• Title/Summary/Keyword: ACLD

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Prediction of Decompensation and Death in Advanced Chronic Liver Disease Using Deep Learning Analysis of Gadoxetic Acid-Enhanced MRI

  • Subin Heo;Seung Soo Lee;So Yeon Kim;Young-Suk Lim;Hyo Jung Park;Jee Seok Yoon;Heung-Il Suk;Yu Sub Sung;Bumwoo Park;Ji Sung Lee
    • Korean Journal of Radiology
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    • v.23 no.12
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    • pp.1269-1280
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    • 2022
  • Objective: This study aimed to evaluate the usefulness of quantitative indices obtained from deep learning analysis of gadoxetic acid-enhanced hepatobiliary phase (HBP) MRI and their longitudinal changes in predicting decompensation and death in patients with advanced chronic liver disease (ACLD). Materials and Methods: We included patients who underwent baseline and 1-year follow-up MRI from a prospective cohort that underwent gadoxetic acid-enhanced MRI for hepatocellular carcinoma surveillance between November 2011 and August 2012 at a tertiary medical center. Baseline liver condition was categorized as non-ACLD, compensated ACLD, and decompensated ACLD. The liver-to-spleen signal intensity ratio (LS-SIR) and liver-to-spleen volume ratio (LS-VR) were automatically measured on the HBP images using a deep learning algorithm, and their percentage changes at the 1-year follow-up (ΔLS-SIR and ΔLS-VR) were calculated. The associations of the MRI indices with hepatic decompensation and a composite endpoint of liver-related death or transplantation were evaluated using a competing risk analysis with multivariable Fine and Gray regression models, including baseline parameters alone and both baseline and follow-up parameters. Results: Our study included 280 patients (153 male; mean age ± standard deviation, 57 ± 7.95 years) with non-ACLD, compensated ACLD, and decompensated ACLD in 32, 186, and 62 patients, respectively. Patients were followed for 11-117 months (median, 104 months). In patients with compensated ACLD, baseline LS-SIR (sub-distribution hazard ratio [sHR], 0.81; p = 0.034) and LS-VR (sHR, 0.71; p = 0.01) were independently associated with hepatic decompensation. The ΔLS-VR (sHR, 0.54; p = 0.002) was predictive of hepatic decompensation after adjusting for baseline variables. ΔLS-VR was an independent predictor of liver-related death or transplantation in patients with compensated ACLD (sHR, 0.46; p = 0.026) and decompensated ACLD (sHR, 0.61; p = 0.023). Conclusion: MRI indices automatically derived from the deep learning analysis of gadoxetic acid-enhanced HBP MRI can be used as prognostic markers in patients with ACLD.

A Comparison of the ASHRAE Simplified Energy Analysis Procedure with the HASP/ACLD Results (간이 에너지 계산법과 동적 열부하 계산법의 비교 연구)

  • Kim, D.C.;Choi, J.H.;Won, Y.S.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.1 no.3
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    • pp.210-218
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    • 1989
  • The ASHRAE Simplified Energy Analysis Procedure using the Modified Bin Method(SEAP) is compared with the hourly calculation program, HASP/ACLD. The HASP/ACLD model office building with VAV system in Seoul is used as the basis for comparison. And the parameters considered are glass to wall area ratio and internal heat gains. The results show that SEAP predictions of annual energy use agree with HASP/ACLD predictions within 5% deviation. But there is a large difference in cooling and heating energy as glass to wall area ratio is varied. The SEAP cooling energy is 65-85% and the heating energy is 104-160% of the HASP/ACLD results. This is probably due to the solar heat gain data. the data related to the SEAP must be developed prior to use it.

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Vibration Characteristic Study of Arc Type Shell Using Active Constrained Layer Damping (능동 구속감쇠층을 이용한 아크형태 셸 모델에 대한 진동특성 연구)

  • 고성현;박현철;황운봉;박철휴
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.14 no.3
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    • pp.193-200
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    • 2004
  • The Active Constrained Layer Damping(ACLD) combines the simplicity and reliability of passive damping with the low weight and high efficiency of active control to attain high damping characteristics. The proposed ACLD treatment consists of a viscoelastic damping which is sandwiched between an active piezoelectric layer and a host structure. In this manner, the smart ACLD consists of a Passive Constrained Layer Damping(PCLD) which is augmented with an active control in response to the structural vibrations. The arc type shell model is introduced to describe the interactions between the vibrating host structure, piezoelectric actuator and viscoelastic damping. The system is modeled by applying ARMAX model and changing a state-space form through the system identification method. An optimum control law for the piezo actuator is obtain by LQR(Linear Quadratic Regulator) method. The performance of the ACLD system is determined and compared with PCLD in order to demonstrate the effectiveness of the ACLD treatment. Also, the actuation capability of a piezo actuator is examined experimentally by varying thickness of viscoelastic material(VEM).

