• Molecules and Cells
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• v.46 no.7
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• pp.420-429
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• 2023

Age-related macular degeneration (AMD) is one of the leading causes of blindness in elderly individuals. However, the currently used intravitreal injections of anti-vascular endothelial growth factor are invasive, and repetitive injections are also accompanied by a risk of intraocular infection. The pathogenic mechanism of AMD is still not completely understood, but a multifactorial mechanism that combines genetic predisposition and environmental factors, including cellular senescence, has been suggested. Cellular senescence refers to the accumulation of cells that stop dividing due to the presence of free radicals and DNA damage. Characteristics of senescent cells include nuclear hypertrophy, increased levels of cell cycle inhibitors such as p16 and p21, and resistance to apoptosis. Senolytic drugs remove senescent cells by targeting the main characteristics of these cells. One of the senolytic drugs, ABT-263, which inhibits the antiapoptotic functions of Bcl-2 and Bcl-xL, may be a new treatment for AMD patients because it targets senescent retinal pigment epithelium (RPE) cells. We proved that it selectively kills doxorubicin (Dox)-induced senescent ARPE-19 cells by activating apoptosis. By removing senescent cells, the expression of inflammatory cytokines was reduced, and the proliferation of the remaining cells was increased. When ABT-263 was orally administered to the mouse model of senescent RPE cells induced by Dox, we confirmed that senescent RPE cells were selectively removed and retinal degeneration was alleviated. Therefore, we suggest that ABT-263, which removes senescent RPE cells through its senolytic effect, has the potential to be the first orally administered senolytic drug for the treatment of AMD.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.3
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• pp.263-270
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• 2014

PURPOSE: The purpose of this study was to examine the immediate changes in the weight-bearing ankle dorsiflexion range of motion (ROM) and the dynamic balance in asymptomatic subjects using the modified Star Excursion Balance Test (SEBT) after ankle balance taping (ABT) and placebo ABT with kinesiology tape METHODS: A total of 23 active participants (11 men, 12 women) volunteered for this study. Ankle flexibility was assessed using the weight-bearing lunge test, and dynamic balance was assessed using the modified SEBT. Participants were asked to respond to questions regarding their perception of stability, reassurance, and confidence when performing modified SEBT. RESULTS: The weight-bearing ankle dorsiflexion ROM did not show a significant decrease after real ABT or placebo ABT compared to the ROM prior to ABT. The anterior, posterolateral, and posteromedial reach distances of SEBT did not increase significantly after real ABT or placebo ABT compared to the distances prior to ABT. However, the participants' perception of stability, reassurance, and confidence, when performing SEBT with real ABT, was increased compared to that during the control trial. CONCLUSION: This study showed that although real ABT did not immediately improve the reach distances in the 3 directions during modified SEBT, it improved the participants' perception of stability, reassurance, and confidence without decreasing weight-bearing ankle dorsiflexion ROM.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.263-263
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• 2022

물봉선속(Impatiens L.)은 일년생 또는 다년생 초본으로 우리나라에 5-7종이 분포한다. 물봉선의 화장품용 항산화제 및 천연 방부제로서의 유용성이 밝혀졌으며, 최근 항염, 항산화 등 생리활성에 대한 연구가 국내 자생하는 물봉선 및 노랑물봉선을 대상으로 수행된 바 있으나 이하 분류군에 대한 연구는 미비한 실정이다. 본 연구에서는 국내 자생하는 물봉선속 분류군들의 항산화활성과 생리 활성물질의 함량을 분석하고 지역 간 분류군별 차이를 확인하고자 하였다. 따라서 국내 자생하는 물봉선속 분류군들의 항산화활성을 검정하기 위하여 DPPH, ABTS, TPC, TFC 4가지 방법을 이용하여 분석하였다. 국내 자생하는 물봉선속 5분류군 가야물봉선(Impatiens atrosanguinea (Nakai) B.U.Oh & Y.P.Hong), 노랑물봉선(Impatiens noli-tangere L), 물봉선(Impatiens textorii Miq), 미색물봉선(Impatiens noli-tangere var. pallescens Nakai), 처진물봉선(Impatiens furcillata Hemsl)이 12개 지역에서 수집되었으며, 잎 추출물(70% 에탄올)에 대해 분석되었다. 물봉선속 분류군들의 잎 추출물의 DPPH 라디칼 소거 활성 검정 결과 가야물봉선(4.91 ± 3.00 mgAAE/g)이 가장 높았고 처진물봉선(1.77 ± 0.55 mgAAE/g)이 가장 낮았으며, ABTS의 경우 가야물봉선(3.14 ± 1.35 mgAAE/g)로 가장 높았고 미색물봉선(1.87 ± 0.16 mgAAE/g)이 가장 낮았다. TPC의 경우 미색물봉선(5.48 ± 1.05 ugGAE)이 가장 높았고 노랑물봉선(2.78 ± 1.98 ugGAE)이 가장 낮았으며, TFC의 경우 물봉선(0.70 ± 0.20 ugGAE/g)이 가장 높았고 노랑물봉선(0.45 ± 0.08 ugGAE/g)이 가장 낮게 나타났다. 수집지역별로는 각각 DPPH와 ABTS의 경우 노랑물봉선, TPC의 경우 가야물봉선, 노랑물봉선, 물봉선, TFC의 경우 처진물봉선이 지역별 차이를 보였다. 이번 연구 결과를 토대로 국내 자생하는 물봉선속 분류군 별 항산화활성과 생리활성물질 차이를 확인할 수 있었고 추후 유용 소재로써의 이용과 우수 개체선발에 도움이 될 것으로 사료 된다.