in Mini-Mental State Examination in the Korean Version of CERAD Assessment Packet (MMSE-KC), word list recognition test and construction praxis recall test. Higher degree of white matter hyperintensities was shown to be associated with poorer performance in MMSE-KC. Conclusions Our results suggest that severe brain degeneration shown in MRI is associated with significantly poorer performance in neurocognitive tests in patients with Alzheimer's disease. Moreover, the degree of GCA, MTA and white matter hyperintensities, represented by scores from different visual rating scales, seems to affect certain neurocognitive domains each, which would provide useful information in clinical settings.

• 생물정신의학
• /
• 제14권4호
• /
• pp.241-248
• /
• 2007

Objectives : Schizophrenia is equally distributed in both sexes. However, later-onset, milder psychopathology, and better outcome are associated with the females. This reason is thought to be partly due to the estrogen system. Recently, it was suggested that estrogen receptor 1(ESR1) gene polymorphisms might affect the expression of ESR1 and were associated with several psychiatric disorders. Thus, we investigated the association between two single nucleotide polymorphisms(SNPs) in the ESR1 gene and Korean schizophrenic patients in this study. Methods : Genotype, allele, and haplotype frequencies of the two SNPs(rs 2234693 and rs 2228480) were analyzed between 218 Korean controls and 158 Korean schizophrenic patients. Also, age of onset and negative symptom scale scores according to genotypes were analyzed in the patients with schizophrenia. Results : There was a significant difference in allele frequencies of rs 2234693 between the schizophrenic patients and the controls(p=0.03). Genotype distributions(p=0.03) and allele frequencies(p=0.01) of rs 2234693 were significantly different between the female schizophrenic patients and the female controls. The frequency of TC-CC genotypes compared with TT genotype in the female schizophrenic patients was significantly higher than that in the female controls(OR=2.36). The mean age of onset in the schizophrenic patients with TC-CC genotypes was significantly lower than that in the patients with TT genotype. The frequency of rs 2234693C- rs 2228480G haplotype in the female schizophrenic patients was relatively higher than that in the female controls. Conclusions : These results of our study support the possibility that the ESR1 gene polymorphisms might be involved in the susceptibility of females to schizophrenia and play a role in sex difference of schizophrenia.

• The Korean Journal of Pain
• /
• 제18권2호
• /
• pp.165-170
• /
• 2005

Background: It is difficult to treat tourniquet-induced hypertension despite adequate anesthesia, and the mechanism of that is not known. And it may be possible that intraoperative continuous infusion of opioid induces preemptive analgesia postoperatively. We investigated the effect of intraoperative continuous i.v. fentanyl on tourniquet induced cardiovascular changes and postoperative preemptive analgesia in total knee replacements. Methods: Sixty patients were randomly assigned to two groups; In study group ($1.5{\mu}g/kg$ loading and $0.5{\mu}g/kg/hr$ continuous infusion of fentanyl before skin incision and tourniquet inflation) and control group (no treatment). Anesthesia was maintained with enflurane (1-2 MAC) and 50% nitrous oxide in oxygen. Arterial pressure and heart rate were compared between two groups. They received postoperative pain treatment with patient-controlled analgesia (PCA) with fentanyl during the postoperative 48 hours after total knee replacement. Visual analog scale (VAS) scores at either rest or movement were used to assess pain. Total fentanyl dose delivered, number of PCA requests, supplemental analgesics, overall satisfaction score and adverse events were evaluated. Results: There were no significant differences between the two groups on cardiovascular changes by tourniquet induced pain effect. VAS, PCA delivered dose and PCA demands at movement in the 24-48 hour decreased in study group compared with control group (P < 0.05). But there were no significant differences between the two groups on the other time periods except 24-48 hour's patient satisfaction and adverse events. Conclusions: We suggest that intraoperative continuous i.v. fentanyl infusion dose not affect cardiovascular change by tourniquet induced pain. But it may induce preemptive analgesia postoperatively.

