• Toxicological Research
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• v.31 no.2
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• pp.165-172
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• 2015

Cornus officinalis is widely distributed in Korea, and its fruit has been used to make as herbal drug for traditional medicine in Korea, Japan, and China because of its tonic, analgesic, and diuretic properties. However, the effects of C. officinalis methanol extract (COME) on melanogenesis remain poorly understood. We evaluated the melanogenic capability of COME in melan-a cells, which are immortalized mouse melanocytes. COME increased melanin synthesis in a dose-dependent manner. Treatment with $12.5{\mu}g/mL$ of COME significantly increased melanin content by 36.1% (p < 0.001) to a level even higher than that (31.6%) of 3-isobutyl-1-methyl-xanthine, a well-known pigmentation agent. COME also upregulated tyrosinase activity and its messenger RNA and protein expression. In addition, COME upregulated the expression of tyrosinase-related proteins 1 and 2 and microphthalmia-associated transcription factor-M messenger RNA expression. These results imply that COME may be appropriate for development as a natural product to treat hair graying.

• Korean Journal of Environmental Agriculture
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• v.12 no.2
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• pp.169-175
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• 1993

O-Ethyl S-methyl ethylphosphonothioate was studied for chemical and metabolic oxidation using $^{31}P-NMR$ analyses. The chemical shifts of O-ethyl ethylphosphonic acid (2) which is one of major metabolites were changed with the variation of oxidation systems. $^{31}P-NMR$ chemical shifts of 2 were observed at 40.15ppm from oxidaton by MCPBA, 30.98 ppm by MMPP, 29.31 ppm from in vitro rat liver microsomal oxidation, and 29.10 ppm from in vivo metabolism in houseflies. $^{31}P-NMR$ chemical shift of 2 in two different solvents such as deutero-chloroform and deuterium oxide were observed at 30.70 ppm and 40.15 ppm, respectively. And those of the metabolites were also observed at around 30 ppm under the conditions of pH 3, 5.6 and 14 and 47.91 ppm under pH 1 which is a strong acidic condition. It could be explained that the ionized form of 2 should have greater shielding effect on phosphorus atom and hence shows upfield chemical shift in polar solvents and alkaline conditions. On the other hand, a protonated form under organic solvents and the strong acidic condition should have less shielding effect than its ionized form, shifting the peak downfield.

• Journal of the Korean Society of Physical Medicine
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• v.6 no.2
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• pp.177-187
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• 2011

Purpose: The purpose of this study was to identify the effect of emotional suppression and burnout on the job satisfaction. Methods: We distributed questionnaires to 216 physical therapists and collected completed questionnaires from 193. We analyzed the data using frequency analysis, independent t-tests, analysis of variance. and multiple regression. Results: The results were as follows; 1) General characteristics of participants were 62.7% male, 43.5% less 30 years old, 31.6% working over 10 years in the hospital. 27.1% participants treated 31 patients or more a day, most(85.5%) participants were regular staff members. 2) Emotional Suppression, exhaustion and diminished self-efficacy were significantly correlated with job satisfaction. According to result of regression analysis on the job satisfaction, the job satisfaction negatively related with the diminished self-efficacy, exhaustion but positively related with the emotional supression. Their power of explanation regarding job satisfaction was 31.2%. Conclusion: These results showed that diminished self-efficacy was importantly influenced on the job satisfaction. So this result of the study means that we must improve the stratege for keeping efficient management.

• Structural Engineering and Mechanics
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• v.31 no.6
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• pp.717-735
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• 2009

The present problem is concerned with the study of deformation of micropolar thermoelastic medium with voids under the influence of various sources acting on the plane surface. The analytic expressions of displacement components, force stress, couple stress, change in volume fraction field and temperature distribution are obtained in the transformed domain for Lord-Shulman (L-S) theory of thermoelasticity after applying the integral transforms. A numerical inversion technique has been applied to obtain the solution in the physical domain. The numerical results are presented graphically. Some useful particular cases have also been deduced.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1995.11a
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• pp.44-47
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• 1995

In this study, dielectric and piezoelectric properties of 0.4[0.1Bi(Ni$\_$1/2/Ti$\_$1/2/)O$_3$0.9Pb(Ni$\_$1/3/Nb$\_$2/3/)O$_3$]-0.6(PbZr$\_$y/Ti$\_$1-y/)O$_3$ceramics with Zr/Ti ratio were observed. As a results, structure of the ceramics with ZrO$_2$(y) 0.425 and 0.45 was MPB. Electromechanical coupling coefficients k$\_$p/, k$\_$31/ of the BN$\_$162/ specimen were 57.2%, 35.6% and piezoelectric constants d$\_$33/, d$\_$31/ were 720, 298[x10$\_$-12/C/N).

