• Radiation Oncology Journal
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• v.26 no.2
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• pp.126-130
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• 2008

Avascular necrosis(AVN) is a disease characterized by the temporary or permanent loss of the blood supply to the bones, resulting from many possible causes, including radiation therapy. The femoral head is known to be the most common site of AVN. The authors encountered two cases of AVN of the femoral head among 557 patients with cervical cancer treated with whole pelvic radiation therapy at the Samsung Medical Center. AVN of the femoral head was presented with a sclerotic density change in a plain roentgenography and a decreased signal intensity lesion on the T1 and T2 weighted phases of a magnetic resonance image(MRI). Although it is a very rare complication after whole pelvic radiation therapy, AVN of the femoral head should be considered when characteristic imaging findings appear on follow-up examinations.

• Nutrition Research and Practice
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• v.11 no.2
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• pp.90-96
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• 2017

BACKGROUND/OBJECTIVES: Although the antioxidative effects of lycopene are generally known, the molecular mechanisms underlying the anti-inflammatory properties of lycopene are not fully elucidated. This study aimed to examine the role and mechanism of lycopene as an inhibitor of inflammation. METHODS/MATERIALS: Lipopolysaccharide (LPS)-stimulated SW 480 human colorectal cancer cells were treated with 0, 10, 20, and $30{\mu}M$ lycopene. The MTT assay was performed to determine the effects of lycopene on cell proliferation. Western blotting was performed to observe the expression of inflammation-related proteins, including nuclear factor-kappa B ($NF-{\kappa}B$), inhibitor kappa B ($I{\kappa}B$), mitogen-activated protein kinase (MAPK), extracellular signal-related kinase (ERK), c-jun NH2-terminal kinase (JNK), and p38 (p38 MAP kinase). Real-time polymerase chain reaction was performed to investigate the mRNA expression of tumor necrosis factor ${\alpha}$ ($TNF-{\alpha}$), interleukin-1 beta ($IL-1{\beta}$), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). Concentrations of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) were determined via enzyme-linked immunosorbent assays. RESULTS: In cells treated with lycopene and LPS, the mRNA expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05). The concentrations of $PGE_2$ and NO decreased according to the lycopene concentration (P < 0.05). The protein expressions of $NF-{\kappa}B$ and JNK were decreased significantly according to lycopene concertation (P < 0.05). CONCLUSIONS: Lycopene restrains $NF-{\kappa}B$ and JNK activation, which causes inflammation, and suppresses the expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.10
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• pp.601-609
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• 2014

This paper proposes a resource allocation scheme suitable for D2D communications in multi-cell environment. In order to solve the inter-cell interference, the proposed scheme allocates the pre-assigned resource group and shares the information with neighbor cells. This paper also proposes a power control scheme for D2D communication to enhance the cell throughput. By the simulation results, the average SINR of the cellular uplink and D2D communication link are mostly higher than 10 dB when the proposed scheme is applied. On the other hand, with the inter-cell non-coordinated resource allocation scheme, the average SINR of the D2D communication link are decreased by 0 dB. In addition, the proposed scheme can enhance the cell throughput up to 8 % compared with the inter-cell non-coordinated resource allocation scheme.

• Korean Journal of Optics and Photonics
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• v.15 no.5
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• pp.415-422
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• 2004

We propose and present a new multiplexed bend loss type single-mode fiber-optic sensor system for displacement measurement in order to measure the displacement of several mm of civil engineering structures such as bridges and buildings. We make a bend loss type fiber-optic sensor for measuring displacements using the signal difference between two reflection signals due to various bend losses generating at a pair of optical connectors by using the optical time domain reflectometer. And we fabricate a multiplexed bend loss type fiber-optic sensor detecting linear displacements of 4 measuring positions of an object by setting these new 4 fiber-optic sensors on a single mode fiber simultaneously. We find that the multiplexed fiber-optics displacement sensor has linearity of 0.9942, maximum displacement of 6 mm, and accuracy of 6% for 4 measuring points.

• Bulletin of the Korean Chemical Society
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• v.34 no.10
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• pp.2900-2904
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• 2013

We present the synthesis and characterization of DTPA-bis(histidylamide) (1a), DTPA-bis(aspartamide) (1b), and their gadolinium complexes of the type $[Gd(L)(H_2O)]$ (2a:L = 1a; 2b:L = 1b). Thermodynamic stabilities and $R_1$ relaxivities of 2a-b compare well with Omniscan$^{(R)}$, a well-known commercial, extracellular (ECF) MRI CA which adopts the DTPA-bis(amide) framework for the chelate: $R_1$ = 5.5 and 5.1 $mM^{-1}$ for 2a and 2b, respectively. Addition of the Cu(II) ion to a solution containing 2b triggers relaxivity enhancement to raise $R_1$ as high as 15.3 $mM^{-1}$, which corresponds to a 300% enhancement. Such an increase levels off at the concentration beyond two equiv. of Cu(II), suggesting the formation of a trimetallic ($Gd/Cu_2$) complex in situ. Such a relaxivity increase is almost negligible with Zn(II) and other endogenous ions such as Na(I), K(I), Mg(II), and Ca(II). In vivo MR images and the signal-to-noise ratio (SNR) obtained with an aqueous mixture of 2b and Cu(II) ion in an 1:2 ratio demonstrate the potentiality of 2 as a copper responsive MRI CA.