• 한국농공학회지
• /
• 제29권3호
• /
• pp.125-137
• /
• 1987

The purpose of this paper is to examine some difficulties in water management of agricultural reservoirs in Korea, for there are approximately more than 15,000 reservoirs which are now being utilized for the purpose of irrigation, along with the much amount of expenses and labors to be invested against droughts and floods periodically occurred. Recently, the effective use of water resources in the agricultural reservoirs with a single purpose, is becomming multiple according to the alterable environment of water use. Therefore, the task to allocate agricultural water rationally and economically must be solved for the multiple use of agricultural reservoirs. On the basis of the above statement, this study aims at suggesting the rational method of water management by introducing an optimal technique to allocate the water in an existing agricultural reservoir rationally, for the sake of maximizing the economic effect. To achieve this objective, a reservoir, called "0-Bongje" as a sample of the case study, is selected for an agricultural water development proiect of medium scale. As a model for the optimum allocation of water in the multi-purpose use of reservoirs a linear programming model is developed and analyzed. As a result, findings of the study are as follows : First, a linear programing model is developed for the optimum allocation of water in the multi-purpose use of agricultural reservoirs. By adopting the model in the case of reservoir called "O-Bongje," the optimum solution for such various objects as irrigation area, the amount of domestic water supply, the size of power generation, and the size of reservoir storage, etc., can be obtained. Second, by comparing the net benefits in each object under the changing condition of inflow into the reservoir, the factors which can most affect the yearly total net benefit can be drawn, and they are in the order of the amount of domestic water supply, irrigation area, and power generation. Third, the sensitivity analysis for the decision variable of irrigation which may have a first priority among the objects indicate that the effective method of water management can be rapidly suggested in accordance with a condition under the decreasing area of irrigation. Fourth, in the case of decision making on the water allocation policy in an existing multi-purpose reservoir, the rapid comparison of numerous alternatives can be possible by adopting the linear programming model. Besides, as the resources can be analyed in connection with various activities, it can be concluded that the linear programing model developed in this study is more quantitative than the traditional methods of analysis. Fifth, all the possible constraint equations, in using a linear programming model for adopting a water allocation problem in the agricultural reservoirs, are presented, and the method of analysis is also suggested in this study. Finally, as the linear programming model in this study is found comprehensive, the model can be adopted in any different kind of conditions of agricultural reservoirs for the purpose of analyzing optimum water allocation, if the economic and technical coefficients are known, and the decision variable is changed in accordance with the changing condition of irrigation area.

• 한국측량학회지
• /
• 제23권3호
• /
• pp.303-312
• /
• 2005

본 연구에서는 l/5,000 항공사진을 12000pi와 6000pi로 자동독취한 영상에 대하여 저가의 PC 기반 수치사진 측량시스템을 사용하여 수치지도, DEM, 정사영상 등의 제작을 수행하고 다양한 방법으로 정확도를 비교 평가하였다. 비숙련자가 PC 기반 수치사진측량시스템을 사용하여 12004pi의 항공사진영상을 도화한 결과, 등고선 삽입은 불가능하였지만 이를 제외한 나머지 부분은 l/l,000 수준의 수치지도 제작 가능성을 나타냈으며, 자동 DEM 제작에 있어서는 자동독취 해상도 및 격자간격이 DEM의 정확도에 크게 영향을 미치지 않음을 알 수있었다. 정사영상의 제작에 있어서는 DEM의 격자간격이 커질수록 정확도가 저하되지만 그 차이는 크지 않았으며, 이보다는 원 영상의 자동독취 해상도가 정사영상의 품질에 더 큰 영향을 미치는 것을 알 수 있었다. 한편 동일한 검사점에 대하여 정사영상과 수치지도 제작 결과를 비교한 결과 정사영상의 정확도가 수치지도보다 더 좋게 나타나, 보다 다양한 분야에서 정사영상이 활용될 수 있을 것으로 판단되며, 향후 민간 부문에서 항공사진영상과 PC 기반 수치사진측량시스템이 GIS분야의 자료 수정 및 갱신에 적극적으로 활용될 수 있을 것으로 기대된다.

