• Journal of the Korean Chemical Society
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• v.19 no.2
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• pp.134-141
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• 1975

DL-1-aminoethylphosphonic acid(1-AEP) and DL-1-aminopropylphosphonic acid(1-APP) were synthesized from the propionic acid and butyric acid respectively using the modified cutius degradation. The following unreported derivatives containing peptide linkage were synthesized: N-phthalylglycyl-1-AEP, N-phthalyl-dl-alanyl-1-AEP, N-phthalyl-dl-phenylalanyl-1-AEP, N-phthalylglycyl-1-APP, N-tosylglycyl-1-AEP and N-tosyl-dl-alanyl-1-AEP These compounds were characterized and identified by means of elemental analysis, potentiometric titration, infrared spectroscopy and ninhydrin test.

• Journal of Preventive Medicine and Public Health
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• v.52 no.5
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• pp.316-322
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• 2019

Objectives: This study was conducted to assess the applicability of the Appropriateness Evaluation Protocol (AEP) for public hospitals in Korea. Methods: In May 2016, 1500 admission claims were collected from Korean public district hospitals using stratified random sampling. Of these claims, 560 admissions to 37 hospitals were retrieved for analysis. Medical records administrators determined the appropriateness of admission using the criteria detailed in the AEP, and a physician separately assessed the appropriateness of admission based on her clinical judgment. To examine the applicability of the AEP, the concordance of the decisions made between a pair of AEP reviewers and between an AEP reviewer and a physician reviewer was compared. Results: The results showed an almost perfect inter-rater agreement between the AEP reviewers and a moderate agreement between the AEP reviewers and the physician. The sensitivity and specificity of the AEP were calculated as 0.86 and 0.56, respectively. Conclusions: Our findings suggest that the AEP could potentially be applied to Korean public hospitals as a reliable and valid instrument for assessing the appropriateness of admissions.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.8
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• pp.94-102
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• 2013

We propose the mirror active element pattern (AEP) method for the radiation pattern computation of linear array antennas versus scan angles. The computation time for the radiation pattern of linear array antennas using the mirror AEP method is reduced by almost half compared to that using the AEP method because the number of AEPs of elements obtained by the full-wave simulation necessary for the radiation pattern computation of linear array antennas is reduced by almost half. The difference between the radiation patterns of linear array antennas obtained by the full-wave simulation and mirror AEP method is very small for wide scan angle range when the radiation pattern of an antenna element is symmetric.

• International Journal of Fluid Machinery and Systems
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• v.10 no.3
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• pp.264-273
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• 2017

In order to be able to predict the maximum Annual Energy Production (AEP) for tidal power plants, an AEP optimization tool based on Evolutionary Algorithms was developed by ANDRITZ HYDRO. This tool can simulate all operating modes of the units (bi-directional turbine, pump and sluicing mode) and provide the optimal plant operation that maximizes the AEP to the control system. For the Swansea Bay Tidal Power Plant, the AEP optimization evaluated all different hydraulic and operating concepts and defined the optimal concept that led to a significant AEP increase. A comparison between the optimal plant operation provided by the AEP optimization and the full load operating strategy is presented in the paper, highlighting the advantage of the method in providing the maximum AEP.

• Tuberculosis and Respiratory Diseases
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• v.45 no.4
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• pp.795-804
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• 1998