• Molecules and Cells
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• v.19 no.1
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• pp.60-66
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• 2005

Low density lipoproteins (LDL) play important roles in the pathogenesis of atherosclerosis. Diabetes is associated with accelerated atherosclerosis leading to cardiovascular disease in diabetic patients. Although LDL stimulates the proliferation of arterial smooth muscle cells (SMC), the mechanisms are not fully understood. We examined the effects of native LDL and glycated LDL on the extracellular signal-regulated kinase (ERK) pathway. Addition of native and glycated LDL to rat aorta SMCs (RASMCs) stimulated ERK phosphorylation. ERK phosphorylation was not affected by exposure to the $Ca^{2+}$ chelator BAPTA-AM but inhibition of protein kinase C (PKC) with GF109203X, inhibition of Src kinase with PP1 ($5{\mu}M$) and inhibition of phospholipase C (PLC) with U73122/U73343 ($5{\mu}M$) all reduced ERK phosphorylation in response to glycated LDL. In addition, pretreatment of the RASMCs with a cell-permeable mitogen-activated protein kinase kinase (MEK) inhibitor (PD98059, $5{\mu}M$) markedly decreased ERK phosphorylation in response to native and glycated LDL. These findings indicate that ERK phosphorylation in response to glycated LDL involves the activation of PKC, PLC, and MEK, but is independent of intracellular $Ca^{2+}$.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.4 s.107
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• pp.341-350
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• 2006

In this paper, a new method for detecting breast cancer is proposed, which utilizes dielectric characteristics of pathological tissues and time delay of back scattered response, and its feasibility was investigated. We have developed a detection algorithm and verified it by numerical simulation and measurement for a prototype system. For a prototype system, we have fabricated experimental model(artificial breast with a cancer) and UWB(ultra-wideband) antenna. The results of the measurement simulation show an excellent detection capability of a cancer tissue. It is found that a good UWB antenna and a good calibration signal are key elements of such detection system. Further study is ongoing to develop a commercial system.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.10
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• pp.1137-1146
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• 2008

OFDM is very effective for the high speed communication system. However, OFDM has the problems of high PAPR and serious ICI, which is different from the single carrier system. Especially, ICI problem caused by phase noise, Doppler effect and frequency offset is main reason for poor performance since it breaks down the orthogonality between subcarriers in OFDM communication system. Therefore, WFMT modulation scheme is studied and the effect of the carrier frequency offset and phase noise is analyzed. WFMT modulation scheme is based on the wavelet theory and complex filter banks for synthesis and analysis of multichannel signal. WFHT modulation scheme keeps on the advantage of filter banks system and can be easily possible for the implementation of filter banks. In this paper, we compare ISI and ICI distortions of the WFMT and OFDM system due to the carrier frequency offset and phase noise. Also, we analyze the PAPR and BER performances in the HPA and ICI situation caused by the Doppler frequency shift and the frequency offset.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.10
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• pp.69-75
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• 2008

This paper presents an algorithm robust to error for estimating partial discharge (PD) location using acoustic emission sensors. In operating transformers, the velocity computing of the acoustic signal is difficult because the temperature of the Insulation oil is not homogeneous. So, some error occurs in the process. Therefore, the algorithm estimating PD location must consider this error to provide maintenance person with useful information. The conventional algorithm shows the PD position as a point, while the new algorithm using LookUp-Table(LUT) shows PD position as error-map visually. The error-map is more useful than the conventional result because of robustness to error. Also, we compared performance of them, by adding error to data on purpose.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.959-962
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• 2005

Servomotors are used as key components of automated system by performing accurate positioning, accurate speed regulation, and precise motion control in response to commands from computers and sensors. Especially linear brushless servomotors have numerous advantages over ball screws, timing belts, rack/pinion drives and friction drives compared with rotary servomotors. This paper proposes the estimation of unknown parameters from the linear brushless DC motor which is operated by sinusoidal commutation. The estimated parameters are used to tune the controller gain and disturbance observer. In order to agree with this purpose, Digital Signal Processor(TMS320F240), developed for implementation of a speed Field Oriented Control(FOC), adopted in this study. The processor playing an important role in controller has A/D converters, PWM generators, riched I/O port internally.