• 한국터널지하공간학회 논문집
• /
• 제20권3호
• /
• pp.640-655
• /
• 2018

최근 도심지 공사가 급증하여 기존 지하구조물의 상부에서 지반굴착 공사가 빈번하게 이루어지고 있다. 특히 지반굴착 후 구조물이 시공되는 경우 굴착 저면 하부 지반 내에서 하중 제하, 재하 과정이 반복되므로 기존 지하구조물에 영향을 미칠 수 있다. 따라서 지반굴착으로 인한 기존 지하구조물의 안정을 유지하기 위해서는 인접부에서의 굴착 및 구조물 하중에 의한 영향을 정확히 파악해야 한다. 본 연구에서는 기존터널 상부에 지반 굴착 및 신규 구조물 하중이 가해지는 경우를 실험적으로 구현하여 인접시공이 기존 터널에 미치는 영향을 파악하였다. 이를 위해 실제 크기의 1/5로 축소한 대형모형시험기를 제작하여 굴착저면과 터널 천단 간의 거리를 일정하게 유지한 체 지반굴착, 구조물 하중의 폭, 기존 터널 중심과 지반 굴착 저면 중심과의 이격거리에 따른 영향을 파악하였다. 연구 결과, 동일 하중 크기에 대하여 굴착 깊이가 깊어질수록 기존 터널에 더 큰 영향을 작용하는 것을 확인하였다. 동일 이격거리에서 기존 터널에 영향은 건물하중 폭 증가에 따라 터널 내공변위가 최대 3배까지 증가하는 것을 확인하였다. 건물하중 폭의 영향이 굴착 깊이보다 더 크게 나타났다. 또한 수평으로 이격하는 경우는 터널 중심에서 1.0D 이격되면 터널 천단변위가 48% 감소하는 것을 확인할 수 있었으며, 이로부터 기존 터널 상부에 터파기 시공 위치에 따른 영향이 가장 크게 발생하는 위치는 1.0D (D: 터널직경)인 것으로 확인하였다.

• 한국콘텐츠학회논문지
• /
• 제13권3호
• /
• pp.271-277
• /
• 2013

본 연구에서는 부산지역 H치과병원에 내원하고 있는 18세 이상의 환자 151명을 대상으로 자료를 분석하여 의료소비자의 치과진료기관 선택기준을 살펴봄으로써 향후 병원경영 및 이미지 향상에 기초자료로 제공하고자 하였다. 연구대상자의 성별 의료기관 선택 기준별 중요도 교차분석에서 청결위생(78.1%), 시설장비(60.9%), 경력입소문(57.6%), 의료진 친절(57.6%), 이용 편리성(32.5%), 기관 규모(22.5%)의 순으로 나타났고, 평균비교에서도 청결위생, 진료진 친절, 시설, 장비, 경력, 입소문 순으로 교차분석과 비슷하게 나타났으며, 연구대상자가 의료기관 선택 시 최우선적으로 고려하는 부분은 통증처치(31.8%), 감염관리(30.5%), 진료비(29.8%), 진료시간(7.9%)의 순이었다. 성별로 최우선적으로 고려하는 부분은 남자는 통증처치(39.2%), 여자는 진료비(39.1%)가 가장 많았다(p<0.001). 의료소비자의 치과의료기관 선택 시 청결위생상태 및 감염관리를 비중있게 생각하는 것으로 나타나 의료소비자의 의료기관 재 이용의사에도 어느 정도 영향을 주고 있으므로 이에 부응하기 위해 의료소비자를 만족시킬 수 있는 치과의료진의 청결위생과 감염관리의 인식과 실천이 필요할 것으로 사료된다.

• 대한환경공학회지
• /
• 제31권8호
• /
• pp.655-662
• /
• 2009

원통형 여과장치의 실규모 설계 및 운전에 필요한 기초자료를 얻기 위하여 산출유량을 단계적으로 증가시키는 파일럿 실험을 수행하면서 수질지표들과 폐색도 진행을 조사하였다. 유량을 0.8 L/min에서 2.4 L/min로 증가시키는 경우 BOD, SS, 그리고 탁도의 제거율은 각각 약 80%, 95% 이상, 그리고 90% 이상으로 거의 일정하게 유지되었으나 COD 제거율은 44%에서 29%로 감소하였다. 산출유량이 증가할수록 오염물 단위농도를 제거하는데 소요되는 체류시간은 감소하였으며, 1 mg-COD/L를 제거하는데 필요한 체류시간은 산출유량 0.8 L/min인 경우 83분이었고 2.4 L/min에서는 45분이어서 양수율이 낮은 것보다는 높은 것이 호소의 오염제거에 더 유리함을 알 수 있었다. 여과장치의 폐색은 표층에서 집수관쪽으로 진행하며, 산출유량이 증가하면 폐색도도 증가하지만 2년 이상의 운전에도 폐색이 문제되지는 않아 본 장치가 호소의 수질개선에 효과적으로 사용될 수 있을 것으로 기대되었다.