Vibration Control of Arc Type Shell using Active Constrained Layer Damping (능동 감쇠층을 이용한 아크형태 쉘 모델에 대한 진동특성 연구)

  • 고성현;박현철;박철휴;황운봉
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2002.05a
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    • pp.1032-1038
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    • 2002
  • The Active Constrained Layer Damping(ACLO) combines the simplicity and reliability of passive damping with the low weight and high efficiency of active control to attain high damping characteristics. The proposed ACLD treatment consists of a viscoelastic damping which is sandwiched between an active piezoelectric layer and a host structure. In this manner, the smart ACLD consists of a Passive Constrained Layer Damping(PCLD) which is augmented with an active control in response to the structural vibrations. The Arc type shell model is introduced to describe the interactions between the vibrating host structure, piezoelectric actuator and visco damping, The system is modeled by applying ARMAX model and changing a state-space form through the system identification method. An optimum control law for piezo actuator is obtain by LQR(Linear Quadratic Regulator) Method. The performance of ACLD system is determined and compared with PCLD in order to demonstrate the effectiveness of the ACLD treatment, Also, the actuation capability of a piezo actuator is examined experimentally by using various thickness of Viscoelastic Materials(VEM).

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Comparison of Methodologies for Typical Meteorological Data Generation for Seoul (서울지역의 표준기상데이터 산출방법론 비교)

  • Yoo, Ho-Chun;Park, So-Hee;Kim, Kyoung-Ryul
    • Journal of the Korean Solar Energy Society
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    • v.28 no.2
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    • pp.10-18
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    • 2008
  • This study aims to figure out typical meteorological data according to Korean time in order to evaluate building energy performance. Various methods of calculating typical meteorological data were compared and examined to improve accuracy and reliability of this study. This study analyzed and examined such methodologies as typical meteorological data for HASP/ACLD-8001, UK CIBSE TRY developed by CIBSE and prEN ISO 15927-4, (=ISO TRY) an international standard to evaluate annual energy demand of cooling and heating devices. In addition, actual data of KMA corresponding to Seoul in $1985{\sim}2005$ were statistically analyzed according to calculation methodology. The calculated typical meteorological data were compared te actual data using MBE, RMSE and t-Statistic. As a result, According to the comparison between average annual for HASP/ACLD-8001 and ISO TRY standard year, the average annual for HASP/ACLD-8001 is closer to actual measurement, showing that the use of typical meteorological data for HASP/ACLD-8001 is preferred. However, since the input format requested by current simulation is the same international standard as TRY. Therefore, it is necessary to improve accuracy of TRY calculation methodology and accordingly figure out Korean typical meteorological data based on average year.

Effectiveness of piezoelectric fiber reinforced composite laminate in active damping for smart structures

  • Chahar, Ravindra Singh;Ravi Kumar, B.
    • Steel and Composite Structures
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    • v.31 no.4
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    • pp.387-396
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    • 2019
  • This paper deals with the effect of ply orientation and control gain on tip transverse displacement of functionally graded beam layer for both active constrained layer damping (ACLD) and passive constrained layer damping (PCLD) system. The functionally graded beam is taken as host beam with a bonded viscoelastic layer in ACLD beam system. Piezoelectric fiber reinforced composite (PFRC) laminate is a constraining layer which acts as actuator through the velocity feedback control system. A finite element model has been developed to study actuation of the smart beam system. Fractional order derivative constitutive model is used for the viscoelastic constitutive equation. The control voltage required for ACLD treatment for various symmetric ply stacking sequences is highest in case of longitudinal orientation of fibers of PFRC laminate over other ply stacking sequences. Performance of symmetric and anti-symmetric ply laminates on damping characteristics has been investigated for smart beam system using time and frequency response plots. Symmetric and anti-symmetric ply laminates significantly reduce the amplitude of the vibration over the longitudinal orientation of fibers of PFRC laminate. The analysis reveals that the PFRC laminate can be used effectively for developing very light weight smart structures.

