• Journal of Life Science
• /
• v.31 no.11
• /
• pp.995-1003
• /
• 2021

Chromatin remodeling regulates gene expression through epigenetic mechanisms. Aberrations in histone modification have been associated with depression-like behaviors in animal models. Additionally, growing evidence also indicates that epigenetic modification is associated with depression. p11 (S100A10) has been implicated in the pathophysiology of depression both in human and rodent models. In the present study, we investigated alterations in histone acetylation and methylation at the promoter of the p11 gene in the hippocampus of mice subjected to chronic unpredictable stress (CUS). C57BL/6 mice were exposed to CUS daily for 3 weeks. Depression-like behaviors were measured with the forced swimming test (FST). The levels of hippocampal p11 expression were analyzed by quantitative real-time polymerase chain reaction (PCR) and Western blotting. The levels of acetylated and methylated histone H3 at the promoter of p11 were measured by chromatin immunoprecipitation followed by real-time PCR. CUS-exposed mice displayed depression-like behaviors with prolonged immobility in FST. CUS led to significant decreases in the expression of p11 at both protein and mRNA levels. Meanwhile, there was a decrease in histone H3 acetylation (Ac-H3) and H3-K4 trimethylation (H3K4met3) and an increase in H3-K27 trimethylation (H3K27met3) at the p11 promoter. These results indicate that chronic stress causes the epigenetic suppression of p11 expression in the hippocampus.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
• /
• 2008.11a
• /
• pp.465-470
• /
• 2008

This paper introduces experimental investigates of an electrical accident of the distributing cable termination with simulated badness construction. We prepared two termination kites, one is built-up type, the other is heat contraction type. Also, we manufactured cable termination that have simulated defect by badness construction and measured their insulation characteristics such as ac (35kV, 1min) and impulse (95kV, $1.2{\times}50{\mu}s$) withstand test. The influence of defects such as thickness and the gap between stress-con of housing and semi-conductor on insulating properties of the termination have been studied. The thickness decrease of insulator decreases ac breakdown strength. Dielectric breakdown traces of insulator that is damaged by knife displayed other shape. The gap of between housing and semiconductor deteriorates dielectric strength of insulator seriously.

• Progress in Superconductivity and Cryogenics
• /
• v.5 no.3
• /
• pp.48-51
• /
• 2003

HTS power transmission cable is expected to transport large electric power with a compact size. We are developing a 3-core, 22.9 kV, 50 MVA class HTS power cable, and each core consists of a conductor and shield wound with Bi-2223 tapes, electrical insulation with laminated polypropylene paper (LPP) impregnated with liquid nitrogen. This paper describes the design and experimental results of the model cable for the 22.9 kV, 50 MVA class HTS power transmission cable. The model cable was used the SUS tapes instead of HTS tapes because of testing the electrical characteristics only. The model cable was 1.3 m long and electrical insulation thickness was 4.5 mm. The model cable was evaluated the partial discharge (PD), AC and Impulse withstand voltage in liquid nitrogen. The AC and Impulse withstands voltage and PD inception stress was satisfied with the standard of Korea Electric Power Corporation (KEPCO) in the test results. The 3-core 22.9 kV, 50 MVA class HTS power cable has been designed and manufactured based on these experimental results.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2005.07b
• /
• pp.944-947
• /
• 2005

Highly stable gate driver circuit using a-Si TFT has been developed. The circuit has dual-pull down structure, in which bias stress to the TFTs is relieved by alternating applied voltage. The circuit has been successfully integrated in 4-in. QVGA and 14-in. XGA TFT-LCD with a normal a-Si process, which are stable for over 2,000 hours at $60^{\circ}C$. The enhancement of stability of the circuit is attributed to retarded degradation of pull-down TFTs by AC driving.

• Proceedings of the KIEE Conference
• /
• 1989.07a
• /
• pp.302-305
• /
• 1989

Ac, dc and impulse dielectric strengths of $LN_2$ at 0.1MPa were investigated experimentally, referring to the behavior of thermally induced bubble, which might be generated at quenching condition of immerged-cooling superconducting devices. The experimental results show that the bubble shape under electric field stress depends significantly on the applied voltage waveform. With ac voltage, the breakdown voltage of $LN_2$ falls suddenly near to one of the saturated gas at the threshold heater power of boiling onset. In control to this, the reduction of impulse breakdown voltage with heater peter is gradual and the time to breakdown depends on the existence of thermal bubble. These breakdown characteristics can be explained satisfactorily by the bubble behavior under electric fields.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.18 no.1
• /
• pp.54-62
• /
• 2013

This paper proposes a high-efficiency DC-DC converter with improved dynamic response characteristics for modular photovoltaic power conversion. High power efficiency is achieved by reducing switching power losses of the DC-DC converter. The voltage stress of power switches is reduced at primary side. Zero-current switching of output diodes is achieved at secondary side. A modified proportional and integral controller is suggested to improve the dynamic responses of the DC-DC converter. The performance of the proposed converter is verified based on a 200 [W] modular power conversion system including the grid-tied DC-AC inverter. The proposed DC-DC converter achieves the efficiency of 97.9 % at 60 [V] input voltage for a 200 [W] output power. The overall system including DC-DC converter and DC-AC inverter achieves the efficiency of 93.0 % when 200 [W] power is supplied into the grid.