• 유통과학연구
• /
• 제14권5호
• /
• pp.91-96
• /
• 2016

Purpose - Although various studies have been conducted on the stress of service employees, there are still lack of studies regarding job stress and job satisfaction of call center workers. Especially there are quite few studies on the job stress according to employment type. This study focused on job stress and job satisfaction for call center employees and the correlation between the two factors and aimed to provide basic materials for seeking for the plans to reduce job stress and improve job satisfaction. Research design, data, and methodology - Frequency, percentage, and mean value were calculated through descriptive statistics in order to find out demographic characteristics, level of job stress, and job satisfaction. Differences in job stress according to employment type were calculated by using one-way ANOVA. Correlation between job stress and job satisfaction were identified through empirical analysis with Pearson's correlation coefficient. 150 materials were used for final analysis. The collected materials were analyzed to get statistics by using SPSS 20. Results - First, as for the job stress of call center workers, overall mean value was 2.54 in 4-point scales. Among the six sub-factors, job demands had the highest score, which was 2.67. Second, as for the job stress according to employment type, others showed higher score than mean value followed by contract job and full-time job in that order, in terms of job insecurity and organizational system. In terms of inappropriate remuneration, contract job showed higher score than mean value followed by others and full-time job. Third, as for the satisfaction with job, the mean value was 2.37 in 4-point scale and "very much satisfied" was only 3.3%. Lastly, in terms of job stress and job satisfaction, all sub-factors except for job demands showed significant correlation. The more job stress increased, the more job satisfaction decreased. Conclusions - First, as a result of analyzing job stress according to the employment type of call center workers, job stress increased more when the employment type was not full-time. Therefore, it was assumed that self-rescue efforts should be followed for effective employment management of call center business where contract employment takes most part as well as efforts to transfer them to full-time job. Second, decrease in job satisfaction of call center workers may affect the performance of an organization as well as service quality of the company providing the service. Therefore, various supports are required to decrease job stress and increase job satisfaction for call center workers through the expansion of rest area or break time. Third, I could recognize that there were lack of academic research on call center business in the whole service industry. Therefore, further research should be conducted more actively in the future. In particular, this study has special significance in the aspect that there were few studies on the job stress of call center workers according to employment type.

• 한국산학기술학회논문지
• /
• 제19권1호
• /
• pp.300-310
• /
• 2018

본 연구는 대학생들이 죽음학 강좌 수강 이전과 이후 웰다잉 인식과 결정이 어떻게 변화되었는가를 비교 연구하고자 한다. 대전광역시 소재 일개 대학교에서 죽음학 관련 교양강좌를 2016년 8월부터 12월까지 15주 동안 수강한 대학생 교육 전 93명, 교육 후 117명 대상으로 연구 참여 희망자에 한해 설문조사를 실시하였다. 설문구성은 일반적인 특성은 성별, 연령, 학년, 전공, 결혼상태, 종교, 가족 동거여부, 건강상태 8항목이었다. 죽음의 인식 측면에 관한 4항목, 죽음의 수용 측면 5항목, 죽음의 결정 측면 7항목, 죽음 교육의 관심도와 중요도 12항목을 리커트 척도로 구성하였다. 통계 검정법으로는 카이제곱검정, 독립표본 t-검정, 의사결정나무 분석을 실시하였다. 연구결과를 의사결정나무 토대로 종합해보면, 죽음 준비 시기가 죽음에 직면한 시기(암환자, 말기환자 등)와 노인(65세 이상)에서 교육 전이 66.7%로 나타났으나, 교육 후에는 성인과 중 고등학교, 초등학교 이하, 대학교, 대학원에서 교육 후가 65.3%로 나타났으며 이는 유의한 차이를 보였다. 따라서 죽음교육의 효과성과 죽음교육의 시기와 내용 등을 어떻게 구체화 시킬 것인가에 대한 방향 제시를 할 수 있을 것으로 기대되며, 초 중 고등학교, 대학교에서의 죽음교육 실시에 대한 부정적인 시각과 우려를 해소하고 죽음 교육이 학생들의 삶에 태도 변화에 긍정적인 영향을 미칠 것으로 사료된다.