Background: Chronic eosinophilic pneumonia(CEP) is interstitial lung disease characterized by multiple infiltration on radiographic study, accumulation of eosinophils in the alveolar space and interstitium of the lung, chronic persistent symptoms and possible relapse. Acute eosinophilic pneumonia(AEP) is a recently described illness, characterized by rapid clinical course, acute respiratory insufficiency and no relapse. Method : To better characterize acute and chronic eosinophilic pneumonia, we studied the clinical and laboratory features of 16 patients(AEP : 7 patients, CEP : 9 patients), which were clinico-pathohistologically diagnosed and not to be associated with organic disorders producing peripheral blood eosinophilia. Results: The mean age was higher for patients with CEP than for patients with AEP ($55.4{\pm}15.1$ vs. $24.6{\pm}7.9$ years, p<0.05). High fever(above $38^{\circ}C$) was presented in all patients of AEP and in one patient(11%) of CEP. All patients of AEP and eight patients (89%) of CEP showed bilateral pulmonary infiltrates, and 6 patients(86%) of AEP and 2 patients(22%) of CEP showed pleural effusion in chest radiograph. The mean white blood cell count of AEP and CEP were $17,186/mm^3$ and $12,867/mm^3$, respectively. The mean peripheral blood eosinophil count of AEP and CEP were $939/mm^3$ and $2,104/mm^3$, respectively. The mean eosinophil fraction of BAL fluid of AEP and CEP were 32.4% (range: 18~47%) and 35.8% (range: 15.3~88.2%), respectively. The mean $PaO_2$ was lower for patients with AEP than for patients with CEP ($44.1{\pm}15.5$ vs. $62.7{\pm}6.9$mmHg, p<0.05). All patients of AEP and CEP were initially treated with antibiotics. All patients of CEP and one patients of AEP were finally required systemic steroid therapy. 6 patients of AEP were improved without steroid therapy. Relapse was observed in 3 patients(33%) of CEP. Conclusion : Compair with of chronic eosinophilic pneumonia, acute eosinophilic pneumonia was characterized by relatively young age, acute onset, high fever, severe hypoxemia, diffuse pulmonary infiltrates with pleural effusion, steroid therapy is effective but spontaneous improvement with conservative therapy was frequent.

• Journal of Nutrition and Health
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• v.2 no.4
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• pp.173-181
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• 1969

Since 1959 ${\beta}-aminoethylphosphonic$ acid was discovered in the living organism, the biosynthesis and biological functions of aminophosphonic acids have been extensively studied. The author designed and carried out this study for 14 weeks to find out the metabolic function of Ethylaminophosphonic acid (AEP) and it's utilization in the living body. Sixty rats, thirty males and thirty females aged $40{\pm}5$ days were divided into two parts, one for alanine supplemented as control group and the other for AEP as experimental group to compare metabolic pathway of ordinary amino acid with that of AEP. Both alamine and AEP group were divived into two subgroups according to the level of supplements, 0.1% and 0.2% of the diet. The major components of the diet in this study were composed of 20% casein, 72% Sugar, 4% fat, 4% salt Mixture, and all kind of Uitamins in adeguate amount. For comparision of biological values between experimental and control group in terms of body weight, uninary nitrogen, creatinine excretion and final orgam weight, there were no statically significant difference in these respects. This meant AEP could be utilized in the body as much as alanine could. Urinary phosphorus excretion was determined by developing the blue color to read on the Spectronic 20. Statistically insignificance in the urinary phosphorus excretion between experimental and control group was observed in spite of the supplementation of phosphorus of AEP for experimental group in the diet. The level of blood phosphorus was higher in experimental group than that in control group this result supported above result. In the analysis of fat and nitrogen contents in the liver, AEP group showed slightly higher than control in both respects. But it was noteworthy 0.2% AEP group in both sex were higher than 0.1% AEP in liver fat content. Histological examinal of internal organs liiver, lung, spleen, heart, kindey, adrenal and sex organs showed no changes in all groups included in this study. The group supplemented higher level of diet. by alanine 0.2% and AEP 0.2% stayed on less body weight gain and lower liver weight. This result could be interpreted that amino acid imbalanced condition was arose in the body.