• Proceedings of the KIEE Conference
• /
• 2002.07c
• /
• pp.1511-1514
• /
• 2002

This paper presents design and construct of flat type step-down piezoelectric transformer for the application to AC adaptor. This piezoelectric transformer operated in resonance vibration mode. In this paper, finite element method(FEM) was used for analysing piezoelectric transformers. Stress and electric field of the transformer were simulated at resonance frequency. Using this simulation results, we manufactured improved Rosen type piezoelecric transfomer and measured its output characteristics. As results, output power was linearly increased by increasing input power at resonance frequency and it was found that the transformer an invariable output power for input power. From these results, we expect that this piezoelecric transfomer can be applied to small size and low capacitive AC adaptor.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.20 no.4
• /
• pp.337-343
• /
• 2015

The multi-level inverters are highly efficient for high-power and medium-voltage AC driving applications, such as high-speed railway systems and renewable energy resources, because such inverters generate lower total harmonic distortion (THD) and electromagnetic interface (EMI). Lower switching stress occurs on switching devices compared with conventional two-level inverters. Depending on the multi-level inverter topology, the required components and number of switching devices are different, influencing the overall efficiency. Comparative studies of multi-level inverters based on loss analysis and output characteristic are necessary to apply multi-level inverters in high-power AC conversion systems. This paper proposes a theoretical loss analysis method based on piecewise linearization of characteristic curves of power semiconductor devices as well as loss analysis and output performance comparison of five-level neutral-point clamped, flying capacitor inverters, and high-level cascaded H-bridge multi-level inverters.

• Journal of Korea Foundry Society
• /
• v.40 no.3
• /
• pp.85-96
• /
• 2020

The effect of an aluminum scrap addition ratio on the tensile and solidification cracking properties of the AC4A aluminum alloy in the as-cast state and heat-treated state were investigated in this study. Generally, the expected problem of using scrap in aluminum casting is an increase of hydrogen and Fe element inside the aluminum melt. Another issue is an oxide film which has a weak interface with the molten aluminum and acts as potent nucleation sites for internal porosity and crack initiation. Solidification cracking is one of the critical defects that must be resolved to produce high quality castings. A conventional evaluation method for solidification cracking is a relative and qualitative analysis method which does not provide quantitative data on the thermal stress in the solidification process. Therefore, a newly designed solidification cracking test apparatus was used in this study, and the device can provide quantitative data. As a result, after conducting experiments with different scrap addition ratios (0%, 20%, 35%, 50%), the tensile strengths and elongations in the as-cast state were 214, 187.7, 182.1 and 170.4MPa and 4.6%, 3.4%, 3.1% and 2.3%, respectively. In the case of the T6 heat-treated state, the tensile strengths and elongations were 314.9, 294.6, 293.1 and 271.1MPa and 5.4%, 4.6%, 3.8% and 3.1%, respectively. The strength of the solidification cracking was 3.1, 2.4, 2.2and 1.6MPa as the scrap addition ratio increases.

• The Korea Journal of Herbology
• /
• v.39 no.1
• /
• pp.39-47
• /
• 2024

Objectives : This study evaluates how various traditional Korean herbal medicines assess MUC5AC expression for esophageal mucosal defense and analyzes the associated mechanisms involved in inflammation. Methods : Forty types of traditional Korean herbal medicines were assessed for in vitro antioxidant activities, and the real-time PCR method was employed to analyze MUC5AC expression under pH 4.5 conditions in human esophageal epithelial cells (HET-1A). Eight types of Korean herbal medicines were evaluated for in vitro antioxidant activities, and Reactive oxygen specise (ROS) expression was analyzed under bile salt (480 𝜇M) and pH 5.5 conditions in human esophageal epithelial cells (HET-1A). Simulation experiments involving bile salts and acidity were conducted for one hour to assess the efficacy of four drugs, and the activities of Mitogen-activated Protein Kinase (MEK), Nuclear Factor Kappa B (NF-𝜅B), and Cyclooxygenase-2 (COX-2) were detected through Western blot analysis. Results : Compared to the Normal group, the Control group exhibited higher ROS generation. Such increased ROS levels were significantly reduced by four extracts: Citrus Unshius Pericarpium (CUP), Cnidium officinale Rhizoma (CR), Ginseng Radix (GR), and Linderae Radix (LR). The protein expression of COX-2 decreased with the treatment of LR, CUP, and CR. Particularly, CUP and CR exhibited superior effects compared to other groups in inhibiting the phosphorylation of NF-𝜅B. Conclusion : Based on the results obtained, we have identified drugs that inhibit oxidative stress and inflammation caused by bile acid in esophageal epithelial cells. Our future plans involve comparing and analyzing the efficacy of these herbal medicines through animal experiments.