Dynamic Analysis of Plates with Active Constrained Layer Damping (능동구속층 감쇠를 이용한 판의 동역학적 해석)

  • 박철휴
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2004.05a
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    • pp.581-586
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    • 2004
  • This paper presents Newtonian formulation of the dynamics of plates treated fully with Active Constrained Layer Damping (ACLD). The developed equations of the plate/ACLD system provide analytical models far predicting the dynamic of laminated plates subjected to passive and active vibration damping controls. Numerical solutions of the analytical models are presented fir simply-supported plates in order to study the performance of the plate/ACLD system for different control strategies. The developed models present invaluable means for designing and predicting the performance of the smart laminated plates that can be used in many critical engineering applications.

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Vibration Analysis of the Active Multi-Layer Beams by Using Spectrally Formulated Exact Natural Modes

  • Lee, Usik;Kim, Joohong;Andrew Y. T. Leung
    • Journal of Mechanical Science and Technology
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    • v.15 no.2
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    • pp.199-209
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    • 2001
  • Modal analysis method (MAM) is introduced for the fully coupled structural dynamic problems. In this paper, the beam with active constrained layered damping (ACLD) treatment is considered as a representative problem. The ACLD beam consists of a viscoelastic layer that is sandwiched between the base beam structure and an active piezoelectric layer. The exact damped natural modes are spectrally formulated from a set of fully coupled dynamic equations of motion. The orthogonality property of the exact damped natural modes is then derived in a closed form to complete the modal analysis method. The accuracy of the present MAM is evaluated through some illustrative examples: the dynamic characteristics obtained by the present MAM are compared with the results by spectral element method (SEM) and finite element method (FEM). It is numerically proved that MAM solutions become identical to the accurate SEM solutions as the number of exact natural used in MAM is increased.

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Analysis and active control for wind induced vibration of beam with ACLD patch

  • Li, Jinqiang;Narita, Yoshihiro
    • Wind and Structures
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    • v.17 no.4
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    • pp.399-417
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    • 2013
  • The structural vibration suppression with active constrained layer damping (ACLD) was widely studied recently. However, the literature seldom concerned with the vibration control on flow-induced vibration using active constrained layer. In this paper the wind induced vibration of cantilevered beam is analyzed and suppressed by using random theory together with a velocity feedback control strategy. The piezoelectric material and frequency dependent viscoelastic layer are used to achieve effective active damping in the vibration control. The transverse displacement and velocity in time and frequency domains, as well as the power spectral density and the mean-square value of the transverse displacement and velocity, are formulated under wind pressure at variable control gain. It is observed from the numerical results that the wind induced vibration can be significantly suppressed by using a small outside active voltage on the constrained layer.

Synthesis and Physical Properties of New Biodegradable Polyester-Polypeptide Copolymer

  • Yong Kiel Sung;Chu
    • Journal of Biomedical Engineering Research
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    • v.13 no.2
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    • pp.147-154
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    • 1992
  • Poly (glycolic aclu-co-glycine-L-lactic aclu) has been prepared by rlng opening polymerlzation. The monomer 6-methyl morpholine-2, 5-dlone was synthe-slzed by bromoproplonylation of 2 bromopropionyl bromide with glycine. Glycolide and 6-methyl morpholine-2, 5-dione have been used as starling materials for polydepsipeptides. The synthesized copolymers have been Identlrled by NMR and FT-lR spectrophotometer. The Tg value of poly(glycollc aclu-co glycine-L-tactic acld ) Is In creased with increasing mole fraction of 6-methylmorpholine-2, 5-dlone(60-$84^{\circ}C$). The glass trasltion temperature of poly(glycolic acid-co-glycine-L-lactic-acid) (62-$86^{\circ}C$) is lower than that of poly (L-lactic acrid-co-glycine-L-lactic acid ). The thermal degradation of poly( L-lactic acid-co- glycine-L-lactic acid ) Is decreased with increasing mole fraction of L-lactide. The thermal degrada pion of poly(glycolic acrid-co-91ycine-L-lactic aclu ) is increased with increasing mole Fraction of glycolide.

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