• Tuberculosis and Respiratory Diseases
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• v.78 no.3
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• pp.232-238
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• 2015

Background: A relationship between low vitamin D levels and the development or outcomes of respiratory diseases has been identified. However, there is no data on the vitamin D status in patients with acute eosinophilic pneumonia (AEP). We evaluated the vitamin D status in patients with AEP among South Korean military personnel. Methods: We prospectively compared the serum levels of total 25-hydroxyvitamin D [25(OH)D], 25(OH)D3, and 25(OH)D2 among patients with AEP, pulmonary tuberculosis (PTB), and community-acquired pneumonia (CAP). Results: In total, 65 patients with respiratory diseases, including AEP (n=24), PTB (n=19), and CAP (n=22), were identified. Of the 24 patients with AEP, 2 (8%) had deficient total 25(OH)D levels (<10 ng/mL), 17 (71%) had insufficient total 25(OH)D levels (${\geq}10$ to <30 ng/mL), and only 5 (21%) had sufficient total 25(OH)D levels (${\geq}30$ to <100 ng/mL). The difference in the total 25(OH)D levels among patients with AEP, PTB, and CAP was not statistically significant (p=0.230). The median levels of total 25(OH)D, 25(OH)D3, and 25(OH)D2 were 22.84, 22.84, and 0.00 ng/mL, respectively, and no differences in the 25(OH)D level were present among patients with AEP, PTB, and CAP with the exception of the total 25(OH)D level between patients with AEP and PTB (p=0.042). Conclusion: We have shown that low vitamin D levels are frequently found in patients with AEP and are comparable with those in patients with PTB and CAP.

• Journal of electromagnetic engineering and science
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• v.18 no.3
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• pp.175-181
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• 2018

The array patterns of a patch array antenna were calculated using an active element pattern (AEP) method that considers ground edge effects. The classical equivalent radiation model of the patch antenna, which is characterized by two radiating slots, was adopted, and the AEPs that include mutual coupling were precisely calculated using full-wave simulated S-parameters. To improve the accuracy of the calculation, the edge diffraction of a ground plane was incorporated into AEP using the uniform geometrical theory of diffraction. The array patterns were then calculated on the basis of the computed AEPs. The array patterns obtained through the conventional AEP approach and the AEP method that takes ground edge effects into account were compared with the findings derived through full-wave simulations conducted using a High Frequency Structure Simulator (HFSS) and FEKO software. Results showed that the array patterns calculated using the proposed AEP method are more accurate than those derived using the conventional AEP technique, especially under a small number of array elements or under increased steering angles.

• Journal of the Korean Solar Energy Society
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• v.36 no.2
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• pp.9-17
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• 2016

In order to examine how accurately the wind farm design software, WindPRO and Meteodyn WT, predict annual energy production (AEP), an investigation was carried out for Seongsan wind farm of Jeju Island. The one-year wind data was measured from wind sensors on met masts of Susan and Sumang which are 2.3 km, and 18 km away from Seongsan wind farm, respectively. MERRA (Modern-Era Retrospective Analysis for Research and Applications) reanalysis data was also analyzed for the same period of time. The real AEP data came from SCADA system of Seongsan wind farm, which was compare with AEP data predicted by WindPRO and Meteodyn WT. As a result, AEP predicted by Meteodyn WT was lower than that by WindPRO. The analysis of using wind data from met masts led to the conclusion that AEP prediction by CFD software, Meteodyn WT, is not always more accurate than that by linear program software, WindPRO. However, when MERRA reanalysis data was used, Meteodyn WT predicted AEP more accurately than WindPRO.

• Tuberculosis and Respiratory Diseases
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• v.58 no.5
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• pp.515-520
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• 2005

Acute eosinophilic pneumonia (AEP) has been described as an idiopathic febrile illness with a duration of less than seven days with severe hypoxemia, pulmonary infiltrates, and no history of asthma. It has been reported that AEP is associated with smoking. Although the pathogenesis of smoking induced AEP is being actively studied, there is no direct histological evidence that smoking actually induces AEP. Recently, we encountered a case of AEP that may have been caused by smoking. We performed a cigarette smoking challenge test to verify that smoking was indeed the cause of AEP in this patient. Smoking induced an increase the proportion of eosinophils in the bronchoalveolar lavage fluid without any respiratory symptoms or abnormal radiological findings. This result suggests that smoking was the cause of AEP in this patient.