• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.284-284
• /
• 1994

Pentazocine은 opioid 수용체에 대한 흥분작용과 길항작용을 겸유한 opioid계 약물로 알려져 있다. 본 연구에서 흰쥐 적출 관류부신 으로 부터 pentazocine의 catecholamine (CA) 분비작용을 관찰하여 그 기전을 규명하고 또한 다른 opioid의 작용과 비교하여 얻어진 결과는 다음과 같다. Pentazocine (30-300$\mu\textrm{g}$)을 부신정맥내에 주사하였을때 현저한 용량 의존성의 CA 분비 작용을 나타내었다. Pentazocine의 이러한 CA 분비작용은 chlorisondamine ($10^{-6}$M), naloxone (1.22 $\times$ $10^{-7}$M), morphine (1.73 $\times$ $10^{-5}$M). enkephalin (9.68 $\times$$10^{-6}$M), nicardipine ($10^{-6}$M) 및 TMB-8 ($10^{-5}$M)등의 전처치로 뚜렷이 억제되었으나 pirenzepine (2 $\times$ $10^{-6}$M)의 전처치에 의해서는 영향을 받지 않았다. $Ca^{++}$-free Krebs 용액으로 30분간 관류한 후에 pentazocine의 CA 분비작용은 현저한 감소를 나타내었다. Pentazocine (1.75 $\times$ $10^{-4}$M)을 20분간 관류시킨 후에 ACh (5.32 $\times$ $10^{-3}$M)과 DMPP ($10^{-4}$M)에 의한 CA 분비작용이 의의있게 감약되었다.

• Korean Journal of Pharmacognosy
• /
• v.19 no.2
• /
• pp.102-110
• /
• 1988

The pharmacological activities on water extracts of Cortex, Ramulus and Folium from the Eucommia ulmoides Oliver were studied, and the following results were observed. The vasodilative action on the rabbit ear blood vessel was recognized in the Cortex, Ramulus and Folium. The spontaneous motility and the contraction induced by Ach., $BaCl_2$ and histamine in the isolated ileum of mice were suppressed and inhibited in the Ramulus only. On the contrary, the analgesic and anti-inflammatory activities were noted in the Cortex and Folium. Furthermore, the hypotensive effect was recognized in the Folium. The diuretic, bile secretory and anti-fatigue effects were shown in the Cortex and Folium.

• Architectural research
• /
• v.9 no.2
• /
• pp.37-45
• /
• 2007

The proliferation of the House Dust Mite(HDM) is affected by temperature, humidity, ventilation, etc. Measuring temperature and humidity was performed at the very location where dust samplings take place and where they live in reality together with temperature and humidity of the ambient of the room. There has been discussion over the key environment factor of HDM survival; absolute humidity or relative humidity. It seems that relative humidity is the more important determinant for the mite's survival through the analysis of previous studies. Temperature, humidity, ventilation rate and Der P1 were measured in 4 flats in London. Mite allergen was detected in every house. Levels of Der P1 varied between <100ng/g and 22,778ng/g. Flats with high relative humidity(>50%) and poor ventilation(<0.5ach) showed higher levels of mite allergen than flats with lower humidity and adequate air change rate. Questionnaire survey was conducted and the result helped to confirm the findings from monitoring of environmental factors and the dust sampling.

• The Korean Journal of Physiology and Pharmacology
• /
• v.13 no.1
• /
• pp.55-59
• /
• 2009

Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor($h{\alpha}4{\beta}2$ and $h{\alpha}3{\beta}4$) agonists was studied using comparative molecular field analysis(CoMFA) and comparative molecular similarity indices analysis(CoMSIA). From 11 CoMFA and CoMSIA models, CoMSIA with steric and electrostatic fields gave the best predictive models($q^2=0.926$ and 0.945, ${r^2}_{ncv}=0.983$ and 0.988). This study can be used to develop potent $h{\alpha}4{\beta}2$ receptor agonists with low activity on $h{\alpha}3{\beta}4$ subtype.