• Journal of Korean Society for Atmospheric Environment
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• v.31 no.6
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• pp.520-529
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• 2015

The ambient $PM_{2.5}$ samples were collected by $PM_{2.5}$ sampler from September 2010 to December 2012 at Daegu University, Gyeongsan. A total of 260 samples were collected and 27 species were analyzed by inductively coupled plasma, ion chromatography, and thermal optical reflectance methods. Factor analysis identified four sources such as biomass burning source/secondary aerosol source, soil source, industry source, and incinerator source/mobile source. Also, backward trajectories were calculated using HYSPLIT 4 (Hybrid single-particle lagrangian integrated trajectory) model and PSCF (Potential source contribution function) model was applied to identify the possible source locations of carbonaceous species and water soluble ions species. PSCF results showed that the possible source locations of most chemical constituents measured in Gyeongsan were the industrial areas in the eastern coast of China, northeast regions of China, the Gobi Desert, and east sea of Korea.

• Journal of Korean Society on Water Environment
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• v.31 no.6
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• pp.632-636
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• 2015

This study aims to evaluate arsenic adsorption efficiencies over various metal oxides (CeO₂, TiO₂, Fe₃O₄, ZrO₂, AlOOH, SiO₂, α-Al₂O₃, and γ-Al₂O₃) and investigate the correlation between physico-chemical characteristics of metal oxides and their efficiencies. From XPS, XRD BET analysis and isotherm adsorption test, TiO₂ powder showed that the best adsorption efficiency, and it's mechanism was highly depended on the chemical adsorption.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.10 no.6
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• pp.62-69
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• 2007

This study has been carried out to estimate aboveground carbon contents in an average 30-years-old Betula platyphylla and 32-years-old Juglans mandshurica stands in Chungju, Chungbuk Province. Nine sample trees were cut in each forest and soil samples were collected. Carbon concentration in stemwood, stembark, branch, and foliage were ranged from 54.6% to 57.0% in Betula platyphylla and 53.5% to 56.9% in Juglans mandshurica stands. Aboveground carbon contents was estimated by the equation model logWt=A+BlogD where Wt is oven-dry weight in kg and D is DBH in cm. Total aboveground carbon contents was 34.31t/ha in Betula platyphylla stand and 21.10t/ha in Juglans mandshurica stand. Aboveground net primary carbon production was estimated at 2.31t/ha/yr in Betula platyphylla stand and 2.03t/ha/yr in Juglans mandshurica stand.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3318-3326
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• 2010

Five new series of 3,4-ethylenedioxythiophene derivatives carrying important pharamacophores, viz., amide, ester, ether and active secondary aryl moieties have been designed and synthesized through multistep reactions starting from thiodiglycolic ester and diethyl oxalate. They have been characterized by elemental and spectral data. All the target compounds have been screened for their anticonvulsant activity at three different models viz. maximal electroshock (MES), subcutaneous metrazole (scMET), and 6 Hz screen and evaluated for their neurotoxicity in rotorod model. Compound 6a emerged as lead with no neurotoxicity. All the five series of compounds are safe in the toxicity studies at the maximum dose of 300 mg/kg of body weight. Amongst the tested compounds, the ester pharmacophore with thioamide fragment has showed better activity than the other analogs.

• Journal of the Chungcheong Mathematical Society
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• v.31 no.4
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• pp.369-379
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• 2018

Let ${\mathbb{H}}_3$ be the 3-dimensional Heisenberg group equipped with a left-invariant metric. In this paper we calculate the volumes of geodesic balls in ${\mathbb{H}}_3$. Let $B_e(R)$ be the geodesic ball with center e (the identity of ${\mathbb{H}}_3$) and radius R in ${\mathbb{H}}_3$. Then, the volume of $B_e(R)$ is given by $$Vol(B_e(R))={\frac{\pi}{6}}\{-16R+(R^2+6){\sin}\;R+(R^3+10R){\cos}\;R+(R^4+12R^2){\int\nolimits_0^R}\;{\frac{{\sin}\;t}{t}}dt\}$$.