• Mycobiology
• /
• v.40 no.4
• /
• pp.225-230
• /
• 2012

This study illustrates the status of thelotremoid Graphidaceae in South Korea. The taxonomy and systematics of thelotremoid lichens in the country have recently advanced greatly. Following the earlier known taxa from the group, four new records of the genus Thelotrema are reported and described briefly. An artificial key for all known species under thelotremoid group of Graphidaceae from South Korea is also provided.

• Mycobiology
• /
• v.42 no.2
• /
• pp.120-131
• /
• 2014

Leptogium (Ach.) Gray is distributed throughout South Korea; however, for nearly two decades no detailed taxonomic or revisionary research on this lichen genus has been conducted. This study examined the specimens deposited in the lichen herbarium at the Korean Lichen Research Institute, and samples were identified using descriptions recently published in the scientific literature. In this revisionary study, a total of fourteen species of Leptogium were documented, including new records of Leptogium delavayi Hue, Leptogium denticulatum Nyl., and Leptogium trichophoroides P. M. J${\o}$rg. & A. K. Wallace. Detailed descriptions of each species are given, including their morphological, anatomical, and chemical characteristics. A key to all Leptogium species known to occur in South Korea is also presented.

• KIEAE Journal
• /
• v.7 no.4
• /
• pp.51-56
• /
• 2007

This study focuses on developing natural ventilation system which is able to satisfy the good indoor air quality and air speed. The natural ventilation system developed in this study is for double window façade and it has two operation modes for summer and winter. Operational sections of the devices have been analyzed by CFD simulation to calculate discharge coefficients of openings and estimated indoor air speed. For the analysis of the appropriate installation area ratio for each room and the optimum installation area, TRNFLOW simulation has been used. As the results, we could see that the natural ventilation system can provide the similar pollutant removal performance to 0.7 ACH of mechanical ventilation with appropriate installation area and installation area ratio.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.18 no.6
• /
• pp.1439-1447
• /
• 1994

Test results of friction-factor for the flow of air in a narrow channel lined with various honeycomb geometries show that, generally, the friction-factor is nearly constant or slightly decreases as the Reynolds number(or Mach number) increases, a characteristic common to turbulent flow in pipes. However, in some test geometries this trend is remarkably different. The friction factor dramatically drops and then rises as the Mach number increases. This phenomenon can be characterized as a "friction-factor jump." Further investigations of the acoustic spectrum indicate that the "friction-factor jump" phenomenon is accompanied by an onset of a normal mode resonance excited coherent flow fluctuation structure, which occurs at Reynolds number of the order of $10^4$. New empirical friction-factor model for "friction-factor jump" cases is developed as a function of Mach number and local pressure.ach number and local pressure.

• Journal of Advanced Marine Engineering and Technology
• /
• v.30 no.2
• /
• pp.260-266
• /
• 2006

A tracer gas technique based on ASTM Standard E741-83 was used to measure ventilation performances in a model chamber ($0.84m{\times}0.68m{\times}0.7m$) with an exhaust fan and a supply fan. Experiments were performed for the ventilation effectiveness on three types of mechanical ventilation systems. For all cases. higher ventilation effectiveness was found in the type to ventilation system due to shorter residual time of air compared to type 1 and type 3.

• Korean Journal of Pharmacognosy
• /
• v.34 no.4 s.135
• /
• pp.318-323
• /
• 2003

Extracts of Black cohosh (Cimicifugae rhizoma) have been used for the treatment of climacteric complaints for decades. A significant number of woman entering menopause exhibit the following symptoms: getting hot flushes, night sweats, irritability, depression, and anxiety, A reduction of the frequency of hot flushes equivalents and hints on the antidepressant activity of Cimcifuga extracts. In the present work, we have screened several 80% ethanol extracts from medicinal plants and found that the extracts from Cimicifugae Rhizoma(Black cohosh:승마) have inhibitory effect on catecholamine secretion in bovine chromaffin cell. Since this extract inhibited 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)-induced catecholamine secretion, but did not inhibit KCl, bradykinin, and veratridine-evoked case, this inhibitory effect is mediated by nicotinic acetylcholine receptors with noncompetitive manner.